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  1. Article: Coexistence of Acquired Hemophilia and Antiphospholipid Serology in Monoclonal Gammopathy Patient.

    Belfeki, Nabil / Hamrouni, Sarra / Strazzulla, Alessio / Diamantis, Sylvain

    International medical case reports journal

    2021  Volume 14, Page(s) 261–264

    Abstract: Acquired hemophilia is a rare coagulopathy with hemorrhage into the skin, muscle, or soft tissues and mucous membranes and caused by inhibitor antibodies, mainly against FVIII. We report a case of acquired hemophilia presenting with diffuse cutaneous ... ...

    Abstract Acquired hemophilia is a rare coagulopathy with hemorrhage into the skin, muscle, or soft tissues and mucous membranes and caused by inhibitor antibodies, mainly against FVIII. We report a case of acquired hemophilia presenting with diffuse cutaneous hemorrhage and hemothorax. The patient was found to have acquired an FVIII inhibitor and a high titer of anti β2 glycoprotein 1 IgG and IgM, and anticardiolipin IgM in the context of IgA kappa-type monoclonal gammopathy. He received 3 injections of recombinant factor VII (rFVIIa) and blood transfusion. He was started on steroids and oral cyclophosphamide for 6 weeks. Thromboprophylaxis with aspirin at 100 mg/day was started 3 months after discharge. Antiphospholipid antibodies remained positive after 3 months as well as prolonged aPTT, factor VIII raised at 100%, and the inhibitor was not detected. The association between acquired hemophilia and antiphospholipid antibodies is rare and its distinction is mandatory because clinical presentation ranges from massive hemorrhage to thrombosis.
    Language English
    Publishing date 2021-04-28
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S293931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of

    Strazzulla, Alessio / Adrien, Vladimir / Houngnandan, Segla Robert / Devatine, Sandra / Bahmed, Ouerdia / Abroug, Sarra / Hamrouni, Sarra / Monchi, Mehran / Diamantis, Sylvain

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2024  Volume 4, Issue 1, Page(s) e60

    Abstract: Objectives: To investigate the factors associated with : Materials: Monocentric retrospective cohort study. Patients admitted to the ICU in 2007-2014 were included. Characteristics of : Results: Overall, 5,263 patients were admitted to the ICU, ... ...

    Abstract Objectives: To investigate the factors associated with
    Materials: Monocentric retrospective cohort study. Patients admitted to the ICU in 2007-2014 were included. Characteristics of
    Results: Overall, 5,263 patients were admitted to the ICU, 274/5,263 (5%) had a
    Conclusions: Antibiotic susceptibility in
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2024.53
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extreme gonococcal susceptibility associated with acquired complement deficiency secondary to hypocomplementemic urticarial vasculitis and systemic lupus erythematosus.

    Belfeki, Nabil / Zayet, Souheil / Hamrouni, Sarra / Diamantis, Sylvain / Boutboul, David

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2021  Volume 28, Issue 2, Page(s) 308–310

    Abstract: Gonococcal infection is rarely associated with septic shock. We describe a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discuss the ... ...

    Abstract Gonococcal infection is rarely associated with septic shock. We describe a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discuss the implication of profound acquired complement deficiency secondary to these auto-immune diseases. This case raises the question of systematic antibioprophylaxis in patients with acquired complement deficiency.
    MeSH term(s) Complement System Proteins ; Hereditary Complement Deficiency Diseases ; Humans ; Lupus Erythematosus, Systemic/complications ; Urticaria/etiology ; Vasculitis
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2021.10.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Successful benralizumab for eosinophilic myocarditis in eosinophilic granulomatosis with polyangiitis.

    Belfeki, Nabil / Abroug, Sarra / Ghriss, Nouha / Chouchane, Ibrahim / Hamrouni, Sarra / Strazzulla, Alessio / Zayet, Souheil

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 4, Page(s) 834–837

    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterised by many features, including asthma, allergic rhinitis, peripheral and tissue eosinophilia, and vasculitis. Its pathophysiology is still unclear and we suggest that there are different ... ...

    Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is characterised by many features, including asthma, allergic rhinitis, peripheral and tissue eosinophilia, and vasculitis. Its pathophysiology is still unclear and we suggest that there are different phenotypes of EGPA, which may respond differently to available treatments. Within the most promising targeting biotherapy, benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, has proved both highly effective and safe. We report herewith a case of EGPA presenting a myocarditis relapse successfully treated with benralizumab.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/drug therapy ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Myocarditis/drug therapy ; Myocarditis/etiology
    Chemical Substances Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2022-05-04
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/ahyqld
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The Predictive Value of Cell Blood Count Parameters to Diagnose Pulmonary Embolism in Patients with SARS-CoV-2 Infection: A Case Control Study.

    Strazzulla, Alessio / Abroug Ben Halima, Sarra / Chouchane, Ibrahim / Rezek, Marwa / Pinto Stiebler, Marcella / Hamrouni, Sarra / Maalaoui, Mohammad / Ghriss, Nouha / Guedec-Ghelfi, Renaud / Moini, Cyrus / Monchi, Mehran / Belfeki, Nabil

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 1

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11010060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects.

    Hamrouni, Sarra / Bras-Gonçalves, Rachel / Kidar, Abdelhamid / Aoun, Karim / Chamakh-Ayari, Rym / Petitdidier, Elodie / Messaoudi, Yasmine / Pagniez, Julie / Lemesre, Jean-Loup / Meddeb-Garnaoui, Amel

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 3, Page(s) e0008093

    Abstract: Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell ... ...

    Abstract Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell epitopes able to induce T cell specific immune responses constitute a promising strategy. Here, we report the identification of human leukocyte antigen class-I (HLA-I) and -II (HLA-II)-restricted multi-epitope peptides from Leishmania proteins that we have previously described as vaccine candidates. Promastigote Surface Antigen (PSA), LmlRAB (L. major large RAB GTPase) and Histone (H2B) were screened, in silico, for T cell epitopes. 6 HLA-I and 5 HLA-II-restricted multi-epitope peptides, able to bind to the most frequent HLA molecules, were designed and used as pools to stimulate PBMCs from individuals with healed cutaneous leishmaniasis. IFN-γ, IL-10, TNF-α and granzyme B (GrB) production was evaluated by ELISA/CBA. The frequency of IFN-γ-producing T cells was quantified by ELISpot. T cells secreting cytokines and memory T cells were analyzed by flow cytometry. 16 of 25 peptide pools containing HLA-I, HLA-II or HLA-I and -II peptides were able to induce specific and significant IFN-γ levels. No IL-10 was detected. 6 peptide pools were selected among those inducing the highest IFN-γ levels for further characterization. 3/6 pools were able to induce a significant increase of the percentages of CD4+IFN-γ+, CD8+IFN-γ+ and CD4+GrB+ T cells. The same pools also induced a significant increase of the percentages of bifunctional IFN-γ+/TNF-α+CD4+ and/or central memory T cells. We identified highly promiscuous HLA-I and -II restricted epitope combinations from H2B, PSA and LmlRAB proteins that stimulate both CD4+ and CD8+ T cell responses in recovered individuals. These multi-epitope peptides could be used as potential components of a polytope vaccine for human leishmaniasis.
    MeSH term(s) Adult ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Enzyme-Linked Immunosorbent Assay ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Female ; Flow Cytometry ; Granzymes/analysis ; Histocompatibility Antigens Class I/metabolism ; Histocompatibility Antigens Class II/metabolism ; Humans ; Interferon-gamma/analysis ; Interleukin-10/analysis ; Leishmania/immunology ; Leishmaniasis, Cutaneous/immunology ; Male ; Middle Aged ; Protein Binding ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Volunteers ; Young Adult
    Chemical Substances Antigens, Protozoan ; Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; IL10 protein, human ; Recombinant Fusion Proteins ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Trypanosomatid Infections: How Do Parasites and Their Excreted-Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

    Holzmuller, Philippe / Geiger, Anne / Nzoumbou-Boko, Romaric / Pissarra, Joana / Hamrouni, Sarra / Rodrigues, Valérie / Dauchy, Frédéric-Antoine / Lemesre, Jean-Loup / Vincendeau, Philippe / Bras-Gonçalves, Rachel

    Frontiers in immunology

    2018  Volume 9, Page(s) 778

    Abstract: Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts. ...

    Abstract Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts. They play essential roles in the outcome of infections caused by trypanosomatids, as they can not only exert a powerful antimicrobial activity but also promote parasite proliferation. These varied functions, linked to their phenotypic and metabolic plasticity, are exerted
    MeSH term(s) Animals ; Arginine/metabolism ; Host-Parasite Interactions/physiology ; Humans ; Macrophages/metabolism ; Macrophages/parasitology ; Protozoan Proteins/metabolism ; Trypanosomiasis/metabolism
    Chemical Substances Protozoan Proteins ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2018-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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