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Article ; Online: Precautions for seafood consumers: An updated review of toxicity, bioaccumulation, and rapid detection methods of marine biotoxins.

Wang, Yifan / Javeed, Ansar / Jian, Cuiqin / Zeng, Qiuyu / Han, Bingnan

2024 Volume 274, Page(s) 116201

Abstract: Seafood products are globally consumed, and there is an increasing demand for the quality and safety of these products among consumers. Some seafoods are easily contaminated by marine biotoxins in natural environments or cultured farming processes. When ... ...

Abstract	Seafood products are globally consumed, and there is an increasing demand for the quality and safety of these products among consumers. Some seafoods are easily contaminated by marine biotoxins in natural environments or cultured farming processes. When humans ingest different toxins accumulated in seafood, they may exhibit different poisoning symptoms. According to the investigations, marine toxins produced by harmful algal blooms and various other marine organisms mainly accumulate in the body organs such as liver and digestive tract of seafood animals. Several regions around the world have reported incidents of seafood poisoning by biotoxins, posing a threat to human health. Thus, most countries have legislated to specify the permissible levels of these biotoxins in seafood. Therefore, it is necessary for seafood producers and suppliers to conduct necessary testing of toxins in seafood before and after harvesting to prohibit excessive toxins containing seafood from entering the market, which therefore can reduce the occurrence of seafood poisoning incidents. In recent years, some technologies which can quickly, conveniently, and sensitively detect biological toxins in seafood, have been developed and validated, these technologies have the potential to help seafood producers, suppliers and regulatory authorities. This article reviews the seafood toxins sources and types, mechanism of action and bioaccumulation of marine toxins, as well as legislation and rapid detection technologies for biotoxins in seafood for official and fishermen supervision.
MeSH term(s)	Animals ; Humans ; Marine Toxins/toxicity ; Seafood/analysis ; Bioaccumulation ; Foodborne Diseases/epidemiology ; Harmful Algal Bloom
Chemical Substances	Marine Toxins
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR axis.

Wang, Lei / Liu, Wang-Qing / Broussy, Sylvain / Han, Bingnan / Fang, Hongming

Frontiers in pharmacology

2024 Volume 14, Page(s) 1307860

Abstract: Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors (VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic therapy. They constitute a crucial system to regulate physiological and ... ...

Abstract	Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors (VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic therapy. They constitute a crucial system to regulate physiological and pathological angiogenesis. In the last 20 years, many anti-angiogenic drugs have been developed based on VEGF/VEGFR system to treat diverse cancers and retinopathies, and new drugs with improved properties continue to emerge at a fast rate. They consist of different molecular structures and characteristics, which enable them to inhibit the interaction of VEGF/VEGFR, to inhibit the activity of VEGFR tyrosine kinase (TK), or to inhibit VEGFR downstream signaling. In this paper, we reviewed the development of marketed anti-angiogenic drugs involved in the VEGF/VEGFR axis, as well as some important drug candidates in clinical trials. We discuss their mode of action, their clinical benefits, and the current challenges that will need to be addressed by the next-generation of anti-angiogenic drugs. We focus on the molecular structures and characteristics of each drug, including those approved only in China.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1307860
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Novel Multifunctional Crosslinking PVA/CMCS Hydrogel Containing Cyclic Peptide Actinomycin X2 and PA@Fe with Excellent Antibacterial and Commendable Mechanical Properties.

Chen, Fengyun / Javeed, Ansar / Zeng, Qiuyu / Zhang, Quan / Han, Bingnan

Chemistry & biodiversity

2023 Volume 20, Issue 8, Page(s) e202300831

Abstract: Bacterial infected environments and resulting bacterial infections have been threatening the human health globally. Due to increased bacterial resistance caused by improper and excessive use of antibiotics, antibacterial biomaterials are being developed ... ...

Abstract	Bacterial infected environments and resulting bacterial infections have been threatening the human health globally. Due to increased bacterial resistance caused by improper and excessive use of antibiotics, antibacterial biomaterials are being developed as alternatives to antibiotics in some cases. Herein, an advanced multifunctional hydrogel with excellent antibacterial properties, enhanced mechanical properties, biocompatibility and self-healing performance, was designed through freezing-thawing method. This hydrogel network is composed of polyvinyl alcohol (PVA), carboxymethyl chitosan (CMCS), protocatechualdehyde (PA), ferric iron (Fe) and an antimicrobial cyclic peptide actinomycin X2 (Ac.X2). The double dynamic bonds among protocatechualdehyde (PA), ferric iron (Fe) and carboxymethyl chitosan containing coordinate bond (catechol-Fe) as well as dynamic Schiff base bonds and hydrogen bonds endowed the hydrogel with enhanced mechanical properties. Successful formation of hydrogel was confirmed through ATR-IR and XRD, and structural evaluation through SEM analysis, whereas mechanical properties were tested with electromechanical universal testing machine. The resulting PVA/CMCS/Ac.X2/PA@Fe (PCXPA) hydrogel has favorable biocompatibility and excellent broad-spectrum antimicrobial activity against both S. aureus (95.3 %) and E. coli (90.2 %) compared with free-soluble Ac.X2, which exhibited subpar performance against E. coli reported in our previous studies. This work provides a new insight on preparing multifunctional hydrogels containing antimicrobial peptides as antibacterial material.
MeSH term(s)	Humans ; Chitosan/chemistry ; Peptides, Cyclic ; Polyvinyl Alcohol/chemistry ; Escherichia coli ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Catechols ; Anti-Infective Agents ; Iron
Chemical Substances	protocatechualdehyde (4PVP2HCH4T) ; actinomycin X2 ; Chitosan (9012-76-4) ; Peptides, Cyclic ; polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Anti-Bacterial Agents ; Hydrogels ; Catechols ; Anti-Infective Agents ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Natural Products from Actinomycetes Associated with Marine Organisms

Chen, Jianing / Xu, Lin / Zhou, Yanrong / Han, Bingnan

Marine drugs. 2021 Nov. 10, v. 19, no. 11

2021

Abstract: The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes ... ...

Abstract	The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.
Keywords	Cyanobacteria ; Micromonospora ; Nocardiopsis ; Streptomyces ; antimicrobial properties ; cytotoxicity ; macroalgae ; peptides ; polyketides ; secondary metabolites ; species diversity
Language	English
Dates of publication	2021-1110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md19110629
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Treatment of allergy: Overview of synthetic anti-allergy small molecules in medicinal chemistry.

Zhang, Shanshan / Liu, Yi / Javeed, Ansar / Jian, Cuiqin / Sun, Jinlyu / Wu, Shandong / Han, Bingnan

European journal of medicinal chemistry

2023 Volume 249, Page(s) 115151

Abstract: The prevalence of allergic diseases has been continuously increasing over the past few decades, affecting approximately 20-30% of the global population. Allergic reactions to infection of respiratory tract, digestive tract, and skin system involve ... ...

Abstract	The prevalence of allergic diseases has been continuously increasing over the past few decades, affecting approximately 20-30% of the global population. Allergic reactions to infection of respiratory tract, digestive tract, and skin system involve multiple different targets. The main difficulty of anti-allergy research is how to develop drugs with good curative effect and less side effects by adopting new multi-targets and mechanisms according to the clinical characteristics of different allergic populations and different allergens. This review focuses on information concerning potential therapeutic targets as well as the synthetic anti-allergy small molecules with respect to their medicinal chemistry. The structure-activity relationship and the mechanism of compound-target interaction were highlighted with perspective to histamine-1/4 receptor antagonists, leukotriene biosynthesis, Th2 cytokines inhibitors, and calcium channel blockers. We hope that the study of chemical scaffold modification and optimization for different lead compounds summarized in this review not only lays the foundation for improvement of success rate and efficiency of virtual screening of antiallergic drugs, but also can provide valuable reference for the drug design of related promising research such as allergy, inflammation, and cancer.
MeSH term(s)	Humans ; Anti-Allergic Agents/pharmacology ; Anti-Allergic Agents/therapeutic use ; Chemistry, Pharmaceutical ; Hypersensitivity/drug therapy ; Cytokines
Chemical Substances	Anti-Allergic Agents ; Cytokines
Language	English
Publishing date	2023-01-27
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115151
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Article ; Online: Preparation and Characterization of a Silk Fibroin/Polyurethane Fiber Blend Membrane Containing Actinomycin X2 with Excellent Mechanical Properties and Enhanced Antibacterial Activities.

Zhang, Quan / Chen, Fengyun / Javeed, Ansar / Wang, Miaofeng / Si, Ranran / Li, Jiaxing / Han, Bingnan

Chemistry & biodiversity

2023 Volume 20, Issue 6, Page(s) e202300445

Abstract: Development of suitable antimicrobial biomaterials for hygienic wound dressing and healing is an important requirement for medical application. Durable mechanical properties increase the application range of biomaterial in different environmental and ... ...

Abstract	Development of suitable antimicrobial biomaterials for hygienic wound dressing and healing is an important requirement for medical application. Durable mechanical properties increase the application range of biomaterial in different environmental and biological conditions. Due to the inherent brittleness of silk fibroin (SF), polyurethane fiber (PUF) was used to modify SF containing actinomycin X2 (Ac.X2) to prepare silk fibroin@actinomycin X
MeSH term(s)	Fibroins/pharmacology ; Fibroins/chemistry ; Polyurethanes/pharmacology ; Polyurethanes/chemistry ; Spectroscopy, Fourier Transform Infrared ; Staphylococcus aureus ; Silk/chemistry ; Biocompatible Materials/chemistry ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Fibroins (9007-76-5) ; Polyurethanes ; actinomycin X2 ; Silk ; Biocompatible Materials ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300445
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Article ; Online: Natural Products from Actinomycetes Associated with Marine Organisms.

Chen, Jianing / Xu, Lin / Zhou, Yanrong / Han, Bingnan

Marine drugs

2021 Volume 19, Issue 11

Abstract	The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of
MeSH term(s)	Actinobacteria ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Aquatic Organisms ; Biological Products ; Humans
Chemical Substances	Anti-Bacterial Agents ; Biological Products
Language	English
Publishing date	2021-11-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md19110629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation and properties of polyvinyl alcohol/chitosan-based hydrogel with dual pH/NH

Zeng, Qiuyu / Wang, Yifan / Javeed, Ansar / Chen, Fengyun / Li, Jiaxing / Guan, Yating / Chen, Baiyu / Han, Bingnan

International journal of biological macromolecules

2024 Volume 263, Issue Pt 2, Page(s) 130440

Abstract: To address the issue of food spoilage causing health and economic loss, we developed a pH/ ... ...

Abstract	To address the issue of food spoilage causing health and economic loss, we developed a pH/NH
MeSH term(s)	Chitosan/chemistry ; Polyvinyl Alcohol/chemistry ; Spectroscopy, Fourier Transform Infrared ; Hydrogels/chemistry ; Seafood ; Hydrogen-Ion Concentration ; Food Packaging/methods ; Anthocyanins/chemistry
Chemical Substances	Chitosan (9012-76-4) ; polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Hydrogels ; Anthocyanins
Language	English
Publishing date	2024-02-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130440
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Article ; Online: Structures and Anti-Allergic Activities of Natural Products from Marine Organisms

Chen, Na / Zhang, Shanshan / Javeed, Ansar / Jian, Cuiqin / Liu, Yi / Sun, Jinlyu / Wu, Shandong / Fu, P. / Han, Bingnan

Mar Drugs. 2023 Feb. 25, v. 21, no. 3

2023

Abstract: In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine ...

Abstract	In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine drugs, which have adverse side effects and drug resistance after long-term use. Therefore, it is essential to find alternative anti-allergic agents from natural products. High pressure, low temperature, and low/lack of light lead to highly functionalized and diverse functional natural products in the marine environment. This review summarizes the information on anti-allergic secondary metabolites with a variety of chemical structures such as polyphenols, alkaloids, terpenoids, steroids, and peptides, obtained mainly from fungi, bacteria, macroalgae, sponges, mollusks, and fish. Molecular docking simulation is applied by MOE to further reveal the potential mechanism for some representative marine anti-allergic natural products to target the H1 receptor. This review may not only provide insight into information about the structures and anti-allergic activities of natural products from marine organisms but also provides a valuable reference for marine natural products with immunomodulatory activities.
Keywords	adjuvants ; adrenal cortex hormones ; anti-allergic agents ; antihistamines ; drug resistance ; fish ; macroalgae ; marine environment ; peptides ; polyphenols ; secondary metabolites ; temperature ; terpenoids
Language	English
Dates of publication	2023-0225
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md21030152
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Homologous High-Level Lipase and Single-Cell Protein Production with Engineered Yarrowia lipolytica via Scale-Up Fermentation for Industrial Applications

Pan, Dujie / Dai, Shuhan / Jiao, Liangcheng / Zhou, Qinghua / Zha, Genhan / Yan, Jinyong / Han, Bingnan / Yan, Yunjun / Xu, Li

Fermentation. 2023 Mar. 09, v. 9, no. 3

2023

Abstract: Yarrowia lipolytica is a promising feed additives. Here, we aimed to produce extracellular lipases and single-cell proteins (SCPs) at high levels simultaneously through fed-batch fermentation of engineered Y. lipolytica. The parameters for 500 mL shake ... ...

Abstract	Yarrowia lipolytica is a promising feed additives. Here, we aimed to produce extracellular lipases and single-cell proteins (SCPs) at high levels simultaneously through fed-batch fermentation of engineered Y. lipolytica. The parameters for 500 mL shake flask cultures were optimized with a single factorial design. The resultant activity of lipase reached 880.6 U/mL after 84 h of fermentation, and 32.0 g/L fermentation broth of dry SCP was obtained at 120 h. To attain high SCP and lipase productivity, the high-density fed-batch fermentation of Y. lipolytica was scaled up in 10 L, 30 L, and 100 L fermentors. Using glycerol as the sole carbon source, the lipase activity peaked to 8083.3 U/mL, and the final dry SCP weight was 183.1 g/L at 94.6 h in 10 L fermentors. The extracellular lipase activity and SCP weight reached 11,100.0 U/mL and 173.3 g of dry SCP/L at 136 h in 30 L fermentors, respectively. Following 136 h of fed-batch fermentation, the extracellular lipase activity and dry SCP weight reached 8532.0 U/mL and 170.3 g/L in 100 L fermentors, respectively. A balance between the lipase secretion and growth of Y. lipolytica recombinant strain was achieved, indicating that an efficient fermentation strategy could promote further scale-up for industrial SCP production from engineered Y. lipolytica.
Keywords	Yarrowia lipolytica ; batch fermentation ; carbon ; carboxylic ester hydrolases ; culture flasks ; culture media ; glycerol ; protein synthesis ; secretion ; single cell protein
Language	English
Dates of publication	2023-0309
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation9030268
Database	NAL-Catalogue (AGRICOLA)

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