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  1. Book ; Online ; E-Book: What makes a person?

    Hanson, Mark / Green, Lucy R.

    secrets of our first 1,000 days

    2023  

    Abstract: Ever wondered why your life and health can sometimes be so hard to control? Or why it seems so easy for other people? Mark Hanson and Lucy Green draw on their years of experience as scientists and educators to cut through the usual information on ... ...

    Author's details Mark Hanson, Lucy Green
    Abstract Ever wondered why your life and health can sometimes be so hard to control? Or why it seems so easy for other people? Mark Hanson and Lucy Green draw on their years of experience as scientists and educators to cut through the usual information on genetics and lifestyle to reveal the secrets of early development which start to make each of us unique, during our first 1,000 days from the moment of conception. Some surprising discoveries, based on little-known new research, show how events during our first 1,000 days make each of us who we are and explain how we control our bodies, processes that go way beyond just the genes which we inherited. Provoking new ways of thinking about being parents, this book empowers individuals and society to give the next generation the gift of a good start to life and future health.
    Keywords Child development
    Subject code 305.231
    Language English
    Size 1 online resource (xvii, 182 pages) :, digital, PDF file(s).
    Publisher Cambridge University Press
    Publishing place Cambridge
    Document type Book ; Online ; E-Book
    Note Title from publisher's bibliographic system (viewed on 03 Nov 2022).
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-009-19529-8 ; 1-009-19524-7 ; 1-009-19531-X ; 9781009195256 ; 978-1-009-19529-4 ; 978-1-009-19524-9 ; 978-1-009-19531-7 ; 1009195255
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Pre-emptive medicine

    Hanson, Mark A. / Sata, Fumihiro / Fukuoka, Hideoki

    public health aspects of developmental origins of health and disease

    (Current topics in environmental health and preventive medicine)

    2019  

    Author's details Fumihiro Sata, Hideoki Fukuoka, Mark Hanson editors
    Series title Current topics in environmental health and preventive medicine
    Language English
    Size 1 Online-Ressource (ix, 217 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019930279
    ISBN 978-981-13-2194-8 ; 9789811321931 ; 981-13-2194-9 ; 9811321930
    DOI 10.1007/978-9811321948
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Developmental Origins of Health and Disease

    Godfrey, Keith M. / Poston, Lucilla / Hanson, Mark A. / Gluckman, Peter D.

    2022  

    Size 320 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_19
    Format 180 x 257 x 17
    ISBN 9781009272247 ; 1009272241
    Database PDA

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  4. Article ; Online: When the microbiome shapes the host: immune evolution implications for infectious disease.

    Hanson, Mark A

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2024  Volume 379, Issue 1901, Page(s) 20230061

    Abstract: The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests ... ...

    Abstract The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests hosts can selectively activate innate immunity upon pathogenic infection, but not mutualist colonization. Another idea posits that hosts can selectively attack pathogens, but not mutualists. Here I review evolutionary principles of microbe recognition and immune activation, and reflect on newly observed immune effector-microbe specificity perhaps supporting the latter idea. Recent work in
    MeSH term(s) Animals ; Microbiota ; Symbiosis ; Host-Pathogen Interactions ; Immunity, Innate ; Drosophila ; Communicable Diseases ; Mammals
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2023.0061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Mapping Gender Differences in Cardiovascular Disease and Diabetes Care

    Bird, Chloe E / Fremont, Allen / Hanson, Mark

    A Pilot Assessment of LDL Cholesterol Testing Rates in a California Health Plan

    2014  

    Keywords Coping with illness & specific conditions ; History of the Americas ; Cardiovascular medicine ; Public health & preventive medicine ; Clinical & internal medicine ; Health Sciences ; Public Health ; History
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030610307
    ISBN 9780833084613 ; 0833084615
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis.

    Hanson, Mark A / Lemaitre, Bruno

    Disease models & mechanisms

    2023  Volume 16, Issue 4

    Abstract: Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are ... ...

    Abstract Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are produced downstream of Toll and Imd NF-κB pathways upon infection. Upon aging, AMPs are upregulated, drawing attention to these molecules as possible causes of age-associated inflammatory diseases. However, functional studies overexpressing or silencing these genes have been inconclusive. Using an isogenic set of AMP gene deletions, we investigated the net impact of AMPs on aging. Overall, we found no major effect of individual AMPs on lifespan, with the possible exception of Defensin. However, ΔAMP14 flies lacking seven AMP gene families displayed reduced lifespan. Increased bacterial load in the food of aged ΔAMP14 flies suggested that their lifespan reduction was due to microbiome dysbiosis, consistent with a previous study. Moreover, germ-free conditions extended the lifespan of ΔAMP14 flies. Overall, our results did not point to an overt role of individual AMPs in lifespan. Instead, we found that AMPs collectively impact lifespan by preventing dysbiosis during aging.
    MeSH term(s) Animals ; Drosophila ; Longevity ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Antimicrobial Peptides ; Dysbiosis ; Aging ; Immunity, Innate
    Chemical Substances Drosophila Proteins ; Antimicrobial Peptides
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The inheritance of cardiovascular disease risk.

    Hanson, Mark

    Acta paediatrica (Oslo, Norway : 1992)

    2019  Volume 108, Issue 10, Page(s) 1747–1756

    Abstract: Cardiovascular disease (CVD) is foremost among the non-communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre-existing conditions still accounting for nearly 25% of maternal deaths and is ... ...

    Abstract Cardiovascular disease (CVD) is foremost among the non-communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre-existing conditions still accounting for nearly 25% of maternal deaths and is linked to gestational diabetes and pre-eclampsia. Markers of CVD risk have been reported even in young children, related to prenatal factors such as mother's diet or body composition. The underlying mechanisms include epigenetic changes which can alter the trajectory of risk across the life course. Preventive interventions need to commence before conception, to reduce transmission of CVD risk by promoting healthy behaviours in prospective parents, as well as in pregnancy, and postpartum through breastfeeding and healthy complementary feeding. Surprisingly, these opportunities are not emphasised in the 2018 United Nations Political Declaration on NCDs. NCDs such as CVD have communicable risk components transmitted across generations by socio-economic as well as biological factors, although the former can also become embodied in the offspring by epigenetic mechanisms. The inheritance of CVD risk, and social inequalities in such risk, thus raises wider questions about responsibility for the health of future generations at societal as well as individual levels.
    MeSH term(s) Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Child Development ; Genetic Predisposition to Disease ; Humans ; Infant ; Risk
    Language English
    Publishing date 2019-04-29
    Publishing country Norway
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.14813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Disparities in Access to Diagnostic Evaluation for Alzheimer's Disease in Individuals Dually Eligible for Medicare and Medicaid: A Modeling Study.

    Mattke, Soeren / Jun, Hankyung / Chu, Samantha / Hanson, Mark

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 4, Page(s) 1403–1414

    Abstract: Background: Individuals dually eligible for Medicare and Medicaid (duals) may face greater obstacles to access to disease-modifying Alzheimer's treatments in spite of their higher disease burden, because of clinicians' reluctance to accept Medicaid and ... ...

    Abstract Background: Individuals dually eligible for Medicare and Medicaid (duals) may face greater obstacles to access to disease-modifying Alzheimer's treatments in spite of their higher disease burden, because of clinicians' reluctance to accept Medicaid and the so-called "lesser of" policy, under which Medicaid may pay providers lower rates.
    Objective: To project differential wait times for duals compared to Medicare-only beneficiaries by state.
    Methods: We used State Medicaid payment policy and Medicare enrollment data and a Markov model to predict differential wait times for duals and non-duals from 2023 to 2050. We estimated available diagnostic appointments by state for both groups based on reluctance of clinicians to accept Medicaid and the "lesser of" policy for each year.
    Results: We estimate overall average wait times of almost two years (22.9 months) but almost three times as long for duals (59.8 months) than non-duals (20.7 months) because of higher disease burden. The effects of Medicaid payment policy would increase average wait times for duals to 89 months with 20 states having wait times of 99 months or more, which would effectively deprive duals of access.
    Conclusions: The added average wait times in many states would effectively deprive duals from access to treatment and translate into avoidable disease progression and mortality. Policy interventions to reduce financial and nonfinancial obstacles are dearly needed to avoid deepening disparities. Examples are coverage arrangements that integrate Medicare and Medicaid coverage, covering the co-payment for physician services in full, and stricter network adequacy requirements for Medicaid Managed Care plans.
    MeSH term(s) Aged ; Humans ; United States ; Medicare ; Medicaid ; Alzheimer Disease/diagnosis ; Alzheimer Disease/therapy
    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Revising economic measures of economic activity to reflect human and environmental health.

    Hanson, Mark / Modi, Neena / Allin, Paul

    Bulletin of the World Health Organization

    2024  Volume 102, Issue 5, Page(s) 357–359

    MeSH term(s) Humans ; Environmental Health ; Global Health
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Editorial
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.23.290662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Sculpting the microbiome.

    Hanson, Mark A / Westlake, Hannah E / Schrankel, Catherine S

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2024  Volume 379, Issue 1901, Page(s) 20230057

    MeSH term(s) Microbiota ; Gastrointestinal Microbiome
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2023.0057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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