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  1. Book: Developmental Origins of Health and Disease

    Godfrey, Keith M. / Poston, Lucilla / Hanson, Mark A. / Gluckman, Peter D.

    2022  

    Size 320 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_19
    Format 180 x 257 x 17
    ISBN 9781009272247 ; 1009272241
    Database PDA

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  2. Article ; Online: When the microbiome shapes the host: immune evolution implications for infectious disease.

    Hanson, Mark A

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2024  Volume 379, Issue 1901, Page(s) 20230061

    Abstract: The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests ... ...

    Abstract The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests hosts can selectively activate innate immunity upon pathogenic infection, but not mutualist colonization. Another idea posits that hosts can selectively attack pathogens, but not mutualists. Here I review evolutionary principles of microbe recognition and immune activation, and reflect on newly observed immune effector-microbe specificity perhaps supporting the latter idea. Recent work in
    MeSH term(s) Animals ; Microbiota ; Symbiosis ; Host-Pathogen Interactions ; Immunity, Innate ; Drosophila ; Communicable Diseases ; Mammals
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2023.0061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; E-Book: Pre-emptive medicine

    Hanson, Mark A. / Sata, Fumihiro / Fukuoka, Hideoki

    public health aspects of developmental origins of health and disease

    (Current topics in environmental health and preventive medicine)

    2019  

    Author's details Fumihiro Sata, Hideoki Fukuoka, Mark Hanson editors
    Series title Current topics in environmental health and preventive medicine
    Language English
    Size 1 Online-Ressource (ix, 217 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019930279
    ISBN 978-981-13-2194-8 ; 9789811321931 ; 981-13-2194-9 ; 9811321930
    DOI 10.1007/978-9811321948
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis.

    Hanson, Mark A / Lemaitre, Bruno

    Disease models & mechanisms

    2023  Volume 16, Issue 4

    Abstract: Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are ... ...

    Abstract Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are produced downstream of Toll and Imd NF-κB pathways upon infection. Upon aging, AMPs are upregulated, drawing attention to these molecules as possible causes of age-associated inflammatory diseases. However, functional studies overexpressing or silencing these genes have been inconclusive. Using an isogenic set of AMP gene deletions, we investigated the net impact of AMPs on aging. Overall, we found no major effect of individual AMPs on lifespan, with the possible exception of Defensin. However, ΔAMP14 flies lacking seven AMP gene families displayed reduced lifespan. Increased bacterial load in the food of aged ΔAMP14 flies suggested that their lifespan reduction was due to microbiome dysbiosis, consistent with a previous study. Moreover, germ-free conditions extended the lifespan of ΔAMP14 flies. Overall, our results did not point to an overt role of individual AMPs in lifespan. Instead, we found that AMPs collectively impact lifespan by preventing dysbiosis during aging.
    MeSH term(s) Animals ; Drosophila ; Longevity ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Antimicrobial Peptides ; Dysbiosis ; Aging ; Immunity, Innate
    Chemical Substances Drosophila Proteins ; Antimicrobial Peptides
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sculpting the microbiome.

    Hanson, Mark A / Westlake, Hannah E / Schrankel, Catherine S

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2024  Volume 379, Issue 1901, Page(s) 20230057

    MeSH term(s) Microbiota ; Gastrointestinal Microbiome
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2023.0057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The prenatal embodiment of racial disparities.

    Hanson, Mark A

    Neuroscience and biobehavioral reviews

    2020  Volume 115, Page(s) 13–14

    MeSH term(s) Female ; Healthcare Disparities ; Humans ; Pregnancy ; Risk Factors ; United States
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2020.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The prenatal embodiment of racial disparities.

    Hanson, Mark A

    Neuroscience and biobehavioral reviews

    2020  Volume 117, Page(s) 317–318

    MeSH term(s) Female ; Healthcare Disparities ; Humans ; Pregnancy ; Risk Factors ; United States
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2020.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Repeated truncation of a modular antimicrobial peptide gene for neural context.

    Hanson, Mark A / Lemaitre, Bruno

    PLoS genetics

    2022  Volume 18, Issue 6, Page(s) e1010259

    Abstract: Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading pathogens. These genes commonly encode multiple products as post-translationally cleaved polypeptides. Recent studies have highlighted roles for AMPs in neurological contexts ...

    Abstract Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading pathogens. These genes commonly encode multiple products as post-translationally cleaved polypeptides. Recent studies have highlighted roles for AMPs in neurological contexts suggesting functions for these defence molecules beyond infection. During our immune study characterizing the antimicrobial peptide gene Baramicin, we recovered multiple Baramicin paralogs in Drosophila melanogaster and other species, united by their N-terminal IM24 domain. Not all paralogs were immune-induced. Here, through careful dissection of the Baramicin family's evolutionary history, we find that paralogs lacking immune induction result from repeated events of duplication and subsequent truncation of the coding sequence from an immune-inducible ancestor. These truncations leave only the IM24 domain as the prominent gene product. Surprisingly, using mutation and targeted gene silencing we demonstrate that two such genes are adapted for function in neural contexts in D. melanogaster. We also show enrichment in the head for independent Baramicin genes in other species. The Baramicin evolutionary history reveals that the IM24 Baramicin domain is not strictly useful in an immune context. We thus provide a case study for how an AMP-encoding gene might play dual roles in both immune and non-immune processes via its multiple peptide products. As many AMP genes encode polypeptides, a full understanding of how immune effectors interact with the nervous system will require consideration of all their peptide products.
    MeSH term(s) Adenosine Monophosphate ; Animals ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Peptides ; Drosophila melanogaster ; Nervous System
    Chemical Substances Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Adenosine Monophosphate (415SHH325A)
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010259
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  9. Book: Fetus and neonate / 4

    Hanson, Mark A.

    physiology and clinical applications

    1998  

    Author's details ed. by Mark A. Hanson
    Collection Fetus and neonate
    Language English
    Size XII, 328 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT008804389
    ISBN 0-521-59392-1 ; 978-0-521-59392-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2624 -4- order for loan Magazin

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  10. Book: Fetus and neonate / 2

    Hanson, Mark A.

    physiology and clinical applications

    1994  

    Author's details ed. by Mark A. Hanson
    Collection Fetus and neonate
    Keywords Neugeborenes ; Atmung ; Fetus
    Subject Respiration ; Fötus ; Neugeborene
    Language English
    Size XIV, 400 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT006698643
    ISBN 0-521-41765-1 ; 978-0-521-41765-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2624 -2- order for loan Magazin

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