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Article ; Online: The Mechanism for the Effect of Chinese Medicine on Strait Episode of Complex Diseases.

Han, Jing-Yan

2016 Volume 65, Issue 2, Page(s) 44

Abstract: Complex diseases always involve some strait episode, such as myocardial hypertrophy and fibrosis caused by hypertension, microcirculation dysfunction and injury in heart, brain, lever, and intestine following ischemia and reperfusion, endotoxin induced ... ...

Abstract	Complex diseases always involve some strait episode, such as myocardial hypertrophy and fibrosis caused by hypertension, microcirculation dysfunction and injury in heart, brain, lever, and intestine following ischemia and reperfusion, endotoxin induced multiorgan injury, and recovery after intestinal mucosa damage, for which intervention by a single medicine remains unsatisfied in clinic.Chinese medicine has been applied in clinic for more than two thousand years, which presents as a healthcare system using compound formula preparation, treatment based on syndrome differentiation and individualization thus has advantage in dealing with strait episode of complex diseases. However, the mechanism underlying Chinese medicine is not fully understood up till now.This report will explain the mechanisms underlying the beneficial role of Chinese medicine in therapy of strait episode of complex diseases based on the resent outcomes in study of aforementioned complex diseases. The speaker, using the theory of blood stasis and activating blood to remove stasis in Chinese medicine, classified microcirculation dysfunction induced by different causes, such as ischemia and reperfusion, stress, LPS, common cold, investigated the pathogenesis and progressing of each of which. Furthermore, the report explored the material basis and mechanism for compound formula of Chinese medicine with potential of tonifying Qi and activating blood, removing heat to cool blood, identified the ingredient in the compound formula responsible for respective effect.(Presented at the 1920th Meeting, June 3, 2016).
MeSH term(s)	Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/psychology ; Microcirculation/drug effects ; Qi
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390981-5
ISSN	1880-1293 ; 0022-9717
ISSN (online)	1880-1293
ISSN	0022-9717
DOI	10.2302/kjm.65-003-ABST
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Article ; Online: Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes.

Liu, Songming / Yue, Shanshan / Guo, Yuxuan / Han, Jing-Yan / Wang, Huan

Pharmacological research

2023 Volume 198, Page(s) 107017

Abstract: Sorafenib, a multi-targeted tyrosine kinase inhibitor, is a first-line treatment for advanced solid tumors, but it induces many adverse cardiovascular events, including myocardial infarction and heart failure. These cardiac defects can be mediated by ... ...

Abstract	Sorafenib, a multi-targeted tyrosine kinase inhibitor, is a first-line treatment for advanced solid tumors, but it induces many adverse cardiovascular events, including myocardial infarction and heart failure. These cardiac defects can be mediated by alternative splicing of genes critical for heart function. Whether alternative splicing plays a role in sorafenib-induced cardiotoxicity remains unclear. Transcriptome of rat hearts or human cardiomyocytes treated with sorafenib was analyzed and validated to define alternatively spliced genes and their impact on cardiotoxicity. In rats, sorafenib caused severe cardiotoxicity with decreased left ventricular systolic pressure, elongated sarcomere, enlarged mitochondria and decreased ATP. This was associated with alternative splicing of hundreds of genes in the hearts, many of which were targets of a cardiac specific splicing factor, RBM20. Sorafenib inhibited RBM20 expression in both rat hearts and human cardiomyocytes. The splicing of RBM20's targets, SLC25A3 and FHOD3, was altered into fetal isoforms with decreased function. Upregulation of RBM20 during sorafenib treatment reversed the pathogenic splicing of SLC25A3 and FHOD3, and enhanced the phosphate transport into mitochondria by SLC25A3, ATP synthesis and cell survival.We envision this regulation may happen in many drug-induced cardiotoxicity, and represent a potential druggable pathway for mitigating sorafenib-induced cardiotoxicity.
MeSH term(s)	Rats ; Animals ; Humans ; Alternative Splicing ; Sorafenib ; Cardiotoxicity/genetics ; Cardiotoxicity/metabolism ; Sarcomeres/metabolism ; Genes, Mitochondrial ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Myocytes, Cardiac/metabolism ; Adenosine Triphosphate/metabolism ; Formins/genetics ; Formins/metabolism
Chemical Substances	Sorafenib (9ZOQ3TZI87) ; RNA-Binding Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; FHOD3 protein, human ; Formins ; RBM20 protein, rat
Language	English
Publishing date	2023-11-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.107017
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Article: Editorial: Traditional Chinese Medicine: Organ Vascular Injury - Volume II.

Han, Jing-Yan / Meininger, Gerald / Luo, Jin-Cai / Huang, Qiao-Bing

Frontiers in physiology

2021 Volume 12, Page(s) 677858

Language	English
Publishing date	2021-06-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.677858
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Article: The Protective Role of Immunomodulators on Tissue-Type Plasminogen Activator-Induced Hemorrhagic Transformation in Experimental Stroke: A Systematic Review and Meta-Analysis.

Ye, Yang / Zhu, Yu-Tian / Tong, Hong-Xuan / Han, Jing-Yan

Frontiers in pharmacology

2020 Volume 11, Page(s) 615166

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.615166
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Article: [Application of "major scientific issues and engineering technology difficulties in traditional Chinese medicine(2019-2021)" in national science and t echnology layout].

Fang, Zi-Han / Wang, Fang / Han, Lan / Li, Geng / Wen, Chang-Lu / Han, Jing-Yan / You, Liang-Zhen / Xu, Yuan / Gao, Zhu-Ye / Fang, Nan-Yuan / Zhang, Xiao-Xiao

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 5, Page(s) 1137–1144

Abstract: In order to judge the future development trend of science and technology, plan ahead and lay out the frontier technology fields and directions, China Association of Chinese Medicine(CACM) has launched consultation projects for collecting "major scienti- ... ...

Abstract	In order to judge the future development trend of science and technology, plan ahead and lay out the frontier technology fields and directions, China Association of Chinese Medicine(CACM) has launched consultation projects for collecting "major scienti-fic issues and engineering technology difficulties in traditional Chinese medicine(TCM)" for the industry for three consecutive years since 2019. Up to now, 18 projects have been selected as major issues for research, and some experience and achievements have been made. These projects have been applied in important scientific and technological work such as scientific and technological planning and deployment at all levels of national, local, and scientific research institutions, the selection and cultivation of major national scientific and technological projects, and the construction of innovation bases, giving full play to the role of the think tank advisory committee of CACM. This study reviewed the selection of major issues for the first time, systematically combed its application in the national layout of science and technology, and put forward the existing problems and improvement suggestions, aiming to provide new ideas for further improving the selection of major issues and research direction, providing a theoretical basis and decision support for the national scientific and technological layout in the field of TCM, and promoting scientific and technological innovation to facilitate the high quality development of TCM.
MeSH term(s)	Medicine, Chinese Traditional ; Inventions ; China ; Drugs, Chinese Herbal
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2023-04-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20221108.601
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Zs.A 3056: Show issues

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Article ; Online: YangXueQingNaoWan attenuated blood brain barrier disruption after thrombolysis with tissue plasminogen activator in ischemia stroke.

Yao, Shu-Qi / Ye, Yang / Li, Quan / Wang, Xiao-Yi / Yan, Li / Huo, Xin-Mei / Pan, Chun-Shui / Fu, Yu / Liu, Jian / Han, Jing-Yan

Journal of ethnopharmacology

2023 Volume 318, Issue Pt B, Page(s) 117024

Abstract: Ethnopharmacological relevant: YangXueQingNaoWan (YXQNW), a compound Chinese medicine, has been widely used for dizziness, irritability, insomnia, and dreaminess caused by blood deficiency and liver hyperactivity in China. However, whether YXQNW can ... ...

Abstract	Ethnopharmacological relevant: YangXueQingNaoWan (YXQNW), a compound Chinese medicine, has been widely used for dizziness, irritability, insomnia, and dreaminess caused by blood deficiency and liver hyperactivity in China. However, whether YXQNW can inhibit cerebral microvascular exudation and cerebral hemorrhage (CH) caused by blood brain barrier (BBB) damage after tissue plasminogen activator (tPA) still unknown. Aim of the research: To observe the effect of YXQNW on cerebral microvascular exudation and CH after tPA and investigate its mechanism in protecting BBB. Materials and methods: Male C57BL/6 N mice suffered from ischemia stroke by mechanical detachment of carotid artery thrombi with the stimulation of ferric chloride. Then mice were treated with tPA (10 mg/kg) and/or YXQNW (0.72 g/kg) at 4.5 h. Cerebral blood flow (CBF), infarct size, survival rate, neurological scores, gait analysis, Evans blue extravasation, cerebral water content, fluorescein isothiocyanate-labeled albumin leakage, hemorrhage, junction and basement membrane proteins expression, leukocyte adhesion and matrix metalloproteinases (MMPs) expression were evaluated 24 h after tPA. Proteomics was used to identify target proteins. Results: YXQNW inhibited cerebral infarction, neurobehavioral deficits, decreased survival, Evans blue leakage, albumin leakage, cerebral water content and CH after tPA thrombolysis; improved CBF, low-expression and degradation of junction proteins, basement membrane proteins, Arhgap21 and its downstream α-catenin and β-catenin proteins expression; and suppressed the increase of adherent leukocytes and the release of MMP-9 derived from macrophage. Conclusion: YXQNW relieved BBB damage and attenuated cerebral microvascular exudation and CH after tPA thrombolysis. The effect of YXQNW on cerebral microvascular exudation was associated with the inhibition of the low-expression of junction proteins, especially AJs mediated by Rho GTPase-activating protein 21 (Arhgap21), while the effect on CH was associated with the inhibition of leukocyte adhesion, the release of MMP-9 derived from macrophage, and low-expression and degradation of collagen IV and laminin in the vascular basement membrane.
MeSH term(s)	Male ; Mice ; Animals ; Tissue Plasminogen Activator/therapeutic use ; Blood-Brain Barrier ; Matrix Metalloproteinase 9/metabolism ; Evans Blue/metabolism ; Evans Blue/pharmacology ; Evans Blue/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Mice, Inbred C57BL ; Cerebral Hemorrhage/drug therapy ; Cerebral Infarction/drug therapy ; Ischemic Stroke/drug therapy ; Thrombolytic Therapy ; Albumins/pharmacology ; Stroke/drug therapy ; Stroke/metabolism
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Evans Blue (45PG892GO1) ; Albumins
Language	English
Publishing date	2023-08-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117024
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Article ; Online: Chanling Gao suppresses colorectal cancer via PI3K/Akt/mTOR pathway modulation and enhances quality of survival.

Chen, Guo / Tian, Ting-Ting / Wang, Fei-Qing / Pan, Chun-Shui / Sun, Kai / Wang, Xiao-Yi / Yang, Bing / Yang, Zhu / Tang, Dong-Xin / Han, Jing-Yan

Environmental toxicology

2023 Volume 39, Issue 3, Page(s) 1107–1118

Abstract: The Chinese medicine formula Chanling Gao (CLG) exhibits significant tumor inhibitory effects in colorectal cancer (CRC) nude mice. However, the detailed mechanisms remain elusive. CRC in situ nude mouse models were treated with CLG. Small animal ... ...

Abstract	The Chinese medicine formula Chanling Gao (CLG) exhibits significant tumor inhibitory effects in colorectal cancer (CRC) nude mice. However, the detailed mechanisms remain elusive. CRC in situ nude mouse models were treated with CLG. Small animal magnetic resonance imaging (MRI) tracked tumor progression, and overall health metrics such as food and water intake, body weight, and survival were monitored. Posttreatment, tissues and blood were analyzed for indicators of tumor inhibition and systemic effects. Changes in vital organs were observed via stereoscope and hematoxylin-eosin staining. Immunohistochemistry quantified HIF-1α and P70S6K1 protein expression in xenografts. Double labeling was used to statistically analyze vascular endothelial growth factor (VEGF) and CD31 neovascularization. Enzyme-linked immunosorbent assay was used to determine the levels of VEGF, MMP-2, MMP-9, IL-6, and IL-10 in serum, tumors, and liver. Western blotting was used to assess the expression of the PI3K/Akt/mTOR signaling pathway-related factors TGF-β1 and smad4 in liver tissues. CLG inhibited tumor growth, improved overall health metrics, and ameliorated abnormal blood cell counts in CRC nude mice. CLG significantly reduced tumor neovascularization and VEGF expression in tumors and blood. It also suppressed HIF-1α, EGFR, p-PI3K, Akt, p-Akt, and p-mTOR expression in tumors while enhancing PTEN oncogene expression. Systemic improvements were noted, with CLG limiting liver metastasis, reducing pro-inflammatory cytokines IL-6 and IL-10 in liver tissues, decreasing MMP-2 in blood and MMP-2 and MMP-9 in tumors, and inhibiting TGF-β1 expression in liver tissues. CLG can enhance survival quality and inhibit tumor growth in CRC nude mice, likely through the regulation of the PI3K/Akt/mTOR signaling pathway.
MeSH term(s)	Mice ; Animals ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Transforming Growth Factor beta1 ; Vascular Endothelial Growth Factor A/metabolism ; Mice, Nude ; Interleukin-10 ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9 ; Interleukin-6 ; TOR Serine-Threonine Kinases/metabolism ; Liver Neoplasms ; Colorectal Neoplasms/metabolism ; Cell Line, Tumor
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Transforming Growth Factor beta1 ; Vascular Endothelial Growth Factor A ; Interleukin-10 (130068-27-8) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Interleukin-6 ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23994
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Article ; Online: Post-treatment with yiqifumai injection and its main ingredients attenuates lipopolysaccharide-induced microvascular disturbance in mesentery and ileum.

Ayididaer, Ayan / Sun, Kai / Pan, Chun-Shui / Yan, Li / Liu, Yu-Ying / Li, Dan-Tong / Fan, Jing-Yu / Han, Jing-Yan

Microcirculation (New York, N.Y. : 1994)

2021 Volume 28, Issue 4, Page(s) e12680

Abstract: Objective: To investigate the effect of Yiqifumai injection (YQFM), a compound Chinese medicine, and its main active ingredients on lipopolysaccharide (LPS)-induced microvascular disturbance in mesentery and ileum.: Methods: Rats were infused with ... ...

Abstract	Objective: To investigate the effect of Yiqifumai injection (YQFM), a compound Chinese medicine, and its main active ingredients on lipopolysaccharide (LPS)-induced microvascular disturbance in mesentery and ileum. Methods: Rats were infused with LPS (5 mg/kg/h) for 90 min. Thirty minutes after initiation of LPS administration, YQFM (160 mg/kg/h), Rb1 (5 mg/kg/h), Sch (2.5 mg/kg/h), or Rb1+Sch (5 mg/kg/h + 2.5 mg/kg/h) was infused until 90 min. Human umbilical vein endothelial cells (HUVECs) were incubated with LPS (100 ng/ml) for 90 min. YQFM (1 mg/ml), Rb1 (100 µM), Sch (100 µM), or Rb1+Sch (200 µM) was added 30 min after initiation of LPS stimulation. Results: Yiqifumai injection and Rb1+Sch inhibited mesenteric venule hyperpermeability, suppressed microvillar erosion and submucosal edema, and protected claudin-5 from downregulation and interleukin-1β from upregulation in ileal tissues after LPS. Study in HUVECs confirmed the effect of YQFM and Rb1+Sch on JAM-1 after LPS and revealed a similar effect on other junction proteins. Moreover, YQFM and Rb1+Sch attenuated the dysfunctional energy metabolism and the activation of TLR-4/Src/NF-κB signaling with Rb1 and Sch being partially effective. Conclusion: These results demonstrated the beneficial effect of post-treatment with YQFM, which is attributable to its main ingredient Rb1 and Sch, and likely mediated by targeting TLR-4/Src/NF-κB signaling pathway.
MeSH term(s)	Animals ; Cardiovascular Agents/administration & dosage ; Drugs, Chinese Herbal/administration & dosage ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Ileum/blood supply ; Lipopolysaccharides/toxicity ; Mesentery/blood supply ; Microvessels/drug effects ; NF-kappa B ; Rats ; Toll-Like Receptor 4 ; Vascular Diseases/drug therapy ; Vascular Diseases/etiology
Chemical Substances	Cardiovascular Agents ; Drugs, Chinese Herbal ; Lipopolysaccharides ; NF-kappa B ; Toll-Like Receptor 4 ; yi-qi-fu-mai
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217758-1
ISSN	1549-8719 ; 1073-9688
ISSN (online)	1549-8719
ISSN	1073-9688
DOI	10.1111/micc.12680
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Article ; Online: Effects and mechanisms of QiShenYiQi pills and major ingredients on myocardial microcirculatory disturbance, cardiac injury and fibrosis induced by ischemia-reperfusion.

Han, Jing-Yan / Li, Quan / Pan, Chun-Shui / Sun, Kai / Fan, Jing-Yu

Pharmacological research

2019 Volume 147, Page(s) 104386

Abstract: Coronary heart disease remains a major threaten for public health worldwide, and pharmacological or mechanical coronary reperfusion are currently used for treatment of acute coronary syndrome. However, restoration of blood flow to ischemic myocardium ... ...

Abstract	Coronary heart disease remains a major threaten for public health worldwide, and pharmacological or mechanical coronary reperfusion are currently used for treatment of acute coronary syndrome. However, restoration of blood flow to ischemic myocardium leads to ischemia/reperfusion (I/R) injury. Microcirculatory disturbance and cardiac injury after I/R occur via a complex pathologic process including metabolism impairment in the ischemia phase and oxidative stress in the reperfusion phase. Obviously, any treatment targeting a single link is insufficient to cope with I/R injury. Investigation in the past decade in our laboratory as well as in other's demonstrated the cardioprotection potential of QiShenYiQi Pills (QSYQ) and ingredients in experimental animal models of I/R injury. These results have offered insight into the mechanism thereby QSYQ prevents against cardiac I/R injury in clinic. This review will outline the results with respect to the effect of QSYQ and major bioactive ingredients on I/R-induced microcirculatory disturbance, cardiac injury and fibrosis, with emphasis on the underlying mechanisms.
MeSH term(s)	Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Coronary Circulation/drug effects ; Coronary Vessels/drug effects ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Fibrosis ; Humans ; Microcirculation/drug effects ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardium/pathology
Chemical Substances	Cardiotonic Agents ; Drugs, Chinese Herbal ; qishen yiqi
Language	English
Publishing date	2019-08-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2019.104386
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Article: Salvianolic acid B ameliorates vascular endothelial dysfunction through influencing a bone morphogenetic protein 4-ROS cycle in diabetic mice

Liu, Jian / Zhang, Yi / Qu, Dan / Zhang, Huina / Wang, Li / Lau, Chi Wai / Han, Jing-Yan / Pingcuo, Danzeng / Huang, Yu / Liu, Limei

Life sciences. 2021 Dec. 01, v. 286

2021

Abstract: This study investigated the roles of bone morphogenetic protein-4 (BMP4) and ROS in diabetic endothelial dysfunction and explored whether Salvianolic acid B (Sal B) improved endothelial function by affecting BMP4-ROS in diabetic mice.db/db mice were ... ...

Abstract	This study investigated the roles of bone morphogenetic protein-4 (BMP4) and ROS in diabetic endothelial dysfunction and explored whether Salvianolic acid B (Sal B) improved endothelial function by affecting BMP4-ROS in diabetic mice.db/db mice were orally administrated with Sal B (10 mg/kg/day) for one week while db/m + mice were injected with adenoviral vectors delivering BMP4 (3 × 10⁸ pfu) and then received one week-Sal B treatment. ROS levels were assayed by DHE staining. Protein expression and phosphorylation were evaluated by Western blot. Aortic rings were suspended in myograph for force measurement. Flow-mediated dilatations in the second-order mesenteric arteries were determined by pressure myograph.We first revealed the existence of a BMP4-ROS cycle in db/db mice, which stimulated p38 MAPK/JNK/caspase 3 and thus participated in endothelial dysfunction. One week-treatment or 24 h-incubation with Sal B disrupted the cycle, suppressed p38 MAPK/JNK/caspase 3 cascade, and improved endothelium-dependent relaxations (EDRs) in db/db mouse aortas. Importantly, in vivo Sal B treatment also improved flow-mediated dilatation in db/db mouse second order mesenteric arteries. Furthermore, in vivo BMP4 overexpression induced oxidative stress, stimulated p38 MAPK/JNK/caspase 3, and impaired EDRs in db/m + mouse aortas, which were all reversed by Sal B.The present study demonstrates that Sal B ameliorates endothelial dysfunction through breaking the BMP4-ROS cycle and subsequently inhibiting p38 MAPK/JNK/caspase 3 in diabetic mice and provides evidence for the additional new mechanism underlying the benefit of Sal B against diabetic vasculopathy.
Keywords	Adenoviridae ; Western blotting ; bone morphogenetic proteins ; caspase-3 ; mice ; mitogen-activated protein kinase ; oxidative stress ; phosphorylation ; protein synthesis ; salvianolic acid
Language	English
Dates of publication	2021-1201
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.120039
Database	NAL-Catalogue (AGRICOLA)

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