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  1. Book ; Online: Deliberation, Representation, Equity: Research Approaches, Tools and Algorithms for Participatory Processes

    Danielson, Mats / Hansson, Karin / Ekenberg, Love / Cars, Göran / al, et

    2017  

    Keywords elicitation ; social policy ; e-democracy ; communication design ; participatory decision making ; decision theory ; risk analysis and computer sciences ; participatory art ; Public interaction ; urban planning ; participatory democracy
    Size 1 electronic resource (380 pages)
    Publisher Open Book Publishers
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021043556
    ISBN 9781783743032 ; 1783743034
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Deliberation, Representation, Equity : Research Approaches, Tools and Algorithms for Participatory Processes

    Ekenberg, Love / Hansson, Karin / Danielson, Mats / Cars, Göran / In de Betou, Lars / Buurman, Joost / Ernst, Manilla / Fasth, Tobias / Forsberg, Rebecca / Gustafsson Fürst, Johanna / Hansson, Karin E. / Karlström, Petter / Kivunike, Florence N. / Larsson, Aron / Liljenberg, Thomas / Liljenström, Hans / Marincea, Adina / Mihai, Adriana / Riabacke, Mona /
    Sauter, Willmar / Svedin, Uno / Thompson, Michael / Tusubira, F.F. / Verhagen, Harko / Wrange, Måns

    2017  

    Keywords Social issues & processes ; Political science & theory ; Political structures: democracy ; social policy ; urban planning ; participatory decision making ; communication design ; decision theory ; risk analysis and computer sciences ; e-democracy ; participatory art ; public interaction ; participatory democracy ; elicitation ; Multiple-criteria decision analysis
    Size 1 electronic resource (380 pages)
    Publisher Open Book Publishers
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021027928
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Identification of the major rabbit and guinea pig semen coagulum proteins and description of the diversity of the REST gene locus in the mammalian clade Glires.

    Lundwall, Åke / Persson, Margareta / Hansson, Karin / Jonsson, Magnus

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0240607

    Abstract: The seminal vesicle secretions of guinea pig and rabbit were analyzed for semen coagulum proteins. Using SDS-PAGE we discovered a previously not fully recognized semen coagulum protein, Svp5, in the guinea pig and a single predominant component, SVP200, ... ...

    Abstract The seminal vesicle secretions of guinea pig and rabbit were analyzed for semen coagulum proteins. Using SDS-PAGE we discovered a previously not fully recognized semen coagulum protein, Svp5, in the guinea pig and a single predominant component, SVP200, in the rabbit. Potential genes of these proteins were identified in genome databases by their homology with human and murine genes. The structure of their fullength transcripts was determined using seminal vesicle cDNA and sequencing primers based on genomic sequences. Homology searching indicated that both Svp5 and SVP200 were synthesized from composite genes that were the result of merger between two genes showing homology with human SEMG2 and PI3. For a deeper understanding of the evolution of the genes, we retrieved and analyzed genome sequences from the REST gene loci, encompassing genes of semen coagulum proteins and related rapidly evolving seminal vesicle-transcribed genes, of 14 rodents and 2 lagomorphs. The analysis showed that rodents of the suborders myomorpha, hystricomorpha, and castorimorpha had unique sets of REST genes, whereas sciuromorpha seemed to be lacking such genes. It also indicated a closer relationship between myomorpha and castorimorpha than to rodents of the two other analyzed suborders. In the lagomorph species, the pika appeared to be devoid of REST genes, whereas the rabbit had a single expressed REST gene, SVP200, and two pseudogenes. The structural similarity of semen coagulum proteins in rabbit and hystricomph species suggests that they are closely related. This was also supported by other similarities at their REST gene loci, e.g. the finding of a PI3-like gene in the rabbit that also had features in common with caltrin2 of hystricomorph rodents. The homologies indicate that hystricomorpha may have separated from myomorpha and castorimorpha before the separation of hystricomorpha from lagomorpha.
    MeSH term(s) Amino Acid Sequence/genetics ; Animals ; Electrophoresis, Polyacrylamide Gel ; Gene Expression/genetics ; Genome/genetics ; Guinea Pigs ; Humans ; Mammals/genetics ; Mice ; Pseudogenes/genetics ; Rabbits ; Repressor Proteins/genetics ; Rodentia ; Semen/metabolism ; Seminal Plasma Proteins/genetics ; Seminal Vesicle Secretory Proteins/genetics
    Chemical Substances RE1-silencing transcription factor ; Repressor Proteins ; Seminal Plasma Proteins ; Seminal Vesicle Secretory Proteins
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0240607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficacy of mecobalamin (vitamin B

    Sall Hansson, Karin / Lindqvist, Gunilla / Stening, Kent / Fohlman, Jan / Wojanowski, Anna / Ponten, Moa / Jensen, Karin / Gerdle, Björn / Elmqvist, Carina

    BMJ open

    2023  Volume 13, Issue 3, Page(s) e066987

    Abstract: Introduction: Fibromyalgia causes long-term pain. It affects at least 2% of the population, the majority being women. In addition, extended symptoms corresponding to vitamin B: Methods and analysis: The study is a randomised, placebo-controlled, ... ...

    Abstract Introduction: Fibromyalgia causes long-term pain. It affects at least 2% of the population, the majority being women. In addition, extended symptoms corresponding to vitamin B
    Methods and analysis: The study is a randomised, placebo-controlled, single-blind, clinical trial with two parallel groups which are administered mecobalamin (vitamin B
    Ethics and dissemination: The protocol for the study is approved by the local ethical committee at Linkoping (EPM; 2018/294-31, appendices 2019-00347 and 2020-04482). The principles of the Helsinki Declaration are followed regarding oral and written consent to participate, confidentiality and the possibility to withdraw participation from the study at any time. The results will primarily be communicated through peer-reviewed journals and conferences.
    Trial registration number: NCT05008042.
    MeSH term(s) Humans ; Female ; Male ; Fibromyalgia/complications ; Fibromyalgia/drug therapy ; Single-Blind Method ; Pain ; Vitamins ; Treatment Outcome ; Double-Blind Method ; Randomized Controlled Trials as Topic
    Chemical Substances mecobalamin (BR1SN1JS2W) ; Vitamins
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-066987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: USP7 controls NGN3 stability and pancreatic endocrine lineage development.

    Manea, Teodora / Nelson, Jessica Kristine / Garrone, Cristina Maria / Hansson, Karin / Evans, Ian / Behrens, Axel / Sancho, Rocio

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2457

    Abstract: Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks endocrine progenitors and ... ...

    Abstract Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks endocrine progenitors and drives beta-cell differentiation. Here we screen for binding partners of NGN3 and identify the deubiquitylating enzyme USP7 as a key regulator of NGN3 stability. Mechanistically, USP7 interacts with, deubiquitinates and stabilizes NGN3. In vivo, conditional knockout of Usp7 in the mouse embryonic pancreas causes a dramatic reduction in islet formation and hyperglycemia in adult mice, due to impaired NGN3-mediated endocrine specification during pancreatic development. Furthermore, pharmacological inhibition of USP7 during endocrine specification in human iPSC models of beta-cell differentiation decreases NGN3 expressing progenitor cell numbers and impairs beta cell differentiation. Thus, the USP7-NGN3 axis is an essential mechanism for driving endocrine development and beta-cell differentiation, which can be therapeutically exploited.
    MeSH term(s) Adult ; Animals ; Humans ; Mice ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation ; Islets of Langerhans/metabolism ; Pancreas/metabolism ; Transcription Factors/metabolism ; Ubiquitin-Specific Peptidase 7/genetics ; Ubiquitin-Specific Peptidase 7/metabolism
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Transcription Factors ; Ubiquitin-Specific Peptidase 7 (EC 3.4.19.12) ; USP7 protein, human (EC 3.4.19.12) ; NEUROG3 protein, human ; Neurog3 protein, mouse
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38146-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Simultaneous determination of folate and methotrexate metabolites in serum by LC-MS/MS during high-dose methotrexate therapy

    Hansson, Karin / Orrling, Henrik / Blomgren, Anders / Isaksson, Anders / Schliamser, Gloria / Heldrup, Jesper / Pronk, Cornelis Jan

    Journal of chromatography. 2021 Dec. 01, v. 1186

    2021  

    Abstract: High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). ... ...

    Abstract High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). Despite FA rescue, many patients suffer severe toxicity. The pharmacokinetics of FA rescue have not been sufficiently studied. However, optimization of FA rescue could potentially increase anti-tumor effects, whilst decreasing organ toxicity. Here, we describe our efforts to establish and optimize a liquid chromatography tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination of five essential components of the folate cycle, as well as MTX and its two metabolites. The method was applied to 6 individual patients receiving HDMTX, with 3 or 4 measurements for each patient. The method allows analysis of samples that were initially frozen. This notion, together with the test results in the 6 pilot patients, shows the feasibility of this method to study MTX and FA pharmacokinetics during HDMTX treatment. The method has the potential to optimize HDMTX and FA rescue treatment in individual patients.
    Keywords blood serum ; brain ; folic acid ; liquid chromatography ; lymphocytic leukemia ; lymphoma ; metabolites ; methotrexate ; osteosarcoma ; patients ; pharmacokinetics ; therapeutics ; toxicity
    Language English
    Dates of publication 2021-1201
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2021.123007
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Anti-tumor effects of rigosertib in high-risk neuroblastoma.

    Radke, Katarzyna / Hansson, Karin / Sjölund, Jonas / Wolska, Magdalena / Karlsson, Jenny / Esfandyari, Javanshir / Pietras, Kristian / Aaltonen, Kristina / Gisselsson, David / Bexell, Daniel

    Translational oncology

    2021  Volume 14, Issue 8, Page(s) 101149

    Abstract: High-risk neuroblastoma has a poor prognosis despite intense treatment, demonstrating the need for new therapeutic strategies. Here we evaluated the effects of rigosertib (ON-01910.Na) in preclinical models of high-risk neuroblastoma. Among several ... ...

    Abstract High-risk neuroblastoma has a poor prognosis despite intense treatment, demonstrating the need for new therapeutic strategies. Here we evaluated the effects of rigosertib (ON-01910.Na) in preclinical models of high-risk neuroblastoma. Among several hundred cancer cell lines representing 24 tumor types, neuroblastoma was the most sensitive to rigosertib. Treatment of MYCN-amplified neuroblastoma organoids resulted in organoid disintegration, decreased cell viability, and increased apoptotic cell death. Neuroblastoma response to rigosertib involved G2M cell cycle arrest and decreased phosphorylation of AKT (Ser473) and ERK1/2 (Thr202/Tyr204). Rigosertib delayed tumor growth and prolonged survival of mice carrying neuroblastoma MYCN-amplified PDX tumors (median survival: 31 days, treated; 22 days, vehicle) accompanied with increased apoptosis in treated tumors. We further identified vincristine and rigosertib as a potential promising drug combination treatment. Our results show that rigosertib might be a useful therapeutic agent for MYCN-amplified neuroblastomas, especially in combination with existing agents.
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2021.101149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Simultaneous determination of folate and methotrexate metabolites in serum by LC-MS/MS during high-dose methotrexate therapy.

    Hansson, Karin / Orrling, Henrik / Blomgren, Anders / Isaksson, Anders / Schliamser, Gloria / Heldrup, Jesper / Pronk, Cornelis Jan

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2021  Volume 1186, Page(s) 123007

    Abstract: High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). ... ...

    Abstract High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). Despite FA rescue, many patients suffer severe toxicity. The pharmacokinetics of FA rescue have not been sufficiently studied. However, optimization of FA rescue could potentially increase anti-tumor effects, whilst decreasing organ toxicity. Here, we describe our efforts to establish and optimize a liquid chromatography tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination of five essential components of the folate cycle, as well as MTX and its two metabolites. The method was applied to 6 individual patients receiving HDMTX, with 3 or 4 measurements for each patient. The method allows analysis of samples that were initially frozen. This notion, together with the test results in the 6 pilot patients, shows the feasibility of this method to study MTX and FA pharmacokinetics during HDMTX treatment. The method has the potential to optimize HDMTX and FA rescue treatment in individual patients.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/blood ; Chromatography, Liquid/methods ; Dose-Response Relationship, Drug ; Folic Acid/administration & dosage ; Folic Acid/blood ; Humans ; Methotrexate/administration & dosage ; Methotrexate/blood ; Pilot Projects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Tandem Mass Spectrometry/methods
    Chemical Substances Antineoplastic Agents ; Folic Acid (935E97BOY8) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-11-10
    Publishing country Netherlands
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2021.123007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Reputation, inequality and meeting techniques

    Hansson, Karin / Karlström, Petter / Larsson, Aron / Verhagen, Harko

    Computational and mathematical organization theory Vol. 20, No. 2 , p. 155-175

    visualising user hierarchy to support collaboration

    2014  Volume 20, Issue 2, Page(s) 155–175

    Author's details Karin Hansson; Petter Karlström; Aron Larsson; Harko Verhagen
    Keywords E-Participation ; Reputation ; Inequality ; Collaboration
    Language English
    Size Ill., graph. Darst.
    Publisher Springer Science + Business Media
    Publishing place Norwell, Mass. [u.a.]
    Document type Article
    ZDB-ID 1305080-1 ; 2012211-1
    ISSN 1572-9346 ; 1381-298X
    ISSN (online) 1572-9346
    ISSN 1381-298X
    Database ECONomics Information System

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  10. Book ; Thesis: The autonomous and the passive progressive in 20th-century Irish

    Hansson, Karin

    (Acta Universitatis Upsaliensis ; Studia Celtica Upsaliensia ; 5)

    2004  

    Author's details Karin Hansson
    Series title Acta Universitatis Upsaliensis
    Studia Celtica Upsaliensia ; 5
    Language English
    Size 175 S
    Publisher Univ
    Publishing place Uppsala
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Uppsala, 2004
    Note Literaturverz. S. 163 - 166
    ISBN 9155458998 ; 9789155458997
    Database Former special subject collection: coastal and deep sea fishing

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