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  1. Article ; Online: Maternal dietary fat intake during pregnancy and newborn body composition.

    Damen, Natalie A / Gillingham, Melanie / Hansen, Joyanna G / Thornburg, Kent L / Purnell, Jonathan Q / Marshall, Nicole E

    Journal of perinatology : official journal of the California Perinatal Association

    2021  Volume 41, Issue 5, Page(s) 1007–1013

    Abstract: Objective: Increased infant birth weight and adiposity are associated with an altered risk of adult chronic diseases. The objective was to investigate the association between maternal dietary fat intake during pregnancy and newborn adiposity.: Study ... ...

    Abstract Objective: Increased infant birth weight and adiposity are associated with an altered risk of adult chronic diseases. The objective was to investigate the association between maternal dietary fat intake during pregnancy and newborn adiposity.
    Study design: The study included 79 singleton pregnancies. Associations between maternal dietary fat intake during each trimester and infant adiposity at birth were assessed.
    Result: Average total grams of maternal total dietary fat and unsaturated fat intake during pregnancy correlated with infant percent body fat after adjusting for potential confounding variables (r = 0.23, p = 0.045; r = 0.24, p = 0.037). Maternal average daily intake of total fat, saturated fat, and unsaturated fat during the second trimester of pregnancy were each associated with infant percent body fat (r = 0.25, p = 0.029; r = 0.23, p = 0.046; r = 0.25, p = 0.031; respectively).
    Conclusions: The second trimester of pregnancy is a key time period for fetal adipose tissue metabolic programming and therefore a target for nutritional intervention.
    MeSH term(s) Adiposity ; Adult ; Birth Weight ; Body Composition ; Body Mass Index ; Dietary Fats ; Female ; Fetal Development ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Pregnancy Trimesters
    Chemical Substances Dietary Fats
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-021-00922-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2412: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Differential expression of vitamin E and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease.

    Agler, Anne H / Crystal, Ronald G / Mezey, Jason G / Fuller, Jennifer / Gao, Chuan / Hansen, Joyanna G / Cassano, Patricia A

    COPD

    2013  Volume 10, Issue 4, Page(s) 450–458

    Abstract: Antioxidant nutritional status is hypothesized to influence chronic obstructive pulmonary disease (COPD) susceptibility and progression. Although past studies relate antioxidants to gene expression, there are no data in patients with COPD. This study ... ...

    Abstract Antioxidant nutritional status is hypothesized to influence chronic obstructive pulmonary disease (COPD) susceptibility and progression. Although past studies relate antioxidants to gene expression, there are no data in patients with COPD. This study investigated the hypothesis that antioxidant status is compromised in patients with COPD, and antioxidant-responsive genes differentially express in a similar pattern. Lung tissue samples from patients with COPD were assayed for vitamin E and gene expression. Selenium and vitamin E were assayed in corresponding plasma samples. Discovery based genome-wide expression analysis compared moderate, severe, and very severe COPD (GOLD II-IV) patients to mild and at-risk/normal (GOLD 0-I). Hypotheses-driven analyses assessed differential gene expression by disease severity for vitamin E-responsive and selenium-responsive genes. GOLD II-IV COPD patients had 30% lower lung tissue vitamin E levels compared to GOLD 0-I participants (p = 0.0082). No statistically significant genome-wide differences in expression by disease severity were identified. Hypothesis-driven analyses of 109 genes found 16 genes differentially expressed (padjusted < 0.05) by disease severity including 6 selenium-responsive genes (range in fold-change -1.39 to 2.25), 6 vitamin E-responsive genes (fold-change -2.30 to 1.51), and 4 COPD-associated genes. Lung tissue vitamin E in patients with COPD was associated with disease severity and vitamin E-responsive genes were differentially expressed by disease severity. Although nutritional status is hypothesized to contribute to COPD risk, and is of therapeutic interest, evidence to date is mainly observational. The findings reported herein are novel, and support a role of vitamin E in COPD progression.
    MeSH term(s) Aged ; Aged, 80 and over ; Antioxidants/analysis ; Antioxidants/metabolism ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Lung/chemistry ; Male ; Middle Aged ; Nutritional Status ; Oligonucleotide Array Sequence Analysis ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/physiopathology ; RNA/analysis ; Selenium/blood ; Severity of Illness Index ; alpha-Tocopherol/analysis ; alpha-Tocopherol/blood
    Chemical Substances Antioxidants ; RNA (63231-63-0) ; alpha-Tocopherol (H4N855PNZ1) ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2013-07-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.3109/15412555.2012.761958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5990: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans.

    Hansen, Joyanna G / Tang, Wenbo / Hootman, Katie C / Brannon, Patsy M / Houston, Denise K / Kritchevsky, Stephen B / Harris, Tamara B / Garcia, Melissa / Lohman, Kurt / Liu, Yongmei / de Boer, Ian H / Kestenbaum, Bryan R / Robinson-Cohen, Cassianne / Siscovick, David S / Cassano, Patricia A

    The Journal of nutrition

    2015  Volume 145, Issue 4, Page(s) 799–805

    Abstract: Background: Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations.: Objective: We investigated whether certain environmental and genetic ... ...

    Abstract Background: Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations.
    Objective: We investigated whether certain environmental and genetic factors are predictors of circulating 25(OH)D in 989 elderly African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study.
    Methods: Regression analysis estimated the cross-sectional association of nongenetic (environmental) factors with 25(OH)D. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D in Caucasian genome-wide association studies (GWASs) were analyzed for association with serum 25(OH)D, including analyses of all imputed SNPs in identified genomic regions. Genome-wide complex trait analysis (GCTA) evaluated the association of all (genome-wide) genotyped SNPs with serum 25(OH)D in the Health ABC Study with replication in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
    Results: Gender, study site, season of blood draw, body mass index, dietary supplement use, dairy and cereal consumption, Healthy Eating Index score, and walking >180 min/wk were associated with 25(OH)D (P < 0.05), jointly explaining 25% of the variation in circulating 25(OH)D. Multivitamin supplement use was the strongest predictor of circulating 25(OH)D, and supplement users had a 6.3-μg/L higher serum 25(OH)D concentration compared with nonusers. Previous GWAS-identified gene regions were not replicated in African Americans, but the nonsynonymous rs7041 SNP in group-specific component (vitamin D binding protein) was close to significance thresholds (P = 0.08), and there was evidence for an interaction between this SNP and use of multivitamin supplements in relation to serum 25(OH)D concentration (P = 0.04). Twenty-three percent (95% CI: 0%, 52%) of the variation in serum 25(OH)D was explained by total genetic variation in a pooled GCTA of 2087 Health ABC Study and MESA African-American participants, but population substructure effects could not be separated from other genetic influences.
    Conclusions: Modifiable dietary and lifestyle predictors of serum 25(OH)D were identified in African Americans. GCTA confirms that a proportion of 25(OH)D variability is attributable to genetic variation, but genomic regions associated with the 25(OH)D phenotype identified in prior GWASs of European Americans were not replicated in the Health ABC Study in African Americans.
    MeSH term(s) Black or African American/genetics ; Aged ; Body Mass Index ; Cross-Sectional Studies ; Dietary Supplements ; Female ; Genome-Wide Association Study ; Genotype ; Humans ; Linear Models ; Male ; Phenotype ; Polymorphism, Single Nucleotide ; Seasons ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/genetics ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism ; White People/genetics
    Chemical Substances Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2015-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.3945/jn.114.202093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.

    Reardon, Brian J / Hansen, Joyanna G / Crystal, Ronald G / Houston, Denise K / Kritchevsky, Stephen B / Harris, Tamara / Lohman, Kurt / Liu, Yongmei / O'Connor, George T / Wilk, Jemma B / Mezey, Jason / Gao, Chuan / Cassano, Patricia A

    BMC medical genetics

    2013  Volume 14, Page(s) 122

    Abstract: Background: Vitamin D is associated with lung health in epidemiologic studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression ... ...

    Abstract Background: Vitamin D is associated with lung health in epidemiologic studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants.
    Methods: Microarray analysis investigated the association of gene expression in small airway epithelial cells with serum 25(OH)D in adult non-smokers. Sequence variants in candidate genes identified by the microarray were investigated in a lung tissue eQTL database, and also in relation to cross-sectional pulmonary function in the Health, Aging, and Body Composition (Health ABC) study, stratified by race, with replication in the Framingham Heart Study (FHS).
    Results: 13 candidate genes had significant differences in expression by serum 25(OH)D (nominal p < 0.05), and a genome-wide significant eQTL association was detected for SGPP2. In Health ABC, SGPP2 SNPs were associated with FEV1 in both European- and African-Americans, and the gene-level association was replicated in European-American FHS participants. SNPs in 5 additional candidate genes (DAPK1, FSTL1, KAL1, KCNS3, and RSAD2) were associated with FEV1 in Health ABC participants.
    Conclusions: SGPP2, a sphingosine-1-phosphate phosphatase, is a novel vitamin D-responsive gene associated with lung function. The identified associations will need to be followed up in further studies.
    MeSH term(s) African Americans/genetics ; Aged ; Aging ; Body Composition ; Cohort Studies ; Epithelial Cells/metabolism ; European Continental Ancestry Group/genetics ; Female ; Forced Expiratory Volume/physiology ; Humans ; Lung/metabolism ; Male ; Membrane Proteins/genetics ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Phosphoric Monoester Hydrolases/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Respiratory Function Tests ; Vitamin D/blood
    Chemical Substances Membrane Proteins ; Vitamin D (1406-16-2) ; SGPP2 protein, human (EC 3.1.3.-) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2013-11-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ISSN 1471-2350
    ISSN (online) 1471-2350
    DOI 10.1186/1471-2350-14-122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

    Tang, Wenbo / Kowgier, Matthew / Loth, Daan W / Soler Artigas, María / Joubert, Bonnie R / Hodge, Emily / Gharib, Sina A / Smith, Albert V / Ruczinski, Ingo / Gudnason, Vilmundur / Mathias, Rasika A / Harris, Tamara B / Hansel, Nadia N / Launer, Lenore J / Barnes, Kathleen C / Hansen, Joyanna G / Albrecht, Eva / Aldrich, Melinda C / Allerhand, Michael /
    Barr, R Graham / Brusselle, Guy G / Couper, David J / Curjuric, Ivan / Davies, Gail / Deary, Ian J / Dupuis, Josée / Fall, Tove / Foy, Millennia / Franceschini, Nora / Gao, Wei / Gläser, Sven / Gu, Xiangjun / Hancock, Dana B / Heinrich, Joachim / Hofman, Albert / Imboden, Medea / Ingelsson, Erik / James, Alan / Karrasch, Stefan / Koch, Beate / Kritchevsky, Stephen B / Kumar, Ashish / Lahousse, Lies / Li, Guo / Lind, Lars / Lindgren, Cecilia / Liu, Yongmei / Lohman, Kurt / Lumley, Thomas / McArdle, Wendy L / Meibohm, Bernd / Morris, Andrew P / Morrison, Alanna C / Musk, Bill / North, Kari E / Palmer, Lyle J / Probst-Hensch, Nicole M / Psaty, Bruce M / Rivadeneira, Fernando / Rotter, Jerome I / Schulz, Holger / Smith, Lewis J / Sood, Akshay / Starr, John M / Strachan, David P / Teumer, Alexander / Uitterlinden, André G / Völzke, Henry / Voorman, Arend / Wain, Louise V / Wells, Martin T / Wilk, Jemma B / Williams, O Dale / Heckbert, Susan R / Stricker, Bruno H / London, Stephanie J / Fornage, Myriam / Tobin, Martin D / O'Connor, George T / Hall, Ian P / Cassano, Patricia A

    PloS one

    2014  Volume 9, Issue 7, Page(s) e100776

    Abstract: Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.: Methods: We performed GWAS of the rate of ... ...

    Abstract Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
    Methods: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.
    Results: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.
    Conclusions: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.
    MeSH term(s) Adult ; Chromosomes, Human, Pair 11/genetics ; Female ; Gene Expression Regulation ; Genetic Loci ; Genome-Wide Association Study ; Humans ; Longitudinal Studies ; Male ; Respiration/genetics
    Language English
    Publishing date 2014-07-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0100776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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