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  1. Article ; Online: Magnetically anisotropic hydrogels for tissue engineering.

    Hao, Lili / Mao, Hongli

    Biomaterials science

    2023  Volume 11, Issue 19, Page(s) 6384–6402

    Abstract: Many soft tissues of the human body possess hierarchically anisotropic structures, exhibiting orientation-specific mechanical properties and biological functionality. Hydrogels have been proposed as promising scaffold materials for tissue engineering ... ...

    Abstract Many soft tissues of the human body possess hierarchically anisotropic structures, exhibiting orientation-specific mechanical properties and biological functionality. Hydrogels have been proposed as promising scaffold materials for tissue engineering applications due to their water-rich composition, excellent biocompatibility, and tunable physico-chemical properties. However, conventional hydrogels with homogeneous structures often exhibit isotropic properties that differ from those of biological tissues, limiting their further application. Recently, magnetically anisotropic hydrogels containing long-range ordered magneto-structures have attracted widespread interest owing to their highly controllable assembly strategy, rapid magnetic responsiveness and remote spatiotemporal regulation. In this review, we summarize the latest progress of magnetically anisotropic hydrogels for tissue engineering. The fabrication strategy of magnetically anisotropic hydrogels from magnetic nanofillers with different dimensions is systemically introduced. Then, the effects of magnetically anisotropic cues on the physicochemical properties of hydrogels and the cellular biological behavior are discussed. And the applications of magnetically anisotropic hydrogels in the engineering of different tissues are emphasized. Finally, the current challenges and the future perspectives for magnetically anisotropic hydrogels are presented.
    MeSH term(s) Humans ; Tissue Engineering/methods ; Hydrogels/chemistry
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm00744h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Plant RNA processing: discovery, mechanism and function.

    Hao, Lili / Chen, Ming / Li, Dayong / Lijavetzky, Diego

    Frontiers in plant science

    2024  Volume 15, Page(s) 1359415

    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1359415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A stackelberg game-based robust optimization for user-side energy storage configuration and power pricing

    Ding, Yixing / Xu, Qingshan / Hao, Lili / Xia, Yuanxing

    Energy. 2023 July 13, p.128429-

    2023  , Page(s) 128429–

    Abstract: With the rapid development of demand-side management, battery energy storage is considered to be an important way to promote the flexibility of the user-side system. In this paper, a Stackelberg game (SG) based robust optimization for user-side energy ... ...

    Abstract With the rapid development of demand-side management, battery energy storage is considered to be an important way to promote the flexibility of the user-side system. In this paper, a Stackelberg game (SG) based robust optimization for user-side energy storage configuration and basic electricity price decisions is proposed. Firstly, this paper put forward a two-stage energy management framework considering the interactive relationship between the supplier-side system and the user-side system. Secondly, based on the two-part electricity price mechanism, a bi-level optimal sizing of user-side energy storage is established in which robust dispatching is considered to deal with the uncertainty of renewable energy. Thus, a three-layer optimization model of “pricing on the power supply side–basic scenario configuration on the user side–worst-case scenario scheduling on the user side” is formulated. Through relaxing the state variables of energy storage in the configuration and scheduling models and combining Karush-Kuhn-Tucher conditions, the user-side model is transformed into a single-layer problem. A distributed algorithm based on the method of bisection is used to solve the two-stage SG problem. The simulation results demonstrate the basic electricity price and energy storage configuration suggestions and prove the superiority of the proposed method.
    Keywords algorithms ; batteries ; electricity costs ; energy ; game theory ; models ; renewable energy sources ; uncertainty ; User-side energy storage configuration ; Stackelberg game ; Distributed robust optimization ; Power pricing
    Language English
    Dates of publication 2023-0713
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2023.128429
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  4. Article: Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants.

    Zhang, Jianmei / Yang, Suhong / Zhang, Yan / Liu, Fei / Hao, Lili / Han, Lianshu

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1343977

    Abstract: Background: This study aimed to characterize the clinical phenotype and genetic variations in patients with Kallmann syndrome (KS).: Methods: This study involved the collection and analysis of clinical data from an individual with sporadic KS. ... ...

    Abstract Background: This study aimed to characterize the clinical phenotype and genetic variations in patients with Kallmann syndrome (KS).
    Methods: This study involved the collection and analysis of clinical data from an individual with sporadic KS. Following this, peripheral blood samples were obtained from the patient and his parents. Genomic deoxyribonucleic acid was extracted and subjected to whole-exome sequencing and genomic copy number variation (CNV) detection. Finally, Sanger sequencing was performed to validate the suspected pathogenic variants.
    Results: Whole-exome sequencing confirmed that the child carried both the
    Conclusion: Bioinformatics analysis shows that the IL17RD protein undergoing Gly701Ser mutation and is speculated to be phosphorylated and modified, thereby disrupting fibroblast growth factor signaling. This study also suggested that the CPEB4 might play a crucial role in the key signaling process affecting olfactory bulb morphogenesis. Overall, the findings of this study broaden the gene expression profile of KS-related pathogenic genes. This offers a new avenue for exploring the pathogenic mechanism of KS and provides valuable insights for precise clinical diagnosis and treatment strategies for this condition.
    MeSH term(s) Female ; Child ; Humans ; Kallmann Syndrome/genetics ; DNA Copy Number Variations ; Mutation ; Phenotype ; Mothers ; Receptors, Interleukin/genetics ; RNA-Binding Proteins/genetics
    Chemical Substances IL17RD protein, human ; Receptors, Interleukin ; CPEB4 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1343977
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  5. Article ; Online: Confocal Scanning Laser Ophthalmoscopy to Image Retinal Ganglion Cells in Real-Time.

    Hao, Lili / Liu, Yuan / Liu, Xiangxiang / Lee, Richard K

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2708, Page(s) 115–121

    Abstract: Real-time imaging of retinal ganglion cells (RGCs) provides an opportunity for detailed investigation of retinal development, disease mechanisms, and the evaluation of interventions affecting ocular structures. Here we use a transgenic model to describe ... ...

    Abstract Real-time imaging of retinal ganglion cells (RGCs) provides an opportunity for detailed investigation of retinal development, disease mechanisms, and the evaluation of interventions affecting ocular structures. Here we use a transgenic model to describe a step-by-step protocol for visualizing RGC survival in real-time by using confocal scanning laser ophthalmoscopy (cSLO).
    MeSH term(s) Retinal Ganglion Cells ; Ophthalmoscopy/methods ; Diagnostic Imaging ; Lasers
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3409-7_12
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  6. Article: High prevalence of spotted fever group rickettsiae in ticks collected from yaks (

    Lin, Baoshan / Ta, Yin / Hao, Lili

    Frontiers in microbiology

    2022  Volume 13, Page(s) 968793

    Abstract: Tick-borne diseases have become a global health concern in recent decades. Spotted fever group (SFG) rickettsiae have been recognized as important pathogens of human tick-borne diseases worldwide. In this study, ...

    Abstract Tick-borne diseases have become a global health concern in recent decades. Spotted fever group (SFG) rickettsiae have been recognized as important pathogens of human tick-borne diseases worldwide. In this study,
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.968793
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  7. Article ; Online: A new lactone from mangrove endophytic fungus Aspergillus sp. GXNU-A9

    Zhang, Wenxiu / Hao, Lili / Qin, Xiaoya / Huang, Jiguo / Yang, Ruiyun / Li, Jun / Huang, Xishan

    Natural Product Research. 2023 Feb. 1, v. 37, no. 3 p.417-423

    2023  

    Abstract: A new lactone, asperlactone A (1), and four known lactone derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR- ... ...

    Abstract A new lactone, asperlactone A (1), and four known lactone derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1–5 were evaluated for their anti-inflammatory activities against nitric oxide (NO) production, and compounds 1–5 showed moderate inhibitory activities with IC₅₀ values ranging from 15.87 to 30.48 µM.
    Keywords Aspergillus ; X-ray diffraction ; electrospray ionization mass spectrometry ; endophytes ; fungi ; nitric oxide ; nuclear magnetic resonance spectroscopy ; research ; spectral analysis ; Aspergillus sp. ; mangrove endophytic fungus ; asperlactone A ; anti-inflammatory effects
    Language English
    Dates of publication 2023-0201
    Size p. 417-423.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1977298
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  8. Article ; Online: Acetyl-CoA-dependent ac

    Bai, Yujia / Zhang, Wenjie / Hao, Lili / Zhao, Yiqing / Tsai, I-Chen / Qi, Yipin / Xu, Qiong

    International immunopharmacology

    2024  Volume 133, Page(s) 112124

    Abstract: The impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated ... ...

    Abstract The impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimately affecting osteogenic differentiation. The mitochondrial dysfunction and impaired osteogenic potential upon inflammatory conditions accompanied by the reduced acetyl-CoA content, which in turn suppressed N4-acetylation (ac
    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.112124
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Investigation on the potential adverse outcome pathway of the sensitive endpoint for nephrotoxicity induced by gardenia yellow based on an integrated strategy using bioinformatics analysis and in vitro testing validation.

    Liang, Jiang / Wei, Hong-Xin / Zhou, Ying-Ying / Hao, Li-Li / Ning, Jun-Yu / Zhang, Lei

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Volume 178, Page(s) 113930

    Abstract: To explore the potential the adverse outcome pathway of Gardenia Yellow (GY)-induced sensitive endpoint for nephrotoxicity, an integrated strategy was applied in the present study. Using bioinformatic analysis, based on the constructed Protein-protein ... ...

    Abstract To explore the potential the adverse outcome pathway of Gardenia Yellow (GY)-induced sensitive endpoint for nephrotoxicity, an integrated strategy was applied in the present study. Using bioinformatic analysis, based on the constructed Protein-protein interaction networks, Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis on the core target network were performed to illustrate the potential gene targets and signal pathways. Then, the most enriched pathway was validated with Cell counting kit-8 assays and Western blot analysis in embryonic kidney epithelial 293 cell models. According to the findings, GY may interact with 321 targets related to the endpoint. The five targets on the top ranking in the PPI network were STAT3, SRC, HRAS, AKT1, EP300. Among them, PI3K/Akt was the most enriched pathway. In vitro testing showed that GY exerted a proliferative effect on the cell variability in a dose-dependent manner. GY at concentration of 1000 μg/ml and stimulation for 30 min can significantly enhance the expression of phosphorylated Akt. Thus, after the quantitative weight of evidence evaluation, Akt phosphorylation induced PI3K/Akt activation was speculated as a molecular initiating event leading to a proliferative and inflammatory response in renal tubular epithelial cells.
    MeSH term(s) Adverse Outcome Pathways ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Computational Biology ; In Vitro Techniques ; Molecular Docking Simulation
    Chemical Substances gardenia yellow (F32BA2H92Z) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.113930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 529: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Bovine kobuvirus—A comprehensive review

    Hao, Lili / Chen, Chaoxi / Bailey, Keith / Wang, Leyi

    Transboundary and emerging diseases. 2021 July, v. 68, no. 4

    2021  

    Abstract: Bovine kobuvirus (BKV) is a single‐stranded, positive sense, non‐enveloped RNA virus in genus Kobuvirus of family Picornavirus. BKV was first identified in the culture media of HeLa cell containing calf serum in 2003. Since then, BKV has been detected in ...

    Abstract Bovine kobuvirus (BKV) is a single‐stranded, positive sense, non‐enveloped RNA virus in genus Kobuvirus of family Picornavirus. BKV was first identified in the culture media of HeLa cell containing calf serum in 2003. Since then, BKV has been detected in 13 countries of four different continents, suggesting widespread in the world. Herein, we review the detection and genomic characterization of BKV in 13 countries. All studies tested bovine faecal samples for BKV. These studies provide evidence that BKV might be a causative agent for neonatal calf diarrhoea. Therefore, further efforts including animal challenge study are urgently needed to unveil the pathogenicity of BKV.
    Keywords Aichivirus B ; blood serum ; calves ; diarrhea ; etiological agents ; genomics ; human cell lines ; pathogenicity
    Language English
    Dates of publication 2021-07
    Size p. 1886-1894.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.13909
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