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Article ; Online: Comparison of Point Accuracy Between Two Widely Used Continuous Glucose Monitoring Systems.

Hanson, Kevin / Kipnes, Mark / Tran, Hien

Journal of diabetes science and technology

2024 Volume 18, Issue 3, Page(s) 598–607

Abstract: Background: Safe and effective self-management of glucose levels requires immediate access to accurate data. We assessed the point accuracy of the Dexcom G7 Continuous Glucose Monitoring System (Dexcom, Inc., San Diego, CA, USA) and FreeStyle Libre 3 ( ... ...

Abstract	Background: Safe and effective self-management of glucose levels requires immediate access to accurate data. We assessed the point accuracy of the Dexcom G7 Continuous Glucose Monitoring System (Dexcom, Inc., San Diego, CA, USA) and FreeStyle Libre 3 (Abbott Diabetes Care, Alameda, CA, USA) sensors in a head-to-head comparison. Method: Multicenter, single-arm, prospective, nonsignificant risk evaluation enrolled adults (≥ 18 years) with diagnosed type 1 diabetes (T1D) or type 2 diabetes (T2D). Accuracy was assessed by comparing sensor data to laboratory reference values Yellow Springs Instrument [YSI] and capillary blood glucose values. Outcome measures were differences in mean absolute relative difference (MARD), number and percentage of matched glucose pairs within ±20 mg/dL/±20 of reference values within glucose ranges: < 54, 54 to 69, 70 to 180, 181 to 250, > 250 mg/dL, and combined. Results: Data from 55 adults were included in the analysis. Analysis showed significantly lower MARD with the FreeStyle Libre 3 sensor vs the Dexcom G7 sensor (8.9% vs 13.6%, respectively, Conclusions: The FreeStyle Libre 3 sensor was more accurate than the Dexcom G7 sensor in all metrics evaluated throughout the study period. This is the first head-to-head study to our knowledge that compares the flagship products currently in widespread use of the two largest CGM manufacturers.
MeSH term(s)	Humans ; Blood Glucose Self-Monitoring/instrumentation ; Blood Glucose Self-Monitoring/standards ; Female ; Male ; Blood Glucose/analysis ; Middle Aged ; Diabetes Mellitus, Type 1/blood ; Adult ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Prospective Studies ; Aged ; Reproducibility of Results ; Continuous Glucose Monitoring
Chemical Substances	Blood Glucose
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Comparative Study ; Multicenter Study ; Research Support, Non-U.S. Gov't
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/19322968231225676
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Article ; Online: Examining the relationship between anxiety and regional brain volumes in the National Alzheimer's Coordinating Center uniform, imaging, and biomarker datasets.

Burke, Shanna L / Grudzien, Adrienne / Li, Tan / Abril, Marlou / Yin, Wupeng / Tyrell, Tahirah A / Barnes, Christopher P / Hanson, Kevin / DeKosky, Steven T

Cerebral circulation - cognition and behavior

2024 Volume 6, Page(s) 100201

Abstract: Anxiety has been associated with a greater risk of Alzheimer's disease (AD). Existing research has identified structural differences in regional brain tissue in participants with anxiety, but results have been inconsistent. We sought to determine the ... ...

Abstract	Anxiety has been associated with a greater risk of Alzheimer's disease (AD). Existing research has identified structural differences in regional brain tissue in participants with anxiety, but results have been inconsistent. We sought to determine the association between anxiety and regional brain volumes, and the moderation effect of APOE ε4. Using data from participants in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set, with complete imaging (MRI) and biomarker data (
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2450
ISSN (online)	2666-2450
DOI	10.1016/j.cccb.2024.100201
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Article ; Online: Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer's Coordinating Center Uniform Data Set.

Burke, Shanna / Grudzien, Adrienne / Li, Tan / Abril, Marlou / Spadola, Christine / Barnes, Christopher / Hanson, Kevin / Grandner, Michael / DeKosky, Steven

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2022 Volume 106, Page(s) 204–212

Abstract: This study aimed to 1) determine the association between sleep disturbance and brain structure volumes, 2) the moderation effect of apolipoprotein ε4 genotype on sleep disturbance and brain structures, and 3) the moderation effect of sleep disturbance on ...

Abstract	This study aimed to 1) determine the association between sleep disturbance and brain structure volumes, 2) the moderation effect of apolipoprotein ε4 genotype on sleep disturbance and brain structures, and 3) the moderation effect of sleep disturbance on cognitive status and regional brain volumes. Using the National Alzheimer's Coordinating Center Uniform Data Set (n = 1,533), multiple linear regressions were used to evaluate the association between sleep disturbance and brain volumes. Sleep disturbance was measured using one question from the NPI-Q. After controlling for intracranial volume, age, sex, years of education, race, ethnicity, and applying the FDR correction, total cerebrospinal fluid volume, left lateral ventricle volume, total lateral ventricle volume, and total third ventricle volume demonstrated significantly higher means for those with sleep disturbance. Total brain volume, total white and gray matter volume, total cerebrum brain volume (including gray but not white matter), left hippocampus volume, total hippocampal volume, the left, right, and total frontal lobe cortical gray matter volume, and the left, right, and total temporal lobe cortical gray matter volume demonstrated significantly lower mean volumes for those with sleep disturbance. Sleep disturbance moderated the association between cognitive status and lateral ventricular volumes. These findings suggest that disrupted sleep is associated with atrophy across multiple brain regions and ventricular hydrocephalus ex vacuo.
MeSH term(s)	Humans ; Alzheimer Disease/complications ; Alzheimer Disease/psychology ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Gray Matter ; Sleep Wake Disorders/complications ; Sleep
Language	English
Publishing date	2022-08-13
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2022.07.012
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Article: Nephroblastoma in a Common Mudpuppy Necturus maculosus simultaneously Present with a Mollicute Bacterium of the Genus Acholeplasma

Standish, Isaac / Leis, Eric / Erickson, Sara / Katona, Ryan / Baumgartner, Wes / Hanson, Kevin / Ibrahim, Iman / Goldberg, Tony

Journal of aquatic animal health. 2021 Mar., v. 33, no. 1

2021

Abstract: In March 2017, a wild‐caught female common mudpuppy Necturus maculosus from Iowa, USA, with an enlarged posterior abdomen was submitted for diagnostic assessment. The cause of the abdominal distension was a large fluid‐filled abdominal mass, diagnosed as ...

Abstract	In March 2017, a wild‐caught female common mudpuppy Necturus maculosus from Iowa, USA, with an enlarged posterior abdomen was submitted for diagnostic assessment. The cause of the abdominal distension was a large fluid‐filled abdominal mass, diagnosed as a nephroblastoma. Parasites and numerous bacteria were isolated and identified from the mudpuppy but were determined to be incidental. Samples of the neoplasm inoculated onto an American toad Anaxyrus americanus cell line (BufoTad) yielded cytopathic effect during several passages. However, standard molecular testing of the cell culture supernatant failed to identify any viruses. Next‐generation sequencing identified the replicating agent as a bacterium of the genus Acholeplasma. Immunohistochemistry confirmed the presence of Acholeplasma within the nephroblastoma, including within tumor cells. This is the first report of nephroblastoma and the second report of neoplasia in this species. The results also suggest that certain bacteria of the genus Acholeplasma might be oncogenic.
Keywords	Acholeplasma ; Anaxyrus americanus ; Necturus maculosus ; abdomen ; animal health ; aquatic animals ; bacteria ; cell culture ; cell lines ; cytopathogenicity ; females ; immunohistochemistry ; neoplasms ; toads ; Iowa
Language	English
Dates of publication	2021-03
Size	p. 44-52.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1019919-6
ISSN	1548-8667 ; 0899-7659
ISSN (online)	1548-8667
ISSN	0899-7659
DOI	10.1002/aah.10119
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Article ; Online: Free-water imaging reveals unique brain microstructural deficits in hispanic individuals with Dementia.

Ofori, Edward / Vaillancourt, David E / Greig-Custo, Maria T / Barker, Warren / Hanson, Kevin / DeKosky, Steven T / Garvan, Cynthia S / Adjouadi, Malek / Golde, Todd / Loewenstein, David A / Stecher, Chad / Fowers, Rylan / Duara, Ranjan

Brain imaging and behavior

2023 Volume 18, Issue 1, Page(s) 106–116

Abstract: Prior evidence suggests that Hispanic and non-Hispanic individuals differ in potential risk factors for the development of dementia. Here we determine whether specific brain regions are associated with cognitive performance for either ethnicity along ... ...

Abstract	Prior evidence suggests that Hispanic and non-Hispanic individuals differ in potential risk factors for the development of dementia. Here we determine whether specific brain regions are associated with cognitive performance for either ethnicity along various stages of Alzheimer's disease. For this cross-sectional study, we examined 108 participants (61 Hispanic vs. 47 Non-Hispanic individuals) from the 1Florida Alzheimer's Disease Research Center (1Florida ADRC), who were evaluated at baseline with diffusion-weighted and T1-weighted imaging, and positron emission tomography (PET) amyloid imaging. We used FreeSurfer to segment 34 cortical regions of interest. Baseline Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used as measures of cognitive performance. Group analyses assessed free-water measures (FW) and volume. Statistically significant FW regions based on ethnicity x group interactions were used in a stepwise regression function to predict total MMSE and MoCA scores. Random forest models were used to identify the most predictive brain-based measures of a dementia diagnosis separately for Hispanic and non-Hispanic groups. Results indicated elevated FW values for the left inferior temporal gyrus, left middle temporal gyrus, left banks of the superior temporal sulcus, left supramarginal gyrus, right amygdala, and right entorhinal cortex in Hispanic AD subjects compared to non-Hispanic AD subjects. These alterations occurred in the absence of different volumes of these regions in the two AD groups. FW may be useful in detecting individual differences potentially reflective of varying etiology that can influence cognitive decline and identify MRI predictors of cognitive performance, particularly among Hispanics.
MeSH term(s)	Humans ; Alzheimer Disease ; Cross-Sectional Studies ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Cognitive Dysfunction ; Positron-Emission Tomography ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-023-00819-w
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Article ; Online: Nephroblastoma in a Common Mudpuppy Necturus maculosus simultaneously Present with a Mollicute Bacterium of the Genus Acholeplasma.

Standish, Isaac / Leis, Eric / Erickson, Sara / Katona, Ryan / Baumgartner, Wes / Hanson, Kevin / Ibrahim, Iman / Goldberg, Tony

Journal of aquatic animal health

2021 Volume 33, Issue 1, Page(s) 44–52

Abstract: In March 2017, a wild-caught female common mudpuppy Necturus maculosus from Iowa, USA, with an enlarged posterior abdomen was submitted for diagnostic assessment. The cause of the abdominal distension was a large fluid-filled abdominal mass, diagnosed as ...

Abstract	In March 2017, a wild-caught female common mudpuppy Necturus maculosus from Iowa, USA, with an enlarged posterior abdomen was submitted for diagnostic assessment. The cause of the abdominal distension was a large fluid-filled abdominal mass, diagnosed as a nephroblastoma. Parasites and numerous bacteria were isolated and identified from the mudpuppy but were determined to be incidental. Samples of the neoplasm inoculated onto an American toad Anaxyrus americanus cell line (BufoTad) yielded cytopathic effect during several passages. However, standard molecular testing of the cell culture supernatant failed to identify any viruses. Next-generation sequencing identified the replicating agent as a bacterium of the genus Acholeplasma. Immunohistochemistry confirmed the presence of Acholeplasma within the nephroblastoma, including within tumor cells. This is the first report of nephroblastoma and the second report of neoplasia in this species. The results also suggest that certain bacteria of the genus Acholeplasma might be oncogenic.
MeSH term(s)	Acholeplasma/isolation & purification ; Animals ; Female ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/veterinary ; Iowa ; Necturus maculosus ; Wilms Tumor/microbiology ; Wilms Tumor/veterinary
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1019919-6
ISSN	1548-8667 ; 0899-7659
ISSN (online)	1548-8667
ISSN	0899-7659
DOI	10.1002/aah.10119
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Article: MEDICAL CONTROL FOR EMTS. King County, Wash., program offers safety net for patients, EMTs and the EMS system.

Husain, Sofia / Lyons, Bill / Hanson, Kevin / Whorton, Adrian

JEMS : a journal of emergency medical services

2016 Volume 41, Issue 2, Page(s) 34–36

MeSH term(s)	Emergency Medical Service Communication Systems ; Emergency Medical Services/organization & administration ; Organizational Case Studies ; Patient Safety ; Referral and Consultation ; Washington
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1292428-3
ISSN	0197-2510
ISSN	0197-2510
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Article ; Online: Can routine office-based audiometry predict cochlear implant evaluation results?

Gubbels, Samuel P / Gartrell, Brian C / Ploch, Jennifer L / Hanson, Kevin D

The Laryngoscope

2017 Volume 127, Issue 1, Page(s) 216–222

Abstract: Objectives/hypothesis: Determining cochlear implant candidacy requires a specific sentence-level testing paradigm in best-aided conditions. Our objective was to determine if findings on routine audiometry could predict the results of a formal cochlear ... ...

Abstract	Objectives/hypothesis: Determining cochlear implant candidacy requires a specific sentence-level testing paradigm in best-aided conditions. Our objective was to determine if findings on routine audiometry could predict the results of a formal cochlear implant candidacy evaluation. We hypothesize that findings on routine audiometry will accurately predict cochlear implant evaluation results in the majority of candidates. Study design: Retrospective, observational, diagnostic study. Methods: The charts of all adult patients who were evaluated for implant candidacy at a tertiary care center from June 2008 through June 2013 were included. Routine, unaided audiologic measures (pure-tone hearing thresholds and recorded monosyllabic word recognition testing) were then correlated with best-aided sentence-level discrimination testing (using either the Hearing in Noise Test or AzBio sentences test). Results: The degree of hearing loss at 250 to 4,000 Hz and monosyllabic word recognition scores significantly correlated with sentence-level word discrimination test results. Extrapolating from this association, we found that 86% of patients with monosyllabic word recognition scores at or below 32% (or 44% for patients with private insurance) would meet candidacy requirements for cochlear implantation. Conclusions: Routine audiometric findings can be used to identify patients who are likely to meet cochlear implant candidacy upon formal testing. For example, patients with pure-tone thresholds (250, 500, 1,000 Hz) of ≥75 dB and/or a monosyllabic word recognition test score of ≤40% have a high likelihood of meeting candidacy criteria. Utilization of these predictive patterns during routine audiometric evaluation may assist hearing health professionals in deciding when to refer patients for a formal cochlear implant evaluation. Level of evidence: 4 Laryngoscope, 127:216-222, 2017.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Audiometry, Pure-Tone ; Cochlear Implantation ; Cochlear Implants ; Female ; Hearing Loss/diagnosis ; Hearing Loss/surgery ; Humans ; Male ; Middle Aged ; Patient Selection ; Physicians' Offices ; Predictive Value of Tests ; Retrospective Studies ; Speech Perception
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.26066
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Article ; Online: Ex vivo canine vocal fold lamina propria rehydration after varying dehydration levels.

Hanson, Kevin P / Zhang, Yu / Jiang, Jack J

Journal of voice : official journal of the Voice Foundation

2010 Volume 25, Issue 6, Page(s) 657–662

Abstract: Objectives: To examine the recoverability of canine vocal fold (VF) lamina propria (LP) on rehydration from varying dehydration levels.: Study design: Open, controlled experimental trial.: Methods: The VF LP was excised en bloc using a scalpel ... ...

Abstract	Objectives: To examine the recoverability of canine vocal fold (VF) lamina propria (LP) on rehydration from varying dehydration levels. Study design: Open, controlled experimental trial. Methods: The VF LP was excised en bloc using a scalpel from 10 canine larynges, providing 20 tissue samples. The initial volume of each sample was measured. Ten samples were dehydrated to 30% by mass and the other 10 samples to 70%. Each sample was rehydrated in 0.9% saline until the mass stabilized. The liquid mass and volume fractions, liquid:solid mass and volume ratios, and the fractions of the original tissue masses and volumes were calculated. Results: All calculated parameters were significantly different between 30% and 70% dehydration recovery, with all parameters lesser in the 70% dehydration treatment group. Half of the tissue samples subjected to 30% dehydration fully recovered to their original volumes, whereas only one of the 10 samples subjected to 70% dehydration fully recovered its volume. Conclusions: The level of attainable rehydration recovery of VF LP tissue in an ex vivo setting depends on the level of dehydration. The results correspond to the biphasic theory and may be used to help model the biomechanical and physiological properties of VF LP tissue during rehydration.
MeSH term(s)	Animals ; Dehydration/therapy ; Dogs ; Fluid Therapy ; In Vitro Techniques ; Vocal Cords
Language	English
Publishing date	2010-10-16
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2010.06.005
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Article ; Online: Parameters quantifying dehydration in canine vocal fold lamina propria.

Hanson, Kevin P / Zhang, Yu / Jiang, Jack J

The Laryngoscope

2010 Volume 120, Issue 7, Page(s) 1363–1369

Abstract: Objectives/hypothesis: The goal of this study was to measure the solid and liquid volume and mass of canine vocal fold lamina propria tissue at varying dehydration levels, and to calculate parameters to test the biphasic theory of vocal fold physiology ... ...

Abstract	Objectives/hypothesis: The goal of this study was to measure the solid and liquid volume and mass of canine vocal fold lamina propria tissue at varying dehydration levels, and to calculate parameters to test the biphasic theory of vocal fold physiology and biomechanics. Study design: Open, controlled, experimental trial. Methods: The vocal fold lamina propria was dissected from 15 canine larynges, yielding 30 tissue samples. The initial volumes and masses of the tissue samples were measured. The masses of the tissue samples were then measured every 2 minutes during 30%, 50%, and 70% dehydration, with 10 samples subjected to each of the three treatments, followed by complete dehydration to yield the solid component of the tissue. The liquid mass and volume fractions and liquid:solid mass and volume ratios of the vocal fold lamina propria samples were calculated. Results: The liquid mass and volume fractions and liquid:solid mass and volume ratios were significantly different at each dehydration level, except for the liquid:solid volume ratios at 30% versus 50% dehydration. Linear regression analysis suggested that all of the solid and liquid parameters measured could be predicted by dehydration level based on inverse, linear relationships. Conclusions: These results provide further experimental evidence supporting the biphasic theory and suggest that the extent of vocal fold lamina propria tissue dehydration may be quantified based on the biphasic model parameters.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Dehydration/physiopathology ; Dogs ; In Vitro Techniques ; Mucous Membrane/anatomy & histology ; Mucous Membrane/physiology ; Organ Size ; Vocal Cords/anatomy & histology ; Vocal Cords/physiology
Language	English
Publishing date	2010-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.20927
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