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  1. Article ; Online: Immunological exhaustion

    Hannah Kaminski / Maël Lemoine / Thomas Pradeu

    PLoS Pathogens, Vol 17, Iss 9, p e

    How to make a disparate concept operational?

    2021  Volume 1009892

    Abstract: In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, ... ...

    Abstract In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Improving pre-emptive access to the kidney transplant waiting list between 2017 and 2021: Assessment of a regional program in Aquitaine

    Mathilde, Prezelin-Reydit / Karine, Moreau / Frederic, Jambon / Eric, Alezra / Grégoire, Robert / Jean-Christophe, Bernhard / Savva, Assatourian / Cécile, Degryse / Noëlle, Boulonne / Arlette, Communier / Brigitte, Bonpunt / Benjamin, Daviller / Olivier, Delorme / Xabina, Larre / Hannah, Kaminski / Karen, Leffondré / Pierre, Merville / Lionel, Couzi

    Nephrologie & therapeutique

    2024  Volume 20, Issue 1, Page(s) 1–10

    Abstract: Introduction: Pre-emptive access to the kidney transplant (KT) waiting list remains limited in France, with only 3.9% of patients on pre-emptive KT and 5.6% of patients registered at the time of initiation of dialysis. A similar trend was observed in ... ...

    Title translation Amélioration de l’accès préemptif à la liste d’attente de transplantation rénale entre 2017 et 2021 : bilan d’un programme régional en Aquitaine
    Abstract Introduction: Pre-emptive access to the kidney transplant (KT) waiting list remains limited in France, with only 3.9% of patients on pre-emptive KT and 5.6% of patients registered at the time of initiation of dialysis. A similar trend was observed in Aquitaine. The aim of this study was to assess the impact of a regional program in terms of access to the waiting list for patients initiating a kidney replacement therapy (KRT).
    Methods: We included all patients assessed for registration on the list between 2017 and 2020, 2017 being the reference year and 2018 the beginning of the program. Using the CRISTAL and REIN registries, we assessed changes in the number of patients on the list at the time of initiation of dialysis or transplantation.
    Results: The number of new assessed candidates increased gradually each year from 255 in 2017 to 352 in 2020 (+38%). The number of patients on the list sharply increased in 2018 from 229 in 2017 to 319 in 2018 (+39.3%) and then remained stable. At the initiation of KRT, the proportion of patients registered on the waiting list increased gradually from 7.1% in 2017 to 18.2% in 2020. The proportion of pre-emptive KT remained stable between 2017 and 2021 (around 7%) with a decrease in 2020 (4.6%). Approximately 60% of patients had a contraindication to transplantation throughout the study.
    Conclusion: This study showed that a regional program aimed at providing better information to healthcare professionals and patients and encouraging rapid assessment of transplant candidates could increase the rate of pre-emptive registration on the KT waiting list for eligible patients over 4 years.
    Language French
    Publishing date 2024-01-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1684/ndt.2024.64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France.

    Thizy, Guillaume / Flahault, Adrien / Scemla, Anne / Roux, Olivier / Jarraud, Sophie / Lebeaux, David / Pouchot, Jacques / Gautier-Vargas, Gabriela / Malvezzi, Paolo / Murris, Marlene / Vuotto, Fanny / Girerd, Sophie / Pansu, Nathalie / Antonini, Teresa / Elkrief, Laure / Barrou, Benoit / Besch, Camille / Blot, Mathieu / Boignard, Aude /
    Brenier, Henri / Coilly, Audrey / Gouezel, Corentin / Hannah, Kaminski / Housssel-Debry, Pauline / Jouan, Jerome / Lecuyer, Hervé / Limelette, Anne / Luyt, Charles Edouard / Melloni, Boris / Pison, Christophe / Rafat, Cédric / Rebibou, Jean-Michel / Savier, Eric / Schvartz, Betoul / Scatton, Olivier / Toure, Fatouma / Varnous, Shaida / Vidal, Pauline / Savoye, Emilie / Ader, Florence / Lortholary, Olivier / Lanternier, Fanny / Lafont, Emmanuel

    Chest

    2023  Volume 165, Issue 3, Page(s) 507–520

    Abstract: Background: Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ transplant recipients. However, the epidemiologic ... ...

    Abstract Background: Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ transplant recipients. However, the epidemiologic features, clinical presentation, and outcomes of LD in this population are poorly described.
    Research question: What are the clinical manifestations, radiologic presentation, risk factors for severity, treatment, and outcome of LD in solid organ transplant recipients?
    Study design and methods: In this 10-year multicenter retrospective cohort study in France, where LD notification is mandatory, patients were identified by hospital discharge databases. Diagnosis of LD relied on positive culture findings from any respiratory sample, positive urinary antigen test (UAT) results, positive specific serologic findings, or a combination thereof. Severe LD was defined as admission to the ICU.
    Results: One hundred one patients from 51 transplantation centers were eligible; 64 patients (63.4%) were kidney transplant recipients. Median time between transplantation and LD was 5.6 years (interquartile range, 1.5-12 years). UAT results were positive in 92% of patients (89/97). Among 31 patients with positive culture findings in respiratory samples, Legionella pneumophila serogroup 1 was identified in 90%. Chest CT imaging showed alveolar consolidation in 98% of patients (54 of 57), ground-glass opacity in 63% of patients (36 of 57), macronodules in 21% of patients (12 of 57), and cavitation in 8.8% of patients (5 of 57). Fifty-seven patients (56%) were hospitalized in the ICU. In multivariate analysis, severe LD was associated with negative UAT findings at presentation (P = .047), lymphopenia (P = .014), respiratory symptoms (P = .010), and pleural effusion (P = .039). The 30-day and 12-month mortality rates were 8% (8 of 101) and 20% (19 of 97), respectively. In multivariate analysis, diabetes mellitus was the only factor associated with 12-month mortality (hazard ratio, 3.2; 95% OR, 1.19-8.64; P = .022).
    Interpretation: LD is a late and severe complication occurring in solid organ transplant recipients that may present as pulmonary nodules on which diabetes impacts its long-term prognosis.
    MeSH term(s) Humans ; Legionnaires' Disease/diagnosis ; Legionnaires' Disease/epidemiology ; Legionnaires' Disease/microbiology ; Retrospective Studies ; Legionella pneumophila ; Risk Factors ; Organ Transplantation/adverse effects
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.09.033
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    Zs.MO 349: Show issues

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  4. Article ; Online: Cryptococcal Meningitis in Kidney Transplant Recipients

    Laurène Tardieu / Gillian Divard / Olivier Lortholary / Anne Scemla / Éric Rondeau / Isabelle Accoceberry / Rémi Agbonon / Alexandre Alanio / Adela Angoulvant / Laetitia Albano / Philippe Attias / Anne Pauline Bellanger / Dominique Bertrand / Julie Bonhomme / Françoise Botterel / Nicolas Bouvier / Matthias Buchler / Taieb Chouaki / Thomas Crépin /
    Marie-Fleur Durieux / Guillaume Desoubeaux / Gary Doppelt / Loïc Favennec / Arnaud Fekkar / Ophélie Fourdinier / Marie Frimat / Jean-Pierre Gangneux / Claire Garandeau / Lilia Hasseine / Christophe Hennequin / Xavier Iriart / Nassim Kamar / Hannah Kaminski / Raphael Kormann / Laurence Lachaud / Christophe Legendre / Moglie Le Quintrec Donnette / Jordan Leroy / Charlène Levi / Marie Machouart / David Marx / Jean Menotti / Valérie Moal / Florent Morio / Natacha Mrozek / Muriel Nicolas / Philippe Poirier / Marie-Noelle Peraldi / Benjamin Poussot / Stéphane Ranque

    Pathogens, Vol 11, Iss 699, p

    A Two-Decade Cohort Study in France

    2022  Volume 699

    Abstract: Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological ... ...

    Abstract Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. We sought to describe overall and graft survival based on whether KT patients with cryptococcosis developed CM or not. Clinical indicators of CNS involvement and brain radiological characteristics were assessed. Eighty-eight cases of cryptococcosis were diagnosed during the study period, with 61 (69.3%) cases of CM. Mortality was high (32.8%) at 12 months (M12) but not significantly different whether or not patients presented with CM. Baseline hyponatremia and at least one neurological symptom were independently associated with CM ( p < 0.001). Positive serum cryptococcal antigen at diagnosis was also significantly associated with CM ( p < 0.001). On magnetic resonance imaging (MRI), three patterns of brain injury were identified: parenchymal, meningeal, and vascular lesions. Although CM does not affect graft function directly, it entails a grim prognosis.
    Keywords cryptococcosis ; opportunistic infection ; transplant associated diseases ; renal transplantation ; cryptococcal meningitis ; graft outcome ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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