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  1. Article ; Online: Intravascular imaging–guided intracoronary lithotripsy

    Hannah Sinclair / Lampson Fan / Eoin Fahy / Farhan Shahid / Karim Ratib / James Nolan / Mamas Mamas / Azfar Zaman / Javed Ahmed

    Health Science Reports, Vol 4, Iss 3, Pp n/a-n/a (2021)

    First real‐world experience

    2021  

    Abstract: Abstract Background and Aims Coronary calcification remains a significant challenge for the contemporary interventional cardiologist. We aim to describe the use of intravascular lithotripsy (IVL) in a range of real‐world settings. Methods A retrospective ...

    Abstract Abstract Background and Aims Coronary calcification remains a significant challenge for the contemporary interventional cardiologist. We aim to describe the use of intravascular lithotripsy (IVL) in a range of real‐world settings. Methods A retrospective two‐center analysis of patients treated with IVL between June 2018 and November 2019. Technical and procedural success, as well as procedural complications and 30‐day outcomes (death, myocardial infarction, or repeat target vessel revascularization), was recorded. Results Sixty‐five patients underwent IVL: 80% were male and the mean age was 70.1 ± 12.0 years. 54% of patients presented with acute coronary syndrome (ACS) and 68% of patients had intracoronary imaging. Twelve patients required IVL within pre‐existing stents, and 12 underwent IVL in the left main stem. All balloons were successfully delivered with 98.5% procedural success. There was a significant gain in MLA post PCI of 261.9 ± 100% following IVL. There were two procedural complications. At 30‐day follow‐up, there was one death, and one patient required a repeat procedure due to stent underexpansion. Conclusions In this largest real‐world series of imaging‐guided IVL for calcified lesions to date, we demonstrate that IVL is deliverable, safe, and effective at calcium modification especially when intracoronary imaging is used.
    Keywords coronary artery disease ; lithotripsy ; optical coherence tomography ; percutaneous coronary intervention ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Predictors of in-hospital mortality in critically ill patients with COVID-19

    Divaka Perera / Georgios Georgiopoulos / Hannah Sinclair / Matthew Ryan / Kevin O’Gallagher / Alexandros Papachristidis / Mark Monaghan / Ajay M Shah / Gerald Carr-White / Ozan M Demir / Mark Zuckerman / Andrew Osborne / Alina Hua / Richard Fisher / Peter Pearson / Kelly Victor / Vasileios Stylianidis / Eleanor Corcoran / Chiara Cirillo /
    Eleni Nakou / Christos Tountas / Apostolia Marvaki / Nishita Desai / Ana Pericao / Anender Dhariwal / Adam Abner Nabeebaccus / Tiago Fonseca / Eva Toth

    BMJ Open, Vol 12, Iss

    a large dual tertiary centre study

    2022  Volume 12

    Abstract: Objectives The aim of this study was to investigate the relationship of echocardiographic parameters, laboratory findings and clinical characteristics with in-hospital mortality in adult patients with COVID-19 admitted to the intensive care units (ICU) ... ...

    Abstract Objectives The aim of this study was to investigate the relationship of echocardiographic parameters, laboratory findings and clinical characteristics with in-hospital mortality in adult patients with COVID-19 admitted to the intensive care units (ICU) in two large collaborating tertiary UK centres.Design Observational retrospective study.Setting The study was conducted in patients admitted to the ICU in two large tertiary centres in London, UK.Participants Inclusion criteria were: (1) patients admitted to the ICU with a COVID-19 diagnosis over a period of 16 weeks. and (2) underwent a transthoracic echocardiogram on the first day of ICU admission as clinically indicated.No exclusion criteria applied.Three hundred patients were enrolled and completed the follow-up.Primary and secondary outcome measures The outcome measure in this study was in-hospital mortality in patients admitted to the ICU with COVID-19 infection.Results Older age (HR: 1.027, 95% CI 1.007 to 1.047; p=0.008), left ventricular (LV) ejection fraction<35% (HR: 5.908, 95% CI 2.609 to 13.376; p<0.001), and peak C reactive protein (CRP) (HR: 1.002, 95% CI 1.001 to 1.004, p=0.001) were independently correlated with mortality in a multivariable Cox regression model. Following multiple imputation of variables with more than 5% missing values, random forest analysis was applied to the imputed data. Right ventricular (RV) basal diameter (RVD1), RV mid-cavity diameter (RVD2), tricuspid annular plane systolic excursion, RV systolic pressure, hypertension, RV dysfunction, troponin level on admission, peak CRP, creatinine level on ICU admission, body mass index and age were found to have a high relative importance (> 0.7).Conclusions In patients with COVID-19 in the ICU, both severely impaired LV function and impaired RV function may have adverse prognostic implications, but older age and inflammatory markers appear to have a greater impact. A combination of echocardiographic and laboratory investigations as well as demographic and clinical ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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