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  1. Article: Pre-hospital stroke monitoring past, present, and future: a perspective.

    Ben Pazi, Hilla / Jahashan, Shady / Har Nof, Sagi / Zibman, Samuel / Yanai-Kohelet, Ornit / Prigan, Limor / Intrator, Nathan / Bornstein, Natan M / Ribo, Marc

    Frontiers in neurology

    2024  Volume 15, Page(s) 1341170

    Abstract: Integrated brain-machine interface signifies a transformative advancement in neurological monitoring and intervention modalities for events such as stroke, the leading cause of disability. Historically, stroke management relied on clinical evaluation and ...

    Abstract Integrated brain-machine interface signifies a transformative advancement in neurological monitoring and intervention modalities for events such as stroke, the leading cause of disability. Historically, stroke management relied on clinical evaluation and imaging. While today's stroke landscape integrates artificial intelligence for proactive clinical decision-making, mainly in imaging and stroke detection, it depends on clinical observation for early detection. Cardiovascular monitoring and detection systems, which have become standard throughout healthcare and wellness settings, provide a model for future cerebrovascular monitoring and detection. This commentary reviews the progression of continuous stroke monitoring, spotlighting contemporary innovations and prospective avenues, and emphasizes the influential roles of cutting-edge technologies in shaping stroke care.
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1341170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis.

    Palande, Vikrant / Siegal, Tali / Detroja, Rajesh / Gorohovski, Alessandro / Glass, Rainer / Flueh, Charlotte / Kanner, Andrew A / Laviv, Yoseph / Har-Nof, Sagi / Levy-Barda, Adva / Viviana Karpuj, Marcela / Kurtz, Marina / Perez, Shira / Raviv Shay, Dorith / Frenkel-Morgenstern, Milana

    Molecular oncology

    2022  Volume 16, Issue 10, Page(s) 2098–2114

    Abstract: Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and mutation acquisition are major impedances for tailoring personalized therapy. We collected blood and tumour tissue samples from 25 GBM ... ...

    Abstract Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and mutation acquisition are major impedances for tailoring personalized therapy. We collected blood and tumour tissue samples from 25 GBM patients and 25 blood samples from healthy controls. Cell-free DNA (cfDNA) was extracted from the plasma of GBM patients and from healthy controls. Tumour DNA was extracted from fresh tumour samples. Extracted DNA was sequenced using a whole-genome sequencing procedure. We also collected 180 tumour DNA datasets from GBM patients publicly available at the TCGA/PANCANCER project. These data were analysed for mutations and gene-gene fusions that could be potential druggable targets. We found that plasma cfDNA concentrations in GBM patients were significantly elevated (22.6 ± 5 ng·mL
    MeSH term(s) Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/genetics ; Cytoskeletal Proteins/genetics ; DNA, Neoplasm ; Gene Fusion ; Glioblastoma/diagnosis ; Glioblastoma/genetics ; Glioblastoma/pathology ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Imatinib Mesylate ; Mutation/genetics ; Oncogene Proteins, Fusion/genetics ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics
    Chemical Substances Biomarkers, Tumor ; CEP85L protein, human ; Cell-Free Nucleic Acids ; Cytoskeletal Proteins ; DNA, Neoplasm ; Oncogene Proteins, Fusion ; Proto-Oncogene Proteins ; Imatinib Mesylate (8A1O1M485B) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.13157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6637: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Radiosurgery for brain metastases and cerebral edema.

    Gazit, Inbal / Har-Nof, Sagi / Cohen, Zvi R / Zibly, Zion / Nissim, Uzi / Spiegelmann, Roberto

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2015  Volume 22, Issue 3, Page(s) 535–538

    Abstract: The objective of this study was to assess reduction in cerebral edema following linear accelerator radiosurgery (LINAC) as first line therapy for brain metastasis. We reviewed the medical records of all patients who underwent LINAC radiosurgery for brain ...

    Abstract The objective of this study was to assess reduction in cerebral edema following linear accelerator radiosurgery (LINAC) as first line therapy for brain metastasis. We reviewed the medical records of all patients who underwent LINAC radiosurgery for brain metastasis at our institution during 2010-2012, and who had not previously undergone either surgery or whole brain radiotherapy. Data were analyzed for 55 brain metastases from 46 patients (24 males), mean age 59.9 years. During the 2 months following LINAC radiosurgery, the mean steroid dose decreased from 4.8 to 2.6 mg/day, the mean metastasis volume decreased from 3.79±4.12 cc to 2.8±4.48 cc (p=0.001), and the mean edema volume decreased from 16.91±30.15 cc to 12.85±24.47 cc (p=0.23). The 17 patients with reductions of more than 50% in brain edema volume had single metastases. Edema volume in the nine patients with two brain metastases remained stable in five patients (volume change <10%, 0-2 cc) and increased in four patients (by >10%, 2-14 cc). In a subanalysis of eight metastases with baseline edema volume greater than 40 cc, edema volume decreased from 77.27±37.21 cc to 24.84±35.6 cc (p=0.034). Reductions in brain edema were greater in metastases for which non-small-cell lung carcinoma and breast cancers were the primary diseases. Overall, symptoms improved in most patients. No patients who were without symptoms or who had no signs of increased intracranial pressure at baseline developed signs of intracranial pressure following LINAC radiosurgery. In this series, LINAC stereotactic radiosurgery for metastatic brain lesions resulted in early reduction in brain edema volume in single metastasis patients and those with large edema volumes, and reduced the need for steroids.
    MeSH term(s) Adult ; Aged ; Brain Edema/etiology ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Breast Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/secondary ; Carcinoma, Non-Small-Cell Lung/surgery ; Female ; Humans ; Intracranial Hypertension/complications ; Intracranial Pressure ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Radiosurgery/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2015-03
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2014.08.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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