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  1. Book ; Online: Handbook of Educational Reform Through Blended Learning

    Li, Ming / Han, Xibin / Cheng, Jiangang

    2024  

    Author's details edited by Ming Li, Xibin Han, Jiangang Cheng
    Keywords Education, Higher ; Educational technology ; Professional education ; Vocational education
    Language English
    Size 1 Online-Ressource (XII, 418 p. 113 illus., 54 illus. in color)
    Edition 1st ed. 2024
    Publisher Springer Nature Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT030390681
    ISBN 978-981-99-6269-3 ; 9789819962686 ; 9789819962709 ; 9789819962716 ; 981-99-6269-2 ; 9819962684 ; 9819962706 ; 9819962714
    DOI 10.1007/978-981-99-6269-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Handbook of Educational Reform Through Blended Learning

    Li, Ming / Han, Xibin / Cheng, Jiangang

    2024  

    Keywords Higher & further education, tertiary education ; Education ; Industrial or vocational training ; Blended Learning in Higher Education ; Blended Learning in TVET ; A Framework to Promote Educational Reform via Blended Learning ; Methods for Instructors to Design Blended Learning ; Instructor Training for Blended Learning ; Changes of Disciplines and Academic Programs in the Digital Age ; Strategies for Institutions to Implement Blended Learning ; Assessment for Institutions to Implement Blended Learning ; Exemplars of Good Practice in Blended Learning
    Language English
    Size 1 electronic resource (418 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English
    HBZ-ID HT030610145
    ISBN 9789819962686 ; 9819962684
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Handbook of Technical and Vocational Teacher Professional Development in the Digital Age

    Han, Xibin / Zhou, Qian / Li, Ming / Wang, Yuping

    (SpringerBriefs in Education)

    2024  

    Author's details edited by Xibin Han, Qian Zhou, Ming Li, Yuping Wang
    Series title SpringerBriefs in Education
    Keywords Teachers/Training of ; Professional education ; Vocational education ; Educational technology
    Language English
    Size 1 Online-Ressource (XII, 125 p. 8 illus., 4 illus. in color)
    Edition 1st ed. 2024
    Publisher Springer Nature Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT030359646
    ISBN 978-981-99-5937-2 ; 9789819959365 ; 9789819959389 ; 981-99-5937-3 ; 9819959365 ; 9819959381
    DOI 10.1007/978-981-99-5937-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Handbook of Technical and Vocational Teacher Professional Development in the Digital Age

    Han, Xibin / Zhou, Qian / Li, Ming / Wang, Yuping

    (SpringerBriefs in Education)

    2024  

    Series title SpringerBriefs in Education
    Keywords Teacher training ; Industrial or vocational training ; Education ; TVET teachers' digital competencies ; Professional development for TVET teachers ; Teacher training in vocational education ; Assessing teacher competence in vocational education ; Digital transformation in vocational education ; A competency framework for TVET teachers ; Indicators of professional competencies in vocational education ; TVET teacher training models ; Exemplars of good practice in TVET
    Language English
    Size 1 electronic resource (125 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English
    HBZ-ID HT030612867
    ISBN 9789819959365 ; 9819959365
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Hyaluronic acid functionalized ZnO nanoparticles co-deliver AS and GOD for synergistic cancer starvation and oxidative damage.

    Ren, Zhenkun / Han, Xibin / Wang, Lixin / Wang, Yi

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4574

    Abstract: Artesunate was reported to have inhibition effect on tumors via amplified oxidative stress while the lack of intratumoral ferrous ions supply greatly hinders its efficacy. Herein, the AS/GOD@HAZnO NPs we proposed could be efficiently taken in by the ... ...

    Abstract Artesunate was reported to have inhibition effect on tumors via amplified oxidative stress while the lack of intratumoral ferrous ions supply greatly hinders its efficacy. Herein, the AS/GOD@HAZnO NPs we proposed could be efficiently taken in by the affinity between hyaluronic acid and the CD44 receptors. DLS and TEM results manifested the nano-size (~ 160 nm) and circular shape of AS/GOD@HAZnO NPs. Due to the acid-responsive degradation, AS/GOD@HAZnO NPs realized responsive release (up to 80%) in acid environment while only 20% was released in neutral medium. The cellular and in vivo experiment showed that co-delivery of AS and GOD via HAZnO NPs could effectively induce the overproduction of ROS and cut the glucose supply of tumor cells, and thus result in efficient cell apoptosis and tumor inhibition.
    MeSH term(s) Cell Line, Tumor ; Humans ; Hyaluronic Acid ; Nanoparticles ; Neoplasms/pathology ; Oxidative Stress ; Zinc Oxide/pharmacology
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-08627-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sources and spatial variations of heavy metals in offshore sediments of the western Pearl River Estuary.

    Zhao, Jianru / Yang, Kehong / Chu, Fengyou / Ge, Qian / Xu, Dong / Han, Xibin / Ye, Liming

    Marine pollution bulletin

    2023  Volume 188, Page(s) 114599

    Abstract: The concentrations of six heavy metals (Cd, Cr, Cu, Pb, Zn, and As) in offshore surface sediments of western Pearl River Estuary were analyzed to investigate their sources and spatial variations using factorial kriging analysis. Three-scale spatial ... ...

    Abstract The concentrations of six heavy metals (Cd, Cr, Cu, Pb, Zn, and As) in offshore surface sediments of western Pearl River Estuary were analyzed to investigate their sources and spatial variations using factorial kriging analysis. Three-scale spatial variations in heavy metal concentrations were identified and separated: nugget, local, and regional scale, which indicated sample errors, anthropogenic pollution and natural variation, respectively. Anthropogenic heavy metals varied sharply and heterogeneous at range of 60 km. Maoming Port, Hailing Bay and coastal area northeastern Hainan Island were potential polluted areas of Cd, Cr, Cu, Pb, Zn and As, also the Nandu River, Baoling River and Wanquan River estuaries were potential polluted areas of As. These polluted areas ranged up to 60 km in size and tended to extend with currents. The natural heavy metals varied continuously and relatively homogeneous at range of 180 km, which was dominated by riverine input and paleo-sea-level changes.
    MeSH term(s) Estuaries ; Rivers ; Cadmium/analysis ; Lead/analysis ; Water Pollutants, Chemical/analysis ; Geologic Sediments/analysis ; Environmental Monitoring ; Metals, Heavy/analysis ; China ; Risk Assessment
    Chemical Substances Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Water Pollutants, Chemical ; Metals, Heavy
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.114599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sources and burial fluxes of sedimentary organic carbon in the northern Bering Sea and the northern Chukchi Sea in response to global warming.

    Wang, Kui / Zhang, Haisheng / Han, Xibin / Qiu, Wenxian

    The Science of the total environment

    2019  Volume 679, Page(s) 97–105

    Abstract: The Arctic and subarctic seas are the major ... ...

    Abstract The Arctic and subarctic seas are the major CO
    Language English
    Publishing date 2019-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.04.374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Sources and burial fluxes of sedimentary organic carbon in the northern Bering Sea and the northern Chukchi Sea in response to global warming

    Wang, Kui / Zhang, Haisheng / Han, Xibin / Qiu, Wenxian

    Science of the total environment. 2019 Aug. 20, v. 679

    2019  

    Abstract: The Arctic and subarctic seas are the major CO2 sink areas on earth. In this study, the vertical variation characteristics of organic carbon, total nitrogen and their ratio (Corg/Nt), stable isotopes δ13C and δ15N, and BIT (branched and isoprenoid ... ...

    Abstract The Arctic and subarctic seas are the major CO2 sink areas on earth. In this study, the vertical variation characteristics of organic carbon, total nitrogen and their ratio (Corg/Nt), stable isotopes δ13C and δ15N, and BIT (branched and isoprenoid tetraether) index of GDGTs (glycerol dialkyl glycerol tetraethers) in combination with 210Pb-dating were used to analyze the changes in the marine and terrestrial sources of organic carbon in the northern Bering Sea (site 1), western Beaufort Sea slope (site 2) and northern Chukchi Sea (site 3). Organic carbon burial fluxes (OCBF) in the context of global warming were also explored at sites 1 and 3. The results showed that organic matter in these sediments were a mixed input of marine and terrestrial sources, and the BIT index and δ13C of site 2 suggested that the terrestrial soil organic matter was dominant. Based on a combination of 210Pb dating and Corg, the sedimentary OCBF at site 1 was 2.29–3.65 mg cm−2 y−1, and at site 3 was 0.00–0.41 mg cm−2 y−1. The temperature anomalies and sea ice changes in the Arctic in the past 100 years were compared with the burial fluxes of the terrestrial organic carbon. At site 1, the results indicated that fast melting of seasonal sea ice led to earlier arrival of ice algae bloom, enhanced zooplankton feeding and reduced carbon burial from 1947 to 2010, and the sudden increase in carbon burial after 2010 was attributed to an increase in primary productivity and terrestrial organic matter input due to an accelerated melting of sea ice. There was a smaller change in marine organic carbon content in site 3, but OCBF increased after a pre-1965 decrease, mainly controlled by terrestrial organic matter input associated with temperature rising and sea ice melting during recent decades.
    Keywords carbon dioxide ; global warming ; glycerol ; ice ; isoprenoids ; lead ; melting ; nitrogen ; organic carbon ; primary productivity ; sediments ; soil organic matter ; stable isotopes ; temperature ; total nitrogen ; zooplankton ; Arctic region ; Beaufort Sea ; Bering Sea ; Chukchi Sea
    Language English
    Dates of publication 2019-0820
    Size p. 97-105.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.04.374
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Enhancing Natural Killer Cell-Mediated Cancer Immunotherapy by the Biological Macromolecule

    Wu, Jie / He, Baojun / Miao, Miao / Han, Xibin / Dai, Hongyan / Dou, Heng / Li, Yanqiu / Zhang, Xiaoqing / Wang, Guangchuan

    Pathology oncology research : POR

    2022  Volume 28, Page(s) 1610555

    Abstract: The biological ... ...

    Abstract The biological macromolecule
    MeSH term(s) Animals ; Cytokines ; Granzymes ; Immunotherapy ; Interleukin-2/pharmacology ; Interleukin-6 ; Killer Cells, Natural ; Lung Neoplasms/therapy ; Melanoma ; Mice ; Perforin ; Rhodococcus ; Tumor Necrosis Factor-alpha
    Chemical Substances Cytokines ; Interleukin-2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Perforin (126465-35-8) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.3389/pore.2022.1610555
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 4936: Show issues Location:
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  10. Article ; Online: Are bacterial communities associated with microplastics influenced by marine habitats?

    Li, Jingjing / Huang, Wei / Jiang, Rijin / Han, Xibin / Zhang, Dongdong / Zhang, Chunfang

    The Science of the total environment

    2020  Volume 733, Page(s) 139400

    Abstract: This study investigates the influence of marine habitats (i.e., the intertidal zone, supralittoral zone, and seawater), and polymer types (i.e., polyethylene, PE; polyethylene terephthalate, PET) on the diversity and structure of bacterial communities in ...

    Abstract This study investigates the influence of marine habitats (i.e., the intertidal zone, supralittoral zone, and seawater), and polymer types (i.e., polyethylene, PE; polyethylene terephthalate, PET) on the diversity and structure of bacterial communities in marine microplastics. A three-month exposure experiment was conducted in Zhairuoshan Island, Zhoushan, China, a typical caldera volcanic island with minor anthropogenic disturbances. At the end of the exposure period, the transition for peaks corresponding to oxidized groups was observed using micro-Fourier transform infrared spectroscopy. Damages, including pits and cracks, and microorganisms were observed on the surfaces of the PE and PET pellets using scanning electron microscopy. Next-generation amplicon sequencing of the bacterial communities that had colonized the microplastics revealed that bacterial composition significantly varied depending on marine habitats and exposure times, rather than polymer type. Plastic debris in the intertidal zone exhibited the highest bacterial richness and diversity, and Bacillus was considered a potential degrader of plastic debris. The findings demonstrate that bacterial communities that colonize on microplastics are more potentially shaped by marine habitat and exposure time, and this would deepen our understanding of the ecological niche of microplastics surface.
    MeSH term(s) China ; Ecosystem ; Environmental Monitoring ; Microplastics ; Plastics ; Water Pollutants, Chemical/analysis
    Chemical Substances Microplastics ; Plastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2020-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.139400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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