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Article ; Online: Potential α -Glucosidase Inhibitors from the Deep-Sea Sediment-Derived Fungus Aspergillus insulicola

Weibo Zhao / Yanbo Zeng / Wenjun Chang / Huiqin Chen / Hao Wang / Haofu Dai / Fang Lv

Marine Drugs, Vol 21, Iss 157, p

2023 Volume 157

Abstract: Three new phenolic compounds, epicocconigrones C–D ( 1 – 2 ) and flavimycin C ( 3 ), together with six known phenolic compounds: epicocconigrone A ( 4 ); 2-(10-formyl-11,13-dihydroxy-12-methoxy-14-methyl)-6,7-dihydroxy-5-methyl-4-benzofurancarboxaldehyde ...

Abstract	Three new phenolic compounds, epicocconigrones C–D ( 1 – 2 ) and flavimycin C ( 3 ), together with six known phenolic compounds: epicocconigrone A ( 4 ); 2-(10-formyl-11,13-dihydroxy-12-methoxy-14-methyl)-6,7-dihydroxy-5-methyl-4-benzofurancarboxaldehyde ( 5 ); epicoccolide B ( 6 ); eleganketal A ( 7 ); 1,3-dihydro-5-methoxy-7-methylisobenzofuran ( 8 ); and 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl-alcohol ( 9 ), were isolated from fermentation cultures of a deep-sea sediment-derived fungus, Aspergillus insulicola . Their planar structures were elucidated based on the 1D and 2D NMR spectra and HRESIMS data. The absolute configurations of compounds 1 – 3 were determined by ECD calculations. Compound 3 represented a rare fully symmetrical isobenzofuran dimer. All compounds were evaluated for their α -glucosidase inhibitory activity, and compounds 1 , 4 – 7 , and 9 exhibited more potent α -glucosidase inhibitory effect with IC 50 values ranging from 17.04 to 292.47 μM than positive control acarbose with IC 50 value of 822.97 μM, indicating that these phenolic compounds could be promising lead compounds of new hypoglycemic drugs.
Keywords	marine fungus ; Aspergillus insulicola ; phenolic compounds ; ECD calculations ; α -glucosidase inhibition ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comprehensive Analysis of NAC Transcription Factors Reveals Their Evolution in Malvales and Functional Characterization of AsNAC019 and AsNAC098 in Aquilaria sinensis

Zhuo Yang / Wenli Mei / Hao Wang / Jun Zeng / Haofu Dai / Xupo Ding

International Journal of Molecular Sciences, Vol 24, Iss 24, p

2023 Volume 17384

Abstract: NAC is a class of plant-specific transcription factors that are widely involved in the growth, development and (a)biotic stress response of plants. However, their molecular evolution has not been extensively studied in Malvales, especially in Aquilaria ... ...

Abstract	NAC is a class of plant-specific transcription factors that are widely involved in the growth, development and (a)biotic stress response of plants. However, their molecular evolution has not been extensively studied in Malvales, especially in Aquilaria sinensis , a commercial and horticultural crop that produces an aromatic resin named agarwood. In this study, 1502 members of the NAC gene family were identified from the genomes of nine species from Malvales and three model plants. The macroevolutionary analysis revealed that whole genome duplication (WGD) and dispersed duplication (DSD) have shaped the current architectural structure of NAC gene families in Malvales plants. Then, 111 NAC genes were systemically characterized in A. sinensis . The phylogenetic analysis suggests that NAC genes in A. sinensis can be classified into 16 known clusters and four new subfamilies, with each subfamily presenting similar gene structures and conserved motifs. RNA-seq analysis showed that AsNACs presents a broad transcriptional response to the agarwood inducer. The expression patterns of 15 AsNACs in A. sinensis after injury treatment indicated that AsNAC019 and AsNAC098 were positively correlated with the expression patterns of four polyketide synthase (PKS) genes. Additionally, AsNAC019 and AsNAC098 were also found to bind with the AsPKS07 promoter and activate its transcription. This comprehensive analysis provides valuable insights into the molecular evolution of the NAC gene family in Malvales plants and highlights the potential mechanisms of AsNACs for regulating secondary metabolite biosynthesis in A. sinensis , especially for the biosynthesis of 2-(2-phenyl) chromones in agarwood.
Keywords	NAC ; Malvales ; evolution ; Aquilaria sinensis ; agarwood ; transcriptional regulation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26

Pei Wang / Huifang Wang / Juchun Yang / Li Yang / Caihong Cai / Jingzhe Yuan / Fei Wu / Cuijuan Gai / Wenli Mei / Haofu Dai

Marine Drugs, Vol 21, Iss 150, p

2023 Volume 150

Abstract: Five new isocoumarins, phaeosphaerins A–E ( 1 – 5 ), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin ( 6 ), and two known pimarane- ... ...

Abstract	Five new isocoumarins, phaeosphaerins A–E ( 1 – 5 ), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin ( 6 ), and two known pimarane-type diterpenes, diaportheins A ( 7 ) and B ( 8 ). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1 – 7 displayed weak neuroprotective effects against H 2 O 2 -induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
Keywords	isocoumarins ; marine fungus ; Phaeosphaeriopsis sp ; neuroprotective effect ; cytotoxicity ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Six Undescribed Capnosane-Type Macrocyclic Diterpenoids from South China Sea Soft Coral Sarcophyton crassocaule

Hanyang Peng / Yanbo Zeng / Hao Wang / Wenjun Chang / Huiqin Chen / Fengjuan Zhou / Haofu Dai / Xiachang Wang

Marine Drugs, Vol 21, Iss 12, p

Structural Determination and Biological Evaluation

2023 Volume 645

Abstract: Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A–F ( 1 – 6 ) and one related known analog pavidolide D ( 7 ) were isolated from Sarcophyton crassocaule , a soft coral collected off the Nansha Islands, in the South China Sea. Their ... ...

Abstract	Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A–F ( 1 – 6 ) and one related known analog pavidolide D ( 7 ) were isolated from Sarcophyton crassocaule , a soft coral collected off the Nansha Islands, in the South China Sea. Their complete structures, relative configurations and absolute configurations were established through comprehensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) and single-crystal X-ray diffraction. Sarcocrassolins D ( 4 ) and E ( 5 ) showed inhibitory activity against lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW264.7 cells with IC 50 values of 76.8 ± 8.0 μM and 93.0 ± 3.8 μM, respectively.
Keywords	soft coral ; Sarcophyton crassocaule ; cembranoids ; capnosane-type macrocyclic diterpenes ; absolute configuration ; anti-inflammation ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

Xi Cao / Lei Guo / Caihong Cai / Fandong Kong / Jingzhe Yuan / Cuijuan Gai / Haofu Dai / Pei Wang / Wenli Mei

Frontiers in Chemistry, Vol

2021 Volume 9

Abstract: Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. ... ...

Abstract	Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh2(OCOCF3)4-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC50 values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.
Keywords	mangrove-derived fungus ; Cladosporium sp ; metabolites ; cytotoxicity ; α-glycosidase inhibitor ; Chemistry ; QD1-999
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Using Extract From the Stems and Leaves of Yizhi (Alpiniae oxyphyllae) as Feed Additive Increases Meat Quality and Intestinal Health in Ducks

Fengjie Ji / Lihong Gu / Guang Rong / Chengjun Hu / Weiping Sun / Dingfa Wang / Weiqi Peng / Dajie Lin / Quanwei Liu / Hongzhi Wu / Haofu Dai / Hanlin Zhou / Tieshan Xu

Frontiers in Veterinary Science, Vol

2022 Volume 8

Abstract: Yizhi (Alpiniae Oxyphyllae, A. oxyphylla) has been widely used as an important traditional Chinese medicinal herb for centuries. Existing studies have shown that A. oxyphylla has numerous benefits in human and animal health. We hypothesized that extract ... ...

Abstract	Yizhi (Alpiniae Oxyphyllae, A. oxyphylla) has been widely used as an important traditional Chinese medicinal herb for centuries. Existing studies have shown that A. oxyphylla has numerous benefits in human and animal health. We hypothesized that extract from the stems and leaves of A. oxyphylla (AOE) as a feed additive may have positive effects on animal health and products. Thus, this study was conducted to evaluate the effects of AOE as a feed additive on growth performance, serum biochemical parameters, intestinal morphology, microbial composition, and meat quality in Jiaji ducks. A total of 240 Jiaji ducks of 42 days old (1675.8 ± 44.2 g, male: female ratio = 1:1) were blocked based on body weight and randomly allocated into four dietary treatments with three replicates that each had 20 duck individuals. The dietary treatments included: basal diet, control group (CK); basal diet supplementation with 30 mg/kg (Y1), 80 mg/kg (Y2), and 130 mg/kg (Y3) AOE, respectively, and lasted for 49 days. The results showed that average daily feed intake from day 42 to day 60 was decreased with the increasing level of AOE (P < 0.05). Compared with the CK group, the groups with AOE supplementation decreased serum LDL-C level (P < 0.05), the addition of 30 mg/kg AOE increased total amino acids, essential amino acids, branched-chain amino acids, nonessential amino acids, and umami taste amino acids (P < 0.05), but decreased selenium and zinc concentrations in breast muscle (P < 0.05). In addition, the supplementation of 30 or 130 mg/kg AOE significantly increased jejunal villus height (P < 0.05) and tended to increase the ratio of villus height to crypt depth in the jejunum (P = 0.092) compared to the CK group. Moreover, the addition of 30 mg/kg AOE showed a higher abundance of genus unclassified Bacteroidales and genus unclassified Ruminococcaceae than the CK group (P < 0.05). Therefore, dietary supplementation with 30 mg/kg AOE increased meat nutrition profile and flavor through promoting amino acid ...
Keywords	Yizhi (Alpinia oxyphylla) ; ducks ; intestinal health ; antibiotic alternatives ; meat quality ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii

Jiaocen Guo / Fandong Kong / Qingyun Ma / Qingyi Xie / Renshuai Zhang / Haofu Dai / Yougen Wu / Youxing Zhao

Frontiers in Chemistry, Vol

2020 Volume 8

Abstract: Ganoderma fungi have long been used as functional foods and traditional medicines in Asian countries. Ganoderma ahmadii is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been used in ... ...

Abstract	Ganoderma fungi have long been used as functional foods and traditional medicines in Asian countries. Ganoderma ahmadii is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of Ganoderma ahmadii led to the isolation of seven new meroterpenoids, named ganoduriporols F-L (1–7). The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds 5–7 represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds 1–4 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control Na3VO4, with IC50 values of 17, 20, 19, and 23 μM, respectively.
Keywords	Ganoderma ahmadii ; meroterpenoid ; spectroscopic ; PTP1B ; cytotoxicity ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

Fei Zhang / Liman Zhou / Fandong Kong / Qingyun Ma / Qingyi Xie / Jiuhui Li / Haofu Dai / Lei Guo / Youxing Zhao

Marine Drugs, Vol 18, Iss 1, p

2020 Volume 67

Abstract: Five new perylenequinone derivatives, altertoxins VIII−XII ( 1 − 5 ), as well as one known compound cladosporol I ( 6 ), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, ... ...

Abstract	Five new perylenequinone derivatives, altertoxins VIII−XII ( 1 − 5 ), as well as one known compound cladosporol I ( 6 ), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1 − 6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
Keywords	cladosporium sp ; altertoxins ; quorum sensing inhibitory activity ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

Pei Wang / Xin Chen / Hao Wang / Shengzhuo Huang / Caihong Cai / Jingzhe Yuan / Guoliang Zhu / Xinglian Xu / Wenli Mei / Haofu Dai

Frontiers in Chemistry, Vol

2019 Volume 7

Abstract: Four picrotoxane-type sesquiterpenes, dendroterpene A–D (1–4), together with four known compounds (5–8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, ... ...

Abstract	Four picrotoxane-type sesquiterpenes, dendroterpene A–D (1–4), together with four known compounds (5–8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3, 5, 6, and 8 exhibited inhibitory activity against α-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.
Keywords	Dendrobium nobile Lindl ; picrotoxane ; sesquiterpenes ; α-glycosidase inhibitor ; cytotoxicity ; Chemistry ; QD1-999
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dietary Supplementation With Didancao (Elephantopus scaber L.) Improves Meat Quality and Intestinal Development in Jiaji Ducks

Chengjun Hu / Lihong Gu / Mao Li / Fengjie Ji / Weiping Sun / Dingfa Wang / Weiqi Peng / Dajie Lin / Quanwei Liu / Haofu Dai / Hanlin Zhou / Tieshan Xu

Frontiers in Veterinary Science, Vol

2021 Volume 8

Abstract: Didancao (Elephantopus scaber L.) has been used as a traditional herbal medicine and has exhibited a beneficial role in animal health. This study aimed to investigate the effects of dietary supplementation with E. scaber on growth performance, meat ... ...

Abstract	Didancao (Elephantopus scaber L.) has been used as a traditional herbal medicine and has exhibited a beneficial role in animal health. This study aimed to investigate the effects of dietary supplementation with E. scaber on growth performance, meat quality, intestinal morphology, and microbiota composition in ducks. A total of 480 Jiaji ducks (42 days old, male:female ratio = 1:1) were randomly assigned to one of four treatments. There were six replicates per treatment, with 20 ducks per replicate. The ducks in the control group (Con) were fed a basal diet; the three experimental groups were fed a basal diet supplementation with 30 (T1), 80 (T2), and 130 mg/kg (T3) of E. scaber. After a 48-day period of supplementation, growth performance, meat quality, intestinal morphology, and microbiota composition were evaluated. The results showed that no differences were observed in the final body weight, average daily feed intake, and average daily gain among the four groups. Compared with that in the Con group, the feed conversion in the T1 and T2 groups was increased significantly; the T2 group was shown to decrease the concentration of alanine aminotransferase in serum; the T3 group was lower than the Con group in the concentration of aspartate aminotransferase and was higher than the Con group in the concentration of high-density lipoprotein-cholesterol. The highest concentration of creatinine was observed in the T1 group. The T2 group was higher than the Con group in the contents of Phe, Ala, Gly, Glu, Arg, Lys, Tyr, Leu, Ser, Thr, Asp, and total amino acids in the breast muscle. Moreover, the T2 group was higher than the Con group in the contents of meat C18:2n−6 and polyunsaturated fatty acid. The concentration of inosinic acid in the T1, T2, and T3 groups was significantly higher than that in the Con group. However, the Con group was higher than the T2 or T3 group in the Zn content. The T2 group was lower than the Con group in the jejunal crypt depth. The T3 group was higher than the Con group in the ileal villus ...
Keywords	Elephantopus scaber L ; ducks ; feed conversion ratio ; growth performance ; meat quality ; Veterinary medicine ; SF600-1100
Subject code	796 ; 630
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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