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  1. AU="Han, SeungHye"
  2. AU="Verbić, Tatjana"
  3. AU="Abernethy, David"
  4. AU=Bianchi Claudio
  5. AU="Antonelli, Donna"
  6. AU="Patrick, Anna E"
  7. AU="Philippe J. Guerin"
  8. AU="Oygucu, I Hakan"
  9. AU="Salem, Mohammad"
  10. AU="Lotan, Dor"
  11. AU="Mattingly, M C K" AU="Mattingly, M C K"
  12. AU="Rastogi Ajay"
  13. AU="Deniz Kantar"
  14. AU="Stucky, Cheryl L"
  15. AU="Higashino, Kosaku"
  16. AU="Johnston, Sara C"
  17. AU=Fisayo Temitope
  18. AU="Buret, Laetitia"
  19. AU=Guirao Antonio
  20. AU="Tang, Anthony"
  21. AU="Garnelo, Luiza"
  22. AU=Sakanari J A AU=Sakanari J A
  23. AU="Ni, Fuchuan"
  24. AU="Anithachristy S Arumanayagam"
  25. AU="Melman, Dick"

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  1. Artikel ; Online: Unveiling an Important New Cell Type in the Lung: Microfold Cells.

    Han, SeungHye

    American journal of respiratory cell and molecular biology

    2024  Band 70, Heft 4, Seite(n) 235–236

    Mesh-Begriff(e) M Cells ; Lung
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2024-0002ED
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Alveolar epithelial regeneration in the aging lung.

    Han, SeungHye / Budinger, G R Scott / Gottardi, Cara J

    The Journal of clinical investigation

    2023  Band 133, Heft 20

    Abstract: Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis. This risk was manifest during the COVID-19 ... ...

    Abstract Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis. This risk was manifest during the COVID-19 pandemic, when elderly people were disproportionately affected and died from SARS-CoV-2 pneumonia. However, the recent pandemic also provided lessons on lung resilience. An overwhelming majority of patients with SARS-CoV-2 pneumonia, even those with severe disease, recovered with near-complete restoration of lung architecture and function. These observations are inconsistent with historic views of the lung as a terminally differentiated organ incapable of regeneration. Here, we review emerging hypotheses that explain how the lung repairs itself after injury and why these mechanisms of lung repair fail in some individuals, particularly the elderly.
    Mesh-Begriff(e) Humans ; Aged ; COVID-19/pathology ; Pandemics ; SARS-CoV-2 ; Lung/pathology ; Pneumonia/pathology ; Aging ; Pulmonary Fibrosis/pathology ; Regeneration
    Sprache Englisch
    Erscheinungsdatum 2023-10-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI170504
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis.

    Han, SeungHye / Chandel, Navdeep S

    American journal of respiratory cell and molecular biology

    2021  Band 65, Heft 2, Seite(n) 134–145

    Abstract: Metabolism is essential for a living organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism) and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways tightly ... ...

    Abstract Metabolism is essential for a living organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism) and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways tightly regulate mammalian cellular metabolism. Simultaneously, metabolism itself serves as a signaling pathway to control many cellular processes, such as proliferation, differentiation, cell death, gene expression, and adaptation to stress. Considerable progress in the metabolism field has come from understanding how cancer cells co-opt metabolic pathways for growth and survival. Recent data also show that several metabolic pathways may participate in the pathogenesis of lung diseases, some of which could be promising therapeutic targets. In this translational review, we will outline the basic metabolic principles learned from the cancer metabolism field as they apply to the pathogenesis of pulmonary arterial hypertension and fibrosis and will place an emphasis on therapeutic potential.
    Mesh-Begriff(e) Animals ; Citric Acid Cycle ; Fibrosis ; Fluorodeoxyglucose F18/therapeutic use ; Glycolysis ; Humans ; Metabolic Networks and Pathways ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Positron-Emission Tomography ; Pulmonary Arterial Hypertension/diagnostic imaging ; Pulmonary Arterial Hypertension/metabolism
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Sprache Englisch
    Erscheinungsdatum 2021-04-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0550TR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Output Performance Enhanced Triboelectric Nanogenerators Induced by Magnetic Ink Trapping Property Act as Wearable Sensors.

    Sun, Jingzhe / Lee, Jiwoo / Han, Seunghye / Li, Yongwei / Park, Jong-Jin / Bae, Jihyun

    ACS omega

    2024  Band 9, Heft 3, Seite(n) 3565–3573

    Abstract: The demand for clean-energy collection has gradually increased in recent years, making triboelectric nanogenerators a promising research field, because of their advantages in convenient manufacturing, diversified materials, and diverse synthesis and ... ...

    Abstract The demand for clean-energy collection has gradually increased in recent years, making triboelectric nanogenerators a promising research field, because of their advantages in convenient manufacturing, diversified materials, and diverse synthesis and modification possibilities. However, recent studies indicate that charge decay, a major limiting factor in the triboelectric output, prevents the induced charge from combining with the bottom electrode, leading to charge loss. The use of charge-trapping sites to retain the induced charge generated during the friction process is an important solution in the field of triboelectric nanogenerator research. This study proposes the use of an elastic ink with macroscopic magnetism as trapping sites by coating the ink as dots between the polytetrafluoroethylene (PTFE) dielectric layer and the electrode layer. Nickel particles in the magnetic ink are doped into the system as microcapacitors, which prevent the combination of the friction layer and induced charges on the back electrode. Because the nickel itself can be used as a charge-potential trap to capture the charge introduced by the charge-injection process, the charge can be maintained for a long time and achieve a long-term high-output state. The output voltage was more than 6 times that of the reference group without the magnetic-ink coating after 3 h. The results provide a reference direction for research on preventing charge decay and trapping charges in triboelectric nanogenerators.
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07460
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: There Is No Smoke without Mitochondria.

    Han, SeungHye / Chandel, Navdeep S

    American journal of respiratory cell and molecular biology

    2018  Band 60, Heft 5, Seite(n) 489–491

    Mesh-Begriff(e) Mitochondria ; Mitochondrial Proteins ; Oxidoreductases ; Plant Proteins ; Smoke ; Smoking ; Nicotiana
    Chemische Substanzen Mitochondrial Proteins ; Plant Proteins ; Smoke ; Oxidoreductases (EC 1.-) ; alternative oxidase (EC 1.-)
    Sprache Englisch
    Erscheinungsdatum 2018-10-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2018-0348ED
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Amplified Performance of Charge Accumulation and Trapping Induced by Enhancing the Dielectric Constant via the Cyano Group of 3D-Structured Textile for a Triboelectric Multi-Modal Sensor.

    Sun, Jingzhe / Ren, Bingqi / Han, Seunghye / Shin, Hyungsub / Cha, Seokjun / Lee, Jiwoo / Bae, Jihyun / Park, Jong-Jin

    Small methods

    2023  Band 7, Heft 10, Seite(n) e2300344

    Abstract: To further improve the output performance of triboelectric devices, reducing charge attenuation and loss has become a hot research topic. Particularly, textiles have emerged as one of the promising research directions for triboelectric devices owing to ... ...

    Abstract To further improve the output performance of triboelectric devices, reducing charge attenuation and loss has become a hot research topic. Particularly, textiles have emerged as one of the promising research directions for triboelectric devices owing to their special internal structure and large specific surface area. In the present work, polyacrylonitrile fibers are fabricated with two distinct structures to provide a higher dielectric constant due to the strong polar properties brought about by higher dipole moment of the CN group. In addition, the complex and closely connected structure of the textile increases specific internal surface area. As a friction layer, the output voltage is shown to increase to 625% of the initial value (from 8 to 60 V) after the application of friction for a short time due to accumulation property. When acting as a trapping layer, the charge loss after injection is effectively prevented due to excellent charge trapping effect. After 24 h, the triboelectric output performance remains at ≈70% of the initial value (decreasing from 320 to 220 V), which is more than 20 times that of the polytetrafluoroethylene film, which decreases from 125 to 19 V. The device is realized for the advanced application of multi-modal sensors.
    Sprache Englisch
    Erscheinungsdatum 2023-06-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202300344
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.

    Han, SeungHye / Mallampalli, Rama K

    Annals of the American Thoracic Society

    2015  Band 12, Heft 5, Seite(n) 765–774

    Abstract: Pulmonary surfactant is essential for life as it lines the alveoli to lower surface tension, thereby preventing atelectasis during breathing. Surfactant is enriched with a relatively unique phospholipid, termed dipalmitoylphosphatidylcholine, and four ... ...

    Abstract Pulmonary surfactant is essential for life as it lines the alveoli to lower surface tension, thereby preventing atelectasis during breathing. Surfactant is enriched with a relatively unique phospholipid, termed dipalmitoylphosphatidylcholine, and four surfactant-associated proteins, SP-A, SP-B, SP-C, and SP-D. The hydrophobic proteins, SP-B and SP-C, together with dipalmitoylphosphatidylcholine, confer surface tension-lowering properties to the material. The more hydrophilic surfactant components, SP-A and SP-D, participate in pulmonary host defense and modify immune responses. Specifically, SP-A and SP-D bind and partake in the clearance of a variety of bacterial, fungal, and viral pathogens and can dampen antigen-induced immune function of effector cells. Emerging data also show immunosuppressive actions of some surfactant-associated lipids, such as phosphatidylglycerol. Conversely, microbial pathogens in preclinical models impair surfactant synthesis and secretion, and microbial proteinases degrade surfactant-associated proteins. Deficiencies of surfactant components are classically observed in the neonatal respiratory distress syndrome, where surfactant replacement therapies have been the mainstay of treatment. However, functional or compositional deficiencies of surfactant are also observed in a variety of acute and chronic lung disorders. Increased surfactant is seen in pulmonary alveolar proteinosis, a disorder characterized by a functional deficiency of the granulocyte-macrophage colony-stimulating factor receptor or development of granulocyte-macrophage colony-stimulating factor antibodies. Genetic polymorphisms of some surfactant proteins such as SP-C are linked to interstitial pulmonary fibrosis. Here, we briefly review the composition, antimicrobial properties, and relevance of pulmonary surfactant to lung disorders and present its therapeutic implications.
    Mesh-Begriff(e) Humans ; Lung Diseases/metabolism ; Pulmonary Surfactants/metabolism ; Respiratory Tract Infections/metabolism
    Chemische Substanzen Pulmonary Surfactants
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2015-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201411-507FR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The acute respiratory distress syndrome: from mechanism to translation.

    Han, SeungHye / Mallampalli, Rama K

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Band 194, Heft 3, Seite(n) 855–860

    Abstract: The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although ... ...

    Abstract The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.
    Mesh-Begriff(e) Animals ; Humans ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Distress Syndrome, Adult/therapy ; Translational Medical Research
    Sprache Englisch
    Erscheinungsdatum 2015-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1402513
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Correction: The acute respiratory distress syndrome: from mechanism to translation.

    Han, SeungHye / Mallampalli, Rama K

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Band 194, Heft 11, Seite(n) 5569

    Sprache Englisch
    Erscheinungsdatum 2015-06-01
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1500741
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Sizing up surfactant synthesis.

    Han, SeungHye / Mallampalli, Rama K

    Cell metabolism

    2014  Band 20, Heft 2, Seite(n) 195–196

    Abstract: Phosphatidylcholine is generated through de novo synthesis and remodeling involving a lysophospholipid. In this issue of Cell Metabolism, research from the Shimizu lab (Harayama et al., 2014) demonstrates the highly selective enzymatic behavior of ... ...

    Abstract Phosphatidylcholine is generated through de novo synthesis and remodeling involving a lysophospholipid. In this issue of Cell Metabolism, research from the Shimizu lab (Harayama et al., 2014) demonstrates the highly selective enzymatic behavior of lysophospholipid acyltransferases. The authors present an enzymatic model for phosphatidylcholine molecular species diversification that impacts surfactant formation.
    Mesh-Begriff(e) 1-Acylglycerophosphocholine O-Acyltransferase/metabolism ; Animals ; Phosphatidylcholines/metabolism
    Chemische Substanzen Phosphatidylcholines ; 1-Acylglycerophosphocholine O-Acyltransferase (EC 2.3.1.23)
    Sprache Englisch
    Erscheinungsdatum 2014-08-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2014.07.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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