Article ; Online: [Determination of phenoxyacetic herbicides, metabolites of organophosphorus and pyrethroid pesticides in human urine using solid phase extraction coupled with ultra-performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography
2023 Volume 41, Issue 3, Page(s) 224–232
Abstract: Pesticides are widely used in most agricultural areas to protect food crops but adversely affect ecosystems and human beings. Pesticides have attracted great public concern due to their toxic properties and ubiquitous occurrence in the environment. China ...
| Abstract | Pesticides are widely used in most agricultural areas to protect food crops but adversely affect ecosystems and human beings. Pesticides have attracted great public concern due to their toxic properties and ubiquitous occurrence in the environment. China is one of the largest users and producers of pesticides globally. However, limited data are available on pesticide exposure in humans, which warrants a method for quantification of pesticides in human samples. In the present study, we validated and developed a comprehensive and sensitive method for the quantification of two phenoxyacetic herbicides, two metabolites of organophosphorus pesticides and four metabolites of pyrethroid pesticides in human urine using 96-well plate solid phase extraction (SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). For this purpose, a systematic optimization of the chromatographic separation conditions and MS/MS parameters was conducted. Six solvents were optimized for the extraction and clean-up of human urine samples. The targeted compounds in the human urine samples were well separated within 16 min in one analytical run. A 1 mL aliquot of human urine sample was mixed with 0.5 mL sodium acetate buffer (0.2 mol/L) and hydrolyzed by |
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| MeSH term(s) | Humans ; Pesticides ; Herbicides ; Pyrethrins ; Tandem Mass Spectrometry ; Chromatography, Liquid ; Ecosystem ; Organophosphorus Compounds ; Benzoic Acid ; 2,4,5-Trichlorophenoxyacetic Acid ; 2,4-Dichlorophenoxyacetic Acid |
| Chemical Substances | Pesticides ; Herbicides ; Pyrethrins ; 3-phenoxybenzoic acid (69DC2655VH) ; Organophosphorus Compounds ; Benzoic Acid (8SKN0B0MIM) ; 2,4,5-Trichlorophenoxyacetic Acid (9Q963S4YMX) ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262) |
| Language | Chinese |
| Publishing date | 2023-03-01 |
| Publishing country | China |
| Document type | English Abstract ; Journal Article |
| ISSN | 1872-2059 |
| ISSN (online) | 1872-2059 |
| DOI | 10.3724/SP.J.1123.2022.05005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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