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  1. Article: Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis.

    Shen, Li-Ping / Jiang, Han-Tao

    Open medicine (Warsaw, Poland)

    2024  Volume 19, Issue 1, Page(s) 20240929

    Abstract: Disulfidptosis was recently reported to be caused by abnormal disulfide accumulation in cells with high SLC7A11 levels subjected to glucose starvation, suggesting that targeting disulfidptosis was a potential strategy for cancer treatment. We analyzed ... ...

    Abstract Disulfidptosis was recently reported to be caused by abnormal disulfide accumulation in cells with high SLC7A11 levels subjected to glucose starvation, suggesting that targeting disulfidptosis was a potential strategy for cancer treatment. We analyzed the relationships between gene expression and mutations and prognoses of patients. In addition, the correlation between gene expression and immune cell infiltration was explored. The potential regulatory mechanisms of these genes were assessed by investigating their related signaling pathways involved in cancer, their expression patterns, and their cellular localization. Most cancer types showed a negative correlation between the gene-set variation analysis (GSVA) scores and infiltration of B cells and neutrophils, and a positive correlation between GSVA scores and infiltration of natural killer T and induced regulatory T cells. Single-cell analysis revealed that
    Language English
    Publishing date 2024-03-30
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2024-0929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Progression/Recurrence of Meningioma: An Imaging Review Based on Magnetic Resonance Imaging.

    Han, Tao / Liu, Xianwang / Zhou, Junlin

    World neurosurgery

    2024  Volume 186, Page(s) 98–107

    Abstract: Meningiomas are the most common primary central nervous system tumors. The preferred treatment is maximum safe resection, and the heterogeneity of meningiomas results in a variable prognosis. Progression/recurrence (P/R) can occur at any grade of ... ...

    Abstract Meningiomas are the most common primary central nervous system tumors. The preferred treatment is maximum safe resection, and the heterogeneity of meningiomas results in a variable prognosis. Progression/recurrence (P/R) can occur at any grade of meningioma and is a common adverse outcome after surgical treatment and a major cause of postoperative rehospitalization, secondary surgery, and mortality. Early prediction of P/R plays an important role in postoperative management, further adjuvant therapy, and follow-up of patients. Therefore, it is essential to thoroughly analyze the heterogeneity of meningiomas and predict postoperative P/R with the aid of noninvasive preoperative imaging. In recent years, the development of advanced magnetic resonance imaging technology and machine learning has provided new insights into noninvasive preoperative prediction of meningioma P/R, which helps to achieve accurate prediction of meningioma P/R. This narrative review summarizes the current research on conventional magnetic resonance imaging, functional magnetic resonance imaging, and machine learning in predicting meningioma P/R. We further explore the significance of tumor microenvironment in meningioma P/R, linking imaging features with tumor microenvironment to comprehensively reveal tumor heterogeneity and provide new ideas for future research.
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.03.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications.

    Yin, Hailian / Jiang, Meiyun / Han, Tao / Xu, Xiaolei

    Peptides

    2024  Volume 176, Page(s) 171211

    Abstract: Animal and human studies have demonstrated that intranasal oxytocin (OT) can penetrate the brain and induce cognitive, emotional, and behavioral changes, particularly in social functioning. Consequently, numerous investigations have explored the ... ...

    Abstract Animal and human studies have demonstrated that intranasal oxytocin (OT) can penetrate the brain and induce cognitive, emotional, and behavioral changes, particularly in social functioning. Consequently, numerous investigations have explored the potential of OT as a treatment for anxiety and autism, conditions characterized by social deficits. Although both subclinical and clinical studies provide converging evidence of the therapeutic effects of OT in reducing anxiety levels and improving social symptoms in autism, results are not always consistent. Additionally, the pharmacological mechanism of OT requires further elucidation for its effective clinical application. Therefore, this review aims to examine the contentious findings concerning the effects of OT on anxiety and autism, offer interpretations of the inconsistent results from the perspectives of individual differences and varying approaches to OT administration, and shed light on the underlying mechanisms of OT. Ultimately, standardization of dosage, frequency of administration, formulation characteristics, and nasal spray devices is proposed as essential for future human studies and clinical applications of OT treatment.
    MeSH term(s) Oxytocin/administration & dosage ; Oxytocin/therapeutic use ; Oxytocin/pharmacology ; Humans ; Administration, Intranasal ; Anxiety/drug therapy ; Autistic Disorder/drug therapy ; Animals
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2024.171211
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1649: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: [FPGA Implementation of Digital Coordinate Conversion of Intravascular Ultrasound Imaging System Based on CORDIC Algorithm].

    Han, Tao / Qiu, Weibao

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2022  Volume 46, Issue 5, Page(s) 485–489

    Abstract: In order to facilitate doctors to better obtain cardiovascular images by using intravascular ultrasound imaging system and make a more accurate diagnosis, a digital coordinate conversion method of intravascular ultrasound imaging system based on CORDIC ... ...

    Abstract In order to facilitate doctors to better obtain cardiovascular images by using intravascular ultrasound imaging system and make a more accurate diagnosis, a digital coordinate conversion method of intravascular ultrasound imaging system based on CORDIC algorithm is proposed, it converts polar coordinates into rectangular coordinates through angular rotation and orientation calculation. The experimental simulation test is carried out on the platform of intravascular ultrasound imaging system by FPGA. Experimental simulation shows that, CORDIC algorithm can effectively output sine and cosine values, compared with the traditional table finding method, this algorithm has faster speed, stronger real-time performance and needs less hardware resources. It is more suitable for intravascular ultrasound imaging system.
    MeSH term(s) Algorithms ; Computer Simulation ; Computers ; Ultrasonography, Interventional
    Language Chinese
    Publishing date 2022-09-29
    Publishing country China
    Document type Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CASC7

    Han, Tao / Liao, Aijun

    International journal of radiation biology

    2022  Volume 98, Issue 10, Page(s) 1510–1518

    Abstract: Aim: To explore the novel lncRNA CASC7 and its potential clinical applications. Long non-coding RNAs (IncRNAs) are defined as non-coding genes with a length exceeding 200 nt. As transcripts of RNA polymerase Il, they have limited coding potential due to ...

    Abstract Aim: To explore the novel lncRNA CASC7 and its potential clinical applications. Long non-coding RNAs (IncRNAs) are defined as non-coding genes with a length exceeding 200 nt. As transcripts of RNA polymerase Il, they have limited coding potential due to the lack of an open reading frame in the gene segment. Research has confirmed that lncRNAs are important biological factors that regulate many life processes in the human body through different mechanisms. This work focused on Cancer Susceptibility Candidate 7 (CASC7), a lncRNA with nuclear and cytoplasmic localization. Publicly available databases show that CASC7 is differentially expressed in human organs as well as in tumor tissues. A study confirmed that CASC7 is abnormally expressed in colorectal cancer, glioma, breast cancer, non-small cell lung cancer and thyroid cancer. In male infertility, asthma and heart failure, it may also be a potential therapeutic target and promising biomarker. CASC7 mainly plays a biological effect through direct or indirect effects of promoting or inhibiting the expression of related genes. Currently, only few studies have assessed CASC7, and its mechanisms are not clear. The main purpose of this review was to examine CASC7 and its possible molecular mechanisms and clinical significance in cancer.
    Conclusion: We reviewed the recent research progress of
    MeSH term(s) Biological Factors ; Biomarkers ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms ; Male ; RNA, Long Noncoding/genetics
    Chemical Substances Biological Factors ; Biomarkers ; RNA, Long Noncoding
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2022.2055801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.280: Show issues Location:
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  6. Article ; Online: Neural network-based predefined-time bipartite formation tracking control of uncertain heterogeneous Euler-Lagrange systems in task space.

    Zhang, Xiao-Yu / Han, Tao / Xiao, Bo / Yan, Huaicheng

    ISA transactions

    2024  

    Abstract: The main problem addressed in this paper is the task-space bipartite formation tracking problem of uncertain heterogeneous Euler-Lagrange systems in predefined time. To solve this problem, an effective hierarchical predefined-time control algorithm is ... ...

    Abstract The main problem addressed in this paper is the task-space bipartite formation tracking problem of uncertain heterogeneous Euler-Lagrange systems in predefined time. To solve this problem, an effective hierarchical predefined-time control algorithm is designed. This algorithm utilizes a non-singular sliding surface, allowing for the adjustment of the upper bound of the settling time as a flexible parameter. Key components of the proposed approach include an estimator for the leader's states and a controller tailored to the formation problem. To mitigate the effects of dynamic uncertainties in the system, the radial basis function neural network is integrated into the methodology. Finally, the effectiveness and validity of the proposed algorithm are demonstrated through numerical simulations, showcasing their practical applicability and efficacy.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2024.03.013
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  7. Article ; Online: Determining the Mechanism of Banxia Xiexin Decoction for Gastric Cancer Treatment through Network Analysis and Experimental Validation.

    Li, Yaxing / Li, Ling / Wang, Xue / Huang, Hailiang / Han, Tao

    ACS omega

    2024  Volume 9, Issue 9, Page(s) 10119–10131

    Abstract: Gastric cancer (GC) is a widespread malignancy. Banxia Xiexin decoction (BXD) has been used for GC treatment, but the specific mechanisms underlying its therapeutic effects remain controversial. This study used a comprehensive approach to network ... ...

    Abstract Gastric cancer (GC) is a widespread malignancy. Banxia Xiexin decoction (BXD) has been used for GC treatment, but the specific mechanisms underlying its therapeutic effects remain controversial. This study used a comprehensive approach to network pharmacology combined with experimental validation to elucidate the mechanism of BXD's anti-GC effects. Initially, we used the UHPLC-LTQ-Orbitrap-MS/MS technology to identify the main chemical constituents of BXD, as well as potential targets associated with these constituents. Then, we employed the Genecard and Online Mendelian Inheritance in Man (OMIM) to determine the targets specifically related to GC. We employed a combination of Gene Ontology (GO), the Kyoto Encyclopedia of Genes and Genomes pathway, and protein-protein interaction analysis to predict the crucial targets of BXD and uncover the pathways involved in its therapeutic effects against GC. The results were subsequently verified through cell experiments. The analysis revealed 174 common targets shared by BXD and GC. GO enrichment analysis highlighted biological processes, such as autophagy, protein kinase activity, and apoptosis. Moreover, the enrichment analysis revealed several significant pathways that serve as the primary mechanisms by which BXD exerts its effects. Notably, these pathways include PI3K-Akt, HIF-1, and Pathways in cancer. Subsequent in vitro experiments demonstrated that BXD effectively hindered GC cell proliferation, stimulated autophagy, and facilitated apoptosis by PI3K-Akt-mTOR signaling pathway regulation. These findings reveal the effectiveness of BXD against GC through diverse components, targets, and pathways, indicating that BXD holds potential therapeutic value in GC treatment. This study uncovers the intricate biological mechanisms that underlie BXD's efficacy in treating GC through the integration of network pharmacology analysis and rigorous in vitro experiments.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cerebral venous sinus thrombosis potentially caused by internal jugular vein thrombosis in a male patient with congenital skull defect.

    Jiang, Shan / Tang, Meng / Shao, Shuo / Jiang, Han-Tao

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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  9. Article ; Online: Surgical repair for congenital macrostomia using three small triangular flaps: Long-term follow-up and outcomes.

    Shen, Weimin / Cui, Jie / Chen, Jianbin / Ji, Yi / Han, Tao

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2024  Volume 93, Page(s) 170–172

    Language English
    Publishing date 2024-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2024.04.056
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    Uk I Zs.157: Show issues Location:
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  10. Article ; Online: Research on Vision-based Position Measurement System for Rocket Propellant Loading

    Han Tao / Dacheng Cong

    E3S Web of Conferences, Vol 267, p

    2021  Volume 01046

    Abstract: In the process of rocket propellant loading, the propellant's own gravity and wind pendulum may cause the connector to exert a large force on the rocket body, which may lead to connector disconnection and fuel leakage, or even damage to the rocket body. ... ...

    Abstract In the process of rocket propellant loading, the propellant's own gravity and wind pendulum may cause the connector to exert a large force on the rocket body, which may lead to connector disconnection and fuel leakage, or even damage to the rocket body. To improve the reliability and safety of rocket propellant loading, a position measurement system based on dynamic orientation detection alignment technology is proposed to achieve tracking of the rocket refueling port. In this paper, the two-dimensional position of the target in the camera plane is quickly extracted by identifying the direction of the target image and the size of the marker in the image, while the distance between the target and the camera is accurately obtained by a laser rangefinder. With this measurement solution, the deviation of the connector from the propellant filler port at the current moment can be modified in real time, thus reducing the forces on the rocket and increasing its launch reliability.
    Keywords Environmental sciences ; GE1-350
    Subject code 620
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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