Article ; Online: Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time.
Circulation. Cardiovascular imaging
2023 Volume 16, Issue 10, Page(s) e015009
Abstract: Background: Single-center studies have shown that single photon emission computed tomography myocardial blood flow (MBF) measurement is accurate compared with MBF measured with microspheres in a porcine model, positron emission tomography, and ... ...
| Abstract | Background: Single-center studies have shown that single photon emission computed tomography myocardial blood flow (MBF) measurement is accurate compared with MBF measured with microspheres in a porcine model, positron emission tomography, and angiography. Clinical implementation requires consistency across multiple sites. The study goal is to determine the intersite processing repeatability of single photon emission computed tomography MBF and the additional camera time required. Methods: Five sites (Canada, Italy, Japan, Germany, and Singapore) each acquired 25 to 35 MBF studies at rest and with pharmacological stress using technetium-99m-tetrofosmin on a pinhole-collimated cadmium-zinc-telluride-based cardiac single photon emission computed tomography camera with standardized list-mode imaging and processing protocols. Patients had intermediate to high pretest probability of coronary artery disease. MBF was measured locally and at a core laboratory using commercially available software. The time a room was occupied for an MBF study was compared with that for a standard rest/stress myocardial perfusion study. Results: With motion correction, the overall correlation in MBF between core laboratory and local site was 0.93 (range, 0.87-0.97) at rest, 0.90 (range, 0.84-0.96) at stress, and 0.84 (range, 0.70-0.92) for myocardial flow reserve. The local-to-core difference in global MBF (bias Conclusions: The average bias Registration: URL: https://www. Clinicaltrials: gov; Unique identifier: NCT03427749. |
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| MeSH term(s) | Animals ; Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Circulation ; Feasibility Studies ; Heart ; Myocardial Perfusion Imaging/methods ; Positron-Emission Tomography/methods ; Swine ; Tomography, Emission-Computed, Single-Photon/methods |
| Language | English |
| Publishing date | 2023-10-06 |
| Publishing country | United States |
| Document type | Clinical Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2435045-X |
| ISSN | 1942-0080 ; 1941-9651 |
| ISSN (online) | 1942-0080 |
| ISSN | 1941-9651 |
| DOI | 10.1161/CIRCIMAGING.122.015009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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