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  1. Book ; Online: The Stockholm School and the Development of Dynamic Method

    Hansson, Björn A

    (Routledge Library Editions: The History of Economic Thought)

    2017  

    Abstract: 2. 'What happens first' and the 'case-by-case' approach. -- 3. A critique of the 'neo-Wicksellians' or an autonomous change in the demand for consumption goods. -- 4. The equilibrating mechanism. -- IX. A fully developed sequence analysis: Lindahl (1934- ... ...

    Series title Routledge Library Editions: The History of Economic Thought
    Abstract 2. 'What happens first' and the 'case-by-case' approach. -- 3. A critique of the 'neo-Wicksellians' or an autonomous change in the demand for consumption goods. -- 4. The equilibrating mechanism. -- IX. A fully developed sequence analysis: Lindahl (1934-1935). -- 1. The dating of Lindahl's contribution. -- 2. A general dynamic theory as a basis for all economic theory. -- 3. The vision behind the construction of a general dynamic theory. -- 4. Sequence analysis. -- 5. The disequilibrium method applied to the analysis of price movements. -- X. Disequilibrium sequence analysis: Lundberg (1937). -- 1. The background to the model sequences. -- 2. The equilibrium notion in a disequilibrium sequence analysis. -- 3. The limitations of model sequence analysis. -- XI. The immediate response to The General Theory. -- 1. Ohlin on Keynes. -- 2. Lundberg on Keynes. -- XII. Summary -- Bibliography. -- A. Published Works. -- B. Unpublished Works. -- C. Correspondence. -- Appendix. Keynes' General Theory

    Cover -- Half Title -- Title Page -- Copyright Page -- Original Title Page -- Original Copyright Page -- Table of Contents -- Preface -- I. Introduction. -- 1. The main purpose of the work. -- 2. The idea of a reconstruction as an expository device. -- 3. An outline of the work. -- II. The analytical framework. -- 1. Sequence analysis as the point of reference. -- 2. The static method. -- 3. Intertemporal equilibrium. -- 4. Temporary equilibrium. -- 5. Disequilibrium methods: Equilibrium and disequilibrium sequence analysis. -- III. The 'method of expectations': Myrdal's dissertation (1927). -- 1. Myrdal's purpose. -- 2. The construction of a concept of dynamic equilibrium. -- 3. Two dynamic methods. -- 4. Objective and subjective risk. -- IV. The equilibrium approach: Lindahl's development of intertemporal and temporal equilibrium (1929-1930). -- 1. The object of Lindahl's analysis. -- 2. The dynamic method. -- 3. The savings-investment mechanism during a cumulative process. -- 4. Lindahl's critique of Wicksell's conception of a normal rate. -- Appendix to Chapter IV. -- V. A critique of static equilibrium theory: Lundberg (1930). -- 1. Lundberg's purpose. -- 2. A critique of static equilibrium theory. -- 3. Lundberg's comments on dynamic method. -- VI. The disequilibrium approach: Myrdal's development of ex ante and ex post (1931-1932). -- 1. The purpose of Monetary Equilibrium. -- 2. The dynamic method. -- 3. Myrdal's analysis of Wicksell's three conditions for monetary equilibrium. -- 4. The savings-investment mechanism during a cumulative process. -- VII. Profit as a link between consecutive periods: Hammarskjöld (1932-1933). -- 1. Hammarskjöld's purpose. -- 2. The dynamic method. -- 3. The formula for the price level. -- VIII. Autonomous changes in consumption demand: Ohlin (1932-1934). -- 1. Ohlin's dynamic method
    Language English
    Size 1 Online-Ressource (299 pages)
    Document type Book ; Online
    ISBN 9781138230200 ; 9781315386614 ; 9781138230200 ; 1138230200 ; 1315386615 ; 1138230200
    Database ECONomics Information System

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  2. Article ; Online: Improvements in Maximal Oxygen Uptake After Sprint-Interval Training Coincide with Increases in Central Hemodynamic Factors.

    Mandić, Mirko / Hansson, Björn / Lovrić, Alen / Sundblad, Patrik / Vollaard, Niels B J / Lundberg, Tommy R / Gustafsson, Thomas / Rullman, Eric

    Medicine and science in sports and exercise

    2022  Volume 54, Issue 6, Page(s) 944–952

    Abstract: Introduction: Sprint-interval training has been shown to improve maximal oxygen uptake, in part through peripheral muscle adaptations that increase oxygen utilization. In contrast, the adaptations of central hemodynamic factors in this context remain ... ...

    Abstract Introduction: Sprint-interval training has been shown to improve maximal oxygen uptake, in part through peripheral muscle adaptations that increase oxygen utilization. In contrast, the adaptations of central hemodynamic factors in this context remain unexplored.
    Purpose: The aim of the current study was to explore the effects of sprint-interval training on maximal oxygen uptake and central hemodynamic factors.
    Methods: Healthy men and women (n = 29; mean age, 27 ± 5 yr; height, 175 ± 8 cm; body mass, 72.5 ± 12.0 kg) performed 6 wk of sprint-interval training consisting of three weekly sessions of 10-min low-intensity cycling interspersed with 3 × 30-s all-out sprints. Maximal oxygen uptake, total blood volume, and maximal cardiac output were measured before and after the intervention.
    Results: Maximal oxygen uptake increased by 10.3% (P < 0.001). Simultaneously, plasma volume, blood volume, total hemoglobin mass, and cardiac output increased by 8.1% (276 ± 234 mL; P < 0.001), 6.8% (382 ± 325 mL; P < 0.001), 5.7% (42 ± 41 g; P < 0.001), and 8.5% (1.0 ± 0.9 L·min-1; P < 0.001), respectively. Increased total hemoglobin mass along with measures of body surface area had a significant impact on the improvements in maximal oxygen uptake.
    Conclusions: Six weeks of sprint-interval training results in significant increases in hemoglobin mass, blood volume, and cardiac output. Because these changes were associated with marked improvements in maximal oxygen uptake, we conclude that central hemodynamic adaptations contribute to the improvement in maximal oxygen uptake during sprint-interval training.
    MeSH term(s) Adult ; Female ; Hemodynamics ; Hemoglobins ; High-Intensity Interval Training/methods ; Humans ; Male ; Oxygen ; Oxygen Consumption/physiology ; Young Adult
    Chemical Substances Hemoglobins ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000002872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A hypothesis for insulin resistance in primary human adipocytes involving MRTF-A and suppression of PPARγ

    Hansson, Björn / Schumacher, Sara / Fryklund, Claes / Morén, Björn / Björkqvist, Maria / Swärd, Karl / Stenkula, Karin G

    Biochemical and biophysical research communications. 2020 Nov. 26, v. 533, no. 1

    2020  

    Abstract: Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short- ... ...

    Abstract Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature adipocyte function.Primary human adipocytes were subjected to adenoviral overexpression of MRTF-A or MRTF-B, followed by Western blot analysis and tracer glucose uptake assay. Further, we assessed cell size distribution, insulin response, MRTF-A localization, actin organization and degree of polymerization in adipocytes isolated from Ob/Ob mice.Overexpression of MRTF-A, but not MRTF-B, markedly suppressed PPARγ expression. Further, MRTF-A expression resulted in decreased IRS-1 level, shifted phosphorylation of Akt (pS473/pT308), IRS-1 (pS302) and AS160 (pT642), and lowered insulin-stimulated glucose uptake. Hypertrophic adipocytes from Ob/Ob mice displayed an increased proportion of polymerized actin, and increased nuclear translocation of MRTF-A compared with control (Ob/+). Similar with human adipocytes overexpressing MRTF-A, adipocytes isolated from Ob/Ob mice had reduced expression of IRS-1 and PPARγ, as well as impaired insulin response.Together, these data demonstrate that MRTF-A negatively influences insulin sensitivity and the expression of key targets in fully mature human adipocytes. This suggests that MRTF-A is poised to exert a transcriptional response in hypertrophic adipocytes, contributing to adipocyte dysfunction and insulin resistance.
    Keywords Adenoviridae ; Western blotting ; actin ; adipocytes ; glucose ; humans ; insulin ; insulin resistance ; noninsulin-dependent diabetes mellitus ; obesity ; phosphorylation ; polymerization ; research ; risk factors ; transcription (genetics)
    Language English
    Dates of publication 2020-1126
    Size p. 64-69.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.08.105
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Early accentuated muscle hypertrophy is strongly associated with myonuclear accretion.

    Lundberg, Tommy R / Martínez-Aranda, Luis Manuel / Sanz, Gema / Hansson, Björn / von Walden, Ferdinand / Tesch, Per A / Fernandez-Gonzalo, Rodrigo

    American journal of physiology. Regulatory, integrative and comparative physiology

    2020  Volume 319, Issue 1, Page(s) R50–R58

    Abstract: The current study explored whether the marked hypertrophic response noted with a short-term unilateral concurrent exercise paradigm was associated with more prominent changes in myonuclei accretion, ribosome biogenesis, and capillarization compared with ... ...

    Abstract The current study explored whether the marked hypertrophic response noted with a short-term unilateral concurrent exercise paradigm was associated with more prominent changes in myonuclei accretion, ribosome biogenesis, and capillarization compared with resistance exercise alone (RE). Ten men (age 25 ± 4 yr) performed aerobic and resistance exercise (AE + RE) for one leg while the other leg did RE. Muscle biopsies were obtained before and after 5 wk of training and subjected to fiber-type specific immunohistochemical analysis, and quantification of total RNA content and mRNA/rRNA transcript abundance. Type II fiber cross-sectional area (CSA) increased with both AE + RE (22%) and RE (16%), while type I fiber CSA increased mainly with AE + RE (16%). The change score tended to differ between legs for type I CSA (
    MeSH term(s) Adult ; Capillaries/physiology ; Cell Nucleus/metabolism ; Exercise/physiology ; Humans ; Hypertrophy ; Leg/anatomy & histology ; Leg/physiology ; Magnetic Resonance Imaging ; Male ; Muscle Fibers, Fast-Twitch/physiology ; Muscle Fibers, Fast-Twitch/ultrastructure ; Muscle Fibers, Slow-Twitch/physiology ; Muscle Fibers, Slow-Twitch/ultrastructure ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/physiology ; Muscle, Skeletal/ultrastructure ; Physical Endurance ; RNA/biosynthesis ; Resistance Training ; Ribosomes/metabolism ; Young Adult
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00061.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A hypothesis for insulin resistance in primary human adipocytes involving MRTF-A and suppression of PPARγ.

    Hansson, Björn / Schumacher, Sara / Fryklund, Claes / Morén, Björn / Björkqvist, Maria / Swärd, Karl / Stenkula, Karin G

    Biochemical and biophysical research communications

    2020  Volume 533, Issue 1, Page(s) 64–69

    Abstract: Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short- ... ...

    Abstract Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature adipocyte function. Primary human adipocytes were subjected to adenoviral overexpression of MRTF-A or MRTF-B, followed by Western blot analysis and tracer glucose uptake assay. Further, we assessed cell size distribution, insulin response, MRTF-A localization, actin organization and degree of polymerization in adipocytes isolated from Ob/Ob mice. Overexpression of MRTF-A, but not MRTF-B, markedly suppressed PPARγ expression. Further, MRTF-A expression resulted in decreased IRS-1 level, shifted phosphorylation of Akt (pS473/pT308), IRS-1 (pS302) and AS160 (pT642), and lowered insulin-stimulated glucose uptake. Hypertrophic adipocytes from Ob/Ob mice displayed an increased proportion of polymerized actin, and increased nuclear translocation of MRTF-A compared with control (Ob/+). Similar with human adipocytes overexpressing MRTF-A, adipocytes isolated from Ob/Ob mice had reduced expression of IRS-1 and PPARγ, as well as impaired insulin response. Together, these data demonstrate that MRTF-A negatively influences insulin sensitivity and the expression of key targets in fully mature human adipocytes. This suggests that MRTF-A is poised to exert a transcriptional response in hypertrophic adipocytes, contributing to adipocyte dysfunction and insulin resistance.
    MeSH term(s) Adipocytes/metabolism ; Animals ; Cells, Cultured ; Down-Regulation ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance ; Mice, Obese ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Up-Regulation
    Chemical Substances Insulin ; MRTFA protein, human ; PPAR gamma ; Trans-Activators ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.08.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: A two-state capital asset pricing model with unobserval states

    Hansson, Björn / Nilsson, Birger

    (Working paper / Department of Economics, Lund University ; 2004,28)

    2004  

    Institution Nationalekonomiska Institutionen
    Author's details Birger Nilsson and Björn Hansson
    Series title Working paper / Department of Economics, Lund University ; 2004,28
    Keywords CAPM ; Risikoprämie ; Statistische Verteilung
    Language English
    Size Online-Ressource, 23 p., text, ill
    Edition [Elektronische Ressource]
    Publisher Dep. of Economics
    Publishing place Lund
    Document type Book ; Online
    Note IMD-Felder maschinell generiert ; nBibliography
    Database ECONomics Information System

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  7. Article: Book-to-market and size effects

    Asgharian, Hossein / Hansson, Björn

    The European journal of finance Vol. 16, No. 1/2 , p. 119-136

    compensations for risks or outcomes of market inefficiencies?

    2010  Volume 16, Issue 1, Page(s) 119–136

    Author's details Hossein Asgharian and Björn Hansson
    Keywords Marktwert ; Kapitaleinkommen ; CAPM ; Portfolio-Management ; USA
    Language English
    Size graph. Darst.
    Publisher Routledge
    Publishing place London
    Document type Article
    ZDB-ID 1282412-4
    Database ECONomics Information System

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  8. Article: The components of the illiquidity premium

    Hagströmer, Björn / Hansson, Björn / Nilsson, Birger

    Journal of banking & finance Vol. 37, No. 11 , p. 4476-4487

    an empirical analysis of US stocks ; 1927 - 2010

    2013  Volume 37, Issue 11, Page(s) 4476–4487

    Author's details Björn Hagströmer; Björn Hansson; Birger Nilsson
    Keywords Illiquidity level premium ; Illiquidity risk premium ; Conditional LCAPM ; Effective tick
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 752905-3 ; 1460614-8
    ISSN 1872-6372 ; 0378-4266
    ISSN (online) 1872-6372
    ISSN 0378-4266
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  9. Article: Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells

    Hansson, Björn / Medina, Anya / Fryklund, Claes / Fex, Malin / Stenkula, Karin G

    Biochemical and biophysical research communications. 2016 May 27, v. 474

    2016  

    Abstract: Serotonin (5-HT) is a biogenic monoamine that functions both as a neurotransmitter and a circulating hormone. Recently, the metabolic effects of 5-HT have gained interest and peripheral 5-HT has been proposed to influence lipid metabolism in various ways. ...

    Abstract Serotonin (5-HT) is a biogenic monoamine that functions both as a neurotransmitter and a circulating hormone. Recently, the metabolic effects of 5-HT have gained interest and peripheral 5-HT has been proposed to influence lipid metabolism in various ways. Here, we investigated the metabolic effects of 5-HT in isolated, primary rat adipose cells. Incubation with 5-HT suppressed β-adrenergically stimulated glycerol release and decreased phosphorylation of protein kinase A (PKA)-dependent substrates, hormone sensitive lipase (Ser563) and perilipin (Ser522). The inhibitory effect of 5-HT on lipolysis enhanced the anti-lipolytic effect of insulin, but sustained in the presence of phosphodiesterase inhibitors, OPC3911 and isobuthylmethylxanthine (IBMX). The relative expression of 5-HT1A, -2B and -4 receptor class family were significantly higher in adipose tissue compared to adipose cells, whereas 5-HT1D, -2A and -7 were highly expressed in isolated adipose cells. Similar to 5-HT, 5-HT2 receptor agonists reduced lipolysis while 5-HT1 receptor agonists rather decreased non-stimulated and insulin-stimulated glucose uptake. Together, these data provide evidence of a direct effect of 5-HT on adipose cells, where 5-HT suppresses lipolysis and glucose uptake, which could contribute to altered systemic lipid- and glucose metabolism.
    Keywords adipose tissue ; agonists ; cAMP-dependent protein kinase ; carboxylic ester hydrolases ; glucose ; glycerol ; insulin ; lipolysis ; neurotransmitters ; protein phosphorylation ; rats ; serotonin
    Language English
    Dates of publication 2016-0527
    Size p. 357-363.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2016.04.110
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Adipose cell size changes are associated with a drastic actin remodeling.

    Hansson, Björn / Morén, Björn / Fryklund, Claes / Vliex, Lars / Wasserstrom, Sebastian / Albinsson, Sebastian / Berger, Karin / Stenkula, Karin G

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 12941

    Abstract: Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies ... ...

    Abstract Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies have shown that enlarged, hypertrophic adipocytes are less responsive to insulin, and that adipocyte size could serve as a predictor for the development of type 2 diabetes. In the present study, we demonstrate that changes in adipocyte size correlate with a drastic remodeling of the actin cytoskeleton. Expansion of primary adipocytes following 2 weeks of high-fat diet (HFD)-feeding in C57BL6/J mice was associated with a drastic increase in filamentous (F)-actin as assessed by fluorescence microscopy, increased Rho-kinase activity, and changed expression of actin-regulating proteins, favoring actin polymerization. At the same time, increased cell size was associated with impaired insulin response, while the interaction between the cytoskeletal scaffolding protein IQGAP1 and insulin receptor substrate (IRS)-1 remained intact. Reversed feeding from HFD to chow restored cell size, insulin response, expression of actin-regulatory proteins and decreased the amount of F-actin filaments. Together, we report a drastic cytoskeletal remodeling during adipocyte expansion, a process which could contribute to deteriorating adipocyte function.
    MeSH term(s) Actin Cytoskeleton/pathology ; Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis ; Animals ; Diet, High-Fat/adverse effects ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/metabolism ; Obesity/pathology
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-49418-0
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