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  1. Article ; Online: Epidemiological, Radiographical, and Laboratorial Characteristics of Chinese Asymptomatic Cases With COVID-19

    Haohao Yan / Yudan Ding / Wenbin Guo

    Frontiers in Public Health, Vol

    A Systematic Review and Meta-Analysis

    2022  Volume 10

    Abstract: The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, ... ...

    Abstract The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, 2022 for relevant articles. Data synthesis, subgroup analysis, and sensitivity analysis were performed on the included studies. I2 and Q tests were applied to evaluate heterogeneity across studies. The risk of publication bias was assessed and visualized using a funnel plot. A total of 45 studies consisting of 2,655 patients with no symptoms at the screening point were included. Pooled results showed that in China, 65% of initial no-symptoms COVID-19 patients did not present any COVID-19-related symptom during follow-up or by end of disease course (asymptomatic infections). High proportions of initial no-symptoms COVID-19 patients (76%) and patients with asymptomatic infection (55%) had abnormal CT features at the screening point. High proportion of patients with asymptomatic infection had been detected Ig G+ (72%) and/or Ig M+ (57%) at the screening point. The chest CT scan and SARS-CoV-2-specific antibody testing could serve as effective supplementary methods to identify asymptomatic cases in the early stage of SARS-CoV-2 infection. However, the chest CT scan and the SARS-CoV-2-specific IgM and IgG testing should not replace reverse transcription–polymerase chain reaction (RT-PCR) for screening in asymptomatic patients. The combination of repeated RT-PCR, chest CT scans, and the SARS-CoV-2-specific IgM and IgG testing should be performed for those highly suspected SARS-CoV-2 infections.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD 42021261130.
    Keywords COVID-19 ; SARS-CoV-2 ; asymptomatic infection ; presymptomatic infection ; CT ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Data_Sheet_1_Clinical Characteristics of Children With COVID-19

    Yudan Ding / Haohao Yan / Wenbin Guo

    A Meta-Analysis.docx

    2020  

    Abstract: Background: With the global spread of novel coronavirus disease 2019 (COVID-19), health care systems are facing formidable challenges. Scientists are conducting studies to explore this new disease, and numerous studies have been shared. However, the ... ...

    Abstract Background: With the global spread of novel coronavirus disease 2019 (COVID-19), health care systems are facing formidable challenges. Scientists are conducting studies to explore this new disease, and numerous studies have been shared. However, the number of studies on children with COVID-19 is limited, and no meta-analysis of this group has been performed. Methods: A random-effect meta-analysis was conducted to determine the characteristics of children with COVID-19, including their demographic, epidemiological, clinical, laboratory, imaging features, and outcomes. Four databases and reference lists were screened. Percentages were calculated, and pooled prevalence with 95% confidence intervals (CIs) were reported. Results: Of 195 studies, 33 were selected, and 14 (371 patients) of them were included in the meta-analysis. Then, 19 case reports (25 patients) were summarized separately. Our meta-analysis revealed that 17.4% (95% CI = 9.1–27.3) of children had asymptomatic infection. Fever (51.2%, 95% CI = 40.2–62.2) and cough (37.0%, 95% CI = 25.9–48.8) were the most frequent symptoms. The prevalence of severe or critical illness was almost 0% (95% CI = 0–1.0). The most frequent abnormal laboratory findings, in pediatric patients, were leukopenia/lymphopenia (28.9%, 95% CI = 19.5–39.2) and increased creatine kinase (20.1%, 95% CI = 1.3–49.9). Ground-glass opacity was observed in the CT scan of 53.9% (95% CI = 38.4–68.7) of children diagnosed with pneumonia. Conclusions: Children are at a lower risk of developing COVID-19 and have a milder disease than adults. However, the evidence presented in this study is not satisfactory. Further investigations are urgently needed, and our data will be continuously updated.
    Keywords Foetal Development and Medicine ; Obstetrics and Gynaecology ; Paediatrics ; Paediatrics and Reproductive Medicine not elsewhere classified ; SARS-CoV-2 ; coronavirus disease 2019 ; children ; epidemic ; clinical characteristics ; covid19
    Subject code 610
    Publishing date 2020-07-03T13:13:46Z
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Clinical Characteristics of Children With COVID-19

    Yudan Ding / Haohao Yan / Wenbin Guo

    Frontiers in Pediatrics, Vol

    A Meta-Analysis

    2020  Volume 8

    Abstract: Background: With the global spread of novel coronavirus disease 2019 (COVID-19), health care systems are facing formidable challenges. Scientists are conducting studies to explore this new disease, and numerous studies have been shared. However, the ... ...

    Abstract Background: With the global spread of novel coronavirus disease 2019 (COVID-19), health care systems are facing formidable challenges. Scientists are conducting studies to explore this new disease, and numerous studies have been shared. However, the number of studies on children with COVID-19 is limited, and no meta-analysis of this group has been performed.Methods: A random-effect meta-analysis was conducted to determine the characteristics of children with COVID-19, including their demographic, epidemiological, clinical, laboratory, imaging features, and outcomes. Four databases and reference lists were screened. Percentages were calculated, and pooled prevalence with 95% confidence intervals (CIs) were reported.Results: Of 195 studies, 33 were selected, and 14 (371 patients) of them were included in the meta-analysis. Then, 19 case reports (25 patients) were summarized separately. Our meta-analysis revealed that 17.4% (95% CI = 9.1–27.3) of children had asymptomatic infection. Fever (51.2%, 95% CI = 40.2–62.2) and cough (37.0%, 95% CI = 25.9–48.8) were the most frequent symptoms. The prevalence of severe or critical illness was almost 0% (95% CI = 0–1.0). The most frequent abnormal laboratory findings, in pediatric patients, were leukopenia/lymphopenia (28.9%, 95% CI = 19.5–39.2) and increased creatine kinase (20.1%, 95% CI = 1.3–49.9). Ground-glass opacity was observed in the CT scan of 53.9% (95% CI = 38.4–68.7) of children diagnosed with pneumonia.Conclusions: Children are at a lower risk of developing COVID-19 and have a milder disease than adults. However, the evidence presented in this study is not satisfactory. Further investigations are urgently needed, and our data will be continuously updated.
    Keywords SARS-CoV-2 ; coronavirus disease 2019 ; children ; epidemic ; clinical characteristics ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Use of Lentinan and Fluopimomide to Control Cotton Seedling Damping-Off Disease Caused by Rhizoctonia solani

    Shoumin Sun / Haohao Yan / Gang Chen / Shuai Yang / Jie Wang / Yuanxue Yang / Hongyan Wang

    Agriculture, Vol 12, Iss 75, p

    2022  Volume 75

    Abstract: Lentinan (LNT) is a natural and functional polysaccharide isolated from Lentinus edodes fruiting bodies, which functions in stimulating the plant immune response, improving plant disease resistance and regulating plant growth. This study explores the use ...

    Abstract Lentinan (LNT) is a natural and functional polysaccharide isolated from Lentinus edodes fruiting bodies, which functions in stimulating the plant immune response, improving plant disease resistance and regulating plant growth. This study explores the use of LNT as a plant growth regulator and attractant in cotton production. After treatment with LNT, the content of malondialdehyde (MDA) in cotton seeds decreased, whereas the activities of polyphenol oxidase (PPO), superoxide dismutase (SOD) and peroxidase (POD) in leaves increased significantly. LNT also promoted the growth and development of cotton plants and significantly reduced the incidence of cotton damping-off disease. The relative expression of salicylic acid pathway-related genes in cotton also increased significantly. The prevention mechanism of fluopimomide was also evaluated, and the result showed lower EC 50 values and was effective in controlling cotton seedling disease caused by Rhizoctonia solani in both greenhouse experiments and field trials. The use of LNT and fluopimomide in controlling cotton seedling damping-off disease showed a synergistic effect in field trials. These results will provide a new insight into the agricultural application of LNT as a biological fungicide in the field of biological controls.
    Keywords cotton damping-off disease ; lentinan ; Rhizoctonia solani ; environmentally friendly biopesticide ; defensive enzymes ; Agriculture (General) ; S1-972
    Subject code 630
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Uncovering the Neural Correlates of Anhedonia Subtypes in Major Depressive Disorder

    Yudan Ding / Yangpan Ou / Haohao Yan / Feng Liu / Huabing Li / Ping Li / Guangrong Xie / Xilong Cui / Wenbin Guo

    Biomedicines, Vol 11, Iss 12, p

    Implications for Intervention Strategies

    2023  Volume 3138

    Abstract: Major depressive disorder (MDD) represents a serious public health concern, negatively affecting individuals’ quality of life and making a substantial contribution to the global burden of disease. Anhedonia is a core symptom of MDD and is associated with ...

    Abstract Major depressive disorder (MDD) represents a serious public health concern, negatively affecting individuals’ quality of life and making a substantial contribution to the global burden of disease. Anhedonia is a core symptom of MDD and is associated with poor treatment outcomes. Variability in anhedonia components within MDD has been observed, suggesting heterogeneity in psychopathology across subgroups. However, little is known about anhedonia subgroups in MDD and their underlying neural correlates across subgroups. To address this question, we employed a hierarchical cluster analysis based on Temporal Experience of Pleasure Scale subscales in 60 first-episode, drug-naive MDD patients and 32 healthy controls. Then we conducted a connectome-wide association study and whole-brain voxel-wise functional analyses for identified subgroups. There were three main findings: (1) three subgroups with different anhedonia profiles were identified using a data mining approach; (2) several parts of the reward network (especially pallidum and dorsal striatum) were associated with anticipatory and consummatory pleasure; (3) different patterns of within- and between-network connectivity contributed to the disparities of anhedonia profiles across three MDD subgroups. Here, we show that anhedonia in MDD is not uniform and can be categorized into distinct subgroups, and our research contributes to the understanding of neural underpinnings, offering potential treatment directions. This work emphasizes the need for tailored approaches in the complex landscape of MDD. The identification of homogeneous, stable, and neurobiologically valid MDD subtypes could significantly enhance our comprehension and management of this multifaceted condition.
    Keywords major depressive disorder ; mental health ; anhedonia ; subgroup ; neuroimaging ; fMRI ; Biology (General) ; QH301-705.5
    Subject code 150
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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