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  1. Article ; Online: Pharmacokinetic and Pharmacodynamic Characteristics of Insulin Icodec After Subcutaneous Administration in the Thigh, Abdomen or Upper Arm in Individuals with Type 2 Diabetes Mellitus.

    Plum-Mörschel, Leona / Andersen, Lizette Ravn / Hansen, Solvejg / Hövelmann, Ulrike / Krawietz, Patricia / Kristensen, Niels Rode / Lehrskov, Lars Lang / Haahr, Hanne

    Clinical drug investigation

    2023  Volume 43, Issue 2, Page(s) 119–127

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Arm ; Thigh ; Abdomen ; Injections, Subcutaneous ; Glucose/therapeutic use ; Hypoglycemic Agents
    Chemical Substances insulin icodec ; Glucose (IY9XDZ35W2) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-01-11
    Publishing country New Zealand
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-022-01243-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2807: Show issues Location:
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  2. Article ; Online: Oral Motor Impairments Contribute to Weight Status of Adults with Severe Cerebral Palsy.

    Lyster, Aslak Emil / Hansen, Solvejg Lis / Andersen, Christina Therese / Nielsen, Jens Bo / Westerterp, Klaas / Wouters, Loek / Kiens, Bente / Ritterband-Rosenbaum, Anina

    Nutrients

    2023  Volume 15, Issue 24

    Abstract: Adults with severe cerebral palsy (CP) are susceptible to malnutrition and metabolic disorders due to limited daily physical activity and challenges related to eating. We hypothesized that the condition of being underweight arises from inadequate energy ... ...

    Abstract Adults with severe cerebral palsy (CP) are susceptible to malnutrition and metabolic disorders due to limited daily physical activity and challenges related to eating. We hypothesized that the condition of being underweight arises from inadequate energy intake due to difficulties in eating, rather than heightened total energy expenditure or an elevated resting metabolic rate. The present study encompassed 17 adults with severe CP (classified as GMFSC III-V). Energy intake, utilization, and expenditure were gauged via thorough dietary recordings and double-labeled water (DLW) analyses. Resting metabolic rates were assessed through indirect calorimetry, and metabolic health was investigated via blood samples. Oral motor function, eating assessment during meals, and weight fluctuations throughout the experimental period were also evaluated. We found significant correlations between weight, oral impairments (
    MeSH term(s) Adult ; Humans ; Thinness/complications ; Cerebral Palsy/complications ; Motor Disorders ; Body Mass Index ; Malnutrition/complications ; Energy Metabolism
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15245042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma

    Hansen, Solvejg L / Lorentzen, Jakob / Pedersen, Lin T / Hendrich, Frederikke L / Jorsal, Martin / Pingel, Jessica / Nielsen, Jens B / Kiens, Bente

    Nutrients

    2019  Volume 11, Issue 3

    Abstract: Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and ... ...

    Abstract Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I⁻II,
    MeSH term(s) Brain-Derived Neurotrophic Factor/blood ; Cerebral Palsy/blood ; Cerebral Palsy/epidemiology ; Cerebral Palsy/physiopathology ; Child ; Denmark/epidemiology ; Energy Intake ; Energy Metabolism/physiology ; Exercise/physiology ; Female ; Humans ; Male ; Nutritional Status/physiology ; Oxygen Consumption
    Chemical Substances Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2019-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11030620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma <i>Brain-Derived Neurotrophic Factor</i> (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)

    Hansen, Solvejg L / Lorentzen, Jakob / Pedersen, Lin T / Hendrich, Frederikke L / Jorsal, Martin / Pingel, Jessica / Nielsen, Jens B / Kiens, Bente

    Nutrients. 2019 Mar. 14, v. 11, no. 3

    2019  

    Abstract: Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and ... ...

    Abstract Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I–II, n = 31, age 10.6 ± 0.6 years), severe CP (GMFCS IV–V, n = 14, age 10.9 ± 1.1 years) and typically developed (TD) children (n = 22, age 10.9 ± 0.6 years). Children with severe CP had ~40% lower plasma BDNF concentration than TD children (p < 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p < 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only ~50% of TD (p > 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.
    Keywords blood sampling ; cerebral palsy ; children ; dietary fiber ; energy ; exercise ; nutritional status ; omega-3 fatty acids ; questionnaires
    Language English
    Dates of publication 2019-0314
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11030620
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Molecular Mechanisms in Skeletal Muscle Underlying Insulin Resistance in Women Who Are Lean With Polycystic Ovary Syndrome.

    Hansen, Solvejg L / Svendsen, Pernille F / Jeppesen, Jacob F / Hoeg, Louise D / Andersen, Nicoline R / Kristensen, Jonas M / Nilas, Lisbeth / Lundsgaard, Anne-Marie / Wojtaszewski, Jørgen F P / Madsbad, Sten / Kiens, Bente

    The Journal of clinical endocrinology and metabolism

    2018  Volume 104, Issue 5, Page(s) 1841–1854

    Abstract: Context: Skeletal muscle molecular mechanisms underlying insulin resistance in women with polycystic ovary syndrome (PCOS) are poorly understood.: Objective: To provide insight into mechanisms regulating skeletal muscle insulin resistance in women ... ...

    Abstract Context: Skeletal muscle molecular mechanisms underlying insulin resistance in women with polycystic ovary syndrome (PCOS) are poorly understood.
    Objective: To provide insight into mechanisms regulating skeletal muscle insulin resistance in women who are lean with PCOS.
    Participants and methods: A hyperinsulinemic-euglycemic clamp with skeletal muscle biopsies was performed. Thirteen women who are lean who have hyperandrogenism and PCOS and seven age- and body mass index-matched healthy control subjects were enrolled. Skeletal muscle protein expression and phosphorylation were analyzed by Western blotting and intramuscular lipid content was measured by thin-layer chromatography.
    Results: Women with PCOS had 25% lower whole-body insulin sensitivity and 40% lower plasma adiponectin concentration than in control subjects. Intramuscular triacylglycerol, sn-1.3 diacylglycerol, and ceramide contents in skeletal muscle were higher (40%, 50%, and 300%, respectively) in women with PCOS than in control subjects. Activation of insulin signaling did not differ between groups. In women with PCOS, the insulin-stimulated glucose oxidation was reduced and insulin-stimulated dephosphorylation of pyruvate dehydrogenase (PDH) Ser293 was absent. AMP-activated protein kinase (AMPK) α2 protein expression and basal Thr172 phosphorylation were 45% and 50% lower in women with PCOS than in control subjects, respectively.
    Conclusions: Whole-body insulin resistance in women who are lean who have hyperandrogenism and PCOS was not related to changes in the proximal part of the insulin signaling cascade in skeletal muscle despite lipid accumulation. Rather, reduced insulin sensitivity was potentially related to plasma adiponectin levels playing a modulating role in human skeletal muscle via AMPK. Furthermore, abnormal PDH regulation may contribute to reduced whole-body metabolic flexibility and thereby insulin resistance.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Adiponectin/metabolism ; Adult ; Biomarkers/metabolism ; Body Mass Index ; Case-Control Studies ; Female ; Follow-Up Studies ; Glucose Clamp Technique ; Humans ; Hyperandrogenism/physiopathology ; Insulin/metabolism ; Insulin Resistance ; Ketone Oxidoreductases/metabolism ; Male ; Muscle, Skeletal/physiopathology ; Phosphorylation ; Polycystic Ovary Syndrome/physiopathology ; Prognosis ; Thinness/physiopathology
    Chemical Substances ADIPOQ protein, human ; Adiponectin ; Biomarkers ; Insulin ; Ketone Oxidoreductases (EC 1.2.-) ; pyruvate dehydrogenase (NADP+) (EC 1.2.1.51) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2018-01771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  6. Article ; Online: Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome.

    Hansen, Solvejg L / Bojsen-Møller, Kirstine N / Lundsgaard, Anne-Marie / Hendrich, Frederikke L / Nilas, Lisbeth / Sjøberg, Kim A / Hingst, Janne R / Serup, Annette K / Olguín, Carlos Henríquez / Carl, Christian S / Wernblad, Louise F / Henneberg, Marie / Lustrup, Katja M / Hansen, Christine / Jensen, Thomas E / Madsbad, Sten / Wojtaszewski, Jørgen F P / Richter, Erik A / Kiens, Bente

    Diabetes

    2020  Volume 69, Issue 11, Page(s) 2267–2280

    Abstract: Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism ... ...

    Abstract Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In the current study, lean hyperandrogenic women with PCOS (
    MeSH term(s) Adaptation, Physiological ; Exercise/physiology ; Female ; Homeostasis ; Humans ; Hyperandrogenism/metabolism ; Insulin ; Liver/metabolism ; Muscle, Skeletal/metabolism ; Oxidation-Reduction ; Polycystic Ovary Syndrome/metabolism ; Testosterone/blood
    Chemical Substances Insulin ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db20-0062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.175: Show issues Location:
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  7. Article ; Online: Supplementation of docosahexaenoic acid (DHA), vitamin D

    Hansen, Solvejg L / Ritterband-Rosenbaum, Anina / Voigt, Camilla B / Hellgren, Lars I / Sørensen, Ann-Dorit M / Jacobsen, Charlotte / Greve, Line Z / Jørgensen, Katrine D / Bilde, Peder E / Kiens, Bente / Nielsen, Jens B

    BMC nutrition

    2017  Volume 3, Page(s) 37

    Abstract: Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect ... ...

    Abstract Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D
    Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed.
    Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D
    Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D
    Trial registration: Clinical registration ID: NCT02426554 (clinical Trial.gov). January 2015 retrospectively registered.
    Language English
    Publishing date 2017-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809847-X
    ISSN 2055-0928 ; 2055-0928
    ISSN (online) 2055-0928
    ISSN 2055-0928
    DOI 10.1186/s40795-017-0155-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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