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  1. Article: No Added Neuroprotective Effect of Remote Ischemic Postconditioning and Therapeutic Hypothermia After Mild Hypoxia-Ischemia in a Piglet Model.

    Andelius, Ted C K / Pedersen, Mette V / Andersen, Hannah B / Andersen, Mads / Hjortdal, Vibeke E / Pedersen, Michael / Ringgaard, Steffen / Hansen, Lærke H / Henriksen, Tine B / Kyng, Kasper J

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 299

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2020-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impaired dynamic cerebral autoregulation at extreme high altitude even after acclimatization.

    Iwasaki, Ken-ichi / Zhang, Rong / Zuckerman, Julie H / Ogawa, Yojiro / Hansen, Lærke H / Levine, Benjamin David

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2010  Volume 31, Issue 1, Page(s) 283–292

    Abstract: Cerebral blood flow (CBF) increases and dynamic cerebral autoregulation is impaired by acute hypoxia. We hypothesized that progressive hypocapnia with restoration of arterial oxygen content after altitude acclimatization would normalize CBF and dynamic ... ...

    Abstract Cerebral blood flow (CBF) increases and dynamic cerebral autoregulation is impaired by acute hypoxia. We hypothesized that progressive hypocapnia with restoration of arterial oxygen content after altitude acclimatization would normalize CBF and dynamic cerebral autoregulation. To test this hypothesis, dynamic cerebral autoregulation was examined by spectral and transfer function analyses between arterial pressure and CBF velocity variabilities in 11 healthy members of the Danish High-Altitude Research Expedition during normoxia and acute hypoxia (10.5% O(2)) at sea level, and after acclimatization (for over 1 month at 5,260 m at Chacaltaya, Bolivia). Arterial pressure and CBF velocity in the middle cerebral artery (transcranial Doppler), were recorded on a beat-by-beat basis. Steady-state CBF velocity increased during acute hypoxia, but normalized after acclimatization with partial restoration of SaO(2) (acute, 78% ± 2%; chronic, 89% ± 1%) and progression of hypocapnia (end-tidal carbon dioxide: acute, 34 ± 2 mm Hg; chronic, 21 ± 1 mm Hg). Coherence (0.40 ± 0.05 Units at normoxia) and transfer function gain (0.77 ± 0.13 cm/s per mm Hg at normoxia) increased, and phase (0.86 ± 0.15 radians at normoxia) decreased significantly in the very-low-frequency range during acute hypoxia (gain, 141% ± 24%; coherence, 136% ± 29%; phase, -25% ± 22%), which persisted after acclimatization (gain, 136% ± 36%; coherence, 131% ± 50%; phase, -42% ± 13%), together indicating impaired dynamic cerebral autoregulation in this frequency range. The similarity between both acute and chronic conditions suggests that dynamic cerebral autoregulation is impaired by hypoxia even after successful acclimatization to an extreme high altitude.
    MeSH term(s) Acclimatization/physiology ; Acute Disease ; Adult ; Algorithms ; Altitude ; Altitude Sickness/physiopathology ; Blood Flow Velocity/physiology ; Blood Pressure/physiology ; Carbon Dioxide/blood ; Cerebrovascular Circulation/physiology ; Chronic Disease ; Female ; Homeostasis/physiology ; Humans ; Hypoxia/physiopathology ; Male ; Respiratory Mechanics/physiology ; Young Adult
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2010-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1038/jcbfm.2010.88
    Database MEDical Literature Analysis and Retrieval System OnLINE

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