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Book ; Online ; E-Book: A transdiagnostic approach to develop organization, attention and learning skills

Hansen, Laura K.

the GOALS treatment manual for college students

2023

Author's details	Laura K. Hansen
Keywords	Executive functions (Neuropsychology) ; Study skills
Subject code	616.8900835
Language	English
Size	1 online resource (151 pages)
Publisher	Routledge
Publishing place	London, England ; New York, New York
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-00-319961-5 ; 1-003-19961-5 ; 1-000-62731-4 ; 1-03-205877-3 ; 978-1-00-319961-8 ; 978-1-003-19961-8 ; 978-1-000-62731-2 ; 978-1-03-205877-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Thesis: Einfluss von verschiedenen Kontrollstrategien auf die oberflächenelektromyographische Aktivitätscharakteristik der Rumpfmuskulatur

Hansen, Laura

2018

Author's details	vorgelegt von Laura Hansen
Language	German ; English
Size	I, 72 Seiten, Illustrationen, Diagramme, 30 cm
Publishing place	Jena
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Friedrich-Schiller-Universität Jena, 2018
HBZ-ID	HT019725199
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Optimization of Oxygen Delivery Within Hydrogels.

Mavris, Sophia M / Hansen, Laura M

Journal of biomechanical engineering

2021 Volume 143, Issue 10

Abstract: The field of tissue engineering has been continuously evolving since its inception over three decades ago with numerous new advancements in biomaterials and cell sources and widening applications to most tissues in the body. Despite the substantial ... ...

Abstract	The field of tissue engineering has been continuously evolving since its inception over three decades ago with numerous new advancements in biomaterials and cell sources and widening applications to most tissues in the body. Despite the substantial promise and great opportunities for the advancement of current medical therapies and procedures, the field has yet to capture wide clinical translation due to some remaining challenges, including oxygen availability within constructs, both in vitro and in vivo. While this insufficiency of nutrients, specifically oxygen, is a limitation within the current frameworks of this field, the literature shows promise in new technological advances to efficiently provide adequate delivery of nutrients to cells. This review attempts to capture the most recent advances in the field of oxygen transport in hydrogel-based tissue engineering, including a comparison of current research as it pertains to the modeling, sensing, and optimization of oxygen within hydrogel constructs as well as new technological innovations to overcome traditional diffusion-based limitations. The application of these findings can further the advancement and development of better hydrogel-based tissue engineered constructs for future clinical translation and adoption.
MeSH term(s)	Hydrogels
Chemical Substances	Hydrogels
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	243094-0
ISSN	1528-8951 ; 0148-0731
ISSN (online)	1528-8951
ISSN	0148-0731
DOI	10.1115/1.4051119
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Article ; Online: Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma.

Kamayirese, Seraphine / Maity, Sibaprasad / Dieckman, Lynne M / Hansen, Laura A / Lovas, Sándor

ACS omega

2024 Volume 9, Issue 2, Page(s) 2719–2729

Abstract: 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion, or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is overexpressed and mislocalized from the nucleus to the ... ...

Abstract	14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion, or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is overexpressed and mislocalized from the nucleus to the cytoplasm where it interacts with the cell division cycle 25 A (CDC25A) and suppresses apoptosis. Hence, inhibition of the 14-3-3ε-CDC25A interaction is an attractive target for promoting apoptosis in cSCC. In this work, we optimized the structure of our previously designed inhibitor of the 14-3-3ε-CDC25A interaction, pT, a phosphopeptide fragment corresponding to one of the two binding regions of CDC25A to 14-3-3ε. Starting from pT, we developed peptide analogs that bind 14-3-3ε with nanomolar affinities. Peptide analogs were designed by shortening the pT peptide and introducing modifications at position 510 of the pT(502-510) analog. Both molecular dynamics (MD) simulations and biophysical methods were used to determine peptide binding to 14-3-3ε. Shortening the pT peptide from 14 to 9 amino acid residues resulted in a peptide (pT(502-510)) that binds 14-3-3ε with a
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c07740
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Article: Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma.

Kamayirese, Seraphine / Maity, Sibaprasad / Dieckman, Lynne M / Hansen, Laura A / Lovas, Sándor

bioRxiv : the preprint server for biology

2023

Abstract: 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is over expressed and mislocalized from the nucleus to the ... ...

Abstract	14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is over expressed and mislocalized from the nucleus to the cytoplasm where it interacts with the cell division cycle 25 A (CDC25A) and suppresses apoptosis. Hence inhibition of the 14-3-3ε - CDC25A interaction is an attractive target for promoting apoptosis in cSCC. In this work, we optimized the structure of our previously designed inhibitor of 14-3-3ε - CDC25A interaction, pT, a phosphopeptide fragment corresponding to one of the two binding regions of CDC25A to 14-3-3ε. Starting from pT, we developed peptide analogs that bind 14-3-3ε with nanomolar affinities. Peptide analogs were designed by shortening the pT peptide, and introducing modifications at position 510 of the pT(502-510) analog. Both molecular dynamics (MD) simulations and biophysical methods were used to determine peptides binding to 14-3-3ε. Shortening the pT peptide from 14 to 9 amino acid residues resulted in a peptide (pT(502-510)) that binds 14-3-3ε with a K
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.03.560749
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Article ; Online: PKCμ promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication.

Pun, Renju / Cavanaugh, Ann M / Aldrich, Emily / Tran, Olivia / Rudd, Justin C / Hansen, Laura A / North, Brian J

iScience

2024 Volume 27, Issue 3, Page(s) 109033

Abstract: Downregulation of intercellular communication through suppression of gap junctional conductance is necessary during wound healing. Connexin 43 (Cx43), a prominent gap junction protein in skin, is downregulated following wounding to restrict communication ...

Abstract	Downregulation of intercellular communication through suppression of gap junctional conductance is necessary during wound healing. Connexin 43 (Cx43), a prominent gap junction protein in skin, is downregulated following wounding to restrict communication between keratinocytes. Previous studies found that PKCμ, a novel PKC isozyme, regulates efficient cutaneous wound healing. However, the molecular mechanism by which PKCμ regulates wound healing remains unknown. We have identified that PKCμ suppresses intercellular communication and enhances cell migration in an
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109033
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Article ; Online: Indocyanine green angiography in oncoplastic breast surgery, a prospective study.

Lauritzen, Elisabeth / Bredgaard, Rikke / Laustsen-Kiel, Cecilie Mullerup / Hansen, Laura / Tvedskov, Tove / Damsgaard, Tine Engberg

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 85, Page(s) 276–286

Abstract: Introduction: The use of Indocyanine green angiography (ICG-A) in oncoplastic breast-conserving surgery (OBCS) has not yet been investigated. This prospective trial applied ICG-A in volume displacement and replacement OBCS to localize perforators and ... ...

Abstract	Introduction: The use of Indocyanine green angiography (ICG-A) in oncoplastic breast-conserving surgery (OBCS) has not yet been investigated. This prospective trial applied ICG-A in volume displacement and replacement OBCS to localize perforators and determine tissue supplied by the perforator. Furthermore, to investigate and correlate the intraoperative ICG-A to postoperative surgical site infection, skin necrosis, epidermolysis, and timely onset of adjuvant therapy. Methods: ICG-A was performed at three pre-set timepoints during surgery; after lumpectomy, upon dissection of possible perforators, and after wound closure. All patients were followed with clinical evaluations before surgery, 4 weeks, 4-6 months, and 12 months postoperatively. Results: Eleven patients were included: seven volume displacement and four volume replacement OBCS. ICG-A located the tissue supplied by the perforator and demonstrated sufficient perfusion in all cases. The ICG-A corresponded to the surgeons' clinical assessment. One patient developed a postoperative infection and seroma and was treated conservatively. No patients had postoperative necrosis, loss of reconstruction, or lymphedema of the arm. Edema of the breast occurred in four patients (36.4%). Scar assessments were significantly worse at 4-weeks and 4-6 months. The quality of life improved significantly during follow-up. Adjuvant treatment was administered timely in all cases. Conclusion: ICG-A was feasible for OBCS in assessing intraoperative perfusion. Perfusion was sufficient in all patients and corresponded to the surgeon's clinical evaluation. No patients developed postoperative necrosis. Though edema of the breast occurred in 36.4%, a larger sample size is needed to investigate a possible correlation with ICG-A. Further studies, which includes patients requiring extensive tissue replacement challenging the borders of perfusion, are needed.
MeSH term(s)	Humans ; Female ; Prospective Studies ; Indocyanine Green ; Quality of Life ; Angiography ; Necrosis ; Breast Neoplasms/surgery ; Fluorescein Angiography
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-07-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.07.022
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Article ; Online: Surgical Rehabilitation for Research Residents: A Pilot Program to Offset Surgical Skill Decay.

Nofi, Colleen P / Roberts, Bailey K / Hansen, Laura / Coppa, Gene F / Patel, Vihas

Journal of surgical education

2023 Volume 80, Issue 10, Page(s) 1385–1394

Abstract: Objective: Select general surgery residents in the surgeon-scientist pipeline dedicate time away from clinical residency to conduct research. However, these research residents (RR) are vulnerable to operative skill decay. The aim of this study is to ... ...

Abstract	Objective: Select general surgery residents in the surgeon-scientist pipeline dedicate time away from clinical residency to conduct research. However, these research residents (RR) are vulnerable to operative skill decay. The aim of this study is to assess the feasibility of implementation and impact of an organized intervention designed to combat skill decay experienced by RR. Design: RR were enrolled in a pilot Surgical Rehabilitation Program (SRP). The SRP is comprised of 12 cadaver-based simulation sessions and supplemented with Fundamentals of Laparoscopic Surgery-based simulation workouts. The RR were integrated with the clinical residents (CR) during the cadaver sessions and were subsequently performance tested, surveyed, and interviewed. Setting: One academic general surgery residency program graduating 8 chief residents yearly in New York. Participants: General surgery CR and residents on dedicated research years. Results: Data were collected for all local RR (n = 8) and 77% (n = 37) of CR. Local RR conducted research within the same health system that sponsors the residency. RR experienced gaps in training ranging from 2 to 4 years. All RR were permitted to moonlight on surgical services, however performed 0 operations and only 0.88 procedures on average per shift. Although RR performed similarly to level-matched CR on basic laparoscopic tasks, they required significantly more time on laparoscopic suturing-based skills than CR (p < 0.001). RR had significantly lower confidence levels precadaver sessions but gained confidence postcadaver sessions (p < 0.05), whereas CR confidence was unchanged. Regarding the SRP, qualitative interviews revealed major themes emphasizing the integration of RR, exposure to CR and faculty, technical skill development, maintenance of surgical know-how, and improved confidence for RR. Conclusions: The implementation of such structured interventions, like our SRP, aimed at supporting RR over gap years is essential to help residents maintain skills and confidence needed to achieve their goals of becoming surgeon scientists.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2023.07.016
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Article ; Online: The effect of early follow-up after open cardiac surgery in a student clinic.

Ilkjær, Christine / Hoffmann, Torben / Heiberg, Johan / Hansen, Laura Sommer / Hjortdal, Vibeke E

Scandinavian cardiovascular journal : SCJ

2023 Volume 57, Issue 1, Page(s) 2184861

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Humans ; Risk Factors ; Follow-Up Studies ; Quality of Life ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Postoperative Complications/diagnosis ; Cardiac Surgical Procedures/adverse effects ; Students ; Patient Readmission
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1379906-x
ISSN	1651-2006 ; 1401-7431
ISSN (online)	1651-2006
ISSN	1401-7431
DOI	10.1080/14017431.2023.2184861
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Article ; Online: Social Media, Misinformation, and Online Patient Education in Emergency General Surgical Procedures.

Roberts, Bailey / Kobritz, Molly / Nofi, Colleen / Demyan, Lyudmyla / Guevara, Jonathan / Hansen, Laura / Giangola, Matthew

The Journal of surgical research

2023 Volume 287, Page(s) 16–23

Abstract: Introduction: Patients use the internet to learn about diagnoses and treatment options. These sources vary in quality and accuracy of medical information. Thus, utilization of social media may lead to misinformation regarding treatment for patients in ... ...

Abstract	Introduction: Patients use the internet to learn about diagnoses and treatment options. These sources vary in quality and accuracy of medical information. Thus, utilization of social media may lead to misinformation regarding treatment for patients in need of emergent general surgery procedures. Methods: YouTube was searched with keywords "cholecystectomy," "cholecystitis," and "gallbladder surgery" and "appendectomy," "appendicitis," and "appendix surgery." For each procedure, the 100 videos with the greatest views were reviewed. Videos were assessed by four surgical trainees using validated instruments, DISCERN and the Patient Education Materials Assessment Tool (PEMAT), and Likert scales for patient education and misinformation. After appendectomy or cholecystectomy, patients completed a survey assessing use of social media preoperatively. Results: The median DISCERN score was 28.0 of 75. The median PEMAT scores were 66.7% for understandability and 0% for actionability. Nearly half (49%) of videos provided no patient education and only 22% provided moderate or more. More than a third (35%) of videos contained misinformation. Doctors, medical education, and healthcare systems published videos with less misinformation, whereas patients, health/wellness groups published more misinformation (P < 0.001). Videos discoverable with colloquial terms "appendix surgery" and "gallbladder surgery" were more likely to contain misinformation (45.3%) compared to 20.5% of videos with misinformation discoverable using medical search terms only (P < 0.001). Conclusions: There is a range of video quality online with most videos of poor quality and provide little patient education. Understanding information available to patients online can tailor surgeon-patient discussions to combat misinformation and improve the informed consent process for patients.
MeSH term(s)	Humans ; Social Media ; Patient Education as Topic ; Communication ; Biliary Tract Surgical Procedures ; Appendectomy ; Video Recording/methods ; Information Dissemination/methods
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.01.009
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