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  1. Article ; Online: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T

    Guan, Xiangnan / Hu, Ruozhen / Choi, Yoonha / Srivats, Shyam / Nabet, Barzin Y / Silva, John / McGinnis, Lisa / Hendricks, Robert / Nutsch, Katherine / Banta, Karl L / Duong, Ellen / Dunkle, Alexis / Chang, Patrick S / Han, Chia-Jung / Mittman, Stephanie / Molden, Nandini / Daggumati, Pallavi / Connolly, Wendy / Johnson, Melissa /
    Abreu, Delvys Rodriguez / Cho, Byoung Chul / Italiano, Antoine / Gil-Bazo, Ignacio / Felip, Enriqueta / Mellman, Ira / Mariathasan, Sanjeev / Shames, David S / Meng, Raymond / Chiang, Eugene Y / Johnston, Robert J / Patil, Namrata S

    Nature

    2024  Volume 627, Issue 8004, Page(s) 646–655

    Abstract: Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab ... ...

    Abstract Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone
    MeSH term(s) Animals ; Humans ; Mice ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Drug Therapy, Combination ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/therapeutic use ; Macrophage Activation ; Myeloid Cells/immunology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Receptors, IgG/immunology ; Receptors, Immunologic/immunology ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/immunology
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; atezolizumab (52CMI0WC3Y) ; B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Receptors, IgG ; Receptors, Immunologic ; TIGIT protein, human ; T cell Ig and ITIM domain protein, mouse
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07121-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Correction: LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8

    Kim, Aeryon / Han, Chia-Jung / Driver, Ian / Olow, Aleksandra / Sewell, Andrew K / Zhang, Zemin / Ouyang, Wenjun / Egen, Jackson G / Yu, Xin

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 203, Issue 7, Page(s) 2023–2024

    Language English
    Publishing date 2019-08-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1900968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  3. Article ; Online: LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8

    Kim, Aeryon / Han, Chia-Jung / Driver, Ian / Olow, Aleksandra / Sewell, Andrew K / Zhang, Zemin / Ouyang, Wenjun / Egen, Jackson G / Yu, Xin

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 203, Issue 4, Page(s) 1076–1087

    Abstract: Elicitation of tumor cell killing by ... ...

    Abstract Elicitation of tumor cell killing by CD8
    MeSH term(s) Antibodies, Bispecific/immunology ; Antibodies, Bispecific/pharmacology ; Antigens, CD/immunology ; Humans ; Immunotherapy/methods ; Leukocyte Immunoglobulin-like Receptor B1/antagonists & inhibitors ; Leukocyte Immunoglobulin-like Receptor B1/immunology ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Neoplasms/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Cells, Cultured
    Chemical Substances Antibodies, Bispecific ; Antigens, CD ; LILRB1 protein, human ; Leukocyte Immunoglobulin-like Receptor B1
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1801472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer.

    Galsky, Matthew D / Guan, Xiangnan / Rishipathak, Deepali / Rapaport, Aaron S / Shehata, Hesham M / Banchereau, Romain / Yuen, Kobe / Varfolomeev, Eugene / Hu, Ruozhen / Han, Chia-Jung / Li, Haocheng / Liang, Yuxin / Vucic, Domagoj / Wang, Li / Zhu, Jun / Yu, Haocheng / Herbst, Rebecca H / Hajaj, Emma / Kiner, Evgeny /
    Bamias, Aristotelis / De Santis, Maria / Davis, Ian D / Arranz, José Ángel / Kikuchi, Eiji / Bernhard, Sandrine / Williams, Patrick / Lee, Chooi / Mellman, Ira / Sanjabi, Shomyseh / Johnston, Robert / Black, Peter C / Grande, Enrique / Mariathasan, Sanjeev

    Cell reports. Medicine

    2024  Volume 5, Issue 2, Page(s) 101393

    Abstract: In metastatic urothelial cancer (mUC), cisplatin versus carboplatin leads to durable disease control in a subset of patients. The IMvigor130 trial reveals more favorable effects with atezolizumab combined with gemcitabine and cisplatin (GemCis) versus ... ...

    Abstract In metastatic urothelial cancer (mUC), cisplatin versus carboplatin leads to durable disease control in a subset of patients. The IMvigor130 trial reveals more favorable effects with atezolizumab combined with gemcitabine and cisplatin (GemCis) versus gemcitabine and carboplatin (GemCarbo). This study investigates the immunomodulatory effects of cisplatin as a potential explanation for these observations. Our findings indicate that improved outcomes with GemCis versus GemCarbo are primarily observed in patients with pretreatment tumors exhibiting features of restrained adaptive immunity. In addition, GemCis versus GemCarbo ± atezolizumab induces transcriptional changes in circulating immune cells, including upregulation of antigen presentation and T cell activation programs. In vitro experiments demonstrate that cisplatin, compared with carboplatin, exerts direct immunomodulatory effects on cancer cells, promoting dendritic cell activation and antigen-specific T cell killing. These results underscore the key role of immune modulation in cisplatin's efficacy in mUC and highlight the importance of specific chemotherapy backbones in immunotherapy combination regimens.
    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized ; Carboplatin/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/chemically induced ; Carcinoma, Transitional Cell/pathology ; Cisplatin/therapeutic use ; Deoxycytidine/therapeutic use ; Gemcitabine ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Urologic Neoplasms/drug therapy ; Urologic Neoplasms/chemically induced ; Urologic Neoplasms/pathology
    Chemical Substances Antibodies, Monoclonal, Humanized ; atezolizumab (52CMI0WC3Y) ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J) ; Deoxycytidine (0W860991D6) ; Gemcitabine
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T

    Guan, Xiangnan / Hu, Ruozhen / Choi, Yoonha / Srivats, Shyam / Nabet, Barzin Y / Silva, John / McGinnis, Lisa / Hendricks, Robert / Nutsch, Katherine / Banta, Karl L / Duong, Ellen / Dunkle, Alexis / Chang, Patrick S / Han, Chia-Jung / Mittman, Stephanie / Molden, Nandini / Daggumati, Pallavi / Connolly, Wendy / Johnson, Melissa /
    Abreu, Delvys Rodriguez / Cho, Byoung Chul / Italiano, Antoine / Gil-Bazo, Ignacio / Felip, Enriqueta / Mellman, Ira / Mariathasan, Sanjeev / Shames, David S / Meng, Raymond / Chiang, Eugene Y / Johnston, Robert J / Patil, Namrata S

    Nature

    2024  Volume 627, Issue 8005, Page(s) E11

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07280-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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