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Article ; Online: Accurate computational modelling for impacts of microcapsule size and interfacial fracture properties on the fracture of self-healing concrete

Hanna, John

International Journal of Hydromechatronics

2022 Volume 5, Issue 4, Page(s) 397

Keywords	General Medicine
Language	English
Publisher	Inderscience Publishers
Publishing country	ch
Document type	Article ; Online
ISSN	2515-0464
DOI	10.1504/ijhm.2022.127036
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MAML2 Gene Rearrangement Occurs in Nearly All Hidradenomas: A Reappraisal in a Series of 20 Cases.

Russell-Goldman, Eleanor / Hanna, John

The American Journal of dermatopathology

2022 Volume 44, Issue 11, Page(s) 806–811

Abstract: Abstract: Hidradenoma is a benign cutaneous adnexal neoplasm that occurs across a wide age range and at a variety of anatomic sites. Its most characteristic morphologic feature is the presence of diverse cell types including squamoid, clear, ... ...

Abstract	Abstract: Hidradenoma is a benign cutaneous adnexal neoplasm that occurs across a wide age range and at a variety of anatomic sites. Its most characteristic morphologic feature is the presence of diverse cell types including squamoid, clear, plasmacytoid, and mucinous cells. Hidradenoma is morphologically and molecularly similar to mucoepidermoid carcinoma, and both tumors are characterized by recurrent CRTC1-MAML2 cytogenetic translocations. Previous studies have suggested that approximately half of hidradenomas possess this translocation. This finding raised the question of whether translocation-negative hidradenomas might have an alternate molecular basis. Here, we sought to reevaluate the frequency of MAML2 translocation in hidradenoma in a series of 20 cases. We find that 90% show evidence of MAML2 translocation, suggesting that this genetic event is a nearly invariant feature of hidradenoma. These results inform our molecular understanding of this tumor and may be useful in challenging cases to distinguish hidradenoma from its histologic mimics.
MeSH term(s)	Acrospiroma/genetics ; Adenoma, Sweat Gland ; Carcinoma, Mucoepidermoid ; DNA-Binding Proteins/genetics ; Gene Rearrangement ; Humans ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Sweat Gland Neoplasms/genetics ; Trans-Activators/genetics ; Transcription Factors/genetics ; Translocation, Genetic
Chemical Substances	DNA-Binding Proteins ; MAML2 protein, human ; Nuclear Proteins ; Oncogene Proteins, Fusion ; Trans-Activators ; Transcription Factors
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000002276
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Article: DUB-le vision: snapshots of the proteasome during substrate processing.

Schnell, Helena M / Hanna, John

Trends in biochemical sciences

2022 Volume 47, Issue 11, Page(s) 903–905

Abstract: Covalent modification by the small protein ubiquitin can target proteins for destruction by the proteasome, but the ubiquitin signal itself is recycled. Surprisingly, proteasomes contain three different deubiquitinating enzymes (DUBs). Recent work by ... ...

Abstract	Covalent modification by the small protein ubiquitin can target proteins for destruction by the proteasome, but the ubiquitin signal itself is recycled. Surprisingly, proteasomes contain three different deubiquitinating enzymes (DUBs). Recent work by Zhang and Zou et al. reveals how one of these enzymes, Usp14, regulates, and is regulated by, the proteasome.
MeSH term(s)	Deubiquitinating Enzymes/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin/metabolism
Chemical Substances	Ubiquitin ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2022.07.007
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Article: DUB-le vision: snapshots of the proteasome during substrate processing

Schnell, Helena M. / Hanna, John

Trends in biochemical sciences. 2022,

2022

Abstract	Covalent modification by the small protein ubiquitin can target proteins for destruction by the proteasome, but the ubiquitin signal itself is recycled. Surprisingly, proteasomes contain three different deubiquitinating enzymes (DUBs). Recent work by Zhang and Zou et al. reveals how one of these enzymes, Usp14, regulates, and is regulated by, the proteasome.
Keywords	proteasome endopeptidase complex ; ubiquitin ; vision
Language	English
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	194220-7
ISSN	0968-0004 ; 0376-5067
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2022.07.007
Database	NAL-Catalogue (AGRICOLA)

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Article: No Stone Left Unturned: Bouveret Syndrome Treated With Electrohydraulic Lithotripsy and Open Extraction With Pyloric Exclusion and Gastrojejunostomy.

Kabir, Kaiser F / Hanna, John P / Haghbin, Hossein

Cureus

2023 Volume 15, Issue 5, Page(s) e39661

Abstract: Bouveret syndrome is ectopic gallstone impaction and obstruction of the duodenum or pylorus affecting a small minority of gallstone ileus cases. There have been advances in its endoscopic management, but this remains a challenging condition to treat ... ...

Abstract	Bouveret syndrome is ectopic gallstone impaction and obstruction of the duodenum or pylorus affecting a small minority of gallstone ileus cases. There have been advances in its endoscopic management, but this remains a challenging condition to treat successfully. We present a patient with Bouveret syndrome who required open surgical extraction and gastrojejunostomy after attempts of endoscopic retrieval and electrohydraulic lithotripsy (EHL). A 79-year-old man with a medical history of gastroesophageal reflux disease, chronic obstructive pulmonary disease on 5 liters of oxygen at baseline, and coronary artery disease with recent stenting presented to the hospital with three days of abdominal pain and vomiting. CT of the abdomen/pelvis demonstrated gastric outlet obstruction, a 4.5 cm gallstone in the proximal duodenum, cholecystoduodenal fistula, gallbladder wall thickening, and pneumobilia. Esophagogastroduodenoscopy (EGD) demonstrated a black pigmented stone impacted in the duodenal bulb with ulceration of the inferior wall. Repeated Roth net retrieval attempts of the stone were unsuccessful even after biopsy forceps were used to trim the stone's margins. The next day, EGD with EHL used 20 shocks of 200 watts, allowing for partial stone removal and fragmentation, but the majority of the stone remained stuck to the wall. Laparoscopic cholecystectomy was attempted but was converted to an open extraction of the gallstone from the duodenum, pyloric exclusion, and gastrojejunostomy. The gallbladder remained in place, and the cholecystoduodenal fistula was not surgically repaired. The patient experienced significant postoperative pulmonary insufficiency and remained on the ventilator with failure of multiple spontaneous breathing trials. Postoperative imaging showed resolution of pneumobilia but a small amount of contrast leaked from the duodenum revealing the fistula's persistence. After 14 days of unsuccessful ventilator weaning, the family opted for palliative extubation. Advanced endoscopic techniques have been regarded as the first-line intervention for Bouveret syndrome as there is low morbidity and mortality associated with them. However, there is a reduced success rate compared to surgical intervention. Open surgical management has high morbidity and mortality in the elderly and comorbid patients commonly affected by this condition. Thus, the risks and benefits must be weighed and individualized for each patient with Bouveret syndrome before therapeutic intervention.
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.39661
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Innominate artery occlusion: a case study.

Nashnoush, Mohamed / Sahak, Hosna / Shin, Yoojin / Ahimsadasan, Roja / Raveendran, Yanuga / Hanna, John / Nurani, Khulud

Journal of ultrasonography

2024 Volume 24, Issue 96, Page(s) 20240008

Abstract: Aim of the study: The aim of this case report is to evaluate carotid duplex and hemodynamic patterns in an asymptomatic male patient with innominate artery occlusion. Innominate artery occlusion is a rare clinical entity that can lead to a range of ... ...

Abstract	Aim of the study: The aim of this case report is to evaluate carotid duplex and hemodynamic patterns in an asymptomatic male patient with innominate artery occlusion. Innominate artery occlusion is a rare clinical entity that can lead to a range of cerebrovascular symptoms, including arm claudication, subclavian steal syndrome, and stroke. The case report emphasizes key learning points in diagnosing innominate artery occlusion using imaging and physiological methods. Case description: A 64-year-old asymptomatic male patient with a history of carotid bruit, hypertension, coronary artery bypass grafting, aortic aneurysm, hyperlipidemia, mild aortic stenosis, long-term tobacco use, and a body mass index of 24 was referred for a carotid ultrasound. Conclusions: Innominate artery occlusion is a rare condition requiring a comprehensive assessment of collateralization before any intervention is attempted. Considering waveform features such as transient end-diastolic flow reversal and tardus parvus, along with brachial pressures and transcranial Doppler, can assist in evaluating the extent of disease.
Language	English
Publishing date	2024-02-27
Publishing country	Poland
Document type	Case Reports
ZDB-ID	2843824-3
ISSN	2084-8404
ISSN	2084-8404
DOI	10.15557/jou.2024.0008
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Article ; Online: Epidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features.

Russell-Goldman, Eleanor / Baranov, Esther / Siegmund, Stephanie / Yang, Catherine S / Laga, Alvaro C / Hanna, John

Virchows Archiv : an international journal of pathology

2024 Volume 484, Issue 3, Page(s) 423–427

Abstract: Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection including Kaposi sarcoma, nasopharyngeal carcinoma, and others. Human papillomavirus (HPV) is an especially common cause of ... ...

Abstract	Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection including Kaposi sarcoma, nasopharyngeal carcinoma, and others. Human papillomavirus (HPV) is an especially common cause of epithelial cancers and hyperplasias. Epidermodysplasia verruciformis (EDV) is a rare type of HPV infection with characteristic histopathologic features and a unique spectrum of HPV subtypes. We report here a distinctive form of EDV-associated eccrine neoplasia. Seven tumors from two patients were analyzed and show highly uniform features including multiple clustered clinical lesions, multifocal epidermal origin, eccrine differentiation with close association with the acrosyringium, an anastomosing growth pattern, and a bland monotonous poroid-to-basaloid cytomorphology. Clinical follow-up for one patient has been benign to date. These tumors show strong similarity to two previously reported cases, suggesting that this type of EDV-associated eccrine neoplasia may represent a rare but reproducible form of skin adnexal tumor with distinctive clinicopathologic features.
MeSH term(s)	Humans ; Epidermodysplasia Verruciformis/genetics ; Epidermodysplasia Verruciformis/pathology ; Papillomavirus Infections ; Sweat Gland Neoplasms ; Skin Neoplasms/complications ; Sarcoma, Kaposi ; Papillomaviridae/genetics
Language	English
Publishing date	2024-03-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-024-03785-w
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Article: Assessing Racial and Ethnic Bias in Text Generation for Healthcare-Related Tasks by ChatGPT

Hanna, John J / Wakene, Abdi D / Lehmann, Christoph U / Medford, Richard J

medRxiv : the preprint server for health sciences

2023

Abstract: Large Language Models (LLM) are AI tools that can respond human-like to voice or free-text commands without training on specific tasks. However, concerns have been raised about their potential racial bias in healthcare tasks. In this study, ChatGPT was ... ...

Abstract	Large Language Models (LLM) are AI tools that can respond human-like to voice or free-text commands without training on specific tasks. However, concerns have been raised about their potential racial bias in healthcare tasks. In this study, ChatGPT was used to generate healthcare-related text for patients with HIV, analyzing data from 100 deidentified electronic health record encounters. Each patient's data were fed four times with all information remaining the same except for race/ethnicity (African American, Asian, Hispanic White, Non-Hispanic White). The text output was analyzed for sentiment, subjectivity, reading ease, and most used words by race/ethnicity and insurance type. Results showed that instructions for African American, Asian, Hispanic White, and Non-Hispanic White patients had an average polarity of 0.14, 0.14, 0.15, and 0.14, respectively, with an average subjectivity of 0.46 for all races/ethnicities. The differences in polarity and subjectivity across races/ethnicities were not statistically significant. However, there was a statistically significant difference in word frequency across races/ethnicities and a statistically significant difference in subjectivity across insurance types with commercial insurance eliciting the most subjective responses and Medicare and other payer types the lowest. The study suggests that ChatGPT is relatively invariant to race/ethnicity and insurance type in terms of linguistic and readability measures. Further studies are needed to validate these results and assess their implications.
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.28.23294730
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clear cell tumor with melanocytic differentiation and MITF::CREM translocation.

Alexandrescu, Sanda / Imamovic-Tuco, Alma / Janeway, Katherine / Hanna, John

Journal of cutaneous pathology

2023 Volume 50, Issue 7, Page(s) 619–622

Abstract: In addition to melanoma, a large and diverse family of tumors shows melanocytic differentiation. The best characterized member of this family is clear cell sarcoma, which is characterized by EWSR1::ATF1 and EWSR1::CREB1 fusions. These fusions drive the ... ...

Abstract	In addition to melanoma, a large and diverse family of tumors shows melanocytic differentiation. The best characterized member of this family is clear cell sarcoma, which is characterized by EWSR1::ATF1 and EWSR1::CREB1 fusions. These fusions drive the transcription of MITF, the master regulator of melanocytic differentiation. Clear cell tumor with melanocytic differentiation and MITF::CREM translocation is a recently described tumor with some similarities to clear cell sarcoma. However, only a single case has been reported. Here, we describe a second molecularly proven case that arose on the scalp of a newborn baby. In contrast to the prior reported case, the current case showed predominantly high-grade cytomorphologic features with only focal clear cell areas. Similar to the prior case, the tumor showed immunohistochemical evidence of neural crest origin/differentiation with prominent melanocytic differentiation. The fusion breakpoints were also similar and preserved the transcriptional activation domain of CREM, suggesting that CREM hyperactivity is a major feature of this tumor type. The current tumor showed a short-interval recurrence. These results expand the clinical and pathologic spectrum of this potentially new entity.
MeSH term(s)	Infant, Newborn ; Humans ; Sarcoma, Clear Cell/genetics ; Translocation, Genetic ; Melanoma ; Cell Differentiation ; Oncogene Proteins, Fusion/genetics ; Microphthalmia-Associated Transcription Factor ; Cyclic AMP Response Element Modulator/genetics
Chemical Substances	Oncogene Proteins, Fusion ; MITF protein, human ; Microphthalmia-Associated Transcription Factor ; CREM protein, human ; Cyclic AMP Response Element Modulator (135844-64-3)
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14427
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Article: Management Principles and Current Debates Surrounding Common Pediatric Elbow Fractures.

Hanna, John R / Canastra, Neal Gerard / Cruz, Aristides I / Eberson, Craig P

Instructional course lectures

2023 Volume 73, Page(s) 447–457

Abstract: Elbow fractures are among the most common fractures sustained in pediatric patients. A specific set of pediatric elbow fractures (olecranon, radial neck, and lateral condyle fractures) comprises the ones that occur most often. It is important to review ... ...

Abstract	Elbow fractures are among the most common fractures sustained in pediatric patients. A specific set of pediatric elbow fractures (olecranon, radial neck, and lateral condyle fractures) comprises the ones that occur most often. It is important to review commonly accepted principles in the evaluation and treatment of these injuries as well as highlight some debates that exist within the literature regarding the optimal management of these injuries. Although management of pediatric olecranon, radial neck, and lateral condyle fractures has been well described, controversy persists among orthopaedic surgeons regarding the surgical indications and preferred fixation techniques for these injuries.
MeSH term(s)	Child ; Humans ; Elbow ; Elbow Fractures ; Elbow Injuries ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; Fracture Fixation, Internal ; Fractures, Bone ; Treatment Outcome
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	802490-x
ISSN	0065-6895
ISSN	0065-6895
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