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  1. AU="Hao, Lei"
  2. AU="Ferreira, Letícia de Castro Martins"
  3. AU="Piattelli, P"
  4. AU=Shi Xiaoming
  5. AU="Khalid, G"
  6. AU=Marinella M A
  7. AU="Šolc, Jaroslav"
  8. AU="Feng, M."
  9. AU="Zaveri, Jatin"
  10. AU="Dohnalova, Lenka"
  11. AU="Lynn, A M"
  12. AU="Green, Manfred S" AU="Green, Manfred S"
  13. AU="Albers, Gesa"
  14. AU="Armbrecht, Linda"
  15. AU="Celentano, Angelica"
  16. AU="Vargo, John A"
  17. AU="Zhu, Zhiqiang"
  18. AU="Schreiber, Emil"
  19. AU="Gravel, Jocelyn"
  20. AU="Wall, Patrick"
  21. AU="Crandall, Wallace V"
  22. AU="Lamontagne, Steven J"
  23. AU="Lum, Krystal K"
  24. AU="Peschke, Robert"
  25. AU="Kaliappan, Abinaya"
  26. AU="Ford, Gregory"
  27. AU="Ahmad Kassim, Affifah Saadah"
  28. AU=Scharfenberger Angela
  29. AU="Zhang, J A"
  30. AU="Ramírez-Rangel, Pamela"
  31. AU="Omar, Michael"
  32. AU="Flores-Campos, Rocío"
  33. AU="Pandit, Jayvardhan"
  34. AU="Peter M. Visscher"
  35. AU=Martn-Begu Nieves
  36. AU="Kiang, David"
  37. AU="Helal, Shaaban R"
  38. AU=Meltzer H Y
  39. AU="Gambhir, Prakash S"
  40. AU="El-Sayed, Saad A."
  41. AU="Hena Das"

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  1. Buch ; Online: Zigzag dice lattice ribbons

    Hao, Lei

    Distinct edge morphologies and structure-spectrum correspondences

    2023  

    Abstract: Ribbons of two-dimensional lattices have properties depending sensitively on the morphology of the two edges. For regular ribbons with two parallel straight edges, the atomic chains terminating the two edges may have more than one choices for a general ... ...

    Abstract Ribbons of two-dimensional lattices have properties depending sensitively on the morphology of the two edges. For regular ribbons with two parallel straight edges, the atomic chains terminating the two edges may have more than one choices for a general edge orientation. We enumerate the possible choices for zigzag dice lattice ribbons, which are regular ribbons of the dice lattice with edges parallel to a zigzag direction, and explore the relation between the edge morphologies and their electronic spectra. A formula is introduced to count the number of distinct edge termination morphologies for the regular ribbons, which gives 18 distinct edge termination morphologies for the zigzag dice lattice ribbons. For the pure dice model, because the equivalence of the two rim sublattices, the numerical spectra of the zigzag ribbons show qualitative degeneracies among the different edge termination morphologies. For the symmetrically biased dice model, we see a one-to-one correspondence between the 18 edge termination morphologies and their electronic spectra, when both the zero-energy flat bands and the dispersive or nonzero-energy in-gap states are considered. We analytically study several interesting features in the electronic spectra, including the number and wave functions of the zero-energy flat bands, and the analytical spectrum of novel in-gap states. The in-gap states of the zigzag dice lattice ribbons both exhibit interesting similarities and show salient differences when compared to the spectra of the zigzag ribbons of the honeycomb lattice.

    Comment: 20 pages, 10 figures
    Schlagwörter Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
    Thema/Rubrik (Code) 530
    Erscheinungsdatum 2023-04-26
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    Dokumenttyp Buch ; Online
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  2. Buch ; Online: One-dimensional flat bands and Dirac cones in narrow zigzag dice lattice ribbons

    Hao, Lei

    2023  

    Abstract: We show that four narrow zigzag dice lattice ribbons, which have the minimal widths among their separate categories, constitute a unique collection of systems to study physics related to one-dimensional Dirac cones and flat bands. In zero magnetic field, ...

    Abstract We show that four narrow zigzag dice lattice ribbons, which have the minimal widths among their separate categories, constitute a unique collection of systems to study physics related to one-dimensional Dirac cones and flat bands. In zero magnetic field, all three combinations, including only Dirac cones, only flat bands, coexisting Dirac cones and flat bands, are realized in the low-energy band structures of one or two of the four ribbons. In particular, we identify flat bands and Dirac cones corresponding to the edge states of wide ribbons. In a perpendicular magnetic field that gives half a flux quantum per elementary rhombus, two of the four minimal ribbons have fully pinched spectrum, and dynamical evolutions from initially localized wave packets always lead to compact Aharonov-Bohm (AB) cages. The experimental realizations of these narrow zigzag dice lattice ribbons, and the opportunities of exploring novel single-body and many-body physics therein are discussed.

    Comment: 21 pages, 6 figures
    Schlagwörter Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
    Thema/Rubrik (Code) 190
    Erscheinungsdatum 2023-04-26
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    Dokumenttyp Buch ; Online
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  3. Buch ; Online: Valley-contrasting interband transitions and excitons in symmetrically biased dice model

    Hao, Lei

    2023  

    Abstract: We study the exciton states in the symmetrically biased dice model, the electronic structures of which have an isolated flat band between two dispersive bands. At 1/3 or 2/3 filling, the model describes a two-dimensional semiconductor with the band edge ... ...

    Abstract We study the exciton states in the symmetrically biased dice model, the electronic structures of which have an isolated flat band between two dispersive bands. At 1/3 or 2/3 filling, the model describes a two-dimensional semiconductor with the band edge at two degenerate valleys. Because of qualitative changes in the eigenvectors resulting from the bias term, the interband transition between the flat band and a dispersive band is valley contrasting under circularly polarized light. In terms of an effective-mass model and a realistic electron-hole interaction, we numerically calculate the spectrum and wave functions of the intravalley excitons, which are treated as Wannier-Mott excitons. We also discuss the fine structures of the exciton spectrum induced by the intravalley and intervalley exchange interactions. The symmetrically biased dice model thereby proves to be a new platform for valley-contrasting optoelectronics.

    Comment: 12 pages, 5 figures
    Schlagwörter Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
    Thema/Rubrik (Code) 530
    Erscheinungsdatum 2023-04-26
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    Dokumenttyp Buch ; Online
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  4. Artikel ; Online: Brain structural plasticity in rats subjected to early binocular enucleation characterized by high resolution anatomical magnetic resonance imaging and diffusion tensor imaging

    Xuxia Wang / Fuchun Lin / Yan Kang / Hao Lei

    Magnetic Resonance Letters, Vol 3, Iss 1, Pp 14-

    2023  Band 21

    Abstract: Visual deprivation leads to structural neuroplasticity in the blind subjects, including gray matter (GM) and white matter (WM) atrophy and alterations in structural connectivity. The rat model of binocular enucleation (BE) is a frequently used animal ... ...

    Abstract Visual deprivation leads to structural neuroplasticity in the blind subjects, including gray matter (GM) and white matter (WM) atrophy and alterations in structural connectivity. The rat model of binocular enucleation (BE) is a frequently used animal model for studying brain plasticity induced by early blindness. Yet few neuroimaging studies have been performed on this model to investigate whether or not the BE rats have image phenotypes similar to or comparable to, those observed in the early blind subjects. The current study aimed to assess brain structural plasticity in BE rats using anatomical magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The results demonstrated that early BE at postnatal day 4 (P4) caused almost complete degeneration of optic nerve (ON) and optic chiasma (OCH), atrophy in a number of visual and non-visual structures, including optic tract (OT), dorsal lateral geniculate nucleus (DLG) and corpus callosum (CC). The BE rats also exhibited impairments of WM microstructural integrity in the OT, and reduction of structural connectivity between the normal-appearing visual cortex (VC) and somatosensory/motor cortices at 4 months of age, likely as manifestations of deafferentation-induced maldevelopment. The structural neuroplasticity in BE rats observable to structural MRI parallels largely with what has been reported in blind subjects, suggesting that longitudinal neuroimaging studies on animal models of sensory deprivation can provide insights into how the brain changes its wiring and function during development/adaption in response to the lack of sensory stimuli.
    Schlagwörter Blindness ; Brain ; Structural plasticity ; MRI ; Rats ; Physical and theoretical chemistry ; QD450-801 ; Analytical chemistry ; QD71-142
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag KeAi Communications Co. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Extraction and characterization of polysaccharides from Schisandra sphenanthera fruit by Lactobacillus plantarum CICC 23121-assisted fermentation.

    Wang, Qian / Hao, Lei / Zhang, Anqi / Zhao, Hongfei / Zhang, Bolin

    International journal of biological macromolecules

    2024  Band 259, Heft Pt 1, Seite(n) 129135

    Abstract: Improving the yield of polysaccharides extracted from Schisandra sphenanthera is a major challenge in traditional Chinese medicinal plants. In this study, we investigated the potential of Lactobacillus plantarum CICC 23121-assisted fermentation as an ... ...

    Abstract Improving the yield of polysaccharides extracted from Schisandra sphenanthera is a major challenge in traditional Chinese medicinal plants. In this study, we investigated the potential of Lactobacillus plantarum CICC 23121-assisted fermentation as an extraction tool for S. sphenanthera polysaccharides (SSP). We observed that 11.12 ± 0.28 % of polysaccharides were extracted from S. sphenanthera using strain CICC 23121 -assisted fermentation (F-SSP), which was 53.38 % higher than that using hot water extraction (NF-SSP). The optimized parameters were a fermentation time of 15.5 h, substrate concentration of 4 %, and inoculum size of 3 %. Lactic acid produced by strain CICC 23121 increased the release of intracellular polysaccharides by breaking down cell walls. Compared to NF-SSP, F-SSP contained higher and lower total carbohydrate and protein contents, respectively, and its monosaccharide composition was the same as that of NF-SSP; however, their distributions were different. F-SSP had a higher molecular weight, better aqueous stability, and looser surface morphology, and strain CICC 23121-assisted fermentation did not change the molecular structure of SSP. Both NF-SSP and F-SSP showed the potential to regulate human intestinal microflora. Our findings revealed that strain CICC 23121-assisted fermentation is an efficient method for extracting S. sphenanthera polysaccharides without affecting their physicochemical and bioactive properties.
    Mesh-Begriff(e) Humans ; Lactobacillus plantarum ; Schisandra/chemistry ; Fermentation ; Fruit/chemistry ; Polysaccharides/chemistry
    Chemische Substanzen Polysaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.129135
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  6. Artikel ; Online: Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease

    Jiahui Hu / Hao Lei / Leiling Liu / Danyan Xu

    Frontiers in Cell and Developmental Biology, Vol

    2022  Band 10

    Abstract: Calcified aortic valve disease (CAVD) is the most common valvular cardiovascular disease with increasing incidence and mortality. The primary treatment for CAVD is surgical or transcatheter aortic valve replacement and there remains a lack of effective ... ...

    Abstract Calcified aortic valve disease (CAVD) is the most common valvular cardiovascular disease with increasing incidence and mortality. The primary treatment for CAVD is surgical or transcatheter aortic valve replacement and there remains a lack of effective drug treatment. Recently, lipoprotein (a) (Lp(a)) has been considered to play a crucial role in CAVD pathophysiology. Multiple studies have shown that Lp(a) represents an independent risk factor for CAVD. Moreover, Lp(a) mediates the occurrence and development of CAVD by affecting aortic valve endothelial dysfunction, indirectly promoting foam cell formation through oxidized phospholipids (OxPL), inflammation, oxidative stress, and directly promotes valve calcification. However, there is a lack of clinical trials with Lp(a) reduction as a primary endpoint. This review aims to explore the relationship and mechanism between Lp(a) and CAVD, and focuses on the current drugs that can be used as potential therapeutic targets for CAVD.
    Schlagwörter calcific aortic valve disease ; lipoprotein (a) ; apolipoprotein ; oxidized phospholipid ; autotaxin ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Personalized Item Recommendation Algorithm for Outdoor Sports

    Hao Lei / Xinru Shan / Liwei Jiang

    Computational Intelligence and Neuroscience, Vol

    2022  Band 2022

    Abstract: With the rapid development of China’s economy, people are eager for an effective way to relieve work pressure and strengthen their health at the same time. Outdoor sport is one of the best choices for people. However, the amount of recommended data on ... ...

    Abstract With the rapid development of China’s economy, people are eager for an effective way to relieve work pressure and strengthen their health at the same time. Outdoor sport is one of the best choices for people. However, the amount of recommended data on the network is very large. As a result, when people understand outdoor sports through the network, they cannot effectively obtain the information they want. This is the problem of “information overload,” and personalized recommendation system can effectively alleviate this problem. In order to effectively recommend outdoor sports to users, a useful attempt was made in the personalized recommendation system for outdoor sports in this paper. The specific work of this paper is as follows: firstly, the current situation of outdoor sports in China was summarized, and the related technologies of the recommendation system were studied, including user modeling technology, recommendation target modeling technology, and recommendation algorithm. In order to obtain better recommendation effect, this paper proposes to mix user-based collaborative filtering recommendation algorithm, project-based collaborative filtering recommendation algorithm, and content-based recommendation algorithm. The hybrid algorithm adopts the way of feature expansion and weighted combination. Firstly, the hybrid model (model 1) of user-based collaborative filtering recommendation and content-based recommendation is obtained. Secondly, the hybrid model (model 2) based on project collaborative filtering recommendation and content-based recommendation was obtained. Finally, model 1 and model 2 were combined together to get a hybrid model with better final recommendation effect. For the common cold start problem in the recommendation system, the system adopts content-based recommendation algorithm to solve it.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  8. Artikel: Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population.

    Cai, Hao-Lei / Tong, Yu-Ling

    World journal of clinical cases

    2021  Band 9, Heft 31, Seite(n) 9431–9439

    Abstract: Background: Atrophic gastritis is a precancerous lesion of the stomach. It has been reported that pepsinogen (PG) can reflect the morphology and function of the gastric mucosa, and it is therefore used as a marker for the early diagnosis of atrophic ... ...

    Abstract Background: Atrophic gastritis is a precancerous lesion of the stomach. It has been reported that pepsinogen (PG) can reflect the morphology and function of the gastric mucosa, and it is therefore used as a marker for the early diagnosis of atrophic gastritis.
    Aim: To evaluate the diagnostic value of serum PG for degree of gastric mucosal atrophy in asymptomatic Chinese upon physical examination.
    Methods: Medical data were collected from subjects who underwent transnasal gastroscopy between October 2016 and October 2018. For each study subject, serum PG levels and presence of
    Results: A total of 2256 subjects were enrolled and 1922 cases were finally included in the study. Based on the OLGA grading system, the levels of PGI were slightly decreased, while those of PGII were slightly increased. The PGI/PGII ratio (PGR) was reduced with increasing atrophy. The association between PG and OLGA grading was higher compared with that between PG and the OLGIM grading system. Compared with the OLGA-0 group, a statistically significant difference was observed in the mean age of OLGA-I, III, and IV groups (
    Conclusion: Serum PG levels may represent a non-invasive screening marker for gastric mucosal atrophy in asymptomatic subjects.
    Sprache Englisch
    Erscheinungsdatum 2021-11-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i31.9431
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  9. Artikel: Unlocking the Promise of Decellularized Pancreatic Tissue: A Novel Approach to Support Angiogenesis in Engineered Tissue.

    Hao, Lei / Khajouei, Fariba / Rodriguez, Jaselin / Kim, Soojin / Lee, Eun Jung A

    Bioengineering (Basel, Switzerland)

    2024  Band 11, Heft 2

    Abstract: Advancements in regenerative medicine have highlighted the potential of decellularized extracellular matrix (ECM) as a scaffold for organ bioengineering. Although the potential of ECM in major organ systems is well-recognized, studies focusing on the ... ...

    Abstract Advancements in regenerative medicine have highlighted the potential of decellularized extracellular matrix (ECM) as a scaffold for organ bioengineering. Although the potential of ECM in major organ systems is well-recognized, studies focusing on the angiogenic effects of pancreatic ECM are limited. This study investigates the capabilities of pancreatic ECM, particularly its role in promoting angiogenesis. Using a Triton-X-100 solution, porcine pancreas was successfully decellularized, resulting in a significant reduction in DNA content (97.1% removal) while preserving key pancreatic ECM components. A three-dimensional ECM hydrogel was then created from this decellularized tissue and used for cell culture. Biocompatibility tests demonstrated enhanced adhesion and proliferation of mouse embryonic stem cell-derived endothelial cells (mES-ECs) and human umbilical vein endothelial cells (HUVECs) in this hydrogel compared to conventional scaffolds. The angiogenic potential was evaluated through tube formation assays, wherein the cells showed superior tube formation capabilities in ECM hydrogel compared to rat tail collagen. The RT-PCR analysis further confirmed the upregulation of pro-angiogenic genes in HUVECs cultured within the ECM hydrogel. Specifically, HUVECs cultured in the ECM hydrogel exhibited a significant upregulation in the expression of MMP2, VEGF and PAR-1, compared to those cultured in collagen hydrogel or in a monolayer condition. The identification of ECM proteins, specifically PRSS2 and Decorin, further supports the efficacy of pancreatic ECM hydrogel as an angiogenic scaffold. These findings highlight the therapeutic promise of pancreatic ECM hydrogel as a candidate for vascularized tissue engineering application.
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11020183
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  10. Artikel ; Online: Construction and verification of a histone deacetylases-related prognostic signature model for colon cancer.

    Hao, Lei / Lu, Weiqi / Wu, Jianyu / Chen, Yuzhong / Xu, Dongni / Wang, Peizong

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 8983

    Abstract: Histone deacetylases (HDACs) contribute significantly to the initiation, progression, and prognosis of colorectal adenocarcinoma (COAD). Additionally, HDACs regulate the tumor microenvironment, immune escape, and tumor stem cells, and are closely linked ... ...

    Abstract Histone deacetylases (HDACs) contribute significantly to the initiation, progression, and prognosis of colorectal adenocarcinoma (COAD). Additionally, HDACs regulate the tumor microenvironment, immune escape, and tumor stem cells, and are closely linked to COAD prognosis. We developed a prognostic model for COAD that incorporates HDACs to evaluate their specific roles. The COAD dataset containing clinical and mutation data was collected using the TCGA and GEO databases to obtain genes associated with HDAC. LASSO analysis and univariate and multivariate Cox regression analysis were used to determine the presence of prognostic genes. Multivariate Cox analysis was also used to determine risk scores for HDAC-related features. Furthermore, genomic alterations, immune infiltration, and drug response were compared between high- and low-risk groups. Cellular experiments validated the potential regulatory role of BRD3 on COAD proliferation, migration, and apoptosis. The median risk scores, calculated based on the characteristics, demonstrated a more significant prognostic improvement in patients in the low-risk group. Furthermore, HDAC-related features were identified as important independent prognostic factors for patients with COAD. Additionally, genomic mutation status, immune infiltration, and function, as well as response to immunotherapy and chemotherapy, were found to be associated with risk scores. Subgroup analyses indicate that anti-PD-1 therapy may be beneficial for patients in the low-risk group. Additionally, a decrease in risk score was associated with a decrease in immune infiltration. Finally, HCT116 and HT29 cells exhibited inhibition of BRD3 gene proliferation and migration, as well as promotion of apoptosis. In patients with COAD, HDAC-related characteristics may be useful in predicting survival and selecting treatment.
    Mesh-Begriff(e) Humans ; Prognosis ; Colonic Neoplasms/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Genes, Regulator ; Adenocarcinoma ; Histone Deacetylases/genetics ; Tumor Microenvironment/genetics
    Chemische Substanzen Histone Deacetylases (EC 3.5.1.98)
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59724-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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