LIVIVO - Search results -

Search results

Result 1 - 10 of total 240

Search options

Book ; Online ; E-Book: Perinatal stem cells

Han, Zhong Chao / Takahashi, Tsuneo A. / Han, Zhibo / Li, Zongjin

biology, manufacturing and translational medicine

2019

Author's details	Zhong Chao Han, Tsuneo A. Takahashi, Zhibo Han, Zongjin Li editors
Language	English
Size	1 Online-Ressource (vi, 173 Seiten), Illustrationen
Publisher	Springer
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020019201
ISBN	978-981-13-2703-2 ; 9789811327025 ; 981-13-2703-3 ; 9811327025
DOI	10.1007/978-981-13-2703-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: [Comparative Study of the Two High-Efficient Strategies for

Wang, Ti-Er / Sun, Yun-Yan / Han, Zhong-Chao / Zhang, Lei-Sheng / Shi, Ming-Xia

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 2, Page(s) 553–561

Abstract: Objective: To explore the similarities and variations of biological phenotype and cytotoxicity of human umbilical cord blood natural killer cells (hUC- NK) after human umbilical cord blood-derived mononuclear cells (hUC-MNC) activated and expanded by ... ...

Abstract	Objective: To explore the similarities and variations of biological phenotype and cytotoxicity of human umbilical cord blood natural killer cells (hUC- NK) after human umbilical cord blood-derived mononuclear cells (hUC-MNC) activated and expanded by two Methods: Umbilical cord blood mononuclear cells (MNC) from healthy donor were enriched by Ficoll-based density gradient centrifugation. Then, the phenotype, subpopulations, cell viability and cytotoxicity of NK cells derived from Miltenyi medium (denoted as M-NK) and X-VIVO 15 (denoted as X-NK) were compared using a "3IL" strategy. Results: After a 14-day's culture, the contents of CD3 Conclusion: The two strategies were adequate for high-efficient generation of NK cells with high level of activation
MeSH term(s)	Humans ; Fetal Blood ; Killer Cells, Natural ; T-Lymphocytes ; Leukocytes, Mononuclear/metabolism ; Cell Proliferation ; CD56 Antigen/metabolism
Chemical Substances	CD56 Antigen
Language	Chinese
Publishing date	2023-04-25
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.02.035
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Heterogeneity of Human Mesenchymal Stromal/Stem Cells.

Wang, Weiqiang / Han, Zhong Chao

Advances in experimental medicine and biology

2019 Volume 1123, Page(s) 165–177

Abstract: Increasing evidence has shown that mesenchymal stem cells (MSCs) isolated from body tissues are heterogeneous while being examined in vitro and in vivo. Besides some common characteristics, MSCs derived from different tissues exhibit unique biological ... ...

Abstract	Increasing evidence has shown that mesenchymal stem cells (MSCs) isolated from body tissues are heterogeneous while being examined in vitro and in vivo. Besides some common characteristics, MSCs derived from different tissues exhibit unique biological properties. In addition, the therapeutic effects of MSCs may vary widely due to their heterogeneity and the technical differences in large-scale ex vivo expansion. In this chapter, the heterogeneity of MSCs will be discussed in three levels: the individual donors, the tissue sources, and the cell surface markers.
MeSH term(s)	Bone Marrow Cells/cytology ; Cell Differentiation ; Humans ; Membrane Proteins ; Mesenchymal Stem Cells/cytology
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2019-04-23
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-11096-3_10
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Therapeutic prospects of mesenchymal stem/stromal cells in COVID-19 associated pulmonary diseases: From bench to bedside.

Zhang, Lei-Sheng / Yu, Yi / Yu, Hao / Han, Zhong-Chao

World journal of stem cells

2021 Volume 13, Issue 8, Page(s) 1058–1071

Abstract: The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has become a sudden public emergency of international concern and seriously threatens millions of people's life health. Two ... ...

Abstract	The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has become a sudden public emergency of international concern and seriously threatens millions of people's life health. Two current studies have indicated a favorable role for mesenchymal stem/stromal cells (MSCs) in clinical remission of COVID-19 associated pulmonary diseases, yet the systematical elaboration of the therapeutics and underlying mechanism is far from satisfaction. In the present review, we summarize the therapeutic potential of MSCs in COVID-19 associated pulmonary diseases such as pneumonia induced acute lung injury, acute respiratory distress syndrome, and pulmonary fibrosis. Furthermore, we review the underlying mechanism of MSCs including direct- and trans-differentiation, autocrine and paracrine anti-inflammatory effects, homing, and neovascularization, as well as constitutive microenvironment. Finally, we discuss the prospects and supervision of MSC-based cytotherapy for COVID-19 management before large-scale application in clinical practice. Collectively, this review supplies overwhelming new references for understanding the landscapes of MSCs in the remission of COVID-19 associated pulmonary diseases.
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583482-4
ISSN	1948-0210
ISSN	1948-0210
DOI	10.4252/wjsc.v13.i8.1058
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Clinical Efficacy of an Indwelling Transanal Tube for the Prevention of Anastomotic Leakage After Hirschsprung's Disease: A Single Center Experience with Chinese Patients.

Wang, Yun-Jin / Han, Zhong-Chao / Chen, Liu / He, Yuan-Bin / Lin, Yu / Zhou, Chao-Ming

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 32, Issue 3, Page(s) 342–346

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Anal Canal/surgery ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Child ; China/epidemiology ; Digestive System Surgical Procedures/methods ; Hirschsprung Disease/surgery ; Humans ; Infant ; Postoperative Complications/prevention & control ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0644
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3246: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection.

Huang, Anan / Liu, Yue / Qi, Xin / Chen, Shang / Huang, Haoyan / Zhang, Jun / Han, Zhibo / Han, Zhong-Chao / Li, Zongjin

Stem cell research & therapy

2022 Volume 13, Issue 1, Page(s) 253

Abstract: Background: Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence of cardiac repair, despite a lack of systematic description of the underlying biological mechanisms. The lung, but not the heart, is the main ... ...

Abstract	Background: Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence of cardiac repair, despite a lack of systematic description of the underlying biological mechanisms. The lung, but not the heart, is the main trapped site for intravenously transplanted MSCs, which leaves a spatial gap between intravenously transplanted MSCs and the injured myocardium. How lung-trapped MSCs after intravenous transplantation rejuvenate the injured myocardium remains unknown. Methods: MSCs were isolated from human placenta tissue, and DF-MSCs or Gluc-MSCs were generated by transduced with firefly luciferase (Fluc)/enhanced green fluorescence protein (eGFP) or Gaussia luciferase (Gluc) lactadherin fusion protein. The therapeutic efficiency of intravenously transplanted MSCs was investigated in a murine model of doxorubicin (Dox)-induced cardiotoxicity. Trans-organ communication from the lung to the heart with the delivery of blood was investigated by testing the release of MSC-derived extracellular vesicles (MSC-EVs), and the potential miRNA inner MSC-EVs were screened out and verified. The potential therapeutic miRNA inner MSC-EVs were then upregulated or downregulated to assess the further therapeutic efficiency RESULTS: Dox-induced cardiotoxicity, characterized by cardiac atrophy, left ventricular dysfunction, and injured myocardium, was alleviated by consecutive doses of MSCs. These cardioprotective effects might be attributed to suppressing GRP78 triggering endoplasmic reticulum (ER) stress-induced apoptosis in cardiomyocytes. Our results confirmed that miR-181a-5p from MSCs-derived EVs (MSC-EVs) inhibited GRP78. Intravenous DF-MSCs were trapped in lung vasculature, secreted a certain number of EVs into serum, which could be confirmed by the detection of eGFP Conclusions: This study identifies intravenously transplanted MSCs, as an endocrine reservoir, to secrete cardioprotective EVs into blood continuously and gradually to confer the trans-organ communication that relieves Dox-induced cardiotoxicity.
MeSH term(s)	Animals ; Cardiotoxicity/therapy ; Disease Models, Animal ; Doxorubicin/pharmacology ; Extracellular Vesicles/metabolism ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/metabolism ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	MicroRNAs ; Doxorubicin (80168379AG)
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-022-02922-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy.

Huang, Haoyan / Qian, Meng / Liu, Yue / Chen, Shang / Li, Huifang / Han, Zhibo / Han, Zhong-Chao / Chen, Xiang-Mei / Zhao, Qiang / Li, Zongjin

eLife

2023 Volume 12

Abstract: Nitric oxide (NO), as a gaseous therapeutic agent, shows great potential for the treatment of many kinds of diseases. Although various NO delivery systems have emerged, the immunogenicity and long-term toxicity of artificial carriers hinder the potential ...

Abstract	Nitric oxide (NO), as a gaseous therapeutic agent, shows great potential for the treatment of many kinds of diseases. Although various NO delivery systems have emerged, the immunogenicity and long-term toxicity of artificial carriers hinder the potential clinical translation of these gas therapeutics. Mesenchymal stem cells (MSCs), with the capacities of self-renewal, differentiation, and low immunogenicity, have been used as living carriers. However, MSCs as gaseous signaling molecule (GSM) carriers have not been reported. In this study, human MSCs were genetically modified to produce mutant β-galactosidase (β-GAL
MeSH term(s)	Mice ; Animals ; Humans ; Nitric Oxide ; Mesenchymal Stem Cells ; Stem Cells ; Genetic Engineering ; Acute Kidney Injury/therapy
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.84820
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Superior protective effects of PGE2 priming mesenchymal stem cells against LPS-induced acute lung injury (ALI) through macrophage immunomodulation.

Hezam, Kamal / Wang, Chen / Fu, Enze / Zhou, Manqian / Liu, Yue / Wang, Hui / Zhu, Lihong / Han, Zhibo / Han, Zhong-Chao / Chang, Ying / Li, Zongjin

Stem cell research & therapy

2023 Volume 14, Issue 1, Page(s) 48

Abstract: Background: Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS). MSC secretomes contain various immunoregulatory mediators that ... ...

Abstract	Background: Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS). MSC secretomes contain various immunoregulatory mediators that modulate both innate and adaptive immune responses. Priming MSCs has been widely considered to boost their therapeutic efficacy for a variety of diseases. Prostaglandin E2 (PGE2) plays a vital role in physiological processes that mediate the regeneration of injured organs. Methods: This work utilized PGE2 to prime MSCs and investigated their therapeutic potential in ALI models. MSCs were obtained from human placental tissue. MSCs were transduced with firefly luciferase (Fluc)/eGFP fusion protein for real-time monitoring of MSC migration. Comprehensive genomic analyses explored the therapeutic effects and molecular mechanisms of PGE2-primed MSCs in LPS-induced ALI models. Results: Our results demonstrated that PGE2-MSCs effectively ameliorated lung injury and decreased total cell numbers, neutrophils, macrophages, and protein levels in bronchoalveolar lavage fluid (BALF). Meanwhile, treating ALI mice with PGE2-MSCs dramatically reduced histopathological changes and proinflammatory cytokines while increasing anti-inflammatory cytokines. Furthermore, our findings supported that PGE2 priming improved the therapeutic efficacy of MSCs through M2 macrophage polarization. Conclusion: PGE2-MSC therapy significantly reduced the severity of LPS-induced ALI in mice by modulating macrophage polarization and cytokine production. This strategy boosts the therapeutic efficacy of MSCs in cell-based ALI therapy.
MeSH term(s)	Pregnancy ; Female ; Mice ; Humans ; Animals ; Lipopolysaccharides/toxicity ; Dinoprostone/metabolism ; Mesenchymal Stem Cell Transplantation/methods ; Placenta/metabolism ; Acute Lung Injury/chemically induced ; Acute Lung Injury/therapy ; Acute Lung Injury/metabolism ; Mesenchymal Stem Cells/metabolism ; Cytokines/metabolism ; Immunomodulation ; Macrophages/metabolism ; Immunity ; Lung/pathology
Chemical Substances	Lipopolysaccharides ; Dinoprostone (K7Q1JQR04M) ; Cytokines
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03277-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Human umbilical cord-derived mesenchymal stem cells treatment for refractory uveitis: a case series.

Yang, Jing / Ren, Xin-Jun / Chen, Xi-Teng / Jiang, Yuan-Feng / Han, Zhi-Bo / Han, Zhong-Chao / Li, Xiao-Rong / Zhang, Xiao-Min

International journal of ophthalmology

2021 Volume 14, Issue 11, Page(s) 1784–1790

Abstract: Aim: To evaluate therapeutic outcomes of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) treatment in patients with refractory uveitis.: Methods: A retrospective and noncomparative review was performed on four patients with refractory ... ...

Abstract	Aim: To evaluate therapeutic outcomes of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) treatment in patients with refractory uveitis. Methods: A retrospective and noncomparative review was performed on four patients with refractory uveitis from December 2013 to December 2017. HUC-MSCs were administered intravenously at a dose of 1×10 Results: All four patients presented with responses to HUC-MSCs treatment, with three males and one female. The numbers of uveitis attacks per year after the HUC-MSCs treatment (0, 2, 0, 0 respectively) all decreased compared with the numbers before the treatment (3, 6, 4, 4 respectively). The oral steroid and immunosuppressive agents were tapered in all patients without recrudescence of ocular inflammation, and three patients discontinued their oral medicine at the last visit. The best corrected visual acuity (BCVA) of 3 patients was improved to varying degrees, and the BCVA of 1 patient remained at 20/20 (Snellen chart) from the first to the last consultation. Conclusion: The study provides an effective therapy of HUC-MSCs in maintaining remission in patients affected by uveitis refractory to previous immunosuppressant treatments.
Language	English
Publishing date	2021-11-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2021.11.20
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Vascular differentiation of hematopoietic stem cells and possible application in the treatment of limb ischemic diseases].

Han, Zhong-chao

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2005 Volume 27, Issue 6, Page(s) 782–785

Abstract: Hematopoietic stem cell (HSC) is the first discovered and well studied tissue stem cell. HSC transplantation has been successfully applied to cure a variety of diseases of hematological and immunological systems. It has long believed that HSC and ... ...

Abstract	Hematopoietic stem cell (HSC) is the first discovered and well studied tissue stem cell. HSC transplantation has been successfully applied to cure a variety of diseases of hematological and immunological systems. It has long believed that HSC and angioblast come from the common stem cell, the hemangioblast. Recently, HSC has been demonstrated to be able to differentiate into vascular endothelial cells. In animal in vivo models, HSC transplantation can promote angiogenesis and improve limb ischemia. Several pilot clinical studies have shown that transplantation of bone marrow and granulocyte colony stimulating factor mobilized peripheral blood HSC promoted vascular reconstitution in ischemic limbs. Umbilical cord blood has been an important source of HSC for clinical transplantation. Animal studies have demonstrated the efficiency of cord blood HSC transplantation in improving critical limb ischemia. These studies have provided evidences that HSC can be used for the treatment of vascular diseases.
MeSH term(s)	Animals ; Cell Differentiation ; Extremities/blood supply ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/cytology ; Humans ; Ischemia/therapy
Language	Chinese
Publishing date	2005-12
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2554: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito