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  1. AU="Hammad, Maha O"
  2. AU="Jelińska, Anna"
  3. AU="Socarrás, Moisés Rodríguez"
  4. AU="Kwon, Sun-Jung"
  5. AU="Losa Garcia, Juan Emilio"
  6. AU="Ortiz, Jesús"
  7. AU="Kallio, Merja"
  8. AU="Nicola Cirillo"
  9. AU="Lee, Hyung Chul"
  10. AU="Luo, Anping"
  11. AU="Kuosmanen, Pekka"
  12. AU=Wu Feng
  13. AU="Mufti, Hani N"
  14. AU="Przyborski, Stefan"
  15. AU="Helio Garcia Leite"
  16. AU="Chang, Yi-Yao"
  17. AU="Ren, Xiangzhong"
  18. AU="Ha, Van Thi Cam"
  19. AU="Zheng, Jinhong"
  20. AU="Tomatis-Souverbielle, Cristiana"
  21. AU="Al-Jumaily, Adel A"
  22. AU="Marallo, Carmine"
  23. AU="Alshammari, Afraj"
  24. AU="Min, Dong-Joon"
  25. AU=Fattorini Daniele AU=Fattorini Daniele
  26. AU="Lou, L X"
  27. AU="Yadollah Haji-Heydari"
  28. AU="Placidi, A"
  29. AU="Olivé, Claudia"
  30. AU="Türk, Y"
  31. AU="Brosnan, Hannah"
  32. AU="Hardy, Rowan S"
  33. AU="Demirci, Yılmaz Mehmet"
  34. AU="Dlugosz, Andrzej A"

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  1. Artikel ; Online: The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: A retrospective cohort study.

    Hammad, Maha O / Alseoudy, Mahmoud M

    Primary care diabetes

    2021  Band 15, Heft 4, Seite(n) 713–718

    Abstract: Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.: Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were ... ...

    Abstract Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.
    Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression.
    Results: Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO
    Conclusion: In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males.
    Mesh-Begriff(e) Age Factors ; Aged ; Alanine Transaminase/blood ; Bilirubin/blood ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/mortality ; Female ; Health Status Disparities ; Humans ; Lymphocyte Count ; Lymphocytes/metabolism ; Male ; Mean Platelet Volume ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sex Factors
    Chemische Substanzen Biomarkers ; C-Reactive Protein (9007-41-4) ; Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49)
    Sprache Englisch
    Erscheinungsdatum 2021-05-12
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2021.05.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Artemisinin attenuates type 2 diabetic cardiomyopathy in rats through modulation of AGE-RAGE/HMGB-1 signaling pathway.

    Farrag, Eman A E / Hammad, Maha O / Safwat, Sally M / Hamed, Shereen / Hellal, Doaa

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 11043

    Abstract: Diabetes mellitus is a common metabolic disorder. About two-thirds of diabetic patients develop diabetic cardiomyopathy (DCM), which becomes a challenging issue as it severely threatens the patient's life. Hyperglycemia and the resulting advanced ... ...

    Abstract Diabetes mellitus is a common metabolic disorder. About two-thirds of diabetic patients develop diabetic cardiomyopathy (DCM), which becomes a challenging issue as it severely threatens the patient's life. Hyperglycemia and the resulting advanced glycated end products (AGE) and their receptor (RAGE)/High Mobility Group Box-1 (HMGB-1) molecular pathway are thought to be key players. Recently, artemisinin (ART) has gained more attention owing to its potent biological activities beyond its antimalarial effect. Herein, we aim to evaluate the effect of ART on DCM and the possible underlying mechanisms. Twenty-four male Sprague-Dawley rats were divided into: control, ART, type 2 diabetic and type 2 diabetic treated with ART groups. At the end of the research, the ECG was recorded, then the heart weight to body weight (HW/BW) ratio, fasting blood glucose, serum insulin and HOMA-IR were evaluated. Cardiac biomarkers (CK-MB and LDH), oxidative stress markers, IL-1β, AGE, RAGE and HMGB-1 expression were also measured. The heart specimens were stained for H&E as well as Masson's trichrome. DCM induced disturbances in all studied parameters; contrary to this, ART improved these insults. Our study concluded that ART could improve DCM through modulation of the AGE-RAGE/HMGB-1 signaling pathway, with subsequent impacts on oxidative stress, inflammation and fibrosis. ART could therefore be a promising therapy for the management of DCM.
    Mesh-Begriff(e) Rats ; Male ; Animals ; Diabetic Cardiomyopathies/drug therapy ; Diabetic Cardiomyopathies/metabolism ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Receptor for Advanced Glycation End Products/metabolism ; Signal Transduction ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; HMGB Proteins/metabolism
    Chemische Substanzen Receptor for Advanced Glycation End Products ; Artemisinins ; HMGB Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-07-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37678-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study.

    Hammad, Maha O / Alseoudy, Mahmoud M / Borg, Asmaa M / El-Mesery, Ahmed / Elgamal, Mohamed / Abdelghany, Dalia A / Elzeiny, Dina

    Cytokine

    2024  Band 176, Seite(n) 156500

    Abstract: Introduction: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant ...

    Abstract Introduction: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant data on the potential role of IFN-λ1/IL-29 in COVID-19, we investigated the association of IFN-λ1/IL-29 serum level and the IFNL1 single-nucleotide polymorphism (SNP) (rs30461) with severe course of COVID-19.
    Material and methods: This cross-sectional study included 400 COVID-19 patients, in which 262 mild COVID-19 patients and 138 severe COVID-19 patients were recruited and compared. The IFN-λ1/IL-29 serum levels were assessed in both the mild and severe COVID-19 groups. All participants were genotyped for the IFNL1 SNP (rs30461) by allelic discrimination RT-PCR using specific Taqman probes and primers. The associations between IFNL1 variants and risk of severe COVID-19 were examined via the logistic regression analysis.
    Results: The serum IFN-λ1/IL-29 levels showed no statistically significant difference between mild and severe COVID-19 patients (P = 0.993). The genotype and allele frequencies of IFNL1 SNP (rs30461) were significantly different between the mild and severe groups, in which the minor G allele carried a highly significant risk of severe COVID-19 compared with the wild A allele [OR (95 %CI): 2.1 (1.5-2.9), P ≤ 0.001]. In multivariate analysis, the A/G and G/G genotypes of IFNL1 SNP (rs30461) were independent predictors of COVID-19 severity (P < 0.05).
    Conclusion: The study concluded that the IFNL1 SNP (rs30461) may constitute an independent risk factor for COVID-19 severity.
    Mesh-Begriff(e) Humans ; COVID-19/genetics ; Cross-Sectional Studies ; Cytokines ; Interferons/genetics ; Interleukins/genetics ; Risk Factors
    Chemische Substanzen Cytokines ; Interferons (9008-11-1) ; Interleukins ; interferon-lambda, human
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2024.156500
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2840: Hefte anzeigen Standort:
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  4. Artikel ; Online: Probiotics Attenuate Myopathic Changes in Aging Rats via Activation of the Myogenic Stellate Cells.

    Abdel-Halim, Nehal H M / Farrag, Eman A E / Hammad, Maha O / Habotta, Ola Ali / Hassan, Hend M

    Probiotics and antimicrobial proteins

    2023  

    Abstract: Aging represents a complex biological process associated with decline in skeletal muscle functions. Aging impairs satellite cells that serve as muscle progenitor cells. Probiotic supplementation may have many beneficial effects via various mechanisms. We ...

    Abstract Aging represents a complex biological process associated with decline in skeletal muscle functions. Aging impairs satellite cells that serve as muscle progenitor cells. Probiotic supplementation may have many beneficial effects via various mechanisms. We examined the possible effects of probiotics in stimulating the proliferation of myogenic stellate cells in aging rats. Twenty-four male albino Sprague-Dawley rats were classified equally into four groups: adult control, old control, adult + probiotics, and old + probiotics. Probiotics (Lactobacillus LB) were administered gavage at a dose of 1 ml (1 × 10
    Sprache Englisch
    Erscheinungsdatum 2023-12-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-023-10202-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study.

    Alseoudy, Mahmoud M / Elgamal, Mohamed / Abdelghany, Dalia A / Borg, Asmaa M / El-Mesery, Ahmed / Elzeiny, Dina / Hammad, Maha O

    Clinical immunology (Orlando, Fla.)

    2022  Band 235, Seite(n) 108929

    Abstract: Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the ... ...

    Abstract Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia accompanying SARS-COV-2 infection. This case-control study included 236 individuals: 136 COVID-19 pneumonia patients and 100 age and sex-matched controls. Two polymorphisms (TLR3 rs3775290 and TLR7 rs179008) were genotyped by allelic discrimination through TaqMan real-time PCR. This study also investigated predictors of mortality in COVID-19 pneumonia through logistic regression. The mutant 'T/T' genotypes and the 'T' alleles of TLR3(rs3775290) and TLR7(rs179008) polymorphisms were significantly associated with increased risk of COVID-19 pneumonia. This study did not report association between the mutant 'T/T' genotypes of TLR3(rs3775290) and TLR7(rs179008) and the disease outcome. In multivariate analysis, the independent predictors of mortality in COVID-19 pneumonia were male sex, SPO
    Mesh-Begriff(e) Aged ; Alleles ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/virology ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Middle Aged ; Pneumonia/diagnosis ; Pneumonia/genetics ; Pneumonia/virology ; Polymorphism, Single Nucleotide ; Prognosis ; ROC Curve ; Risk Factors ; SARS-CoV-2/physiology ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 7/genetics
    Chemische Substanzen TLR3 protein, human ; Toll-Like Receptor 3 ; Toll-Like Receptor 7
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.108929
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 880: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Artikel: Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and

    Hassan, Hend M / Abdel-Halim, Nehal H M / El-Shenbaby, Ibrahim / Helmy, Manar A / Hammad, Maha O / Habotta, Ola A / El Nashar, Eman M / Alghamdi, Mansour A / Aldahhan, Rashid A / Al-Khater, Khulood M / Almohaywi, Basmah / Farrag, Eman A E

    Frontiers in pharmacology

    2024  Band 15, Seite(n) 1384834

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1384834
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  7. Artikel ; Online: Significance of CEP78 and WDR62 gene expressions in differentiated thyroid carcinoma: Possible predictors of lateral lymph node metastasis.

    Hammad, Maha O / Elabbasy, Lamiaa M / Abd Elghaffar, Mahmoud A / Zaki, Marwa M A / Bazeed, Fagr B / Zahran, Mohammed A

    Asia-Pacific journal of clinical oncology

    2019  Band 15, Heft 5, Seite(n) e154–e161

    Abstract: Objectives: This study aimed at investigating the clinical significance of CEP78 and WDR62 in differentiated thyroid carcinoma (DTC). This study also aimed at finding predictors that help in detecting patients with DTC who have high risk for lateral ... ...

    Abstract Objectives: This study aimed at investigating the clinical significance of CEP78 and WDR62 in differentiated thyroid carcinoma (DTC). This study also aimed at finding predictors that help in detecting patients with DTC who have high risk for lateral lymph node metastasis (LNM).
    Methods: Quantitative real-time polymerase chain reaction (RT-qPCR) was performed to examine CEP78, and WDR62 mRNA expressions in 40 tissue specimens of DTC, and 40 goiter tissue specimens. Additionally, we reviewed clinical, ultrasound, laboratory, pathological data of patients to analyze the associations between these characteristics and lateral LNM.
    Results: Our results demonstrated that relative CEP78 mRNA levels were significantly decreased in thyroid cancer tissues than goiter tissues (P = 0.002). ROC curve analysis confirmed the diagnostic value of CEP78 mRNA expression, providing an AUC equals to 0.698 (95% confidence intervals (CI), 0.583-0.813; P = 0.002). The relative WDR62 mRNA expression was not statistically different in DTC tissues and goiter tissues (P = 0.686). Furthermore, the DTC patients had been included to examine risk factors for lateral LNM. In multivariate analysis, the significant factors for predicting lateral LNM were low CEP78 mRNA expression (cut off value ≤0.54; P = 0.03; OR = 19.62; 95% CI, 1.3-296.23), central LNM (P = 0.011; OR = 33.6; 95% CI, 2.24-503.6) and calcifications (P = 0.023; OR = 27.187; 95% CI, 1.57-469.5).
    Conclusions: CEP78 can be used as a promising molecular biomarker for differentiation between DTC and goiter tissues, in addition it might serve as a predictor of lateral LNM in DTC along with central LNM and calcifications. Unlike CEP78, WDR62 mRNA expression was not statistically different in DTC and goiter.
    Mesh-Begriff(e) Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/secondary ; Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/metabolism ; Adenocarcinoma, Follicular/secondary ; Adult ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/metabolism ; Carcinoma, Papillary/secondary ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Predictive Value of Tests ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; ROC Curve ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Risk Factors ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology
    Chemische Substanzen Biomarkers, Tumor ; CEP78 protein, human ; Cell Cycle Proteins ; Nerve Tissue Proteins ; RNA, Messenger ; WDR62 protein, human
    Sprache Englisch
    Erscheinungsdatum 2019-03-18
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13143
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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