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  1. Article ; Online: Racial-ethnic disparities in childhood hypertension.

    Hanevold, Coral D

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 38, Issue 3, Page(s) 619–623

    MeSH term(s) Humans ; United States/epidemiology ; Racial Groups ; Hypertension ; Healthcare Disparities
    Language English
    Publishing date 2022-08-13
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05707-x
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    Zs.A 2196: Show issues Location:
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  2. Article ; Online: Screening and Management of Pediatric High Blood Pressure-Challenges to Implementing the Clinical Practice Guideline.

    Hanevold, Coral D / Brady, Tammy M

    Current hypertension reports

    2024  

    Abstract: Purpose of review: Elevated blood pressure (BP) and hypertension in childhood convey risk for hypertension and cardiovascular events in adulthood. Early recognition of abnormal BPs is key to preventing or lessening this risk. However, the process for ... ...

    Abstract Purpose of review: Elevated blood pressure (BP) and hypertension in childhood convey risk for hypertension and cardiovascular events in adulthood. Early recognition of abnormal BPs is key to preventing or lessening this risk. However, the process for making the diagnosis of hypertension is complex, and overall adherence to the 2017 American Academy of Pediatrics Clinical Practice Guidelines (CPG) is poor. We will review obstacles to adherence to the CPG and approaches designed to improve the diagnosis and management of hypertension in children.
    Recent findings: Baseline data from the multi-center quality improvement intervention, "Boosting Primary Care Awareness and Treatment of Hypertension" (BP-CATCH), demonstrate that childhood hypertension remains underdiagnosed. Other studies confirm a lack of compliance with the process outlined in the CPG. The provision of electronic prompts, coaching, and education results in modest improvements. The combination of embedded medical record tools and education seems to offer the most hope for improvement.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-024-01298-0
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    Zs.A 5522: Show issues Location:
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  3. Article ; Online: Salt sensitivity of blood pressure in childhood and adolescence.

    Hanevold, Coral D

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 37, Issue 5, Page(s) 993–1005

    Abstract: Although moderation of sodium intake is recommended population-wide, it remains uncertain who benefits from salt restriction. Salt sensitivity refers to changes in blood pressure in response to sodium intake and may occur with or without hypertension. ... ...

    Abstract Although moderation of sodium intake is recommended population-wide, it remains uncertain who benefits from salt restriction. Salt sensitivity refers to changes in blood pressure in response to sodium intake and may occur with or without hypertension. Unfortunately, there is no practical way to assess salt sensitivity in daily practice. Assessment of salt sensitivity even in research studies is challenging with varying protocols utilized which may contribute to differing results. Building on studies in animals and adults, risk factors and conditions associated with salt sensitivity have been identified in the pediatric and young adult populations. This review presents the limited evidence linking obesity, low birth weight, diabetes, chronic kidney disease, and race/ethnicity with salt sensitivity in children, adolescents, and young adults. The impact of stress on sodium handling is also reviewed. The influence of age on the timing of introduction of dietary salt restriction and the long-term influence of salt sensitivity on risk for hypertension are considered. Lastly, interventions other than salt restriction that may improve salt sensitivity and may inform recommendations to families are reviewed.
    MeSH term(s) Adolescent ; Animals ; Blood Pressure/physiology ; Child ; Female ; Humans ; Hypertension ; Male ; Renal Insufficiency, Chronic/complications ; Sodium Chloride, Dietary/adverse effects ; Sodium, Dietary/adverse effects
    Chemical Substances Sodium Chloride, Dietary ; Sodium, Dietary
    Language English
    Publishing date 2021-07-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05178-6
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    Zs.A 2196: Show issues Location:
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  4. Article ; Online: White Coat Hypertension in Children and Adolescents.

    Hanevold, Coral D

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 73, Issue 1, Page(s) 24–30

    MeSH term(s) Adolescent ; Child ; Disease Progression ; Humans ; Risk Factors ; White Coat Hypertension/diagnosis ; White Coat Hypertension/epidemiology ; White Coat Hypertension/physiopathology
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.118.11172
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    Zs.A 1488: Show issues Location:
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  5. Article ; Online: Letter to the editor.

    Hanevold, Coral D / Faino, Anna V / Flynn, Joseph T

    Blood pressure

    2022  Volume 32, Issue 1, Page(s) 4–5

    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1170048-8
    ISSN 1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
    ISSN (online) 1651-1999 ; 1651-2480
    ISSN 0803-7051 ; 0803-8023
    DOI 10.1080/08037051.2022.2141682
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    Zs.A 3843: Show issues Location:
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  6. Article ; Online: Use of Automated Office Blood Pressure Measurement in the Evaluation of Elevated Blood Pressures in Children and Adolescents.

    Hanevold, Coral D / Faino, Anna V / Flynn, Joseph T

    The Journal of pediatrics

    2020  Volume 227, Page(s) 204–211.e6

    Abstract: Objectives: To determine the level of agreement between automated office blood pressures (AOBP), auscultated or manual office BP (manual office blood pressure), and 24-hour ABPM, and to explore the ability of AOBP and manual office blood pressure to ... ...

    Abstract Objectives: To determine the level of agreement between automated office blood pressures (AOBP), auscultated or manual office BP (manual office blood pressure), and 24-hour ABPM, and to explore the ability of AOBP and manual office blood pressure to correctly identify daytime ambulatory hypertension in children.
    Study design: We retrospectively compared BPs obtained by AOBP and manual office blood pressure to predict daytime hypertension on ABPM. Six BPs were taken by AOBP followed by manual office blood pressure. Office hypertension was defined by BPs ≥95th percentile for sex and height percentiles for those <13 years of age and a BP of ≥130/80 mm Hg for ages ≥13 years. Daytime ambulatory hypertension was diagnosed if mean wake BPs were ≥95th percentile and BP loads were ≥25%. Application of adult ABPM thresholds for daytime hypertension (130/80 mm Hg) was assessed in ages ≥13 years. Sensitivity and specificity were calculated considering ABPM as the reference.
    Results: Complete data were available for 187 patient encounters. Overall, the best agreement was found if both AOBP and manual office blood pressure showed hypertension, but owing to low sensitivity up to 49% of children with hypertension would be misclassified. The use of adult thresholds for ABPM did not improve agreement.
    Conclusions: Neither AOBP nor manual office blood pressure confirm or exclude daytime ambulatory hypertension with confidence. These results suggest an ongoing role for ABPM in evaluation of hypertension in children.
    MeSH term(s) Adolescent ; Blood Pressure Determination/methods ; Child ; Female ; Humans ; Hypertension/diagnosis ; Male ; Office Visits ; Retrospective Studies
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.06.059
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  7. Article ; Online: Sodium intake and blood pressure in children.

    Hanevold, Coral D

    Current hypertension reports

    2013  Volume 15, Issue 5, Page(s) 417–425

    Abstract: Elevation of blood pressure (BP) and the risk for progression to hypertension (HTN) is of increasing concern in children and adolescents. Indeed, it is increasingly recognized that target organ injury may begin with even low levels of BP elevation. ... ...

    Abstract Elevation of blood pressure (BP) and the risk for progression to hypertension (HTN) is of increasing concern in children and adolescents. Indeed, it is increasingly recognized that target organ injury may begin with even low levels of BP elevation. Sodium intake has long been recognized as a modifiable risk factor for HTN. While it seems clear that sodium impacts BP in children, its effects may be enhanced by other factors including obesity and increasing age. Evidence from animal and human studies indicates that sodium may have adverse consequences on the cardiovascular system independent of HTN. Thus, moderation of sodium intake over a lifetime may reduce risk for cardiovascular morbidity in adulthood. An appetite for salt is acquired, and intake beyond our need is almost universal. Considering that eating habits in childhood have been shown to track into adulthood, modest sodium intake should be advocated as part of a healthy lifestyle.
    MeSH term(s) Animals ; Blood Pressure/physiology ; Child ; Humans ; Hypertension/etiology ; Life Style ; Risk Factors ; Sodium/adverse effects ; Sodium/metabolism
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2013-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-013-0382-z
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    Zs.A 5522: Show issues Location:
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  8. Article: Ambulatory Blood Pressure and Number of Subclinical Target Organ Injury Markers in Youth: The SHIP AHOY Study.

    Hamdani, Gilad / Urbina, Elaine M / Daniels, Stephen R / Falkner, Bonita E / Ferguson, Michael A / Flynn, Joseph T / Hanevold, Coral D / Ingelfinger, Julie R / Khoury, Philip R / Lande, Marc B / Meyers, Kevin E / Samuels, Joshua / Mitsnefes, Mark

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Hypertension in adolescence is associated with subclinical target organ injury (TOI). We aimed to determine whether different blood pressure (BP) thresholds were associated with increasing number of TOI markers in healthy adolescents.: ... ...

    Abstract Background: Hypertension in adolescence is associated with subclinical target organ injury (TOI). We aimed to determine whether different blood pressure (BP) thresholds were associated with increasing number of TOI markers in healthy adolescents.
    Methods: 244 participants (mean age 15.5±1.8 years, 60.1% male) were studied. Participants were divided based on both systolic clinic and ambulatory BP (ABP), into low- (<75
    Results: 47.5% of participants had at least one TOI marker: 31.2% had one, 11.9% two, 3.7% three, and 0.8% four. The number of TOI markers increased according to the BP risk groups: the percentage of participants with more than one TOI in the low-, mid-, and high groups based on clinic BP was 6.7%, 19.1%, and 21.8% (p=0.02), and based on ABP was 9.6%, 15.8%, and 32.2% (p<0.001). In a multivariable regression analysis, both clinic BP percentile and ambulatory SBP index were independently associated with the number of TOI markers. When both clinic and ABP were included in the model, only the ambulatory SBP index was significantly associated with the number of markers.
    Conclusion: High SBP, especially when assessed by ABPM, was associated with an increasing number of subclinical cardiovascular injury markers in adolescents.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.15.24304137
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  9. Article ; Online: Concepts guiding therapy for hypertension in children.

    Hanevold, Coral D

    Expert review of cardiovascular therapy

    2009  Volume 7, Issue 6, Page(s) 647–657

    Abstract: Increasing attention has been focused on identifying children with prehypertension and hypertension (HTN). Obesity and low birthweight are two risk factors that predispose children to develop HTN during their childhood years or later as adults. Early ... ...

    Abstract Increasing attention has been focused on identifying children with prehypertension and hypertension (HTN). Obesity and low birthweight are two risk factors that predispose children to develop HTN during their childhood years or later as adults. Early onset of pre-HTN and HTN increases the lifetime risk for cardiovascular sequelae. Lifestyle modification should be part of the initial recommendations for management of all hypertensive children. In those children requiring pharmacologic therapy, the choice of medication should be guided by the etiology of HTN, the needs of the child and the risk and benefit profiles of the various drug classes. The long-term impact of antihypertensive therapy in children is not known. Concerns regarding the effects of HTN and its treatment on cognitive function are of particular importance in the growing child and warrant further study. Ongoing investigations that offer promise for innovative therapeutic approaches in the future are discussed.
    MeSH term(s) Age Factors ; Age of Onset ; Antihypertensive Agents/therapeutic use ; Birth Weight ; Cardiovascular Diseases/etiology ; Child ; Cognition Disorders/etiology ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension/therapy ; Infant, Low Birth Weight ; Infant, Newborn ; Life Style ; Obesity/complications ; Risk Factors
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2009-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1586/erc.09.44
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    Zs.A 6107: Show issues Location:
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  10. Article ; Online: Changes in Ambulatory Blood Pressure Phenotype over Time in Children and Adolescents with Elevated Blood Pressures.

    Hanevold, Coral D / Miyashita, Yosuke / Faino, Anna V / Flynn, Joseph T

    The Journal of pediatrics

    2019  Volume 216, Page(s) 37–43.e2

    Abstract: Objective: To determine the stability of ambulatory blood pressure monitoring (ABPM) over time in children referred for evaluation of elevated BPs and assess for factors predicting change.: Study design: This retrospective chart review conducted at ... ...

    Abstract Objective: To determine the stability of ambulatory blood pressure monitoring (ABPM) over time in children referred for evaluation of elevated BPs and assess for factors predicting change.
    Study design: This retrospective chart review conducted at Seattle Children's Hospital and University of Pittsburgh Medical Center Children's Hospital of Pittsburgh identified 124 children referred for elevated BPs with 2 ABPM studies at least 6 months apart. All subjects received lifestyle counseling. Subjects with secondary hypertension (HTN) or on antihypertensive medication were excluded. ABPM phenotype was classified using American Heart Association guidelines as showing normal BP, prehypertension, and HTN. Generalized linear mixed effect regression models were used to regress stable, improving, or worsening HTN outcomes at study follow-up on baseline BP index and load variables.
    Results: The median age of patients was 14.1 years (73% males) and the median interval between studies was 18 months. ABPM phenotype changed in 58 of 124 children, with 16% worsening and 31% improving. Older age was associated with persistence of HTN. Although not significant, decrease in body mass index z-score tracked with sustained normal ambulatory BPs.
    Conclusions: Although the sample size is small, our study suggests ABPM phenotype shows variability over time. Further study is required to identify factors supporting risk for progression of ABPM phenotype over time.
    MeSH term(s) Adolescent ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory/methods ; Case-Control Studies ; Child ; Child, Preschool ; Disease Progression ; Female ; Humans ; Hypertension/diagnosis ; Male ; Phenotype ; Prehypertension/diagnosis ; Retrospective Studies
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2019.09.070
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