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  1. Book: Biochemie light

    Rehm, Hubert / Hammar, Friederike

    2008  

    Author's details Hubert Rehm ; Friederike Hammar
    Keywords Biochemie
    Subject Biologische Chemie
    Language German
    Size VIII, II, 142 S. : zahlr. Ill. und graph. Darst.
    Edition 4., korrigierte Aufl.
    Publisher Deutsch
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book
    HBZ-ID HT015417405
    ISBN 978-3-8171-1819-9 ; 3-8171-1819-8
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Biochemie light

    Rehm, Hubert / Hammar, Friederike

    1999  

    Author's details Hubert Rehm ; Friederike Hammar
    Keywords Biochemie
    Subject Biologische Chemie
    Language German
    Size 99 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Deutsch
    Publishing place Thun u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT010728254
    ISBN 3-8171-1554-7 ; 978-3-8171-1554-9
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Biochemie light

    Rehm, Hubert / Hammar, Friederike

    2013  

    Author's details Hubert Rehm; Friederike Hammar
    Keywords Biochemie
    Language German
    Size VIII, II, 175 S., 230 mm x 160 mm
    Edition 5., korr. u. erw. Aufl.
    Publisher Deutsch
    Publishing place Frankfurt am Main
    Document type Book
    Note Früher mit der Nummer 9783817117673
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Biochemie light

    Rehm, Hubert / Hammar, Friederike

    (Edition Harri Deutsch ; Europa-Lehrmittel)

    2013  

    Author's details Hubert Rehm ; Friederike Hammar
    Series title Edition Harri Deutsch
    Europa-Lehrmittel
    Keywords Biochemie
    Language German
    Size VIII, II, 175 S., Ill., graph. Darst., 302 g
    Edition 5., korrigierte und erw. Aufl.
    Publisher Verl. Europa-Lehrmittel Nourney, Vollmer
    Publishing place Haan-Gruiten
    Document type Book
    ISBN 3808554436 ; 9783808554432
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: History of modern genetics in Germany.

    Hammar, Friederike

    Advances in biochemical engineering/biotechnology

    2001  Volume 75, Page(s) 1–29

    Abstract: The history of modern genetics in Germany during the 20th century is a story of missed chances. In the USA the genetic revolution opened a fascinating new field for ambitious scientists and created a rapidly growing new industry. Meanwhile Germany stood ... ...

    Abstract The history of modern genetics in Germany during the 20th century is a story of missed chances. In the USA the genetic revolution opened a fascinating new field for ambitious scientists and created a rapidly growing new industry. Meanwhile Germany stood aside, combating with political and social restrictions. Promising young scientists who wanted to work in the field left Germany for the US, and big companies moved their facilities out of the country. Up until the middle of the 1990s molecular biology in Germany remained a "sleeping beauty" even though many brilliant scientists did their jobs very well. Then a somewhat funny idea changed everything: the German minister for education and science proclaimed the BioRegio contest in order to award the most powerful biotechnology region in Germany concerning academia and especially industry. Since then Germany's biotechnology industry has grown constantly and rapidly due to the foundation of a number of small biotech companies; big companies have returned their interests and their investments to Germany, paralleled by an improvement in academic research because of more funding and better support especially for younger scientists. In respect to biotechnology and molecular biology, Germany is still a developing country, but it has started to move and to take its chances in an exciting global competition.
    MeSH term(s) Agriculture/trends ; Animals ; Biotechnology/history ; Drug Industry/history ; Ethics, Medical ; Forecasting ; Genetic Engineering/history ; Genetic Testing/history ; Genetics/history ; Genetics/trends ; Germany ; History, 19th Century ; History, 20th Century ; Human Genome Project/history ; Humans ; Molecular Biology/history ; Patents as Topic ; Societies, Scientific/history
    Language English
    Publishing date 2001-12-06
    Publishing country Germany
    Document type Historical Article ; Journal Article
    ISSN 0724-6145
    ISSN 0724-6145
    DOI 10.1007/3-540-44604-4_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Standardisation of PR3-ANCA and MPO-ANCA: evaluation of certified reference materials.

    Bossuyt, Xavier / Dillaerts, Doreen / Mahler, Michael / Roggenbuch, Dirk / Leinfelder, Ulrich / Hammar, Friederike / Schlumberger, Wolfgang / Olschowka, Nina / Damoiseaux, Jan

    Annals of the rheumatic diseases

    2020  Volume 79, Issue 11, Page(s) 1520–1522

    MeSH term(s) Antibodies, Antineutrophil Cytoplasmic/blood ; Autoantigens/immunology ; Granulomatosis with Polyangiitis/blood ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/immunology ; Humans ; Immunoassay/standards ; Myeloblastin/immunology ; Peroxidase/immunology ; Reference Standards
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Autoantigens ; MPO protein, human (EC 1.11.1.7) ; Peroxidase (EC 1.11.1.7) ; Myeloblastin (EC 3.4.21.76)
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Automated Fecal Biomarker Profiling - a Convenient Procedure to Support Diagnosis for Patients with Inflammatory Bowel Diseases.

    Kraemer, Anette / Bulgakova, Tatiana / Schukina, Oksana / Kharitidis, Aleksandra / Kharitonov, Andrei / Korostovtseva, Ekaterina / Hammar, Friederike / Bang, Holger / Lapin, Sergey

    Clinical laboratory

    2020  Volume 66, Issue 7

    Abstract: Background: Fecal calprotectin is a valuable non-invasive marker for intestinal inflammation and contributes to the selection of patients with suspected inflammatory bowel disease (IBD) for endoscopy. The aim of this study was to evaluate the ... ...

    Abstract Background: Fecal calprotectin is a valuable non-invasive marker for intestinal inflammation and contributes to the selection of patients with suspected inflammatory bowel disease (IBD) for endoscopy. The aim of this study was to evaluate the performance of three automated immunoassays for fecal calprotectin (FC), fecal lactoferrin (FL) and fecal alpha-1-antitrypsin (A1AT) for diagnosis and follow-up of IBD, to investigate if automated analysis of this biomarker profile may further improve the diagnostic process, and to compare them to manual ELISA tests from different manufacturers.
    Methods: Stool samples from 72 patients with Crohn's disease (42), ulcerative colitis (17), irritable bowel syndrome (5), other gastrointestinal inflammation (8), and 72 healthy controls were analyzed for FC, FL, and A1AT on the automated Alegria® system (ORGENTEC Diagnostika, Germany). The results were verified by commercially available manual ELISA tests and discrepancies were further analyzed by immunoblotting. The fecal test results were correlated with the patients' endoscopic findings and with disease activity.
    Results: The automated assays FC and FL for Alegria® detected endoscopically active intestinal inflammation with a sensitivity and specificity of 74% and 87% (FC) and 62% and 87% (FL), respectively, and efficiently discriminated IBD from non-IBD samples in the patient cohort. Healthy controls tested negative in all assays. The results of the automated biomarker assays significantly correlated to those of the manual ELISAs. Alegria® results for FC were confirmed by immunoblotting in 7 discrepant samples. Levels of A1AT out of the normal range were detectable in a substantial number of IBD and irritable bowel syndrome (IBS) samples: 50% Crohn's disease, 35% ulcerative colitis, and 60% IBS, reflecting the disease-related changes of intestinal permeability in these patients. In IBD patients, elevated levels of A1AT correlated with relapsing disease.
    Conclusions: Measurement of FC concentrations with Alegria® is a convenient, promising, and useful tool for improving laboratory diagnostic accuracy and accelerating the diagnostic process and helps to identify those patients in whom endoscopy may be avoided. Automated analysis of a comprehensive profile of fecal biomarkers with Alegria®, including A1AT, provides further substantial benefit for laboratory diagnostics of IBD by improving stratification of patients for treatment and care.
    MeSH term(s) Biomarkers ; Feces ; Germany ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Leukocyte L1 Antigen Complex
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2020-07-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2020.191029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Methoden der Proteomforschung

    Hammar, Friederike / Schrattenholz, André

    molekulare Analyse der Proteinexpression

    2001  

    Author's details hrsg. von André Schrattenholz. Unter Mitarb. von Friederike Hammar
    Keywords Untersuchungsmethode ; Proteom
    Language German
    Size X, 266 S., Ill., graph. Darst., 24 cm
    Publisher Spektrum, Akad. Verl
    Publishing place Heidelberg u.a.
    Document type Book
    Note Literaturangaben ; Ringbuch
    ISBN 382741153X ; 9783827411532
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Methoden der Proteomforschung

    Hammar, Friederike / Schrattenholz, André

    molekulare Analyse der Proteinexpression

    2001  

    Author's details hrsg. von André Schrattenholz. Unter Mitarb. von Friederike Hammar
    Keywords Untersuchungsmethode ; Proteom
    Language German
    Size X, 266 S., Ill., graph. Darst., 24 cm
    Document type Book
    Note Literaturangaben ; Ringbuch
    ISBN 382741153X ; 9783827411532
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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  10. Book: Methoden der Proteomforschung

    Hammar, Friederike / Schrattenholz, André

    molekulare Analyse der Proteinexpression

    2001  

    Author's details hrsg. von André Schrattenholz. Unter Mitarb. von Friederike Hammar
    Keywords Untersuchungsmethode ; Proteom
    Language German
    Size X, 266 S., Ill., graph. Darst., 24 cm
    Document type Book
    Note Literaturangaben ; Ringbuch
    ISBN 382741153X ; 9783827411532
    Database Leibniz Institute of Plant Genetics and Crop Plant Research

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