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  1. Article: [Research Progress and Design Strategy of Hemostatic Adhesives].

    Zhao, Chenyu / Wang, Han / Han, Qianqian

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2024  Volume 48, Issue 1, Page(s) 57–64

    Abstract: Adhesives have emerged as an effective method for wound closure, hemostasis and tissue engineering in recent years, which not only are suitable for the adhesion of wet tissues, but also can adapt to the peristalsis and mechanical stretching of tissues ... ...

    Abstract Adhesives have emerged as an effective method for wound closure, hemostasis and tissue engineering in recent years, which not only are suitable for the adhesion of wet tissues, but also can adapt to the peristalsis and mechanical stretching of tissues and organs, especially for arteries and organize bleeding. With the further development of technology, existing adhesives can be modified through different strategies, and new materials are explored, giving new properties and uses to adhesives, such as drug delivery, temperature sensitivity, light sensitivity and so on. Nevertheless, there are many questions about the design and practical clinical application of adhesives in the future. The recent research progress of traditional adhesives and their application in hemostasis is reviewed, and the design and development ideas of future adhesives are discussed in the study.
    MeSH term(s) Adhesives ; Hemostatics/therapeutic use ; Biocompatible Materials ; Tissue Adhesives/therapeutic use ; Hemostasis
    Chemical Substances Adhesives ; Hemostatics ; Biocompatible Materials ; Tissue Adhesives
    Language Chinese
    Publishing date 2024-02-22
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.230152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regarding: The risk of renal comorbidities in celiac disease patients depends on the phenotype of celiac disease.

    Han, Qianqian / Gao, Rui

    Journal of internal medicine

    2022  Volume 292, Issue 5, Page(s) 840–841

    MeSH term(s) Celiac Disease/complications ; Celiac Disease/epidemiology ; Comorbidity ; Humans ; Kidney ; Phenotype
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Letter
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter to the Editor from Han and Xu: "Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes".

    Han, Qianqian / Xu, Huan

    The Journal of clinical endocrinology and metabolism

    2022  Volume 108, Issue 4, Page(s) e56–e57

    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Incidence ; Hypoglycemic Agents ; Liver Cirrhosis/epidemiology ; Neoplasms/epidemiology ; Kidney Failure, Chronic/epidemiology ; Diabetes Mellitus
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The association between atherosclerosis and nonalcoholic fatty liver disease.

    Lv, Qing / Han, Qianqian / Wen, Ziyun / Pan, Yunyun / Chen, Jisheng

    Medicine

    2024  Volume 103, Issue 1, Page(s) e36815

    Abstract: Atherosclerosis (AS) is closely related to nonalcoholic fatty liver disease (NAFLD), which promotes and exacerbates the development of AS. However, it is uncertain how the precise underlying mechanism occurs. Here, we attempted to further explore the ... ...

    Abstract Atherosclerosis (AS) is closely related to nonalcoholic fatty liver disease (NAFLD), which promotes and exacerbates the development of AS. However, it is uncertain how the precise underlying mechanism occurs. Here, we attempted to further explore the association underlying atherosclerosis and nonalcoholic fatty liver disease through integrated bioinformatics analysis. Microarray data for atherosclerosis and nonalcoholic fatty liver disease were retrieved from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was used to identify the genes related to atherosclerosis and nonalcoholic fatty liver disease showing co-expression. Additionally, the common gene targets associated with atherosclerosis and nonalcoholic fatty liver disease were also analyzed and screened using data from 3 public databases [comparative toxicogenomics database (CTD), DISEASES, and GeneCards]. The Gene Ontology (GO) enrichment analysis and the Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were performed using Metascape R, respectively. The protein-protein interaction networks (PPI) network was constructed using Cytoscape. According to the results of an analysis of common genes, matrix metalloproteinase 9 (MMP9) is co-expressed up-regulated in AS and NAFLD and is enriched in inflammatory and immune-related collaterals. Consequently, MMP9 may work together through immunity and inflammation to treat AS and NAFLD and may be a potential therapeutic target in the future. The findings of this study provide new insights into the shared association between AS and NAFLD. MMP9 is co-expressed up-regulated in AS and NAFLD, which be able to reveal the presence of co-expressed genes in atherosclerosis and NAFLD.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/genetics ; Matrix Metalloproteinase 9/genetics ; Atherosclerosis/genetics ; Computational Biology ; Databases, Factual
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Demographic distribution analysis of different glomerular diseases in Southwest China from 2008 to 2022.

    Han, Qianqian / Xu, Huan / Li, Lin / Lei, Song / Yang, Mei

    International urology and nephrology

    2024  

    Abstract: Background: Environmental and lifestyle factors play an etiological role in the pathogenesis of different glomerular diseases. Thus, exploring the epidemic characteristics of renal disease in different nationalities and regions is important.: ... ...

    Abstract Background: Environmental and lifestyle factors play an etiological role in the pathogenesis of different glomerular diseases. Thus, exploring the epidemic characteristics of renal disease in different nationalities and regions is important.
    Materials and methods: Patients who underwent renal biopsy from October 2008 to October 2022 were included. The proportion and change tendency of glomerular diseases and the differences between the sexes and different ages and races were analyzed.
    Results: There were 15,146 cases of glomerular diseases (98.5%), involving 7538 males (49.8%) and 7608 females (50.2%). The mean age was 37.0 years (range 0-80 years). The proportion of membranous nephropathy (MN) and diabetic nephropathy (DN) showed an increased trend. The most common primary glomerulonephritis (PGN) was IgA nephropathy (IgAN, 44.6%), followed by minimal-change disease (MCD, 24.3%) and MN (15.4%). Lupus nephritis (LN, 30%) accounted for the largest proportion of SGNs, followed by Henoch-Schonlein purpura nephritis (HSPN, 20.9%) and DN (19.8%). Compared with adults aged 18-60 years old, MCD and HSPN were more common in children and MN and DN in elderly individuals, statistically significant differences. Additionally, the sex and age distribution of PGN and SGN between the Tibetan and Han populations differed significantly, whereby LN was higher in the Han population and HSPN in the Tibetan population.
    Conclusion: The distribution of glomerular diseases showed age, sex and race differences. This research will be beneficial for providing epidemiological evidence for clinical diagnosis, disease prevention and public health decision-making.
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03902-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Fabrication of a Probe-Integrated Electrochemiluminescence Aptasensor Based on Double-Layered Nanochannel Array with Opposite Charges for the Sensitive Determination of C-Reactive Protein.

    Li, Feng / Han, Qianqian / Xi, Fengna

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 23

    Abstract: The effective and sensitive detection of the important biomarker, C-reactive protein (CRP), is of great significance in clinical diagnosis. The development of a convenient and highly sensitive electrochemiluminescence (ECL) aptasensor with an immobilized ...

    Abstract The effective and sensitive detection of the important biomarker, C-reactive protein (CRP), is of great significance in clinical diagnosis. The development of a convenient and highly sensitive electrochemiluminescence (ECL) aptasensor with an immobilized emitter probe is highly desirable. In this work, a probe-integrated ECL aptamer sensor was constructed based on a bipolar silica nanochannel film (bp-SNF) modified electrode for the highly sensitive ECL detection of CRP. The bp-SNF, modified on an ITO electrode, consisted of a dual-layered SNF film, including the negatively charged inner SNF (n-SNF) and the outer SNF with a positive charge and amino groups (p-SNF). The ECL emitter, tris(bipyridine) ruthenium (II) (Ru(bpy)
    MeSH term(s) Biosensing Techniques/methods ; Electrochemical Techniques/methods ; C-Reactive Protein ; Luminescent Measurements/methods ; Aptamers, Nucleotide ; Silicon Dioxide
    Chemical Substances C-Reactive Protein (9007-41-4) ; Aptamers, Nucleotide ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28237867
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  7. Article: [Research Advances in Medical Materials and Products for Soft Tissue Repairs].

    Li, Jiaqi / Wang, Rui / Han, Qianqian / Sun, Xue

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2023  Volume 47, Issue 4, Page(s) 415–423

    Abstract: Soft tissue is an indispensable tissue in human body. It plays an important role in protecting the body from external physical, chemical or biological factors. Mild soft tissue injuries can self-heal, while severe soft tissue injuries may require related ...

    Abstract Soft tissue is an indispensable tissue in human body. It plays an important role in protecting the body from external physical, chemical or biological factors. Mild soft tissue injuries can self-heal, while severe soft tissue injuries may require related treatment. Natural polymers (such as chitosan, hyaluronic acid, and collagen) and synthetic polymers (such as polyethylene glycol and polylactic acid) exhibit good biocompatibility, biodegradability and low toxicity. It can be used for soft tissue repairs for antibacterial, hemostatic and wound healing purposes. Their related properties can be enhanced through modification or preparation of composite materials. Commonly used soft tissue repairs include wound dressings, biological patches, medical tissue adhesives, and tissue engineering scaffolds. This study introduces the properties, mechanisms of action and applications of various soft tissue repair medical materials, including chitosan, hyaluronic acid, collagen, polyethylene glycol and polylactic acid, and provides an outlook on the application prospects of soft tissue repair medical materials and products.
    MeSH term(s) Humans ; Biocompatible Materials/chemistry ; Chitosan/chemistry ; Hyaluronic Acid ; Tissue Scaffolds/chemistry ; Collagen/chemistry ; Polymers/chemistry ; Polyethylene Glycols ; Soft Tissue Injuries
    Chemical Substances Biocompatible Materials ; Chitosan (9012-76-4) ; Hyaluronic Acid (9004-61-9) ; Collagen (9007-34-5) ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
    Language Chinese
    Publishing date 2023-08-14
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2023.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Electrochemical aptasensor fabricated by anchoring recognition aptamers and immobilizing redox probes on bipolar silica nanochannel array for reagentless detection of carbohydrate antigen 15-3.

    Xing, Jun / Han, Qianqian / Liu, Jiyang / Yan, Zhengzheng

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1324469

    Abstract: Timely, convenient, and efficient detection of carbohydrate antigen 15-3 (CA15-3) levels in serum holds significant importance in early screening, diagnostic assistance and prognosis prediction of breast cancer. The development of efficient and ... ...

    Abstract Timely, convenient, and efficient detection of carbohydrate antigen 15-3 (CA15-3) levels in serum holds significant importance in early screening, diagnostic assistance and prognosis prediction of breast cancer. The development of efficient and convenient electrochemical aptasensors with immobilized redox probes for label-free detection of CA15-3 is highly desirable. In this work, a bipolar silica nanochannel array film (bp-SNA) with two distinct functional domains including nanochannels and an outer surface was employed for the immobilization of recognition ligands and electrochemical redox probes, enabling the construction of a probe-integrated aptasensor for reagentless electrochemical detection of CA15-3. Cost-effective and readily available indium tin oxide (ITO) was used as the supporting electrode for sequential growth of a negatively charged inner layer (n-SNA) followed by a positively charged outer layer (p-SNA). The preparation process of bp-SNA is convenient. Functionalization of amino groups on the outer surface of bp-SNA was modified by aldehyde groups for covalent immobilization of recognition aptamers, further establishing the recognition interface. Within the nanochannels of bp-SNA, the electrochemical redox probe, tri (2,2'-dipyridyl) cobalt (II) (Co(bpy)
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1324469
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  9. Article ; Online: Aflibercept versus ranibizumab for diabetic macular edema: A meta-analysis.

    Chen, Haiyan / Shi, Xuehui / Zhang, Wang / Han, Qianqian

    European journal of ophthalmology

    2023  , Page(s) 11206721231178658

    Abstract: Objective: The purpose of this study was to compare the efficacy and safety of aflibercept (AFL) versus ranibizumab (RAN) for the treatment of diabetic macular edema (DME).: Methods: The PubMed, Embase, Cochrane Library, and CNKI databases were ... ...

    Abstract Objective: The purpose of this study was to compare the efficacy and safety of aflibercept (AFL) versus ranibizumab (RAN) for the treatment of diabetic macular edema (DME).
    Methods: The PubMed, Embase, Cochrane Library, and CNKI databases were searched up to September 2022 to identify prospective randomized controlled trials (RCTs) comparing AFL with RAN for the treatment of DME. Review Manager 5.3 software was used for data analysis. We used the GRADE system to evaluate the quality of the evidence for each outcome.
    Results: A total of 8 RCTs involving 1067 eyes (939 patients) were included; there were 526 eyes in the AFL group and 541 eyes in the RAN group. Meta-analysis revealed that there was no significant difference between RAN and AFL in the best-corrected visual acuity (BCVA) of DME patients at 6 months (WMD: -0.05, 95% CI  =  -0.12 to 0.01, moderate quality) and 12 months after injection (WMD: -0.02, 95% CI  =  -0.07 to 0.03, moderate quality). Additionally, there was no significant difference between RAN and AFL in the reduction of central macular thickness (CMT) at 6 months (WMD: -0.36, 95% CI  =  -24.99 to 24.26, very low quality) and 12 months after injection (WMD: -6.36, 95% CI  =  -16.30 to 3.59, low quality). Meta-analysis showed that the number of intravitreal injections (IVIs) for AFL was significantly lower than that for RAN (WMD: -0.47, 95% CI  =  -0.88 to -0.05, very low quality). There were fewer adverse reactions to AFL than to RAN, but the difference was not significant.
    Conclusion: This study found that there was no difference in BCVA, CMT or adverse reactions between AFL and RAN at 6 and 12 months of follow-up, but AFL needed fewer IVIs than RAN.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721231178658
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  10. Article: [The Status of Industry and Supervision of Medical Devices for Human Assisted Reproductive Technology in China].

    Sun, Xue / Han, Qianqian

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2021  Volume 45, Issue 6, Page(s) 591–593

    Abstract: This study summarizes the status of domestic industries of medical devices for assisted reproductive technology, product category, the status of product classification management, the status of technical review, the progress of quality evaluation ... ...

    Abstract This study summarizes the status of domestic industries of medical devices for assisted reproductive technology, product category, the status of product classification management, the status of technical review, the progress of quality evaluation technology, and the progress of standardization. The domestic industry of medical devices for assisted reproductive technology in my country has begun to take shape, and a solid foundation has been laid for standardization and supervision technology. These will become an important driving force and guarantee for the subsequent development of medical devices for assisted reproductive technology. Under the guidance of the new development concept and the trend of accelerating the construction of the main body of the domestic cycle, my country's independent and controllable assisted reproductive medical device industry is gaining momentum.
    MeSH term(s) China ; Humans ; Industry ; Reference Standards ; Reproductive Techniques, Assisted ; Technology
    Language Chinese
    Publishing date 2021-12-03
    Publishing country China
    Document type Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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