Article ; Online: Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations.
Chemical research in toxicology
2023 Volume 36, Issue 3, Page(s) 535–551
Abstract: Chiral organophosphorus pollutants are found abundantly in the environment, but the neurotoxicity risks of these asymmetric chemicals to human health have not been fully assessed. Using cellular, molecular, and computational toxicology methods, this ... ...
Abstract | Chiral organophosphorus pollutants are found abundantly in the environment, but the neurotoxicity risks of these asymmetric chemicals to human health have not been fully assessed. Using cellular, molecular, and computational toxicology methods, this story is to explore the static and dynamic toxic actions and its stereoselective differences of chiral isocarbophos toward SH-SY5Y nerve cells mediated by acetylcholinesterase (AChE) and further dissect the microscopic basis of enantioselective neurotoxicity. Cell-based assays indicate that chiral isocarbophos exhibits strong enantioselectivity in the inhibition of the survival rates of SH-SY5Y cells and the intracellular AChE activity, and the cytotoxicity of ( |
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MeSH term(s) | Humans ; Stereoisomerism ; Acetylcholinesterase/chemistry ; Neuroblastoma ; Malathion/chemistry ; Malathion/toxicity ; Neurotoxicity Syndromes |
Chemical Substances | isocarbophos (7741NPW06X) ; Acetylcholinesterase (EC 3.1.1.7) ; Malathion (U5N7SU872W) |
Language | English |
Publishing date | 2023-02-17 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 639353-6 |
ISSN | 1520-5010 ; 0893-228X |
ISSN (online) | 1520-5010 |
ISSN | 0893-228X |
DOI | 10.1021/acs.chemrestox.2c00418 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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