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Article: Role of Caveolae family-related proteins in the development of breast cancer.

Han, Qinyu / Qiu, Shi / Hu, Huiwen / Li, Wenjing / Li, Xiangqi

2023 Volume 10, Page(s) 1242426

Abstract: Breast cancer has become the most significant malignant tumor threatening women's lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell ...

Abstract	Breast cancer has become the most significant malignant tumor threatening women's lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell membrane assembly, and signal transduction. In recent years, Caveolae family-related proteins have been found to be closely related to the occurrence and development of breast cancer. The proteins associated with the Caveolae family-related include Caveolin (Cav) and Cavins. The Cav proteins include Cav-1, Cav-2 and Cav-3, among which Cav-1 has attracted the most attention as a tumor suppressor and promoting factor affecting the proliferation, apoptosis, migration, invasion and metastasis of breast cancer cells. Cav-2 also has dual functions of inhibiting and promoting cancer and can be expressed in combination with Cav-1 or play a regulatory role alone. Cav-3 has been less studied in breast cancer, and the loss of its expression can form an antitumor microenvironment. Cavins include Cavin-1, Cavin-2, Cavin-3 and Cavin-4. Cavin-1 inhibits Cav-1-induced cell membrane tubule formation, and its specific role in breast cancer remains controversial. Cavin-2 acts as a breast cancer suppressor, inhibiting breast cancer progression by blocking the transforming growth factor (TGF-β) signaling pathway. Cavin-3 plays an anticancer role in breast cancer, but its specific mechanism of action is still unclear. The relationship between Cavin-4 and breast cancer is unclear. In this paper, the role of Caveolae family-related proteins in the occurrence and development of breast cancer and their related mechanisms are discussed in detail to provide evidence supporting the further study of Caveolae family-related proteins as potential targets for the diagnosis and treatment of breast cancer.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1242426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The relationship between the Hippo signaling pathway and bone metastasis of breast cancer.

Han, Qinyu / Qiu, Shi / Hu, Huiwen / Li, Wenjing / Dang, Xiangguo / Li, Xiangqi

Frontiers in oncology

2023 Volume 13, Page(s) 1188310

Abstract: Bone is the most common site of metastasis from breast cancer, which is the most prevalent cancer affecting women globally. Bone metastasis from breast cancer severely affects the quality of life of patients and increases mortality. The molecular ... ...

Abstract	Bone is the most common site of metastasis from breast cancer, which is the most prevalent cancer affecting women globally. Bone metastasis from breast cancer severely affects the quality of life of patients and increases mortality. The molecular mechanisms of metastasis, colonization, and proliferation of breast cancer cells in bone are complex and involve the interaction between breast cancer cells and the bone microenvironment. However, the precise mechanism is not clear at present. In recent years, the Hippo signaling pathway has attracted much attention due to its important role in regulating the expression of major effector molecules during tumor development. In particular, studies have found that the mutation and aberrant expression of the core components of the Hippo signaling pathway affect breast cancer cell migration and invasion, indicating that this pathway plays a role in bone metastasis, although the molecular mechanism of this pathway in breast cancer metastasis has not been fully elucidated. In this review, we discuss the function of the Hippo signaling pathway, introducing its role in breast cancer metastasis, especially bone metastasis of breast cancer, so as to lay a solid theoretical foundation for further research and for the development of effective targeted therapeutic agents.
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1188310
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Article ; Online: Metallic Nanoparticle-Enabled Sensing of a Drug-of-Abuse: An Attempt at Forensic Application.

Hu, Ming / Han, Qinyu / Xing, Bengang

Chembiochem : a European journal of chemical biology

2020 Volume 21, Issue 17, Page(s) 2512–2517

Abstract: γ-Hydroxybutyric acid (GHB) functions as a depressant on the central nerve system and serves as a pharmaceutical agent in the treatment of narcolepsy and alcohol withdraw. In recent years, GHB has been misused as a recreational drug due to its ability to ...

Abstract	γ-Hydroxybutyric acid (GHB) functions as a depressant on the central nerve system and serves as a pharmaceutical agent in the treatment of narcolepsy and alcohol withdraw. In recent years, GHB has been misused as a recreational drug due to its ability to induce euphoric feelings. Moreover, it has gained increasing attention as a popular drug of abuse that is frequently related to drug-facilitated sexual assaults. At the moment, detection methods based on chromatography exhibit extraordinary sensitivity for GHB sensing. However, such techniques require complicated sample treatment prior to analysis. Optical sensors provide an alternative approach for rapid and simple analysis of GHB samples. Unfortunately, currently reported probes are mostly based on hydrogen bonding to recognize GHB, and this raises concerns about, for example, the lack of specificity. In this work, we report a bioinspired strategy for selective sensing of GHB. The method is based on specific enzyme recognition to allow highly selective detection of GHB with minimum interference, even in a complex sample matrix (e. g., simulated urine). In addition, the result can be obtained by either quantitative spectroscopy analysis or colorimetric change observed by the naked-eye, thus demonstrating its potential application in drug screening and forensic analysis.
MeSH term(s)	Forensic Sciences ; Gold/chemistry ; Hydroxybutyrates/analysis ; Hydroxybutyrates/metabolism ; Illicit Drugs/analysis ; Illicit Drugs/metabolism ; Metal Nanoparticles/chemistry ; Molecular Structure ; Substance Abuse Detection
Chemical Substances	Hydroxybutyrates ; Illicit Drugs ; Gold (7440-57-5)
Language	English
Publishing date	2020-05-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202000157
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Article ; Online: Restoration of Pregnancy Function Using a GT/PCL Biofilm in a Rabbit Model of Uterine Injury.

Huang, Di / Liu, Jing / Yang, Jie / Liang, Junhui / Zhang, Jing / Han, Qinyu / Yu, Jianlong / Yang, Tingting / Meng, Qi / Steinberg, Thorsten / Li, Changzhong / Chang, Zhongle

Tissue engineering. Part A

2024

Abstract: Biomaterial scaffolds have been used successfully to promote the regenerative repair of small endometrial lesions in small rodents, providing partial restoration of gestational function. The use of rabbits in this study allowed us to investigate a larger ...

Abstract	Biomaterial scaffolds have been used successfully to promote the regenerative repair of small endometrial lesions in small rodents, providing partial restoration of gestational function. The use of rabbits in this study allowed us to investigate a larger endometrial tissue defect and myometrial injury model. A gelatin/polycaprolactone (GT/PCL) gradient-layer biofilm was sutured at the defect to guide the reconstruction of the original tissue structure. Twenty-eight days postimplantation, the uterine cavity had been restored to its original morphology, endometrial growth was accompanied by the formation of glands and blood vessels, and the fragmented myofibers of the uterine smooth muscle had begun to resemble the normal structure of the lagomorph uterine cavity, arranging in a circular luminal pattern and a longitudinal serosal pattern. In addition, the repair site supported both embryonic implantation into the placenta and normal embryonic development. Four-dimensional label-free proteomic analysis identified the cell adhesion molecules, phagosome, ferroptosis, rap1 signaling pathways, hematopoietic cell lineage, complement and coagulation cascades, tricarboxylic acid cycle, carbon metabolism, and hypoxia inducible factor (HIF)-1 signaling pathways as important in the endogenous repair process of uterine tissue injury, and acetylation of protein modification sites upregulated these signaling pathways.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2420582-5
ISSN	1937-335X ; 1937-3341
ISSN (online)	1937-335X
ISSN	1937-3341
DOI	10.1089/ten.TEA.2023.0366
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Article ; Online: Taiyi: a bilingual fine-tuned large language model for diverse biomedical tasks.

Luo, Ling / Ning, Jinzhong / Zhao, Yingwen / Wang, Zhijun / Ding, Zeyuan / Chen, Peng / Fu, Weiru / Han, Qinyu / Xu, Guangtao / Qiu, Yunzhi / Pan, Dinghao / Li, Jiru / Li, Hao / Feng, Wenduo / Tu, Senbo / Liu, Yuqi / Yang, Zhihao / Wang, Jian / Sun, Yuanyuan /

Lin, Hongfei

Journal of the American Medical Informatics Association : JAMIA

2024

Abstract: Objective: Most existing fine-tuned biomedical large language models (LLMs) focus on enhancing performance in monolingual biomedical question answering and conversation tasks. To investigate the effectiveness of the fine-tuned LLMs on diverse biomedical ...

Abstract	Objective: Most existing fine-tuned biomedical large language models (LLMs) focus on enhancing performance in monolingual biomedical question answering and conversation tasks. To investigate the effectiveness of the fine-tuned LLMs on diverse biomedical natural language processing (NLP) tasks in different languages, we present Taiyi, a bilingual fine-tuned LLM for diverse biomedical NLP tasks. Materials and methods: We first curated a comprehensive collection of 140 existing biomedical text mining datasets (102 English and 38 Chinese datasets) across over 10 task types. Subsequently, these corpora were converted to the instruction data used to fine-tune the general LLM. During the supervised fine-tuning phase, a 2-stage strategy is proposed to optimize the model performance across various tasks. Results: Experimental results on 13 test sets, which include named entity recognition, relation extraction, text classification, and question answering tasks, demonstrate that Taiyi achieves superior performance compared to general LLMs. The case study involving additional biomedical NLP tasks further shows Taiyi's considerable potential for bilingual biomedical multitasking. Conclusion: Leveraging rich high-quality biomedical corpora and developing effective fine-tuning strategies can significantly improve the performance of LLMs within the biomedical domain. Taiyi shows the bilingual multitasking capability through supervised fine-tuning. However, those tasks such as information extraction that are not generation tasks in nature remain challenging for LLM-based generative approaches, and they still underperform the conventional discriminative approaches using smaller language models.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1093/jamia/ocae037
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Zs.A 4128: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Extraspecific Manifestation of Nanoheater's Position Effect on Distinctive Cellular Photothermal Responses.

Cong, Thang Do / Wang, Zhimin / Hu, Ming / Han, Qinyu / Xing, Bengang

ACS nano

2020 Volume 14, Issue 5, Page(s) 5836–5844

Abstract: Subcellular localization of nanoparticles plays critical roles in precision medicine that can facilitate an in-depth understanding of disease etiology and achieve accurate theranostic ... ...

Abstract	Subcellular localization of nanoparticles plays critical roles in precision medicine that can facilitate an in-depth understanding of disease etiology and achieve accurate theranostic regulation
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Hyperthermia, Induced ; Nanomedicine ; Nanoparticles ; Phototherapy ; Theranostic Nanomedicine
Language	English
Publishing date	2020-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c00951
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Article ; Online: Near-Infrared Light Brightens Bacterial Disinfection: Recent Progress and Perspectives.

Han, Qinyu / Lau, Jun Wei / Do, Thang Cong / Zhang, Zhijun / Xing, Bengang

ACS applied bio materials

2020 Volume 4, Issue 5, Page(s) 3937–3961

Abstract: Bacterial infection is a universal threat to public health, which not only causes many serious diseases but also exacerbates the condition of the patients of cancer, pandemic diseases, ...

Abstract	Bacterial infection is a universal threat to public health, which not only causes many serious diseases but also exacerbates the condition of the patients of cancer, pandemic diseases,
MeSH term(s)	Bacteria/radiation effects ; Bacterial Infections/prevention & control ; Disinfection/methods ; Humans ; Infrared Rays ; Nanomedicine/trends ; Photochemotherapy ; Photothermal Therapy
Language	English
Publishing date	2020-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.0c01341
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recomposition and storage of sunlight with intelligent phosphors for enhanced photosynthesis.

Zhang, Zhijun / Han, Qinyu / Liu, Songhan / Wang, Zhimin / Hu, Ming / Domnic, Szeto Mun Wai / Lau, Raymond / Xing, Bengang

Dalton transactions (Cambridge, England : 2003)

2021 Volume 50, Issue 32, Page(s) 11025–11029

Abstract: This work presents a smart solar energy regulation strategy using photon tunable long persistent phosphors as solar energy harvesting antennas to enhance overall sunlight utilization by photosynthetic organisms in multiple modes. ...

Abstract	This work presents a smart solar energy regulation strategy using photon tunable long persistent phosphors as solar energy harvesting antennas to enhance overall sunlight utilization by photosynthetic organisms in multiple modes.
Language	English
Publishing date	2021-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d1dt02207e
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Article: Luminescent molecules towards precise cellular event regulation

Hu, Ming / Han, Qinyu / Lyu, Linna / Tong, Yan / Dong, Shuo / Loh, Zhi-Heng / Xing, Bengang

Chemical communications. 2020 Sept. 1, v. 56, no. 70

2020

Abstract: A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission of the complex ... ...

Abstract	A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission of the complex can successfully modulate the activities of light-gated membrane channels and regulate the ion flux in vivo.
Keywords	chemical communication ; emissions ; ion channels ; lanthanides ; luminescence ; surfaces
Language	English
Dates of publication	2020-0901
Size	p. 10231-10234.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d0cc01923b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions.

Chen, Lizhen / Zhang, Zhao / Han, Qinyu / Maity, Barun K / Rodrigues, Leticia / Zboril, Emily / Adhikari, Rashmi / Ko, Su-Hyuk / Li, Xin / Yoshida, Shawn R / Xue, Pengya / Smith, Emilie / Xu, Kexin / Wang, Qianben / Huang, Tim Hui-Ming / Chong, Shasha / Liu, Zhijie

Molecular cell

2023 Volume 83, Issue 19, Page(s) 3438–3456.e12

Abstract: Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen receptor (AR) forms condensates ... ...

Abstract	Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen receptor (AR) forms condensates through multivalent interactions mediated by its N-terminal intrinsically disordered region (IDR) to orchestrate enhancer assembly in response to androgen signaling. AR IDR can be substituted by IDRs from selective proteins for AR condensation capacity and its function on enhancers. Expansion of the poly(Q) track within AR IDR results in a higher AR condensation propensity as measured by multiple methods, including live-cell single-molecule microscopy. Either weakening or strengthening AR condensation propensity impairs its heterotypic multivalent interactions with other enhancer components and diminishes its transcriptional activity. Our work reveals the requirement of an optimal level of AR condensation in mediating enhancer assembly and suggests that alteration of the fine-tuned multivalent IDR-IDR interactions might underlie AR-related human pathologies.
MeSH term(s)	Humans ; Enhancer Elements, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Hormones ; Signal Transduction
Chemical Substances	Transcription Factors ; Hormones
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.08.027
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