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Article: Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.

Lv, Mengqi / Zhou, Wanwan / Hao, Yijie / Li, Fudong / Zhang, Huafeng / Yao, Xuebiao / Shi, Yunyu / Zhang, Liang

Cell discovery

2024 Volume 10, Issue 1, Page(s) 11

Abstract: Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The ... ...

Abstract	Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The m
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-023-00634-z
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Article ; Online: Biodegradable CuMoO

Zhang, Jinzha / Peng, Liqi / Hao, Yijie / Yang, Hongna / Zhao, Wenbo / Mao, Chun

Advanced healthcare materials

2023 Volume 12, Issue 22, Page(s) e2300167

Abstract: Due to their complexity and variability, tumors need to be treated with multimodal combined therapy, which requires the development of therapeutic agents that can provide multimodal therapeutic effects. Herein, ... ...

Abstract	Due to their complexity and variability, tumors need to be treated with multimodal combined therapy, which requires the development of therapeutic agents that can provide multimodal therapeutic effects. Herein, CuMoO
MeSH term(s)	Humans ; Cell Line, Tumor ; Phototherapy ; Neoplasms/drug therapy ; Combined Modality Therapy ; Infrared Rays ; Nanoparticles/therapeutic use
Language	English
Publishing date	2023-05-31
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202300167
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Zs.A 6966: Show issues

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Article ; Online: Synergistic therapeutic effect of nanomotors triggered by Near-infrared light and acidic conditions of tumor.

Zhang, Shirong / Liu, Xuan / Hao, Yijie / Yang, Hongna / Zhao, Wenbo / Mao, Chun / Ma, Shenglin

Journal of colloid and interface science

2023 Volume 650, Issue Pt A, Page(s) 67–80

Abstract: Due to the complexity of tumors, multimodal therapy for them has always been of concern to researchers. How to design a multifunctional drug nanoplatform with cascade effect and capable of responding to specific stimuli in the tumor microenvironment is ... ...

Abstract	Due to the complexity of tumors, multimodal therapy for them has always been of concern to researchers. How to design a multifunctional drug nanoplatform with cascade effect and capable of responding to specific stimuli in the tumor microenvironment is the key to achieve efficient multimodal synergistic therapy of cancer. Here, we prepare a kind of GNRs@SiO
MeSH term(s)	Humans ; Phototherapy/methods ; Silicon Dioxide/therapeutic use ; Hydrogen Peroxide/pharmacology ; Cell Line, Tumor ; Infrared Rays ; Neoplasms/drug therapy ; Nanoparticles ; Tumor Microenvironment
Chemical Substances	cupric oxide (V1XJQ704R4) ; Silicon Dioxide (7631-86-9) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.06.120
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Article: Construction of a matchstick-shaped Au@ZnO@SiO₂–ICG Janus nanomotor for light-triggered synergistic antibacterial therapy

Liu, Xuan / Liu, Huaxiao / Zhang, Jinzha / Hao, Yijie / Yang, Hongna / Zhao, Wenbo / Mao, Chun

Biomaterials science. 2022 Sept. 27, v. 10, no. 19

2022

Abstract: The drug-resistance of bacteria poses a serious threat to public health, so the exploration of new antibacterial materials has attracted extensive attention. Here, we report Au@ZnO@SiO₂–ICG nanomotors as an antibacterial candidate. Firstly, we prepared ... ...

Abstract	The drug-resistance of bacteria poses a serious threat to public health, so the exploration of new antibacterial materials has attracted extensive attention. Here, we report Au@ZnO@SiO₂–ICG nanomotors as an antibacterial candidate. Firstly, we prepared the Janus structure Au@ZnO loaded with indocyanine green (ICG) and constructed a synergistic antibacterial platform with photothermal and photodynamic properties triggered by dual light sources. Specifically, the metal/semiconductor heterostructure of Au@ZnO has a synergistic effect under ultraviolet (UV) irradiation, which can adjust the transfer of interface electrons, so as to greatly improve the generation of cytotoxic ROS for photodynamic sterilization. The loaded ICG is an effective photosensitizer, and can induce a stronger photothermal effect in collaboration with Au under near-infrared light (NIR). In addition, the asymmetric structures of nanomotors have autonomous movement with the help of generated temperature gradient when exposed to NIR light, conducive to breaking through the bacterial membrane and improving the membrane insertion ability of antibacterial therapeutic agents. The results indicate that the prepared Au@ZnO@SiO₂–ICG nanomotors show excellent light responses and synergistic sterilization ability to Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). This study will provide a new idea for the application of metal–semiconductor nanocomposites in the treatment of bacterial infection.
Keywords	Escherichia coli ; Staphylococcus aureus ; bacterial infections ; biocompatible materials ; cytotoxicity ; drug resistance ; irradiation ; nanocomposites ; photosensitizing agents ; public health ; semiconductors ; synergism ; temperature ; therapeutics
Language	English
Dates of publication	2022-0927
Size	p. 5608-5619.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm00845a
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Article ; Online: Construction of a matchstick-shaped Au@ZnO@SiO

Liu, Xuan / Liu, Huaxiao / Zhang, Jinzha / Hao, Yijie / Yang, Hongna / Zhao, Wenbo / Mao, Chun

Biomaterials science

2022 Volume 10, Issue 19, Page(s) 5608–5619

Abstract: The drug-resistance of bacteria poses a serious threat to public health, so the exploration of new antibacterial materials has attracted extensive attention. Here, we report Au@ZnO@ ... ...

Abstract	The drug-resistance of bacteria poses a serious threat to public health, so the exploration of new antibacterial materials has attracted extensive attention. Here, we report Au@ZnO@SiO
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Indocyanine Green/chemistry ; Photochemotherapy/methods ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Reactive Oxygen Species/chemistry ; Silicon Dioxide ; Staphylococcus aureus ; Zinc Oxide/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Photosensitizing Agents ; Reactive Oxygen Species ; Silicon Dioxide (7631-86-9) ; Indocyanine Green (IX6J1063HV) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2022-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm00845a
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Article ; Online: PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation.

Fu, Gongyu / Li, Shi-Ting / Jiang, Zetan / Mao, Qiankun / Xiong, Nanchi / Li, Xiang / Hao, Yijie / Zhang, Huafeng

Acta biochimica et biophysica Sinica

2023 Volume 55, Issue 9, Page(s) 1370–1379

Abstract: Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and development. Protein lysine acetylation, which affects a variety of biological functions of proteins, plays an important role under physiological and ... ...

Abstract	Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and development. Protein lysine acetylation, which affects a variety of biological functions of proteins, plays an important role under physiological and pathological conditions. Here, through immunoprecipitation and mass spectrum data, we show that phosphoglycerate mutase 5 (PGAM5) deacetylation enhances malic enzyme 1 (ME1) metabolic enzyme activity to promote lipid synthesis and proliferation of liver cancer cells. Mechanistically, we demonstrate that the deacetylase SIRT2 mediates PGAM5 deacetylation to activate ME1 activity, leading to ME1 dephosphorylation, subsequent lipid accumulation and the proliferation of liver cancer cells. Taken together, our study establishes an important role for the SIRT2-PGAM5-ME1 axis in the proliferation of liver cancer cells, suggesting a potential innovative cancer therapy.
MeSH term(s)	Humans ; Sirtuin 2/genetics ; Sirtuin 2/metabolism ; Lipid Metabolism ; Phosphoglycerate Mutase/genetics ; Phosphoglycerate Mutase/metabolism ; Liver Neoplasms ; Cell Proliferation ; Lipids ; Acetylation ; Phosphoprotein Phosphatases/metabolism ; Mitochondrial Proteins/metabolism
Chemical Substances	Sirtuin 2 (EC 3.5.1.-) ; Phosphoglycerate Mutase (EC 5.4.2.11) ; Lipids ; SIRT2 protein, human (EC 3.5.1.-) ; PGAM5 protein, human (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Mitochondrial Proteins
Language	English
Publishing date	2023-08-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2023155
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Article ; Online: Highly Penetrable Drug-Loaded Nanomotors for Photothermal-Enhanced Ferroptosis Treatment of Tumor.

Zhang, Yawen / Zhang, Ke / Yang, Hongna / Hao, Yijie / Zhang, Jinzha / Zhao, Wenbo / Zhang, Shirong / Ma, Shenglin / Mao, Chun

ACS applied materials & interfaces

2023

Abstract: A kind of drug-loaded nanomotors with deep penetration was developed to improve the therapeutic effect of ferroptosis on tumor. The nanomotors were constructed by co-loading hemin and ferrocene (Fc) on the surface of bowl-shaped polydopamine (PDA) ... ...

Abstract	A kind of drug-loaded nanomotors with deep penetration was developed to improve the therapeutic effect of ferroptosis on tumor. The nanomotors were constructed by co-loading hemin and ferrocene (Fc) on the surface of bowl-shaped polydopamine (PDA) nanoparticles. The near-infrared response of PDA makes the nanomotor have high tumor penetration capability.
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c00297
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Article ; Online: Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis.

Liu, Xin / Wang, Xin / Yang, Qingxia / Luo, Li / Liu, Ziqin / Ren, Xiaoxue / Lei, Kai / Li, Shangru / Xie, Zonglin / Zheng, Gaomin / Zhang, Yifan / Hao, Yijie / Zhou, Qianying / Hou, Yingdong / Fang, Fei / Song, Wu / Cui, Ji / Ma, Jinping / Xie, Wenxuan /

Shen, Shunli / Tang, Ce / Peng, Sui / Yu, Jun / Kuang, Ming / Song, Xinming / Wang, Fang / Xu, Lixia

Cancer research

2024 Volume 84, Issue 8, Page(s) 1352–1371

Abstract: Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given the significance of both epithelial-mesenchymal transition (EMT) of tumor cells and the immune microenvironment in colorectal cancer liver metastasis (CRLM), the ...

Abstract	Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given the significance of both epithelial-mesenchymal transition (EMT) of tumor cells and the immune microenvironment in colorectal cancer liver metastasis (CRLM), the interplay between them could hold the key for developing improved treatment options. We employed multiomics analysis of 130 samples from 18 patients with synchronous CRLM integrated with external datasets to comprehensively evaluate the interaction between immune cells and EMT of tumor cells in liver metastasis. Single-cell RNA sequencing analysis revealed distinct distributions of nonmalignant cells between primary tumors from patients with metastatic colorectal cancer (mCRC) and non-metastatic colorectal cancer, showing that Th17 cells were predominantly enriched in the primary lesion of mCRC. TWEAK, a cytokine secreted by Th17 cells, promoted EMT by binding to receptor Fn14 on tumor cells, and the TWEAK-Fn14 interaction enhanced tumor migration and invasion. In mouse models, targeting Fn14 using CRISPR-induced knockout or lipid nanoparticle-encapsulated siRNA alleviated metastasis and prolonged survival. Mice lacking Il17a or Tnfsf12 (encoding TWEAK) exhibited fewer metastases compared with wild-type mice, while cotransfer of Th17 with tumor cells promoted liver metastasis. Higher TWEAK expression was associated with a worse prognosis in patients with colorectal cancer. In addition, CD163L1+ macrophages interacted with Th17 cells, recruiting Th17 via the CCL4-CCR5 axis. Collectively, this study unveils the role of immune cells in the EMT process and identifies TWEAK secreted by Th17 as a driver of CRLM. Significance: TWEAK secreted by Th17 cells promotes EMT by binding to Fn14 on colorectal cancer cells, suggesting that blocking the TWEAK-Fn14 interaction may be a promising therapeutic approach to inhibit liver metastasis.
MeSH term(s)	Humans ; Animals ; Mice ; Th17 Cells ; Cytokine TWEAK ; Epithelial-Mesenchymal Transition/genetics ; Prognosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Liver Neoplasms/genetics ; Liver Neoplasms/secondary ; TWEAK Receptor/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Tumor Microenvironment
Chemical Substances	Cytokine TWEAK ; TWEAK Receptor
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-23-2123
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Article ; Online: Identification of DNA methylation signatures for hepatocellular carcinoma detection and microvascular invasion prediction.

Hao, Yijie / Yang, Qingxia / He, Qiye / Hu, Huanjing / Weng, Zongpeng / Su, Zhixi / Chen, Shuling / Peng, Sui / Kuang, Ming / Chen, Zhihang / Xu, Lixia

European journal of medical research

2022 Volume 27, Issue 1, Page(s) 276

Abstract: Background and aim: Preoperative evaluation of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) is important for surgical strategy determination. We aimed to develop and establish a preoperative predictive model for MVI ... ...

Abstract	Background and aim: Preoperative evaluation of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) is important for surgical strategy determination. We aimed to develop and establish a preoperative predictive model for MVI status based on DNA methylation markers. Methods: A total of 35 HCC tissues and the matched peritumoral normal liver tissues as well as 35 corresponding HCC patients' plasma samples and 24 healthy plasma samples were used for genome-wide methylation sequencing and subsequent methylation haplotype block (MHB) analysis. Predictive models were constructed based on selected MHB markers and 3-cross validation was used. Results: We grouped 35 HCC patients into 2 categories, including the MVI- group with 17 tissue and plasma samples, and MVI + group with 18 tissue and plasma samples. We identified a tissue DNA methylation signature with an AUC of 98.0% and a circulating free DNA (cfDNA) methylation signature with an AUC of 96.0% for HCC detection. Furthermore, we established a tissue DNA methylation signature for MVI status prediction, and achieved an AUC of 85.9%. Based on the MVI status predicted by the DNA methylation signature, the recurrence-free survival (RFS) and overall survival (OS) were significantly better in the predicted MVI- group than that in the predicted MVI + group. Conclusions: In this study, we identified a cfDNA methylation signature for HCC detection and a tissue DNA methylation signature for MVI status prediction with high accuracy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/genetics ; DNA Methylation/genetics ; Liver Neoplasms/diagnosis ; Liver Neoplasms/genetics ; Cell-Free Nucleic Acids/genetics
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-022-00910-w
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Article ; Online: Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

Shu, Ying / Hao, Yijie / Feng, Junru / Liu, Haiying / Li, Shi-Ting / Feng, Jiaqian / Jiang, Zetan / Ye, Ling / Zhou, Yingli / Sun, Yuchen / Zhou, Zilong / Wei, Haoran / Gao, Ping / Zhang, Huafeng / Sun, Linchong

The EMBO journal

2022 Volume 41, Issue 23, Page(s) e111550

Abstract: Phosphoglycerate dehydrogenase (PHGDH) is a key serine biosynthesis enzyme whose aberrant expression promotes various types of tumors. Recently, PHGDH has been found to have some non-canonical functions beyond serine biosynthesis, but its specific ... ...

Abstract	Phosphoglycerate dehydrogenase (PHGDH) is a key serine biosynthesis enzyme whose aberrant expression promotes various types of tumors. Recently, PHGDH has been found to have some non-canonical functions beyond serine biosynthesis, but its specific mechanisms in tumorigenesis remain unclear. Here, we show that PHGDH localizes to the inner mitochondrial membrane and promotes the translation of mitochondrial DNA (mtDNA)-encoded proteins in liver cancer cells. Mechanistically, we demonstrate that mitochondrial PHGDH directly interacts with adenine nucleotide translocase 2 (ANT2) and then recruits mitochondrial elongation factor G2 (mtEFG2) to promote mitochondrial ribosome recycling efficiency, thereby promoting mtDNA-encoded protein expression and subsequent mitochondrial respiration. Moreover, we show that treatment with a mitochondrial translation inhibitor or depletion of mtEFG2 diminishes PHGDH-mediated tumor growth. Collectively, our findings uncover a previously unappreciated function of PHGDH in tumorigenesis acting via promotion of mitochondrial translation and bioenergetics.
MeSH term(s)	Humans ; Phosphoglycerate Dehydrogenase/genetics ; Phosphoglycerate Dehydrogenase/metabolism ; Cell Line, Tumor ; Serine ; Liver Neoplasms/genetics ; Carcinogenesis ; DNA, Mitochondrial
Chemical Substances	Phosphoglycerate Dehydrogenase (EC 1.1.1.95) ; Serine (452VLY9402) ; DNA, Mitochondrial
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2022111550
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