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  1. Article ; Online: Promoting Technology and Virtual Visits to Improve Older Adult Mental Health in the Face of COVID-19.

    Gould, Christine E / Hantke, Nathan C

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2020  Volume 28, Issue 8, Page(s) 889–890

    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/psychology ; Humans ; Mental Health Services ; Pandemics ; Patient Acceptance of Health Care ; Pneumonia, Viral/psychology ; Practice Guidelines as Topic ; SARS-CoV-2 ; Telemedicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Letter
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2020.05.011
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  2. Article ; Online: Examining Older Adult Cognitive Status in the Time of COVID-19.

    Hantke, Nathan C / Gould, Christine

    Journal of the American Geriatrics Society

    2020  Volume 68, Issue 7, Page(s) 1387–1389

    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Cognition ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Telecommunications
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.16514
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  5. Article ; Online: Promoting Technology and Virtual Visits to Improve Older Adult Mental Health in the Face of COVID-19

    Gould, Christine E. / Hantke, Nathan C.

    The American Journal of Geriatric Psychiatry

    2020  Volume 28, Issue 8, Page(s) 889–890

    Keywords Geriatrics and Gerontology ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2020.05.011
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  6. Article ; Online: Examining Older Adult Cognitive Status in the Time of COVID ‐19

    Hantke, Nathan C. / Gould, Christine

    Journal of the American Geriatrics Society

    2020  Volume 68, Issue 7, Page(s) 1387–1389

    Keywords Geriatrics and Gerontology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.16514
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Preparing the Next Generation of Academic Researchers During the Pandemic: Lessons from a National Mental Health Research Postdoctoral Fellowship.

    Hantke, Nathan C / Samarina, Viktoriya / Hallmayer, Joachim / Anker, Lauren / O'Hara, Ruth / Beaudreau, Sherry A

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2022  Volume 46, Issue 4, Page(s) 466–469

    Abstract: Objective: The COVID-19 pandemic has severely disrupted all aspects of academic medicine, including post-doctoral research fellowship training. The current survey examined ways in which research fellows across 28 U.S. nationally diverse sites have been ... ...

    Abstract Objective: The COVID-19 pandemic has severely disrupted all aspects of academic medicine, including post-doctoral research fellowship training. The current survey examined ways in which research fellows across 28 U.S. nationally diverse sites have been impacted.
    Methods: Survey participants included 62 M.D. and Ph.D. post-doctoral fellows and 27 local fellowship center directors within the Veterans Affairs (VA) Advanced Fellowship in Mental Illness Research and Treatment (MIRT), a national fellowship program tasked to develop academic clinician researchers within the field of mental health. Survey questions focused on productivity and challenges experienced by fellows during the pandemic.
    Results: Half of fellows reported working entirely off-site during the COVID-19 pandemic. All fellows reported some level of disruption in productivity during the pandemic; 73% reported a disruption in data collection, 69% reported decreased scholarly output, 41% reported disruption in grant writing, and 73% reported disruption in ability to provide clinical care. Yet, the majority of fellows (66%) reported not having to change their research goals, pivoting to telehealth-based data collection, and employing extant data for research projects and peer-reviewed publications.
    Conclusions: The results of the fellow and director surveys highlight the associated disruption of the COVID-19 pandemic on fellowship-related activities and parallel ingenuity of programs to continue conducting research and clinical services in a modified fashion. While many research goals continued unabated, the findings suggest alterations in data collection methodology and a focus on using extant data, which may have a residual influence on future early career research grant applications.
    MeSH term(s) COVID-19/epidemiology ; Curriculum ; Fellowships and Scholarships ; Humans ; Mental Health ; Pandemics ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-022-01613-4
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  8. Article ; Online: Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology.

    Hantke, Nathan C / Kaye, Jeffrey / Mattek, Nora / Wu, Chao-Yi / Dodge, Hiroko H / Beattie, Zachary / Woltjer, Randy

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286812

    Abstract: Background: Outcome measures available for use in Alzheimer's disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing and computing ... ...

    Abstract Background: Outcome measures available for use in Alzheimer's disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing and computing generated "digital biomarkers" (DBs) have been shown to be ecologically valid and to improve efficiency of clinical trials. However, DBs have not been assessed for their relationship to AD neuropathology.
    Objectives: The goal of the current study is to perform an exploratory examination of possible associations between DBs and AD neuropathology in an initially cognitively intact community-based cohort.
    Methods: Participants included in this study were ≥65 years of age, living independently, of average health for age, and followed until death. Algorithms, run on the continuously-collected passive sensor data, generated daily metrics for each DB: cognitive function, mobility, socialization, and sleep. Fixed postmortem brains were evaluated for neurofibrillary tangles (NFTs) and neuritic plaque (NP) pathology and staged by Braak and CERAD systems in the context of the "ABC" assessment of AD-associated changes.
    Results: The analysis included a total of 41 participants (M±SD age at death = 92.2±5.1 years). The four DBs showed consistent patterns relative to both Braak stage and NP score severity. Greater NP severity was correlated with the DB composite and reduced walking speed. Braak stage was associated with reduced computer use time and increased total time in bed.
    Discussion: This study provides the first data showing correlations between DBs and neuropathological markers in an aging cohort. The findings suggest continuous, home-based DBs may hold potential to serve as behavioral proxies that index neurodegenerative processes.
    MeSH term(s) Humans ; Aged, 80 and over ; Alzheimer Disease/pathology ; Brain/pathology ; Neurofibrillary Tangles/pathology ; Cognition ; Aging/pathology ; Plaque, Amyloid/pathology
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286812
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  9. Article ; Online: Insights about personality traits and cognitive performance and decline in adults 51-59 Years old from the Wisconsin longitudinal study.

    Beaudreau, Sherry A / Gould, Christine E / Hantke, Nathan C / Kramer, Abigail O / Suresh, Madhuvanthi / Jo, Booil / Fairchild, Jennifer K

    International journal of geriatric psychiatry

    2022  Volume 38, Issue 1, Page(s) e5852

    Abstract: Objectives: To delineate midlife personality dimensions of early cognitive change in an age-homogenous sample of U.S. older adults.: Design: Longitudinal study of 6133 adults from the Wisconsin Longitudinal Study (WLS).: Measures: Middle-aged ... ...

    Abstract Objectives: To delineate midlife personality dimensions of early cognitive change in an age-homogenous sample of U.S. older adults.
    Design: Longitudinal study of 6133 adults from the Wisconsin Longitudinal Study (WLS).
    Measures: Middle-aged participants (mean age = 53.2; SD = 0.6) from the WLS completed the 'Big-5' personality assessment in 1992. Mixed effects models examined whether midlife personality traits were associated with change in cognitive performance from participant's mid-60s (2004-2005) to early 70s (2011). The cognitive battery assessed abstract reasoning (AR), category fluency (CF), working memory (WM), and delayed verbal memory (DVM). Models adjusted for sex, education, and subjective health.
    Results: High Openness was a significant predictor of change in AR, CF, and DVM. These cognitive outcomes declined less among those with high Openness, but the effect sizes for Openness by time were small (R
    Conclusions: None of the midlife personality traits were uniformly associated with change in cognitive performance in early older adulthood. High midlife Openness had the most noteworthy impact on cognition. Interventions designed to target Openness have potential to elevate and maintain a higher threshold of performance in some cognitive domains, but may only have a small impact on cognitive change.
    MeSH term(s) Humans ; Aged ; Middle Aged ; Longitudinal Studies ; Personality ; Cognition ; Wisconsin
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5852
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  10. Article ; Online: Depression, health comorbidities, cognitive symptoms and their functional impact: Not just a geriatric problem.

    Schüssler-Fiorenza Rose, Sophia Miryam / Bott, Nicholas T / Heinemeyer, Erin E / Hantke, Nathan C / Gould, Christine E / Hirst, Rayna B / Jordan, Joshua T / Beaudreau, Sherry A / O'Hara, Ruth

    Journal of psychiatric research

    2021  Volume 139, Page(s) 185–192

    Abstract: Objective: To compare the prevalence of cognitive symptoms and their functional impact by age group accounting for depression and number of other health conditions.: Methods: We analyzed data from the 2011 Behavioral Risk Factor Surveillance System, ... ...

    Abstract Objective: To compare the prevalence of cognitive symptoms and their functional impact by age group accounting for depression and number of other health conditions.
    Methods: We analyzed data from the 2011 Behavioral Risk Factor Surveillance System, a population-based, cross-sectional telephone survey of US adults. Twenty-one US states asked participants (n = 131, 273) about cognitive symptoms (worsening confusion or memory loss in the past year) and their functional impact (interference with activities and need for assistance). We analyzed the association between age, depression history and cognitive symptoms and their functional impact using logistic regression and adjusted for demographic characteristics and other health condition count.
    Results: There was a significant interaction between age and depression (p < 0.0001). In adults reporting depression, the adjusted odds of cognitive symptoms in younger age groups (<75 years) were comparable or greater to those in the oldest age group (≥75 years) with a peak in the middle age (45-54 years) group (OR 1.9 (95% Confidence Interval: 1.4-2.5). In adults without depression, adults <75 years had a significantly lower adjusted odds of cognitive symptoms compared to the oldest age group with the exception of the middle-aged group where the difference was not statistically significant. Over half of adults under age 65 with depression reported that cognitive symptoms interfered with life activities compared to 35.7% of adults ≥65 years.
    Conclusions: Cognitive symptoms are not universally higher in older adults; middle-aged adults are also particularly vulnerable. Given the adverse functional impact associated with cognitive symptoms in younger adults, clinicians should assess cognitive symptoms and their functional impact in adults of all ages and consider treatments that impact both cognition and functional domains.
    MeSH term(s) Aged ; Behavioral Risk Factor Surveillance System ; Cognition ; Cross-Sectional Studies ; Depression/epidemiology ; Humans ; Middle Aged ; Prevalence
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2021.05.013
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