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Article ; Online: Differences in glucose homeostasis and islet injury among diverse mice strains post acute pancreatitis.

Du, Deren / Wang, Xinwu / Zuo, Han / Li, Lianglan / Hao, Haibin / Hou, Gaohuan / Gu, Ping / Shao, Jiaqing / Tong, Zhihui

Biochemical and biophysical research communications

2024 Volume 708, Page(s) 149780

Abstract: Diverse animal models have been used to study postpancreatitis diabetes mellitus (PPDM) development; however, no study has yet conducted a comparative analysis of the specific differences in glucose homeostasis and islet injury between these models. ... ...

Abstract	Diverse animal models have been used to study postpancreatitis diabetes mellitus (PPDM) development; however, no study has yet conducted a comparative analysis of the specific differences in glucose homeostasis and islet injury between these models. Therefore, we investigated the differences in pancreatic islet injury and glucose homeostasis among diverse strains in a cerulein-induced acute pancreatitis (AP) model to determine the appropriate animal model for PPDM. BALB/cJ, C57BL/6J, C57BL/6 N, and FVB/NJ mice were administered cerulein to induce AP. Serum amylase levels, pancreatic acinar injury, blood glucose homeostasis, islet function, and islet injury were measured and analyzed. All strains exhibited elevated amylase secretion post pancreatitis, and BALB/cJ, C57BL/6J, and C57BL/6 N mice exhibited sex-related differences. All strains exhibited pancreatic acinar injury post pancreatitis but mostly recovered within 15 days. Overall, glucose homeostasis remained balanced post pancreatitis in all strains compared to that in the control groups, except in FVB/NJ male and female mice, which exhibited an imbalance in glucose homeostasis on day 7 post pancreatitis. All the strains, except BALB/cJ mice, exhibited a decline in Homeostasis model assessment-β(HOMA-β) values post pancreatitis, with significant decrease in C57BL/6J females and FVB/NJ males. Islet size decreased post pancreatitis in all strains, except BALB/cJ mice. Pancreatic islet insulin secretion levels significantly decreased in male FVB/NJ mice post pancreatitis onset and did not recover within 15 days. Therefore, FVB/NJ male mice are a useful model for studying PPDM.
MeSH term(s)	Mice ; Male ; Female ; Animals ; Pancreatitis/chemically induced ; Ceruletide/toxicity ; Acute Disease ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Blood Glucose ; Homeostasis ; Amylases
Chemical Substances	Ceruletide (888Y08971B) ; Blood Glucose ; Amylases (EC 3.2.1.-)
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149780
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Article: Clinical and Genomic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates from Acute Pancreatitis with Infection in China.

Lin, Hong / Wang, Peng / Lu, Yingying / Gao, Kun / Hao, Haibin / Tong, Zhihui / Li, Weiqin

Clinical laboratory

2023 Volume 69, Issue 7

Abstract: Background: The aim of the study was to provide a clinical treatment reference for acute pancreatitis (AP) with infection, we analyzed the clinical and genomic characteristic of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from AP with ... ...

Abstract	Background: The aim of the study was to provide a clinical treatment reference for acute pancreatitis (AP) with infection, we analyzed the clinical and genomic characteristic of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from AP with infection in China. Methods: Our clinical database was retrospectively analyzed with focus on the carbapenem-resistant characteristics among AP with infection in our Intensive Care Unit (ICU). Whole-genome sequencing (WGS) was used to analyze the antibiotic resistance gene, and antimicrobial susceptibility testing (AST) was performed to study the relevant phenotype in vitro. The CRISPR-Cas9 system was used to verify the relevant phenotype. Results: Based on 2,211 AST data of 627 AP patients with infection, CRKP had the highest proportion among carbapenem-resistant Enterobacteriaceae (CRE), at 37.8% for imipenem and 45.3% for meropenem. WGS revealed key β-lactamase genes, specifically blaCTX-M-15, blaCTX-M-65, blaKPC-2, blaLAP-2, blaNDM-5, blaTEM-181, blaOXA-1, and blaSHV. A total of 31.3% of CRKP were NDM-5-KPC-2-producing strains, and NDM-5-producing CRKP was resistant to imipenem/meropenem combined with avibactam, with an MIC of 512 mg/L. In addition, after knocking out blaKPC-2 and blaNDM-5, NDM-5-producing and KPC-2-producing CRKP had the same resistance level to imipenem/ meropenem. Conclusions: We first provided key insights into the clinical and genomic characteristic of CRKP in AP with infection and then made it clear that NDM-5 and KPC-2 had the same resistance level to carbapenems.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; China ; Drug Resistance, Bacterial/genetics ; Genomics ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Pancreatitis/drug therapy ; Pancreatitis/microbiology ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.221017
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Article ; Online: Metformin as Anti-Aging Therapy: Is It for Everyone?

Soukas, Alexander A / Hao, Haibin / Wu, Lianfeng

Trends in endocrinology and metabolism: TEM

2019 Volume 30, Issue 10, Page(s) 745–755

Abstract: Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans. ...

Abstract	Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans. In spite of its widespread use, the mechanisms by which metformin exerts favorable effects on aging remain largely unknown. Further, not all individuals prescribed metformin derive the same benefit and some develop side effects. Before metformin finds its way to mainstay therapy for anti-aging, a more granular understanding of the effects of the drug in humans is needed. This review provides an overview of recent findings from metformin studies in aging and longevity and discusses the use of metformin to combat aging and aging-related diseases.
MeSH term(s)	Aging/drug effects ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Lysosomes/drug effects ; Lysosomes/metabolism ; Metformin/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Precision Medicine/methods
Chemical Substances	Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2019.07.015
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Article: Conformation-Stabilized Amorphous Nanocoating for Rational Design of Long-Term Thermostable Viral Vaccines

Zhang, Ying / Hao, Haibin / Lin, Jiake / Ma, Zaiqiang / Li, Huixin / Nie, Zihao / Cui, Yihao / Guo, Zhengxi / Zhang, Yaqin / Wang, Xiaoyu / Tang, Ruikang

ACS applied materials & interfaces. 2022 Aug. 26, v. 14, no. 35

2022

Abstract: Despite the great potency of vaccines to combat infectious diseases, their global use is hindered by a lack of thermostability, which leads to a constant need for cold-chain storage. Here, aiming at long-term thermostability and eliminating cold-chain ... ...

Abstract	Despite the great potency of vaccines to combat infectious diseases, their global use is hindered by a lack of thermostability, which leads to a constant need for cold-chain storage. Here, aiming at long-term thermostability and eliminating cold-chain requirements of bioactive vaccines, we propose that efforts should focus on tailoring the conformational stability of vaccines. Accordingly, we design a nanocoating composed of histidine (His)-coordinated amorphous Zn and 2-methylimidazolate complex (His-aZn-mIM) on single nanoparticles of viral vaccines to introduce intramolecular coordinated linkage between viruses and the nanocoatings. The coordinated nanocoating enhances the rigidity of proteins and preserves the vaccine’s activity. Importantly, integrating His into the original Zn–N coordinative environment symbiotically reinforces its tolerance to biological and hydrothermal solutions, resulting in the augmented thermostability following the Hofmeister effect. Thus, even after storage of His-aZn-mIM encapsulated Human adenovirus type 5 (Ad5@His-aZn-mIM) at 25 °C for 90 d, the potency loss of the coated Ad5 is less than 10%, while the native Ad5 becomes 100% ineffective within one month. Such a nanocoating gains thermostability by forming an ultrastable hydration shell, which prevents viral proteins from unfolding under the attack of hydration ions, providing a conformational stabilizer upon heat exposure. Our findings represent an easy-access biomimetic platform to address the long-term vaccine storage without the requirement of a cold chain.
Keywords	Human mastadenovirus C ; biomimetics ; cold chain ; heat ; histidine ; nanoparticles ; stabilizers ; thermal stability ; vaccines
Language	English
Dates of publication	2022-0826
Size	p. 39873-39884.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.2c12065
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses.

Li, Huixin / Xu, Yanpeng / Wang, Yang / Cui, Yihao / Lin, Jiake / Zhou, Yuemin / Tang, Shuling / Zhang, Ying / Hao, Haibin / Nie, Zihao / Wang, Xiaoyu / Tang, Ruikang

Nature communications

2023 Volume 14, Issue 1, Page(s) 4658

Abstract: Material-based tactics have attracted extensive attention in driving the functional evolution of organisms. In aiming to design steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecium caudatum (Para), single- ... ...

Abstract	Material-based tactics have attracted extensive attention in driving the functional evolution of organisms. In aiming to design steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecium caudatum (Para), single-celled microorganisms, with a semiartificial and specific virus-scavenging organelle (VSO). Fe
MeSH term(s)	Viruses ; Hydroxyl Radical ; Peroxidase ; Peroxidases ; Antibodies, Viral
Chemical Substances	Hydroxyl Radical (3352-57-6) ; Peroxidase (EC 1.11.1.7) ; Peroxidases (EC 1.11.1.-) ; Antibodies, Viral
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40397-5
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Article ; Online: Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel.

Hao, Haibin / Wu, Shipo / Lin, Jiake / Zheng, Zitong / Zhou, Yuemin / Zhang, Ying / Guo, Qiang / Tian, Fengchao / Zhao, Mengsu / Chen, Yi / Xu, Xurong / Hou, Lihua / Wang, Xiaoyu / Tang, Ruikang

Nature biomedical engineering

2023 Volume 7, Issue 7, Page(s) 928–942

Abstract: The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited ... ...

Abstract	The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provided mice with effective protection against a lethal viral challenge. The hydrogel prevented the escape of the viral particles and upregulated pattern recognition receptors that activated innate antiviral immunity. The local inflammatory niche facilitated the engulfment of the virus by immune cells infiltrating the hydrogel, the processing and cross-presentation of antigens and the expansion of germinal centre B cells and induced robust antigen-specific adaptive responses and immune memory. Inflammatory immune niches entrapping live viruses may facilitate the rapid development of safe and efficacious vaccines.
MeSH term(s)	Animals ; Mice ; Zika Virus ; Hydrogels ; Antibodies, Viral ; Immunization ; Vaccination ; Zika Virus Infection/prevention & control
Chemical Substances	Hydrogels ; Antibodies, Viral
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-023-01014-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis.

Ye, Huajun / Hao, Haibin / Wang, Jincheng / Chen, Renpin / Huang, Zhiming

OncoTargets and therapy

2017 Volume 10, Page(s) 3685–3696

Abstract: We sought to systematically evaluate the diagnostic and prognostic value of miR-203 in patients with colorectal cancer. To explore the diagnostic performance of miR-203, eligible studies were identified from biomedical databases. Based on these results, ... ...

Abstract	We sought to systematically evaluate the diagnostic and prognostic value of miR-203 in patients with colorectal cancer. To explore the diagnostic performance of miR-203, eligible studies were identified from biomedical databases. Based on these results, 11 studies were pooled and included in this meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratios of miR-203 were 0.83 (95% confidence interval, CI: 0.78-0.86), 0.80 (95% CI: 0.77-0.83), and 19.27 (95% CI: 7.23-51.36) for the diagnosis of colorectal cancer. The area under the curve for miR-203 for diagnosing colorectal cancer was 0.89. Patients with higher expression of tissue miR-203 had poor overall survival (pooled hazard ratio: 1.63; 95% CI: 1.03-2.57,
Language	English
Publishing date	2017-07-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S134252
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Article ; Online: Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans.

Shi, Chongli / Wang, Chen / Zeng, Lingjun / Peng, Yi / Li, Yeyong / Hao, Haibin / Zheng, Yang / Chen, Chao / Chen, Haibo / Zhang, Jin / Xiang, Minghui / Huang, Yuan / Li, Hui

Journal of hazardous materials

2022 Volume 446, Page(s) 130643

Abstract: Triphenyl phosphate (TPHP) is a widely used aryl organophosphate flame retardant (OPFR) that has attracted attention due to its frequent detection in the environment and living organisms. To date, the reproductive toxicity of TPHP has been investigated ... ...

Abstract	Triphenyl phosphate (TPHP) is a widely used aryl organophosphate flame retardant (OPFR) that has attracted attention due to its frequent detection in the environment and living organisms. To date, the reproductive toxicity of TPHP has been investigated in organisms, but its molecular mechanisms are not fully understood. Caenorhabditis elegans (C. elegans) is the ideal animal for the study of reproductive toxicity following environmental pollutants, with short generation times, intact reproductive structures, and hermaphroditic fertilization. This study aimed to explore the reproductive dysfunction and molecular mechanisms induced by TPHP exposure in C. elegans. Specifically, exposure to TPHP resulted in a reduction in the number of eggs laid and developing embryos in utero, an increase in the number of apoptotic gonadal cells, and germ cell cycle arrest. The JNK signaling pathway is a potential pathway inducing reproductive toxicity following TPHP exposure based on transcriptome sequencing (RNA-seq). Moreover, TPHP exposure induced down-regulation of vhp-1 and kgb-2 gene transcription levels, and the knockout of vhp-1 and kgb-2 in the mutant strains exhibited more severe toxicity in apoptotic gonad cells, embryos, and eggs developing in utero, suggesting that vhp-1 and kgb-2 genes play a crucial role in TPHP-induced reproductive toxicity. Our data provide convergent evidence showing that TPHP exposure results in reproductive dysfunction through the JNK signaling pathway and improve our understanding of the ecotoxicity and toxicological mechanisms of aryl-OPFRs.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; MAP Kinase Signaling System ; Organophosphates/toxicity ; Flame Retardants/toxicity ; Flame Retardants/metabolism
Chemical Substances	triphenyl phosphate (YZE19Z66EA) ; Organophosphates ; Flame Retardants
Language	English
Publishing date	2022-12-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130643
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Article ; Online: Conformation-Stabilized Amorphous Nanocoating for Rational Design of Long-Term Thermostable Viral Vaccines.

Zhang, Ying / Hao, Haibin / Lin, Jiake / Ma, Zaiqiang / Li, Huixin / Nie, Zihao / Cui, Yihao / Guo, Zhengxi / Zhang, Yaqin / Wang, Xiaoyu / Tang, Ruikang

ACS applied materials & interfaces

2022 Volume 14, Issue 35, Page(s) 39873–39884

Abstract	Despite the great potency of vaccines to combat infectious diseases, their global use is hindered by a lack of thermostability, which leads to a constant need for cold-chain storage. Here, aiming at long-term thermostability and eliminating cold-chain requirements of bioactive vaccines, we propose that efforts should focus on tailoring the conformational stability of vaccines. Accordingly, we design a nanocoating composed of histidine (His)-coordinated amorphous Zn and 2-methylimidazolate complex (His-aZn-mIM) on single nanoparticles of viral vaccines to introduce intramolecular coordinated linkage between viruses and the nanocoatings. The coordinated nanocoating enhances the rigidity of proteins and preserves the vaccine's activity. Importantly, integrating His into the original Zn-N coordinative environment symbiotically reinforces its tolerance to biological and hydrothermal solutions, resulting in the augmented thermostability following the Hofmeister effect. Thus, even after storage of His-aZn-mIM encapsulated Human adenovirus type 5 (Ad5@His-aZn-mIM) at 25 °C for 90 d, the potency loss of the coated Ad5 is less than 10%, while the native Ad5 becomes 100% ineffective within one month. Such a nanocoating gains thermostability by forming an ultrastable hydration shell, which prevents viral proteins from unfolding under the attack of hydration ions, providing a conformational stabilizer upon heat exposure. Our findings represent an easy-access biomimetic platform to address the long-term vaccine storage without the requirement of a cold chain.
MeSH term(s)	Adenoviruses, Human ; Excipients ; Humans ; Molecular Conformation ; Refrigeration ; Viral Vaccines
Chemical Substances	Excipients ; Viral Vaccines
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c12065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biomineralization State of Viruses and Their Biological Potential.

Wang, Xiaoyu / Liu, Xueyao / Xiao, Yun / Hao, Haibin / Zhang, Ying / Tang, Ruikang

Chemistry (Weinheim an der Bergstrasse, Germany)

2018 Volume 24, Issue 45, Page(s) 11518–11529

Abstract: In nature, viruses can realize self-mineralization under metal-ion-abundant conditions. Interestingly, the mineralized state is a transition state of the virus when the host is not available. Mammalian viruses that share the similar chemical properties ... ...

Abstract	In nature, viruses can realize self-mineralization under metal-ion-abundant conditions. Interestingly, the mineralized state is a transition state of the virus when the host is not available. Mammalian viruses that share the similar chemical properties also stand a chance of transformation into a mineralized state. In this review, we focus on the possibility of mammalian viruses to undergo mineralization under a physiological environment and the development of biomineralized-based virus engineering. We will introduce the effect of biomineralization on the physiochemical or biological properties of viruses and we will discuss the relationship between mineral composition and biological potentials. The new biological prospects of mineralized-state viruses, including bypassing biological barriers, protection, and virus-host recognition, will provide new insight for the biosecurity and prevention of viral infection. With respect to vaccines, the mineralized state can modulate the immune recognition, change the immunization route, and elevate the vaccine efficacy. Together, these findings of the mineralized state of the virus may lead to a new understanding of virus biology, application, and prevention.
MeSH term(s)	Animals ; Humans ; Minerals/chemistry ; Vaccines ; Viral Vaccines/chemistry ; Viral Vaccines/immunology ; Viruses
Chemical Substances	Minerals ; Vaccines ; Viral Vaccines
Language	English
Publishing date	2018-06-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201705936
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