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  1. Book ; Online: English Medium Instruction as a Local Practice

    Han, Jinghe

    Language, culture and pedagogy

    (SpringerBriefs in Education)

    2023  

    Author's details by Jinghe Han
    Series title SpringerBriefs in Education
    Keywords Teachers—Training of ; Language and languages—Study and teaching ; Education—Curricula ; International education  ; Comparative education
    Subject code 370.711
    Language English
    Size 1 Online-Ressource (XV, 126 p. 1 illus)
    Edition 1st ed. 2023
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT021626132
    ISBN 978-3-031-19904-2 ; 9783031199035 ; 9783031199059 ; 3-031-19904-9 ; 3031199030 ; 3031199057
    DOI 10.1007/978-3-031-19904-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: English Medium Instruction as a Local Practice

    Han, Jinghe

    Language, culture and pedagogy

    (SpringerBriefs in Education)

    2023  

    Series title SpringerBriefs in Education
    Keywords Teacher training ; Language: reference & general ; Curriculum planning & development ; Education ; Teaching through English-Medium Instruction ; EMI teaching in China's Higher Education ; Translanguaging use in EMI class ; Pedagogical strategies ; Topicality and methodological issues in EMI research ; Post-monolingual features of EMI class ; Educational internationalization in China ; EMI classroom practices in China ; Teacher preparation Chinese Higher Education
    Language English
    Size 1 electronic resource (126 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030379383
    ISBN 9783031199042 ; 3031199049
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: China's Architecture in a Globalizing World: Between Socialism and the Market

    Han, Jiawen

    2018  

    Keywords Architecture ; History of architecture ; Ethnic studies ; Regional studies
    Size 1 electronic resource (196 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232823
    ISBN 9780367322274 ; 0367322277
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Terminalism and how dying patients are conditioned as docile bodies.

    Han, John

    Journal of medical ethics

    2024  Volume 50, Issue 2, Page(s) 116–117

    MeSH term(s) Humans ; Death ; Terminal Care ; Terminally Ill ; Attitude to Death ; Personhood
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/jme-2023-109552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1163: Show issues Location:
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  5. Article: Can robotic surgery lead the way in the treatment of rectal cancer?

    Han, Jeonghee

    Annals of coloproctology

    2024  Volume 40, Issue 2, Page(s) 87–88

    Language English
    Publishing date 2024-04-05
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 2711906-3
    ISSN 2287-9722 ; 2287-9714
    ISSN (online) 2287-9722
    ISSN 2287-9714
    DOI 10.3393/ac.2024.00234.0033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanism of microRNA regulating apoptosis after reperfusion in patients with mechanical thrombectomy.

    Chen, Z J / Han, J

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

    2024  Volume 75, Issue 2, Page(s) 145–157

    Abstract: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed 'microRNA' represent the most flexible network of gene ... ...

    Abstract Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed 'microRNA' represent the most flexible network of gene expression regulators. To screen out miRNAs that are mainly regulated during reperfusion in mechanically embolized patients, and study their mechanisms of action in reperfusion injury after thrombectomy, in order to find new therapeutic targets for mechanically embolized patients. Serums from 30 patients with moderate to severe stroke after mechanical thrombectomy (MT) were collected to measure miRNA expressions. Clinical information of patients was analyze, and patients were divided into poor prognosis and good prognosis. Factors affecting prognosis was classified, and independent risk factors for poor prognosis were determined. Prognostic value of National Institutes of Health Stroke Scale (NIHSS) score on admission to patients with MT was assessed. ROC (receiver operating characteristic) curves were drawn, and Kaplan-Merier method determined whether different NIHSS scores at admission had any difference in the in-hospital survival rate of consistency index/random consistency index (CI/RI) patients treated with MT. An oxygen-glucose deprivation/reperfusion (OGD/R) cell model and an middle cerebral artery occlusion (MCAO)/reperfusion mouse model were established, in which miR-298 expression was tested. In OGD/R cells, proliferation, apoptosis, and autophagy were assessed after intervention with miR-298 and/or autophagy related gene 5 (ATG5). In MCAO mice, the infarct area was calculated, and neurological function was assessed. The relationship between miR-298 and ATG5 was explored and validated. Age, diabetes, hypertension, hemorrhage transformation, NIHSS score at admission, leukocyte, neutrophil count and neutrophil to lymphocyte ratio (NLR) level were associated with patient's prognosis. Diabetes, NIHSS score at admission, and hemorrhagic transformation were independent risk factors for predicting poor prognosis in patients treated with MT. NIHSS score on admission had a predictive value on patient's prognosis. miR-298 was upregulated in acute cerebral ischemia patients with MT (p<0.05), especially in those with poor prognosis. miR-298 was elevated in both cell and mouse models (p<0.05). Apoptosis and autophagy of cells were weakened after miR-298 knockdown, and infarction in the mouse brain tissues was reduced. ATG5 was a target of miR-298. Overexpressing ATG5 rescued miR-298-induced apoptosis and autophagy. In conclusion: regulation of miR-298 and ATG5 attenuates neuronal apoptosis and autophagy, providing a new strategy for brain injury after reperfusion in patients with MT.
    MeSH term(s) MicroRNAs/genetics ; MicroRNAs/metabolism ; Animals ; Humans ; Apoptosis ; Male ; Aged ; Female ; Middle Aged ; Thrombectomy/methods ; Reperfusion Injury/metabolism ; Mice ; Infarction, Middle Cerebral Artery/surgery ; Infarction, Middle Cerebral Artery/metabolism ; Mice, Inbred C57BL ; Autophagy/physiology ; Prognosis ; Stroke
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-05-06
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1125221-2
    ISSN 1899-1505 ; 0867-5910 ; 0044-6033
    ISSN (online) 1899-1505
    ISSN 0867-5910 ; 0044-6033
    DOI 10.26402/jpp.2024.2.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1358: Show issues Location:
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  7. Article: Cardiac Assist Devices: Early Concepts, Current Technologies, and Future Innovations

    Han, Jooli / Trumble, Dennis

    Bioengineering, 6(1):18

    2019  

    Abstract: Congestive heart failure (CHF) is a debilitating condition that afflicts tens of millions of people worldwide and is responsible for more deaths each year than all cancers combined. Because donor hearts for transplantation are in short supply, a safe and ...

    Abstract Congestive heart failure (CHF) is a debilitating condition that afflicts tens of millions of people worldwide and is responsible for more deaths each year than all cancers combined. Because donor hearts for transplantation are in short supply, a safe and durable means of mechanical circulatory support could extend the lives and reduce the suffering of millions. But while the profusion of blood pumps available to clinicians in 2019 tend to work extremely well in the short term (hours to weeks/months), every long-term cardiac assist device on the market today is limited by the same two problems: infections caused by percutaneous drivelines and thrombotic events associated with the use of blood-contacting surfaces. A fundamental change in device design is needed to address both these problems and ultimately make a device that can support the heart indefinitely. Toward that end, several groups are currently developing devices without blood-contacting surfaces and/or extracorporeal power sources with the aim of providing a safe, tether-free means to support the failing heart over extended periods of time.
    Keywords LVAD ; congestive heart failure ; cardiac assist devices ; destination therapy
    Language English
    Document type Article
    Database Repository for Life Sciences

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  8. Article ; Online: Copper trafficking systems in cells: insights into coordination chemistry and toxicity.

    Han, Jiyeon

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 42, Page(s) 15277–15296

    Abstract: Transition metal ions, such as copper, are indispensable components in the biological system. Copper ions which primarily exist in two major oxidation states Cu(I) and Cu(II) play crucial roles in various cellular processes including antioxidant defense, ...

    Abstract Transition metal ions, such as copper, are indispensable components in the biological system. Copper ions which primarily exist in two major oxidation states Cu(I) and Cu(II) play crucial roles in various cellular processes including antioxidant defense, biosynthesis of neurotransmitters, and energy metabolism, owing to their inherent redox activity. The disturbance in copper homeostasis can contribute to the development of copper metabolism disorders, cancer, and neurodegenerative diseases, highlighting the significance of understanding the copper trafficking system in cellular environments. This review aims to offer a comprehensive overview of copper homeostatic machinery, with an emphasis on the coordination chemistry of copper transporters and trafficking proteins. While copper chaperones and the corresponding metalloenzymes are thoroughly discussed, we also explore the potential existence of low-molecular-mass metal complexes within cellular systems. Furthermore, we summarize the toxicity mechanisms originating from copper deficiency or accumulation, which include the dysregulation of oxidative stress, signaling pathways, signal transduction, and amyloidosis. This perspective review delves into the current knowledge regarding the intricate aspects of the copper trafficking system, providing valuable insights into potential treatment strategies from the standpoint of bioinorganic chemistry.
    MeSH term(s) Copper/chemistry ; Molecular Chaperones/metabolism ; Coordination Complexes/chemistry ; Antioxidants ; Ions
    Chemical Substances Copper (789U1901C5) ; Molecular Chaperones ; Coordination Complexes ; Antioxidants ; Ions
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt02166a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Analysis on the equity of dentist resource allocation in China].

    Han, J / Yang, X

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2023  Volume 58, Issue 6, Page(s) 584–591

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Adult ; Dentists ; Professional Role ; Health Resources ; Resource Allocation ; China
    Language Chinese
    Publishing date 2023-06-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.cn112144-20220818-00447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2507: Show issues Location:
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  10. Article ; Online: Role of late first-trimester ultrasound in women with a positive NIPT result.

    Han, J / Li, D-Z

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2023  Volume 62, Issue 4, Page(s) 611–612

    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Trimester, First ; Prenatal Diagnosis ; Down Syndrome
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Letter
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.27470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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