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  1. Article ; Online: Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study.

    Han, Deheng / Yu, Fangcong / Zheng, Liangrong

    Epidemiology and health

    2024  , Page(s) e2024046

    Abstract: Objectives: Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to ... ...

    Abstract Objectives: Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to explore the causal relationship between serum MMP levels and VTE by using the Mendelian randomization (MR) method.
    Methods: In this study 2-sample MR study, the exposure data on serum MMP levels were derived from genome-wide association studies involving 21,758 individuals from 13 cohorts of European descent. The outcome data on VTE, including deep vein thrombosis and pulmonary embolism, were derived from the FinnGen research project. The primary method used was the inverse-variance weighting method. The MR-Egger intercept test and the Cochran Q test were used to evaluate pleiotropy and heterogeneity.
    Results: Using the inverse-variance weighting method, higher serum MMP-12 levels were found to be associated with an increased risk of VTE (odds ratio, 1.04; 95% confidence interval, 1.01-1.07; p=0.0015). Moreover, there was a weak association between the levels of certain MMPs and VTE. Sensitivity analyses revealed no significant heterogeneity and pleiotropy in our study, and the Steiger directionality test did not reveal a significant reverse causation association.
    Conclusion: : There is a causal association between MMP-12 levels and VTE, which may have substantial implications for the diagnostic and therapeutic strategies used for VTE.
    Language English
    Publishing date 2024-04-24
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2590698-7
    ISSN 2092-7193 ; 2092-7193
    ISSN (online) 2092-7193
    ISSN 2092-7193
    DOI 10.4178/epih.e2024046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Determinants of left atrial thrombus or spontaneous echo contrast in nonvalvular atrial fibrillation.

    Han, Deheng / Chu, Yanan / Wu, Yakui / Wang, Xingxiang

    Thrombosis research

    2020  Volume 195, Page(s) 233–237

    Abstract: Background: The CHADS: Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The ... ...

    Abstract Background: The CHADS
    Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The clinical, echocardiographic and laboratory characteristics of patients were collected from the electronic medical record system.
    Results: In the study, the prevalence of LAT/SEC was only 4.36%. In the multivariate logistic analysis, hypertension, left atrial enlargement, prior stroke/TIA, left ventricular dysfunction, and renal dysfunction were predictors of LAT/SEC. Receiver operating characteristic curve analysis showed that c-statistics of the CHADS
    Conclusion: In our cohort, we found two variables not included in the CHA
    MeSH term(s) Atrial Fibrillation/complications ; Humans ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Thrombosis
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.07.055
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: SARS-CoV-2 was found in the bile juice from a patient with severe COVID-19.

    Han, Deheng / Fang, Qiang / Wang, Xingxiang

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 102–104

    MeSH term(s) Bile/virology ; COVID-19/pathology ; COVID-19/virology ; Cholangiopancreatography, Endoscopic Retrograde ; Cholestasis/pathology ; Cholestasis/surgery ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26169
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study.

    Chen, Lu / Sun, Xingang / Han, Deheng / Zhong, Jiawei / Zhang, Han / Zheng, Liangrong

    Frontiers in public health

    2022  Volume 10, Page(s) 1023935

    Abstract: Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is ... ...

    Abstract Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospitalization, or severity of COVID-19 remains unconfirmed. We aimed to investigate the causal associations between VAT and susceptibility, hospitalization, and severity of COVID-19.
    Methods: We applied a two-sample Mendelian randomization (MR) study to infer causal associations between VAT and COVID-19 outcomes. Single-nucleotide polymorphisms significantly associated with VAT were derived from a large-scale genome-wide association study. The random-effects inverse-variance weighted method was used as the main MR approach, complemented by three other MR methods. Additional sensitivity analyses were also performed.
    Results: Genetically predicted higher VAT mass was causally associated with higher risks of COVID-19 susceptibility [odds ratios (ORs) = 1.13; 95% confidence interval (CI), 1.09-1.17;
    Conclusion: This study provided genetic evidence that higher VAT mass was causally associated with higher risks of susceptibility, hospitalization, and severity of COVID-19. VAT can be a useful tool for risk assessment in the general population and COVID-19 patients, as well as an important prevention target.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Intra-Abdominal Fat ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Hospitalization
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1023935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway.

    Chen, Lu / Sun, Xingang / Wang, Zhen / Chen, Miao / He, Yuxian / Zhang, Han / Han, Deheng / Zheng, Liangrong

    Toxicology and applied pharmacology

    2023  Volume 482, Page(s) 116794

    Abstract: Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective ... ...

    Abstract Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective effect of Res on Dox-induced cardiotoxicity (DIC) and explore whether it was related to attenuating ferroptosis. We established DIC models in C57BL/6 J mice, H9C2 cardiomyoblasts, and neonatal rat cardiomyocytes (NRCMs). We further treated H9C2 cells with RSL3, a ferroptosis agonist, to investigate whether Res exerted protective effects through inhibiting ferroptosis. Ferrostatin-1 (Fer-1) was applied to suppress ferroptosis. Dox treatment caused cardiac dysfunction and resulted in apparent ferroptotic damage in cardiac tissue, involving increased iron accumulation, glutathione depletion, increased expression of ferroptosis-related proteins, and decreased expression of glutathione peroxidase 4, which were alleviated by Fer-1 and Res administration. These findings were also confirmed in Dox-treated H9C2 cells and NRCMs, with Fer-1 and Res effectively attenuating Dox-induced cytotoxicity and ferroptosis. Furthermore, Res protected H9C2 cells from RSL3-induced ferroptotic cell death, and the protective effect was similar to that of Fer-1. Both Dox and RSL3 treatment increased the phosphorylation levels of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinases; however, these changes were hindered by Res. This study demonstrates that Res effectively alleviates DIC by suppressing ferroptosis possibly through modulating the MAPK signaling pathway. Our results highlight that targeting ferroptosis can be a potential cardioprotective strategy for DIC.
    MeSH term(s) Mice ; Rats ; Animals ; Resveratrol/pharmacology ; Cardiotoxicity/pathology ; Ferroptosis ; Apoptosis ; Cell Line ; Mice, Inbred C57BL ; Signal Transduction ; Doxorubicin/pharmacology ; Myocytes, Cardiac ; Oxidative Stress
    Chemical Substances Resveratrol (Q369O8926L) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116794
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 14: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: SARS-CoV-2 was found in the bile juice from a patient with severe COVID-19

    Han, Deheng / Fang, Qiang / Wang, Xingxiang

    J. med. virol

    Abstract: SARS-CoV-2 has infected over 170,000 people worldwide and was associated with substantial mortality. Previous studies have reported that the SARS-CoV-2 could be detected in sputum, faeces, urine and other specimens from COVID-19 patients. In the case ... ...

    Abstract SARS-CoV-2 has infected over 170,000 people worldwide and was associated with substantial mortality. Previous studies have reported that the SARS-CoV-2 could be detected in sputum, faeces, urine and other specimens from COVID-19 patients. In the case report, the novel coronavirus was found in the bile specimen from a patient with severe COVID-19 by real-time fluorescent RT-PCR. In addition, much higher viral load in the bile juice than in the sputum indicated that a false positive error in the specimen was hardly possible. As far as we know, it is the first report about SARS-CoV-2 in the bile juice. We would love to share the information to other researchers. The report may have a significant impact on the clinical management and public health decision making. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32530522
    Database COVID19

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  7. Article ; Online: SARS‐CoV‐2 was found in the bile juice from a patient with severe COVID‐19

    Han, Deheng / Fang, Qiang / Wang, Xingxiang

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26169
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Identification of genes and key pathways underlying the pathophysiological association between nonalcoholic fatty liver disease and atrial fibrillation.

    Chu, Yanan / Yu, Fangcong / Wu, Yakui / Yang, Jinxiu / Shi, Jiaran / Ye, Tianxin / Han, Deheng / Wang, Xingxiang

    BMC medical genomics

    2022  Volume 15, Issue 1, Page(s) 150

    Abstract: Background: Atrial fibrillation (AF) is one of the most prevalent sustained cardiac arrhythmias. The latest studies have revealed a tight correlation between nonalcoholic fatty liver disease (NAFLD) and AF. However, the exact molecular mechanisms ... ...

    Abstract Background: Atrial fibrillation (AF) is one of the most prevalent sustained cardiac arrhythmias. The latest studies have revealed a tight correlation between nonalcoholic fatty liver disease (NAFLD) and AF. However, the exact molecular mechanisms underlying the association between NAFLD and AF remain unclear. The current research aimed to expound the genes and signaling pathways that are related to the mechanisms underlying the association between these two diseases.
    Materials and methods: NAFLD- and AF- related differentially expressed genes (DEGs) were identified via bioinformatic analysis of the Gene Expression Omnibus (GEO) datasets GSE63067 and GSE79768, respectively. Further enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), the construction of a protein-protein interaction (PPI) network, the identification of significant hub genes, and receiver operator characteristic curve analysis were conducted. The gene-disease interactions were analyzed using the Comparative Toxicogenomics Database. In addition, the hub genes were validated by quantitative Real-Time PCR (qRT-PCR) in NAFLD cell model.
    Results: A total of 45 co-expressed differentially expressed genes (co-DEGs) were identified between the NAFLD/AF and healthy control individuals. GO and KEGG pathway analyses revealed that the co-DEGs were mostly enriched in neutrophil activation involved in the immune response and cytokine-cytokine receptor interactions. Moreover, eight hub genes were selected owing to their high degree of connectivity and upregulation in both the NAFLD and AF datasets. These genes included CCR2, PTPRC, CXCR2, MNDA, S100A9, NCF2, S100A12, and S100A8.
    Conclusions: In summary, we conducted the gene differential expression analysis, functional enrichment analysis, and PPI analysis of DEGs in AF and NAFLD, which provides novel insights into the identification of potential biomarkers and valuable therapeutic leads for AF and NAFLD.
    MeSH term(s) Atrial Fibrillation/genetics ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/genetics ; Protein Interaction Maps/genetics
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-022-01300-1
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