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  1. Article ; Online: SARS-CoV-2 Incubation Period during Omicron BA.5–Dominant Period, Japan

    Hao-Yuan Cheng / Andrei R. Akhmetzhanov / Jonathan Dushoff

    Emerging Infectious Diseases, Vol 30, Iss 1, Pp 206-

    2024  Volume 207

    Keywords COVID-19 ; respiratory infections ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; Omicron ; incubation period ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Early Prompt Response to COVID-19 in Taiwan

    Hao-Yuan Cheng / Ding-Ping Liu

    Journal of the Formosan Medical Association, Vol 123, Iss , Pp S2-S

    Comprehensive surveillance, decisive border control, and information technology support

    2024  Volume 7

    Abstract: Since the COVID-19 outbreak was detected in Wuhan in December 2019 by the event-based surveillance of Taiwan Centers for Disease Control, Taiwan has been aligning risk management to policy planning with the assistance of comprehensive surveillance and ... ...

    Abstract Since the COVID-19 outbreak was detected in Wuhan in December 2019 by the event-based surveillance of Taiwan Centers for Disease Control, Taiwan has been aligning risk management to policy planning with the assistance of comprehensive surveillance and regular rapid risk assessments. Taiwan Central Epidemic Command Center (CECC) promptly initiated stepwise border control for major cities and provinces in China, European and American countries, and eventually expanded it to the whole world in March 2020. With stringent quarantine measures, the early response not only successfully blocked the first wave of imported cases, but also slowed down subsequent large local outbreaks. Digital technologies including digital fencing and government database linkage were adopted to facilitate the application of public health interventions and data collection. The experience of Taiwan's prompt and comprehensive response at the early stage may contribute to the preparedness for the next disease X outbreak.
    Keywords COVID-19 ; Quarantine ; Information technology ; Surveillance ; Taiwan ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Initial rapid and proactive response for the COVID-19 outbreak — Taiwan's experience

    Hao-Yuan Cheng / Shu-Ying Li / Chin-Hui Yang

    Journal of the Formosan Medical Association, Vol 119, Iss 4, Pp 771-

    2020  Volume 773

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Safety practices and appropriate infection prevention mitigate potential staffing shortage

    Hao-Yuan Cheng / Shu-Ying Li / Chin-Hui Yang

    Journal of the Formosan Medical Association, Vol 119, Iss 9, Pp 1452-

    2020  Volume 1453

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Contact tracing with digital assistance in Taiwan’s COVID-19 outbreak response

    Shu-Wan Jian / Hao-Yuan Cheng / Xiang-Ting Huang / Ding-Ping Liu

    International Journal of Infectious Diseases, Vol 101, Iss , Pp 348-

    2020  Volume 352

    Abstract: Aim: Comprehensive case investigation and contact tracing are crucial to prevent community spread of COVID-19. We demonstrated a utility of using traditional contact tracing measures supplemented with symptom tracking and contact management system to ... ...

    Abstract Aim: Comprehensive case investigation and contact tracing are crucial to prevent community spread of COVID-19. We demonstrated a utility of using traditional contact tracing measures supplemented with symptom tracking and contact management system to assist public health workers with high efficiency. Methods: A centralized contact tracing system was developed to support data linkage, cross-jurisdictional coordination, and follow-up of contacts’ health status. We illustrated the process of how digital tools support contact tracing and management of COVID-19 cases and measured the timeliness from case detection to contact monitoring to evaluate system performance. Results: Among the 8051 close contacts of the 487 confirmed cases (16.5 close contacts/case, 95% CI [13.9–19.1]), the median elapsed time from last exposure to quarantine was three days (IQR 1–5). By implementing the approach of self-reporting using automatic text-messages and web-app, the percentage of health status updates from self-reporting increased from 22.5% to 61.5%. The high proportion of secondary cases detected via contact tracing (88%) might reduce the R0 to under one and minimize the impact of local transmission in the community. Conclusion: Comprehensive contact tracing and management with complementary technology would still be a pillar of strategies for containing outbreaks during de-escalation or early in the next wave of COVID-19 pandemic.
    Keywords Contact tracing ; COVID-19 ; Digital tool ; Outbreak response ; Coronavirus ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Taiwan's COVID-19 response

    Hao-Yuan Cheng / Yu-Neng Chueh / Chiu-Mei Chen / Shu-Wan Jian / Shu-Kuan Lai / Ding-Ping Liu

    Journal of the Formosan Medical Association, Vol 120, Iss 6, Pp 1400-

    Timely case detection and quarantine, January to June 2020

    2021  Volume 1404

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has become severe threats to economic, societal, and healthcare systems. To analyze the epidemiological characteristics of the COVID-19 outbreak in Taiwan and evaluate the key interventions, we conducted a ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has become severe threats to economic, societal, and healthcare systems. To analyze the epidemiological characteristics of the COVID-19 outbreak in Taiwan and evaluate the key interventions, we conducted a retrospective cohort study during January 17–June 30, 2020. As of June 30, the COVID-19 outbreak, including 447 laboratory-confirmed cases, was eliminated by mixed approaches: border control, enhanced surveillance, case detection with contact tracing, quarantine, and population-based interventions like face mask use. The improvement of median time from disease onset to notification (5 days [range −3 to 27] before March 1 to 1 day [range −8 to 22] after March 1) suggested the timeliness and comprehensiveness of surveillance and contact tracing. Travel restrictions with quarantine, resulting in fewer clusters, were also complementary to minimize disease spread. Under combined interventions, Taiwan successfully contained the COVID-19 spread within the country and minimized its impact on the society.
    Keywords COVID-19 ; SARS-CoV-2 ; Outbreak ; Surveillance ; Quarantine ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Hepatoprotective and antioxidant effects of Wu-Zi-Yuan-Chung-Wan against CCl-induced oxidative damage in rats

    Hao-Yuan Cheng / Jung Chao / Chuan-Sung Chiu / I-Chien Hsieh / Hui-Chi Huang / Lung-Yuan Wu / Wen-Huang Peng

    European Journal of Inflammation, Vol

    2021  Volume 19

    Abstract: This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan (WZYCW) using an animal model of carbon tetrachloride (CCl 4 ) induced liver injury. CCl 4 induced chronic liver hepatotoxicity in adult Sprague-Dawley ... ...

    Abstract This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan (WZYCW) using an animal model of carbon tetrachloride (CCl 4 ) induced liver injury. CCl 4 induced chronic liver hepatotoxicity in adult Sprague-Dawley rats. Excluding the control group, all of the rats with chronic liver fibrosis received 0.4% CCl 4 (1.5 mL/kg of body weight, ip) twice per week for 8 weeks. WZYCW (20, 100, and 500 mg/kg) and silymarin (200 mg/kg) were administered five times per week for 8 weeks. After 8 weeks, the rats were sacrificed, blood samples were obtained, and liver histological examinations were performed for subsequent assays. These results suggest that WZYCW considerably reduced Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT), Triglyceride (TG); and cholesterol activity; and the levels of malonaldehyde (MDA), nitric oxide (NO), and transforming growth factor-β 1 (TGF-β 1 ) in the liver. WZYCW also increased the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in liver tissue. WZYCW produced hepatoprotective and antifibrotic effects. This is the first study to demonstrate that WZYCW expressed hepatoprotective activity against CCl 4 induced acute hepatotoxicity in rat. In addition, the primary compound of WZCYW was analyzed using HPLC. The major peaks of WZCYW, including schizandrin. The results indicate that WZYCW not only enhances hepatic antioxidant enzyme activities and inhibits lipid peroxidation but also suppresses inflammatory responses in CCl 4 induced liver damage. Our findings provide evidence that WZYCW possesses a hepatoprotective activity to ameliorate chronic liver injury.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Epidemiology of Breakthrough Varicella after the Implementation of a Universal Varicella Vaccination Program in Taiwan, 2004–2014

    Hao-Yuan Cheng / Luan-Yin Chang / Chun-Yi Lu / Li-Min Huang

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract National one-dose varicella vaccination at 12 months of age was implemented in Taiwan since 2004.Our study aimed to evaluate breakthrough varicella (BV) in post-vaccine era and its associated risk factors. We retrospectively identified children ... ...

    Abstract Abstract National one-dose varicella vaccination at 12 months of age was implemented in Taiwan since 2004.Our study aimed to evaluate breakthrough varicella (BV) in post-vaccine era and its associated risk factors. We retrospectively identified children vaccinated against varicella between 12–23 months of age during 2004–2008. Their vaccination information was extracted from the national vaccination registry system and linked to the 2004–2014 National Health Insurance database. BV was defined as a diagnosis of varicella (ICD-9-CM codes 052 and 052.0–052.9) beyond 42 days post-vaccination. Multiple Cox regression model was used to identify risk factors for BV. Among 932,874 enrolled vaccinees, 26,446 (2.8%) had BV and 219 (0.024%) required hospitalization over the study period. Varicella incidence declined from 4.71 per 1000 person-year (PY) in 2004 to 0.81/1000 PY in 2014. BV incidence decreased from 3.90/1000 PY at first year to 1.94/1000 PY at 11th year after vaccination. Females had a lower risk for BV than males (hazard ratio [HR] 0.85, 95% CI, 0.83–0.87); Varivax® recipients had a lower risk for BV than Varilrix® recipients (HR 0.75, 95% CI, 0.72–0.78). Our study showed the incidence of varicella, BV and varicella-related hospitalizations in Taiwan were kept low in post-vaccine era.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Potential lessons from the Taiwan and New Zealand health responses to the COVID-19 pandemic

    Dr Jennifer Summers / Dr Hao-Yuan Cheng / Professor Hsien-Ho Lin / Dr Lucy Telfar Barnard / Dr Amanda Kvalsvig / Professor Nick Wilson / Professor Michael G Baker

    The Lancet Regional Health. Western Pacific, Vol 4, Iss , Pp 100044- (2020)

    2020  

    Abstract: Summary: Approaches to preventing or mitigating the impact of the COVID-19 pandemic have varied markedly between nations. We examined the approach up to August 2020 taken by two jurisdictions which had successfully eliminated COVID-19 by this time: ... ...

    Abstract Summary: Approaches to preventing or mitigating the impact of the COVID-19 pandemic have varied markedly between nations. We examined the approach up to August 2020 taken by two jurisdictions which had successfully eliminated COVID-19 by this time: Taiwan and New Zealand. Taiwan reported a lower COVID-19 incidence rate (20.7 cases per million) compared with NZ (278.0 per million). Extensive public health infrastructure established in Taiwan pre-COVID-19 enabled a fast coordinated response, particularly in the domains of early screening, effective methods for isolation/quarantine, digital technologies for identifying potential cases and mass mask use. This timely and vigorous response allowed Taiwan to avoid the national lockdown used by New Zealand. Many of Taiwan's pandemic control components could potentially be adopted by other jurisdictions.
    Keywords COVID-19 ; Public health ; Epidemiology ; Health policy ; Infectious diseases ; Global health ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Study on the wave climate variation to the renewable wave energy assessment

    Ching-Piao, Tsai / Ching-Her, Hwang / Chien, Hwa / Hao-Yuan, Cheng

    Renewable energy. 2012 Feb., v. 38, no. 1

    2012  

    Abstract: To reduce the dependence on fossil fuel and imported energy resources, Taiwan has ever-increasing needs of renewable energy. With the rapid development of the technologies of wave energy converter, the wave energy source will be able to meet parts the ... ...

    Abstract To reduce the dependence on fossil fuel and imported energy resources, Taiwan has ever-increasing needs of renewable energy. With the rapid development of the technologies of wave energy converter, the wave energy source will be able to meet parts the demand. The Energy Research Laboratories of the Industrial Technology Research Institute, Taiwan (2005), based on the statistic of one-year wave data, stated that the mean wave energy at the northeast coast of Taiwan reaches 11.56 kW/m, giving it the potential of wave power utilization. However, one of the major obstacles with the wave energy utilization is lack of long-term ocean wave measurements. The long-term variations in wave parameters impose changes in wave energy converter outputs. Lack of long-term data makes it difficult to assess the cost-benefit of wave energy conversion projects for the policy and decision makers. The present study aims to quantitatively evaluate the wave climate variations of the northwestern Pacific and the Taiwan Waters based on long-term wave data base. Wave observations around Taiwan have been performed since 1998, thus, earlier data of wave climate are not available. This study reconstructs the wave data of the northwest Pacific over the past three decades based on the SWAN numerical wave model that driven by NECP global reanalysis wind fields. The simulation results are compared and validated with measured data. The results show that the long-term wave climate variations around Taiwan consist of oscillations of three different periods, i.e. the seasonal, inter-annual and decade oscillations. The seasonal oscillation has significant amplitude that leads the wave energy one order magnitude greater in winter than in summer. In addition to seasonal changes, the wave energy features inter-annual variations, which are highly related to the El Nino and La Nina phenomena. In the La Nina years, the annual averaged wave energy could be double than in El Nino years. Finally, this study adopted the Man-Kendall Non-Parametric Test and the Hilbert Huang EMD method to analyze the long-term wave variation trends. The results showed that the wave height experienced climbing trends during 1976–1985 and 1997–2006, and a descending trend during 1985–1997. The reasons for wave climate oscillations in the decadal variation should be further investigation.
    Keywords El Nino ; La Nina ; climate ; coasts ; databases ; energy conversion ; fossil fuels ; issues and policy ; models ; oceans ; seasonal variation ; summer ; water power ; water waves ; wind ; winter ; Pacific States ; Taiwan
    Language English
    Dates of publication 2012-02
    Size p. 50-61.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 0960-1481
    ISSN 0960-1481
    DOI 10.1016/j.renene.2011.06.041
    Database NAL-Catalogue (AGRICOLA)

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