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Article ; Online: Cardiac involved and autopsy in two patients with systemic sclerosis

Hang Yu / Qinwen Wen / Xiaolu Zhang / Hanqing Zhang / Xiudi Wu

Heliyon, Vol 9, Iss 5, Pp e15555- (2023)

Two cases report

2023

Abstract: Systemic sclerosis (SSc) is a connective tissue disease with high mortality. One of the most common causes of death in potential SSc patients is cardiac arrest. However, the pathogenesis of cardiac death is not very clear. As far as we know, there are ... ...

Abstract	Systemic sclerosis (SSc) is a connective tissue disease with high mortality. One of the most common causes of death in potential SSc patients is cardiac arrest. However, the pathogenesis of cardiac death is not very clear. As far as we know, there are few autopsy reports on this subject. Our autopsy report on two fatal cases of heart injury in SSc patients revealed evidence of myocarditis, focal myocardial necrosis, and myocardial fibrosis. Our findings suggest that chronic inflammation of the heart may lead to extensive fibrosis, which could contribute to the high mortality rate observed in SSc patients. Early detection of heart injury in SSc patients using existing technology is necessary to improve patient outcomes. Future research should focus on developing more effective methods for early detection and management of heart involvement in SSc.
Keywords	Cardiac involvement ; Systemic sclerosis ; Autopsy ; Case report ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of green space on adverse birth outcomes induced by air pollution

Juan ZHANG / Sijie ZHOU / Hanqing ZHANG / Yajuan ZHANG

环境与职业医学, Vol 39, Iss 3, Pp 343-

2022 Volume 347

Abstract: Air pollution has become one of the most important public health problems worldwide. Exposure to air pollution during pregnancy is one of the important risk factors for adverse birth outcomes such as preterm birth, low birth weight, and birth defects. ... ...

Abstract	Air pollution has become one of the most important public health problems worldwide. Exposure to air pollution during pregnancy is one of the important risk factors for adverse birth outcomes such as preterm birth, low birth weight, and birth defects. Air pollution control has a long way to go. Therefore, it is extremely urgent to analyze and identify relevant protective factors. Some studies have shown that green space may be a protective factor for the adverse birth outcomes related to air pollution. This kind of research mainly utilizes satellite monitoring data, quantifies the green space coverage level in a certain range of buffer zone centered on the pregnant women's home addresses, and analyzes its mediation effect on the adverse pregnancy outcomes related to air pollution. In this paper we reviewed the use of green space data, the estimated effect of green space mediating the relationship between air pollution and adverse birth outcomes, and its possible mechanisms, aiming to clarify the impact of green space on adverse birth outcomes related to air pollution and provide a scientific basis for public health intervention strategies.
Keywords	green space ; air pollution ; adverse birth outcome ; low birth weight ; preterm birth ; mediation effect ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
Subject code	333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Editorial Committee of Journal of Environmental and Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of long-term exposure to ambient PM2.5 on hypertension and role of dietary regulation

Hanqing ZHANG / Sijie ZHOU / Jinxia WANG / Yunhao SHI / Yi ZHAO / Yuhong ZHANG / Yajuan ZHANG

环境与职业医学, Vol 40, Iss 5, Pp 551-

2023 Volume 558

Abstract: BackgroundThe contribution of long-term ambient PM2.5 exposure to hypertension should not be ignored. However, the conclusions of whether dietary factors play a role in regulating PM2.5-related hypertension are still inconsistent. ObjectiveTo explore the ...

Abstract	BackgroundThe contribution of long-term ambient PM2.5 exposure to hypertension should not be ignored. However, the conclusions of whether dietary factors play a role in regulating PM2.5-related hypertension are still inconsistent. ObjectiveTo explore the correlation between long-term exposure to ambient PM2.5 and blood pressure indicators (systolic blood pressure, diastolic blood pressure, mean arterial pressure, and pulse pressure) in adults in Ningxia and a potential moderating effect of dietary factors. MethodsA set of cross-sectional survey data from March, 2013 to May, 2018 was retrieved from the China Northwest Cohort-Ningxia, and the average ambient PM2.5 concentration in the previous three years was also collected to estimate the long-term exposure of the participants. Binary logistic regression model was used to validate the correlation between long-term exposure to ambient PM2.5 and hypertension in Ningxia, and linear model was used to study the correlation between long-term exposure to ambient PM2.5 and blood pressure indicators (systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure), and to explore the influence of dietary factors on ambient PM2.5-related hypertension. ResultsA total of 11470 participants were included in the study, 42.2% male and 57.8% female. The three-year average ambient PM2.5 concentration before the baseline survey was 37.0 μg·m−3. Each 1 μg·m−3 increase in ambient PM2.5 was associated with an increased risk of hypertension (OR=1.111, 95%CI: 1.097, 1.125), and increased systolic blood pressure, diastolic blood pressure, mean arterial pressure, and pulse pressure by 0.886 (95%CI: 0.783, 0.990), 0.570 (95%CI: 0.500, 0.641), 0.676 (95%CI: 0.600, 0.751), and 0.316 (95%CI: 0.243, 0.389) mmHg, respectively. The stratified analysis showed that the OR and 95%CI of hypertension were 1.171 (1.097, 1.254), 1.117 (1.064, 1.174), and 1.160 (1.116, 1.207) respectively for each 1 μg·m−3 increased in PM2.5 with low frequency of vegetable and fruit ...
Keywords	ambient pm2.5 ; long-term exposure ; hypertension ; dietary factor ; moderating effect ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Editorial Committee of Journal of Environmental and Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Circular SAR Incoherent 3D Imaging with a NeRF-Inspired Method

Hanqing Zhang / Yun Lin / Fei Teng / Shanshan Feng / Bing Yang / Wen Hong

Remote Sensing, Vol 15, Iss 3322, p

2023 Volume 3322

Abstract: Circular synthetic aperture radar (CSAR) has the potential to form 3D images with single-pass single-channel radar data, which is very time-efficient. This article proposes a volumetric neural renderer that utilizes CSAR 2D amplitude images to ... ...

Abstract	Circular synthetic aperture radar (CSAR) has the potential to form 3D images with single-pass single-channel radar data, which is very time-efficient. This article proposes a volumetric neural renderer that utilizes CSAR 2D amplitude images to reconstruct the 3D power distribution of the imaged scene. The innovations are two-fold: Firstly, we propose a new SAR amplitude image formation model that establishes a linear mapping relationship between multi-look amplitude-squared SAR images and a real-valued 4D (spatial location ( x , y , z ) and azimuth angle <semantics> θ </semantics> ) radar scattered field. Secondly, incorporating the proposed image formation model and SAR imaging geometry, we extend the neural radiance field (NeRF) methods to reconstruct the 4D radar scattered field using a set of 2D multi-aspect SAR images. Using real-world drone SAR data, we demonstrate our method for (1) creating realistic SAR imagery from arbitrary new viewpoints and (2) reconstructing high-precision 3D structures of the imaged scene.
Keywords	3D imaging ; synthetic aperture radar (SAR) ; circular SAR ; neural radiance field (NeRF) ; differentiable rendering ; Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Azimuth Signal-Reconstruction Method Based on Two-Step Projection Technology for Spaceborne Azimuth Multi-Channel High-Resolution and Wide-Swath SAR

Ning Li / Hanqing Zhang / Jianhui Zhao / Lin Wu / Zhengwei Guo

Remote Sensing, Vol 13, Iss 4988, p

2021 Volume 4988

Abstract: Azimuth non-uniform signal-reconstruction is a critical step for azimuth multi-channel high-resolution wide-swath (HRWS) synthetic aperture radar (SAR) data processing. However, the received non-uniform signal has noise in the actual azimuth multi- ... ...

Abstract	Azimuth non-uniform signal-reconstruction is a critical step for azimuth multi-channel high-resolution wide-swath (HRWS) synthetic aperture radar (SAR) data processing. However, the received non-uniform signal has noise in the actual azimuth multi-channel SAR (MCSAR) operation, which leads to the serious reduction in the signal-to-noise ratio (SNR) of the results processed by a traditional reconstruction algorithm. Aiming to address the problem of reducing the SNR of the traditional reconstruction algorithm in the reconstruction of non-uniform signal with noise, a novel signal-reconstruction algorithm based on two-step projection technology (TSPT) for the MCSAR system is proposed in this paper. The key part of the TSPT algorithm consists of a two-step projection. The first projection is to project the given signal into the selected intermediate subspace, spanned by the integer conversion of the compact support kernel function. This process generates a set of sparse equations, which can be solved efficiently by using the sparse equation solver. The second key projection is to project the first projection result into the subspace of the known sampled signal. The secondary projection can be achieved with a digital linear translation invariant (LSI) filter and generate a uniformly spaced signal. As a result, compared with the traditional azimuth MCSAR signal-reconstruction algorithm, the proposed algorithm can improve SNR and reduce the azimuth ambiguity-signal-ratio (AASR). The processing results of simulated data and real raw data verify the effectiveness of the proposed algorithm.
Keywords	signal-reconstruction ; high-resolution wide-swath (HRWS) ; synthetic aperture radar (SAR) ; non-uniform sampling ; two-step projection technology (TSPT) ; signal-to-noise ratio (SNR) ; Science ; Q
Subject code	518 ; 006
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint

Jake Leyhr / Laura Waldmann / Beata Filipek-Górniok / Hanqing Zhang / Amin Allalou / Tatjana Haitina

eLife, Vol

2022 Volume 11

Abstract: The acquisition of movable jaws was a major event during vertebrate evolution. The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however knowledge about its ... ...

Abstract	The acquisition of movable jaws was a major event during vertebrate evolution. The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however knowledge about its regulatory mechanism is lacking. In this study, we report a proximal enhancer element of Nkx3.2 that is deeply conserved in most gnathostomes but undetectable in the jawless hagfish and lamprey. This enhancer is active in the developing jaw joint region of the zebrafish Danio rerio, and was thus designated as jaw joint regulatory sequence 1 (JRS1). We further show that JRS1 enhancer sequences from a range of gnathostome species, including a chondrichthyan and mammals, have the same activity in the jaw joint as the native zebrafish enhancer, indicating a high degree of functional conservation despite the divergence of cartilaginous and bony fish lineages or the transition of the primary jaw joint into the middle ear of mammals. Finally, we show that deletion of JRS1 from the zebrafish genome using CRISPR/Cas9 results in a significant reduction of early gene expression of nkx3.2 and leads to a transient jaw joint deformation and partial fusion. Emergence of this Nkx3.2 enhancer in early gnathostomes may have contributed to the origin and shaping of the articulating surfaces of vertebrate jaws.
Keywords	cis-regulatory element ; enhancer deletion ; nkx3.2 ; jaw joint ; gnathostome ; optical projection tomography ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.

Laura Waldmann / Jake Leyhr / Hanqing Zhang / Caroline Öhman-Mägi / Amin Allalou / Tatjana Haitina

PLoS ONE, Vol 16, Iss 8, p e

2021 Volume 0255953

Abstract: The transcription factor Nkx3.2 (Bapx1) is an important chondrocyte maturation inhibitor. Previous Nkx3.2 knockdown and overexpression studies in non-mammalian gnathostomes have focused on its role in primary jaw joint development, while the function of ... ...

Abstract	The transcription factor Nkx3.2 (Bapx1) is an important chondrocyte maturation inhibitor. Previous Nkx3.2 knockdown and overexpression studies in non-mammalian gnathostomes have focused on its role in primary jaw joint development, while the function of this gene in broader skeletal development is not fully described. We generated a mutant allele of nkx3.2 in zebrafish with CRISPR/Cas9 and applied a range of techniques to characterize skeletal phenotypes at developmental stages from larva to adult, revealing loss of the jaw joint, fusions in bones of the occiput, morphological changes in the Weberian apparatus, and the loss or deformation of bony elements derived from basiventral cartilages of the vertebrae. Axial phenotypes are reminiscent of Nkx3.2 knockout in mammals, suggesting that the function of this gene in axial skeletal development is ancestral to osteichthyans. Our results highlight the broad role of nkx3.2 in zebrafish skeletal development and its context-specific functions in different skeletal elements.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Zijun Zhou / Yanheng Qiao / Yanru Zhao / Xin Chen / Jie Li / Hanqing Zhang / Qiumei Lan / Bo Yang

Chinese Medicine, Vol 17, Iss 1, Pp 1-

Natural products: potential drugs for the treatment of renal fibrosis

2022 Volume 1

Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrated Transcriptome and Metabolome Analysis Reveals an Essential Role for Auxin in Hypocotyl Elongation during End-of-Day Far-Red Treatment of Cucurbita moschata (Duch. Ex Lam.)

Qi Liu / Hanqing Zhang / Yanhao Mei / Qi Li / Yahui Bai / Huibin Yu / Xiaodong Xu / Jianxiang Ma / Yongjun Wu / Zhenchao Yang

Agronomy, Vol 11, Iss 853, p

2021 Volume 853

Abstract: Long, robust hypocotyls are important for facilitating greenhouse transplant production. The use of far-red light at the end of the day (end-of-day far-red, EOD-FR) is known to prompt hypocotyl elongation, but the mechanism of EOD-FR-mediated hypocotyl ... ...

Abstract	Long, robust hypocotyls are important for facilitating greenhouse transplant production. The use of far-red light at the end of the day (end-of-day far-red, EOD-FR) is known to prompt hypocotyl elongation, but the mechanism of EOD-FR-mediated hypocotyl elongation in pumpkin remains unclear. Here, we found that hypocotyl length, parenchymal cell size in hypocotyls, and plant IAA levels were significantly greater in pumpkin after EOD-FR treatment. This effect was counteracted by the application of the polar auxin transport inhibitor 1-N-naphthylphthalamic acid. Integrated transcriptomic and metabolomic analysis of pumpkin hypocotyls revealed that the expression of auxin-related genes changed significantly after EOD-FR treatment, and the contents of the auxin biosynthetic precursors tryptophan and indole were also significantly higher. Our results show that auxin plays an essential role in EOD-FR-mediated hypocotyl elongation, shed light on the mechanisms of EOD-FR mediated hypocotyl elongation, and provide a theoretical basis for the use of EOD-FR in facility cultivation.
Keywords	Cucurbita moschata (Duch. ex Lam.) ; far-red light ; auxin ; transcriptome ; metabolomics ; Agriculture ; S
Subject code	590
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development and validation of a nomogram to predict cancer-specific survival in patients with hypopharyngeal squamous cell carcinoma treated with primary surgery

Ke Wang / Xia Xu / Ruotao Xiao / Danyi Du / Luqi Wang / Hanqing Zhang / Zehong Lv / Xiangping Li / Gang Li

Journal of International Medical Research, Vol

2021 Volume 49

Abstract: Objective We aimed to develop a nomogram to predict cancer-specific survival (CSS) in patients with hypopharyngeal squamous cell carcinoma (HSCC) treated with primary surgery to provide more accurate risk stratification for patients. Methods We ... ...

Abstract	Objective We aimed to develop a nomogram to predict cancer-specific survival (CSS) in patients with hypopharyngeal squamous cell carcinoma (HSCC) treated with primary surgery to provide more accurate risk stratification for patients. Methods We retrospectively collected data of 1144 eligible patients with HSCC from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Patients were randomly divided into training and validation groups (ratio 6:4) and we used univariate and multivariate Cox analysis. We developed and validated a nomogram using calibration plots and time-dependent receiver operating characteristic, Kaplan–Meier, and decision curves. Results Age; marital status; T, N, and M stage; and postoperative adjuvant therapy were independent factors associated with CSS, which were included in the nomogram. The nomogram’s C-index was 0.705 to 0.723 in the training group and 0.681 to 0.736 in the validation group, which were significantly higher than conventional American Joint Committee on Cancer (AJCC) staging. Calibration curves showed good agreement between prediction and observation in both groups. Kaplan–Meier and decision curves suggested the nomogram had better risk stratification and net benefit than conventional AJCC staging. Conclusions We established a nomogram that was superior to conventional AJCC staging in predicting CSS for HSCC.
Keywords	Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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