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Article ; Online: Automated versus manual oxygen administration for patients admitted with acute cardiovascular disease - a study protocol of a randomised controlled trial.

Taraldsen, Ida Arentz / Grand, Johannes / Lukoschewitz, Jasmin Dam / Hansen, Ejvind Frausing / Hove, Jens Dahlgaard

2023 Volume 70, Issue 4

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Cardiovascular Diseases/therapy ; Prospective Studies ; Hypoxia/therapy ; Oxygen ; Treatment Outcome ; Randomized Controlled Trials as Topic
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-03-27
Publishing country	Denmark
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2648771-8
ISSN	2245-1919 ; 2245-1919
ISSN (online)	2245-1919
ISSN	2245-1919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hypoxemia and not hyperoxemia predicts worse outcome in severe COPD exacerbations - an observational study.

Sandau, Charlotte / Hansen, Ejvind Frausing / Pedersen, Lars / Jensen, Jens Ulrik Stæhr

European clinical respiratory journal

2022 Volume 10, Issue 1, Page(s) 2153644

Abstract: Objectives: For patients admitted with an acute exacerbation of COPD (AECOPD) and a need for supplementary oxygen therapy, to determine if peripheral oxygen saturation ... 92% (hyperoxemia), within first 24 hours of admission, is ... ...

Abstract	Objectives: For patients admitted with an acute exacerbation of COPD (AECOPD) and a need for supplementary oxygen therapy, to determine if peripheral oxygen saturation < 88% (hypoxemia) or >92% (hyperoxemia), within first 24 hours of admission, is associated with 'treatment failure' or fewer days alive and out of hospital within 14 days after admission. Design: A retrospective multicenter observational study, reviewing consecutive data on SpO2, oxygen, and drug administration at three predefined time points, on adverse events in patients admitted with COPD between December 2019 and June 2020. Multivariable logistic regression analysis, Mann Whitney U- and Chi-square-test were used. Setting: Acute hospital setting, across four different hospitals in the capital region of Denmark. Participants: Patients with a confirmed diagnosis of COPD admitted with an acute exacerbation and an oxygen need within the first 24 hours admission. Results: In total 289 COPD patients were included. The median age was 74.8 years [interquartile range (IQR):69.6 to 81.8], 191 were female and 132 patients experienced 'treatment failure'. A minimum of one episode of hypoxemia (SpO Conclusion: For admitted patients with AECOPD, being hypoxemic ever within the first 24 hours after admission is associated with a substantially increased risk of a poor prognosis.
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2834928-3
ISSN	2001-8525
ISSN	2001-8525
DOI	10.1080/20018525.2022.2153644
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Article ; Online: Noninvasiv ventilation ved pneumoni: effektiv ventilationsstøtte eller forsinkende behandling.

Hansen, Ejvind Frausing

Ugeskrift for laeger

2014 Volume 176, Issue 28, Page(s) V66135

Title translation	Non-invasive ventilation in pneumonia: effective ventilation support or delaying treatment.
MeSH term(s)	Humans ; Noninvasive Ventilation/standards ; Pneumonia/therapy
Language	Danish
Publishing date	2014-07-07
Publishing country	Denmark
Document type	Editorial
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article: Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial.

Kofod, Linette Marie / Westerdahl, Elisabeth / Kristensen, Morten Tange / Brocki, Barbara Cristina / Ringbæk, Thomas / Hansen, Ejvind Frausing

Journal of clinical medicine

2021 Volume 10, Issue 21

Abstract: The need for oxygen increases with activity in patients with COPD and on long-term oxygen treatment (LTOT), leading to periods of hypoxemia, which may influence the patient's performance. This study aimed to evaluate the effect of automated oxygen ... ...

Abstract	The need for oxygen increases with activity in patients with COPD and on long-term oxygen treatment (LTOT), leading to periods of hypoxemia, which may influence the patient's performance. This study aimed to evaluate the effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during walking on dyspnea and endurance in patients with COPD and on LTOT. In a double-blinded randomised crossover trial, 33 patients were assigned to use either automated oxygen titration or the usual fixed-dose in a random order in two walking tests. A closed-loop device, O2matic delivered a variable oxygen dose set with a target saturation of 90-94%. The patients had a home oxygen flow of (mean ± SD) 1.6 ± 0.9 L/min. At the last corresponding isotime in the endurance shuttle walk test, the patients reported dyspnea equal to median (IQR) 4 (3-6) when using automated oxygen titration and 8 (5-9) when using fixed doses,
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10214820
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Article ; Online: Patients' Perspective on Automated Oxygen Administration during Hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Qualitative Study Nested in a Randomized Controlled Trial.

Sandau, Charlotte / Poulsen, Ingrid / Nørholm, Vibeke / Hansen, Ejvind Frausing / Ringbaek, Thomas Jørgen / Suppli Ulrik, Charlotte / Bove, Dorthe Gaby

COPD

2022 Volume 19, Issue 1, Page(s) 345–352

Abstract: Recently, health technology systems offering monitoring of the peripheral oxygen saturation level and automated oxygen administration (AOA) have emerged. AOA has been shown to reduce duration of hypoxemia and the length of hospital stay, but the patients' ...

Abstract	Recently, health technology systems offering monitoring of the peripheral oxygen saturation level and automated oxygen administration (AOA) have emerged. AOA has been shown to reduce duration of hypoxemia and the length of hospital stay, but the patients' perspective on AOA has not been investigated. This qualitative study, based on the interpretive description methodology, aimed to explore how patients hospitalized with exacerbation of chronic obstructive pulmonary disease (COPD) experience being treated with AOA. Eighteen patients treated with AOA were included in the study. Data was collected during admission or in the patients' homes using semi-structured interviews focusing on patients' experiences of AOA using the word "robot" as used by patients. The findings revealed two themes "adaptation of behavior to the robot" and "robots can make patients feel safe but not cared for" and six subthemes. Our findings illustrate how patients were willing to compromise their own therapy and thereby safety by avoiding behavior triggering AOA alarms and disturbing their fellow patients and the health care professionals. Adherence, defined as patients' consistency in taking their medications as prescribed, becomes an important point of attention for health professionals when applying individualized robotic therapies such as AOA to patients with COPD. To support patients in the process of managing adherence to therapeutic technology, we propose a person-centered care approach that, through education and communication with the patients, generates an understanding of how they can self-manage AOA and its alarms without activating avoiding behavior that threatens their treatment and recovery.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/therapy ; Qualitative Research ; Oxygen Inhalation Therapy ; Hospitalization ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-10-23
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171107-0
ISSN	1541-2563 ; 1541-2555
ISSN (online)	1541-2563
ISSN	1541-2555
DOI	10.1080/15412555.2022.2141620
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Article: Hospital admission for COVID-19 pneumonitis - long-term impairment in quality of life and lung function.

Vejen, Marie / Hansen, Ejvind Frausing / Al-Jarah, Bakir Nabil Ibrahim / Jensen, Casper / Thaning, Pia / Jeschke, Klaus Nielsen / Ulrik, Charlotte Suppli

European clinical respiratory journal

2022 Volume 9, Issue 1, Page(s) 2024735

Abstract: Background and aim: Knowledge of long-term consequences of severe COVID-19 pneumonitis is of outmost importance. Our aim was, therefore, to assess the long-term impact on quality of life and lung function in adults hospitalized with severe COVID-19.: ... ...

Abstract	Background and aim: Knowledge of long-term consequences of severe COVID-19 pneumonitis is of outmost importance. Our aim was, therefore, to assess the long-term impact on quality of life and lung function in adults hospitalized with severe COVID-19. Methods: All patients hospitalized with COVID-19 pneumonitis at Copenhagen University Hospital-Hvidovre, Denmark, were invited to participate in the study 4-5 months after discharge. Of the 160 invited 128 responded positively (80%). Medical history and symptoms were assessed, and patients rated impact on quality of life and functional status with EuroQol-5D-5L and Post Covid Functional Scale. Lung function was assessed by dynamic spirometry and measurement of diffusing capacity. Results: Fatigue, dyspnea, cough and cognitive dysfunction were the most common symptoms. Of 128 patients, 85% had at least one symptom, and 51% reported two or more symptoms. Self-rated Quality of life was impaired assessed by EuroQol 5D-5L, with dimensions 'Pain or discomfort' (61%) and 'Usual activities' (54%) mostly affected. Functional status was significantly worse than before COVID-19 assessed by Post-COVID Functional Scale. Among lung function parameters, diffusing capacity was most affected, with 45% having diffusing capacity < 80% of predicted. Conclusion: Fatigue, respiratory symptoms and cognitive symptoms are highly common months after hospitalization for severe COVID-19. Compared to pre-COVID-19, functional status and usual activities continued to be impaired. In line with this, almost half of the patients were found to have impaired diffusing capacity.
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2834928-3
ISSN	2001-8525
ISSN	2001-8525
DOI	10.1080/20018525.2021.2024735
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Article ; Online: [CPAP for patients with COVID-19].

Kofod, Linette Marie / Jeschke, Klaus Nielsen / Krogh-Madsen, Rikke / Albek, Carsten Monefeldt / Hansen, Ejvind Frausing

Ugeskrift for laeger

2020 Volume 182, Issue 33

Abstract: Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19). The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or ... ...

Abstract	Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19). The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or avoid intubation. This review describes the physiological rationale behind CPAP therapy for patients with COVID-19 and the clinical experience with CPAP, implemented in a medical ward without prior knowledge of the treatment. CPAP has the potential for reducing the burden on intensive care units if implemented on a medical ward by a multidisciplinary approach.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Continuous Positive Airway Pressure ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
Keywords	covid19
Language	Danish
Publishing date	2020-08-14
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article: Automatic oxygen titration with O2matic® to patients admitted with COVID-19 and hypoxemic respiratory failure.

Hansen, Ejvind Frausing / Bech, Charlotte Sandau / Vestbo, Jørgen / Andersen, Ove / Kofod, Linette Marie

European clinical respiratory journal

2020 Volume 7, Issue 1, Page(s) 1833695

Abstract: Introduction: Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO: ... ...

Abstract	Introduction: Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO Methods: Patients were prospectively enrolled in an observational study on a medical ward dedicated to patients with COVID-19. Closed-loop controlled oxygen was delivered by O2matic® which can deliver 0-15 liters/min and adjusts flow every second based on 15 seconds averaging of SpO Results: Fifteen patients (six women, nine men) participated in the study. Average age was 72 years. Lung function was severely impaired with FEV Conclusion: Closed-loop control of oxygen to patients with COVID-19 is feasible and can maintain SpO
Keywords	covid19
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2834928-3
ISSN	2001-8525
ISSN	2001-8525
DOI	10.1080/20018525.2020.1833695
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Article ; Online: Automated Oxygen Administration Alleviates Dyspnea in Patients Admitted with Acute Exacerbation of COPD: A Randomized Controlled Trial.

Sandau, Charlotte / Hansen, Ejvind Frausing / Ringbæk, Thomas Jørgen / Kallemose, Thomas / Bove, Dorthe Gaby / Poulsen, Ingrid / Nørholm, Vibeke / Pedersen, Lars / Jensen, Jens Ulrik Stæhr / Ulrik, Charlotte Suppli

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 599–614

Abstract: Objective: Devices for Automated Oxygen Administration (AOA) have been developed to optimize the therapeutic benefit of oxygen supplementation. We aimed to investigate the effect of AOA on multidimensional aspects of dyspnea and as-needed consumption of ...

Abstract	Objective: Devices for Automated Oxygen Administration (AOA) have been developed to optimize the therapeutic benefit of oxygen supplementation. We aimed to investigate the effect of AOA on multidimensional aspects of dyspnea and as-needed consumption of opioids and benzodiazepines, as opposed to conventional oxygen therapy, in hospitalized patients with Acute Exacerbation of COPD (AECOPD). Method and patients: A multicenter randomized controlled trial across five respiratory wards in the Capital Region of Denmark. Patients admitted with AECOPD (n=157) were allocated 1:1 to either AOA (O2matic Ltd), a closed loop device automatically delivering oxygen according to the patient's peripheral oxygen saturation (SpO Results: Of the 157 randomized patients, 127 had complete data for the intervention. The AOA reduced patients' perception of overall unpleasantness significantly on the Multidimensional Dyspnea Profile (MDP) with a difference in medians of -3 ( Conclusion: AOA reduces both breathing discomfort and physical perception of dyspnea in patients admitted with AECOPD but did not seem to impact the emotional status or other COPD symptoms.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Oxygen Inhalation Therapy ; Dyspnea/therapy ; Hospitalization ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-04-18
Publishing country	New Zealand
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S397782
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Article ; Online: Antibiotic treatment in acute exacerbation of COPD: patient outcomes with amoxicillin vs. amoxicillin/clavulanic acid-data from 43,636 outpatients.

Bagge, Kristian / Sivapalan, Pradeesh / Eklöf, Josefin / Hertz, Frederik Böetius / Andersen, Christian Østergaard / Hansen, Ejvind Frausing / Jarløv, Jens Otto / Jensen, Jens-Ulrik Stæhr

Respiratory research

2021 Volume 22, Issue 1, Page(s) 11

Abstract: Background: For antibiotic treatment of Acute exacerbations of COPD (AECOPD) the National guidelines in Denmark recommend either first choice amoxicillin 750 mg TID (AMX) or amoxicillin with clavulanic acid 500 mg/125 mg TID (AMC). Addition of ... ...

Abstract	Background: For antibiotic treatment of Acute exacerbations of COPD (AECOPD) the National guidelines in Denmark recommend either first choice amoxicillin 750 mg TID (AMX) or amoxicillin with clavulanic acid 500 mg/125 mg TID (AMC). Addition of clavulanic acid offers a broader spectrum; opposite, AMX alone in a higher dose may offer more time above MIC. The aim of this study was to determine which of these regimens is associated with better outcome. Methods: The Danish Registry of COPD (DrCOPD), a nationwide outpatient COPD registry, was crosslinked with medication data and hospital contacts. The first prescription of AMX or AMC after inclusion in DrCOPD was used as exposure variable. Adjusted Cox proportional hazards models were used to analyze the risk of hospitalization or death (combined) within 30 days and other endpoints. Results: For the first treatment of AECOPD 12,915 received AMX, and 30,721 patients received AMC. AMX was associated with a decreased risk of pneumonia hospitalization or death (aHR 0.6, 95% CI 0.5-0.7; p < 0.0001) compared to AMC. Conclusion: In AECOPD, empirically adding clavulanic acid to amoxicillin is not associated with a better outcome; it seems safe for these patients to be treated with amoxicillin alone.
MeSH term(s)	Aged ; Aged, 80 and over ; Ambulatory Care/methods ; Ambulatory Care/statistics & numerical data ; Amoxicillin/administration & dosage ; Amoxicillin-Potassium Clavulanate Combination/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Cohort Studies ; Data Analysis ; Denmark/epidemiology ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2021-01-07
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-020-01606-7
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