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  1. Article: Drug Response Diversity: A Hidden Bacterium?

    Hannachi, Nadji / Camoin-Jau, Laurence

    Journal of personalized medicine

    2021  Volume 11, Issue 5

    Abstract: Interindividual heterogeneity in response to treatment is a real public health problem. It is a factor that can be responsible not only for ineffectiveness or fatal toxicity but also for hospitalization due to iatrogenic effects, thus increasing the cost ...

    Abstract Interindividual heterogeneity in response to treatment is a real public health problem. It is a factor that can be responsible not only for ineffectiveness or fatal toxicity but also for hospitalization due to iatrogenic effects, thus increasing the cost of patient care. Several research teams have been interested in what may be at the origin of these phenomena, particularly at the genetic level and the basal activity of organs dedicated to the inactivation and elimination of drug molecules. Today, a new branch is being set up, explaining the enigmatic part that could not be explained before. Pharmacomicrobiomics attempts to investigate the interactions between bacteria, especially those in the gut, and drug response. In this review, we provide a state of the art on what this field has brought as new information and discuss the challenges that lie ahead to see the real application in clinical practice.
    Language English
    Publishing date 2021-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11050345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Platelets and

    Ezzeroug Ezzraimi, Amina / Hannachi, Nadji / Mariotti, Antoine / Rolain, Jean-Marc / Camoin-Jau, Laurence

    Biomedicines

    2022  Volume 10, Issue 7

    Abstract: Apart from their involvement in hemostasis, platelets have been recognized for their contribution to inflammation and defense against microbial agents. The interaction between platelets and bacteria has been well studied in the model ... ...

    Abstract Apart from their involvement in hemostasis, platelets have been recognized for their contribution to inflammation and defense against microbial agents. The interaction between platelets and bacteria has been well studied in the model of
    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10071636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of Platelets in Infective Endocarditis.

    Braï, Mustapha Abdeljalil / Hannachi, Nadji / El Gueddari, Nabila / Baudoin, Jean-Pierre / Dahmani, Abderrhamane / Lepidi, Hubert / Habib, Gilbert / Camoin-Jau, Laurence

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no ... ...

    Abstract Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the pathogenesis of IE. The pathogenesis of endocarditis is so complex and atypical that it is still unclear how and why certain bacterial species will induce the formation of vegetation. In this review, we will analyze the key role of platelets in the physiopathology of endocarditis and in the formation of vegetation, depending on the bacterial species. We provide a comprehensive outline of the involvement of platelets in the host immune response, investigate the latest developments in platelet therapy, and discuss prospective research avenues for solving the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
    MeSH term(s) Humans ; Prospective Studies ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/pathology ; Endocarditis ; Blood Platelets/pathology
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aspirin Effect on

    Hannachi, Nadji / Habib, Gilbert / Camoin-Jau, Laurence

    Frontiers in medicine

    2019  Volume 6, Page(s) 217

    Abstract: Infectious endocarditis (IE) is a rare disease associated with high mortality and morbidity rate. The platelet-bacterial interaction presents the cornerstone of the development of endocardial vegetation. The epidemiology of IE has undergone profound ... ...

    Abstract Infectious endocarditis (IE) is a rare disease associated with high mortality and morbidity rate. The platelet-bacterial interaction presents the cornerstone of the development of endocardial vegetation. The epidemiology of IE has undergone profound changes between the last and the new decade, with
    Language English
    Publishing date 2019-10-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2019.00217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Antibacterial Effect of Platelets on

    Ezzeroug Ezzraimi, Amina / Hannachi, Nadji / Mariotti, Antoine / Rolland, Clara / Levasseur, Anthony / Baron, Sophie Alexandra / Rolain, Jean-Marc / Camoin-Jau, Laurence

    Biomedicines

    2022  Volume 10, Issue 7

    Abstract: Platelets play an important role in defense against pathogens; however, the interaction ... ...

    Abstract Platelets play an important role in defense against pathogens; however, the interaction between
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10071533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Statins potentiate the antibacterial effect of platelets on

    Hannachi, Nadji / Fournier, Pierre-Edouard / Martel, Hélène / Habib, Gilbert / Camoin-Jau, Laurence

    Platelets

    2020  Volume 32, Issue 5, Page(s) 671–676

    Abstract: Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly in platelet alpha granules. Previous studies have reported ... ...

    Abstract Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly in platelet alpha granules. Previous studies have reported that
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Blood Platelets/metabolism ; Healthy Volunteers ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1792434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Ultrastructure of a late-stage bacterial endocarditis valve vegetation.

    Baudoin, Jean-Pierre / Camoin-Jau, Laurence / Prasanth, Arsha / Habib, Gilbert / Lepidi, Hubert / Hannachi, Nadji

    Journal of thrombosis and thrombolysis

    2020  Volume 51, Issue 3, Page(s) 821–826

    Abstract: Infective endocarditis (IE) remains a severe illness with high mortality rate, despite advances in antibiotic therapy and cardiac surgery. If infectious bacteria and platelets are two key players of human IE vegetation developmental process, their ... ...

    Abstract Infective endocarditis (IE) remains a severe illness with high mortality rate, despite advances in antibiotic therapy and cardiac surgery. If infectious bacteria and platelets are two key players of human IE vegetation developmental process, their interactions and respective roles in fully developed late-stage IE vegetations remain obscure. The objective of this study was to better understand the organization of the different components of the IE vegetation and to provide a detailed description of this vegetation ultrastructure. A late stage Staphylococcal endocarditic vegetation was provided from a 13 years teenager patient. After reception of the surgical piece, we carried out a histological study using routine methods, notably the hematoxylin-eosin-saffron staining. Labeling with the anti-CD 61 antibody was also carried out. In a second step, we used transmission electron microscopy to describe the different regions making up the vegetation. Our ultrastructural study revealed vegetation was clearly composed by three different regions and identified the specific location of the bacteria and platelets in the vegetation tissues. Histological analysis showed that platelets and Staphylococcus aureus were not co-localized. Electron microscopy study confirmed that S. aureus were found at distance from platelets, as well from immune cells, embedded in a biofilm and/or a necrotic area. These results reveal a development of a deep bacteria-only niche in vegetation, raising questions about medication access to these microorganisms. Vegetation composed of three regions: a region rich in bacteria incorporated into the necrotic tissue, the second region composed of fibrin filaments and the third region rich in platelets and free of bacteria.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/administration & dosage ; Aortic Valve/diagnostic imaging ; Aortic Valve/immunology ; Aortic Valve/microbiology ; Aortic Valve/pathology ; Aortic Valve Insufficiency/diagnosis ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/physiopathology ; Aortic Valve Insufficiency/surgery ; Blood Platelets/pathology ; Echocardiography/methods ; Endocarditis, Bacterial/blood ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/pathology ; Heart Valve Prosthesis Implantation/methods ; Humans ; Immunohistochemistry ; Male ; Microscopy, Electron, Transmission/methods ; Staphylococcal Infections/blood ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/physiopathology ; Staphylococcus aureus/isolation & purification ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-08-24
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02232-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4352: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Effect of antiplatelet agents on platelet antistaphylococcal capacity: An in vitro study.

    Hannachi, Nadji / Grac, Laettitia / Baudoin, Jean-Pierre / Fournier, Pierre-Edouard / Habib, Gilbert / Camoin-Jau, Laurence

    International journal of antimicrobial agents

    2020  Volume 55, Issue 3, Page(s) 105890

    Abstract: The involvement of platelets in anti-infectious immunity has been widely demonstrated. Molecules secreted mainly by α-granules are involved in reducing the growth of certain bacterial species. However, the effect of antiplatelet treatments on the ... ...

    Abstract The involvement of platelets in anti-infectious immunity has been widely demonstrated. Molecules secreted mainly by α-granules are involved in reducing the growth of certain bacterial species. However, the effect of antiplatelet treatments on the platelet antibacterial ability remains poorly understood. This study aimed to evaluate the platelet antibacterial effect against Staphylococcus aureus and to evaluate the influence of antiplatelet drugs on this effect. Blood samples were collected from healthy donors or patients treated with antiplatelet therapy. Six S. aureus strains were included. Bacteria were incubated with platelets for 4 h. Colonies were counted on blood agar. The supernatant's effect was evaluated. The effect of in vitro antiplatelet agents and salicylic acid was also tested. The CD62P expression rate was evaluated under different conditions of infection and platelet treatment. Platelets slowed the growth of the six S. aureus strains (P = 0.006 for P6134, P = 0.001 for P6170 and P6138, and P = 0.003 for the other strains versus bacteria alone). The supernatant of platelets pre-infected with bacteria and that of platelets pre-treated with TRAP retained this antibacterial effect (platelet-bacteria supernatant, P = 0.018; TRAP, P = 0.011 versus bacteria alone). Treatment of platelets by antiplatelet drugs significantly decreased this antibacterial effect (aspirin, P = 0.027; ticagrelor, P = 0.0263; combination, P = 0.0092 versus untreated platelets). Salicylic acid also induced inhibition of this antibacterial effect (P = 0.042 versus untreated platelets). This study showed that antiplatelet agents decreased the antibacterial effect of platelets against S. aureus.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Blood Platelets/drug effects ; Blood Platelets/immunology ; Blood Platelets/metabolism ; Cells, Cultured ; Humans ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Staphylococcal Infections/blood ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2020-01-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.105890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 500: Show issues

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  9. Article: Effect of antiplatelet agents on platelet antistaphylococcal capacity: An in vitro study

    Hannachi, Nadji / Grac, Laettitia / Baudoin, Jean-Pierre / Fournier, Pierre-Edouard / Habib, Gilbert / Camoin-Jau, Laurence

    International journal of antimicrobial agents. 2020 Mar., v. 55, no. 3

    2020  

    Abstract: The involvement of platelets in anti-infectious immunity has been widely demonstrated. Molecules secreted mainly by α-granules are involved in reducing the growth of certain bacterial species. However, the effect of antiplatelet treatments on the ... ...

    Abstract The involvement of platelets in anti-infectious immunity has been widely demonstrated. Molecules secreted mainly by α-granules are involved in reducing the growth of certain bacterial species. However, the effect of antiplatelet treatments on the platelet antibacterial ability remains poorly understood. This study aimed to evaluate the platelet antibacterial effect against Staphylococcus aureus and to evaluate the influence of antiplatelet drugs on this effect. Blood samples were collected from healthy donors or patients treated with antiplatelet therapy. Six S. aureus strains were included. Bacteria were incubated with platelets for 4 h. Colonies were counted on blood agar. The supernatant's effect was evaluated. The effect of in vitro antiplatelet agents and salicylic acid was also tested. The CD62P expression rate was evaluated under different conditions of infection and platelet treatment. Platelets slowed the growth of the six S. aureus strains (P = 0.006 for P6134, P = 0.001 for P6170 and P6138, and P = 0.003 for the other strains versus bacteria alone). The supernatant of platelets pre-infected with bacteria and that of platelets pre-treated with TRAP retained this antibacterial effect (platelet–bacteria supernatant, P = 0.018; TRAP, P = 0.011 versus bacteria alone). Treatment of platelets by antiplatelet drugs significantly decreased this antibacterial effect (aspirin, P = 0.027; ticagrelor, P = 0.0263; combination, P = 0.0092 versus untreated platelets). Salicylic acid also induced inhibition of this antibacterial effect (P = 0.042 versus untreated platelets). This study showed that antiplatelet agents decreased the antibacterial effect of platelets against S. aureus.
    Keywords Staphylococcus aureus ; agar ; anti-infective agents ; antibacterial properties ; aspirin ; bacteria ; blood platelets ; blood sampling ; immunity ; in vitro studies ; patients ; salicylic acid ; therapeutics
    Language English
    Dates of publication 2020-03
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.105890
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 500: Show issues

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  10. Article ; Online: The distinct effects of aspirin on platelet aggregation induced by infectious bacteria.

    Hannachi, Nadji / Baudoin, Jean-Pierre / Prasanth, Arsha / Habib, Gilbert / Camoin-Jau, Laurence

    Platelets

    2019  Volume 31, Issue 8, Page(s) 1028–1038

    Abstract: Bacteria induce platelet aggregation triggered by several mechanisms. The goal of this work was to characterize platelet aggregates induced by different bacterial strains and to quantify the effect of aspirin treatment using aggregation tests, as well as ...

    Abstract Bacteria induce platelet aggregation triggered by several mechanisms. The goal of this work was to characterize platelet aggregates induced by different bacterial strains and to quantify the effect of aspirin treatment using aggregation tests, as well as a novel approach based on confocal analysis. Blood samples were obtained from either healthy donors (n = 27) or patients treated with long-term aspirin (n = 15). The bacterial species included were
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Bacteremia/drug therapy ; Female ; Humans ; Male ; Platelet Aggregation/drug effects
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2019.1704717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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