Article ; Online: Towards Systems Biology of Heterosis
EURASIP Journal on Bioinformatics and Systems Biology, Vol
A Hypothesis about Molecular Network Structure Applied for the Arabidopsis Metabolome
2008 Volume 2009
Abstract: We propose a network structure-based model for heterosis, and investigate it relying on metabolite profiles from Arabidopsis. A simple feed-forward two-layer network model (the Steinbuch matrix) is used in our conceptual approach. It allows for directly ... ...
| Abstract | We propose a network structure-based model for heterosis, and investigate it relying on metabolite profiles from Arabidopsis. A simple feed-forward two-layer network model (the Steinbuch matrix) is used in our conceptual approach. It allows for directly relating structural network properties with biological function. Interpreting heterosis as increased adaptability, our model predicts that the biological networks involved show increasing connectivity of regulatory interactions. A detailed analysis of metabolite profile data reveals that the increasing-connectivity prediction is true for graphical Gaussian models in our data from early development. This mirrors properties of observed heterotic Arabidopsis phenotypes. Furthermore, the model predicts a limit for increasing hybrid vigor with increasing heterozygosity—a known phenomenon in the literature. |
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| Keywords | Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5 |
| Subject code | 004 |
| Language | English |
| Publishing date | 2008-10-01T00:00:00Z |
| Publisher | Springer |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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