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  1. Article ; Online: Written benefit finding for improving psychological health during the Covid-19 pandemic first wave lockdown.

    Hansen, Sarah R / Wetherell, Mark A / Smith, Michael A

    Psychology & health

    2021  Volume 37, Issue 10, Page(s) 1223–1240

    Abstract: Objectives. ...

    Abstract Objectives.
    MeSH term(s) Humans ; Pandemics/prevention & control ; Depression/epidemiology ; Depression/psychology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Communicable Disease Control ; Writing
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 625255-2
    ISSN 1476-8321 ; 0887-0446
    ISSN (online) 1476-8321
    ISSN 0887-0446
    DOI 10.1080/08870446.2021.1936521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins.

    Hansen, Sarah R / Aderounmu, Adedeji M / Donelick, Helen M / Bass, Brenda L

    Cold Spring Harbor symposia on quantitative biology

    2020  Volume 84, Page(s) 185–193

    Abstract: The function of Dicer's helicase domain has been enigmatic since its discovery. Why do only some Dicers require ATP, despite a high degree of sequence conservation in their helicase domains? We discuss evolutionary considerations based on differences ... ...

    Abstract The function of Dicer's helicase domain has been enigmatic since its discovery. Why do only some Dicers require ATP, despite a high degree of sequence conservation in their helicase domains? We discuss evolutionary considerations based on differences between vertebrate and invertebrate antiviral defense, and how the helicase domain has been co-opted in extant organisms as the binding site for accessory proteins. Many accessory proteins are double-stranded RNA binding proteins, and we propose models for how they modulate Dicer function and catalysis.
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 1943-4456 ; 0091-7451
    ISSN (online) 1943-4456
    ISSN 0091-7451
    DOI 10.1101/sqb.2019.84.039750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multi-step recognition of potential 5' splice sites by the

    Hansen, Sarah R / White, David S / Scalf, Mark / Corrêa, Ivan R / Smith, Lloyd M / Hoskins, Aaron A

    eLife

    2022  Volume 11

    Abstract: In eukaryotes, splice sites define the introns of pre-mRNAs and must be recognized and excised with nucleotide precision by the spliceosome to make the correct mRNA product. In one of the earliest steps of spliceosome assembly, the U1 small nuclear ... ...

    Abstract In eukaryotes, splice sites define the introns of pre-mRNAs and must be recognized and excised with nucleotide precision by the spliceosome to make the correct mRNA product. In one of the earliest steps of spliceosome assembly, the U1 small nuclear ribonucleoprotein (snRNP) recognizes the 5' splice site (5' SS) through a combination of base pairing, protein-RNA contacts, and interactions with other splicing factors. Previous studies investigating the mechanisms of 5' SS recognition have largely been done in vivo or in cellular extracts where the U1/5' SS interaction is difficult to deconvolute from the effects of
    MeSH term(s) RNA Precursors/metabolism ; RNA Splice Sites ; RNA Splicing ; Ribonucleoprotein, U1 Small Nuclear/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Spliceosomes/metabolism
    Chemical Substances RNA Precursors ; RNA Splice Sites ; Ribonucleoprotein, U1 Small Nuclear
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.70534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chemical Inhibition of Pre-mRNA Splicing in Living Saccharomyces cerevisiae.

    Hansen, Sarah R / Nikolai, Brandon J / Spreacker, Peyton J / Carrocci, Tucker J / Hoskins, Aaron A

    Cell chemical biology

    2019  Volume 26, Issue 3, Page(s) 443–448.e3

    Abstract: The spliceosome mediates precursor mRNA splicing in eukaryotes, including the model organism Saccharomyces cerevisiae (yeast). Despite decades of study, no chemical inhibitors of yeast splicing in vivo are available. We have developed a system to ... ...

    Abstract The spliceosome mediates precursor mRNA splicing in eukaryotes, including the model organism Saccharomyces cerevisiae (yeast). Despite decades of study, no chemical inhibitors of yeast splicing in vivo are available. We have developed a system to efficiently inhibit splicing and block proliferation in living yeast cells using compounds that target the human spliceosome protein SF3B1. Potent inhibition is observed in yeast expressing a chimeric protein containing portions of human SF3B1. However, only a single point mutation in the yeast homolog of SF3B1 is needed for selective inhibition of splicing by pladienolide B, herboxidiene, or meayamycin in liquid culture. Mutations that enable inhibition also improve splicing of branch sites containing mismatches between the intron and small nuclear RNA-suggesting a link between inhibitor sensitivity and usage of weak branch sites in humans. This approach provides powerful new tools for manipulating splicing in live yeast and studies of spliceosome inhibitors.
    MeSH term(s) Amino Acid Sequence ; Epoxy Compounds/chemistry ; Epoxy Compounds/pharmacology ; Fatty Alcohols/chemistry ; Fatty Alcohols/pharmacology ; Humans ; Macrolides/chemistry ; Macrolides/pharmacology ; Mutagenesis ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism ; Pyrans/chemistry ; Pyrans/pharmacology ; RNA Precursors/antagonists & inhibitors ; RNA Precursors/metabolism ; RNA Splicing/drug effects ; RNA Splicing Factors/chemistry ; RNA Splicing Factors/metabolism ; Ribonucleoprotein, U2 Small Nuclear/genetics ; Ribonucleoprotein, U2 Small Nuclear/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology
    Chemical Substances Epoxy Compounds ; Fatty Alcohols ; HSH155 protein, S cerevisiae ; Macrolides ; Phosphoproteins ; Pyrans ; RNA Precursors ; RNA Splicing Factors ; Ribonucleoprotein, U2 Small Nuclear ; SF3B1 protein, human ; Saccharomyces cerevisiae Proteins ; Small Molecule Libraries ; meayamycin ; pladienolide B ; herboxidiene (142861-00-5)
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2018.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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