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  1. Article ; Online: Modification of milk resulting in low potassium and minimal electrolyte changes with minimal changes in taste.

    Hara, Kazuhiro

    The Journal of dairy research

    2022  , Page(s) 1–5

    Abstract: The objective of this research communication was to produce low potassium milk in which other electrolyte changes and changes in taste were minimized. To reduce potassium concentrations, several studies have reported batch methods of directly mixing milk ...

    Abstract The objective of this research communication was to produce low potassium milk in which other electrolyte changes and changes in taste were minimized. To reduce potassium concentrations, several studies have reported batch methods of directly mixing milk or formula with sodium polystyrene sulfonate, which can exchange cations such as potassium for sodium. However, they also reported increases in sodium content, decreases in calcium and magnesium content, and changes in taste, because sodium polystyrene sulfonate exchanged other substances such as calcium and magnesium for sodium. In the present study, a method of dialyzing whole cow's milk using both sodium polystyrene sulfonate and a small amount of water through cellophane membranes was developed. A batch method for comparison was also performed. Each milk sample was evaluated biochemically and analyzed for taste and aroma in a sensory analysis. We showed that the potassium concentration in the dialyzed milk was reduced to 38% of that in unreacted milk. It was also shown that changes in sodium (increased) as well as calcium and magnesium (decreased) in the dialyzed milk were less than half of those in the batch method milk. Sensory analysis showed that minimal changes occurred in the taste of the dialyzed milk.
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029922000358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1511: Show issues Location:
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  2. Article ; Online: Endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling.

    Okuno, Nozomi / Hara, Kazuo

    Journal of medical ultrasonics (2001)

    2024  

    Abstract: Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood samples feasible in routine clinical practice. In the context of pancreaticobiliary cancer, it is necessary ... ...

    Abstract Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood samples feasible in routine clinical practice. In the context of pancreaticobiliary cancer, it is necessary to consider CGP in formulating individualized treatment strategies. Performing CGP with tumor tissue specimens requires a sufficient number of high-quality samples. EUS-guided tissue acquisition (EUS-TA) is expected to play a significant role in this regard, and endosonographers need to address this role. Here, we review the current status of EUS-TA for CGP focusing on pancreatic cancer and biliary tract cancer.
    Language English
    Publishing date 2024-01-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-023-01403-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2695: Show issues Location:
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  3. Article: Modification of milk resulting in low potassium and minimal electrolyte changes with minimal changes in taste

    Hara, Kazuhiro

    Journal of dairy research. 20222022 May 29, Apr. 29, v. 89, no. 2

    2022  

    Abstract: The objective of this research communication was to produce low potassium milk in which other electrolyte changes and changes in taste were minimized. To reduce potassium concentrations, several studies have reported batch methods of directly mixing milk ...

    Abstract The objective of this research communication was to produce low potassium milk in which other electrolyte changes and changes in taste were minimized. To reduce potassium concentrations, several studies have reported batch methods of directly mixing milk or formula with sodium polystyrene sulfonate, which can exchange cations such as potassium for sodium. However, they also reported increases in sodium content, decreases in calcium and magnesium content, and changes in taste, because sodium polystyrene sulfonate exchanged other substances such as calcium and magnesium for sodium. In the present study, a method of dialyzing whole cow's milk using both sodium polystyrene sulfonate and a small amount of water through cellophane membranes was developed. A batch method for comparison was also performed. Each milk sample was evaluated biochemically and analyzed for taste and aroma in a sensory analysis. We showed that the potassium concentration in the dialyzed milk was reduced to 38% of that in unreacted milk. It was also shown that changes in sodium (increased) as well as calcium and magnesium (decreased) in the dialyzed milk were less than half of those in the batch method milk. Sensory analysis showed that minimal changes occurred in the taste of the dialyzed milk.
    Keywords calcium ; cellophane ; magnesium ; milk ; odors ; polystyrene sulfonic acid ; potassium ; research ; sensory evaluation ; sodium ; taste
    Language English
    Dates of publication 2022-0429
    Size p. 185-189.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029922000358
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: [A competency domains-items set for occupational hygienists in Japan].

    Hara, Kunio

    Sangyo eiseigaku zasshi = Journal of occupational health

    2020  Volume 63, Issue 4, Page(s) 103–116

    Abstract: Objectives: The objective of this study was to summarize a combined competency domains and items set for occupational hygienists in Japan since there is a lack of such a set due to the existence of several national certification specialists in the field ...

    Abstract Objectives: The objective of this study was to summarize a combined competency domains and items set for occupational hygienists in Japan since there is a lack of such a set due to the existence of several national certification specialists in the field of occupational hygiene.
    Methods: A literature search, Kitagawa Jiro's (KJ) method study, Delphi method study, and a questionnaire survey were utilized. The domains, roles, knowledge, and skills included in the home pages and reports of representative organizations in the USA, UK, and Japan, and those in papers found through Google Scholar were compared and rearranged to about 150 items. From these, occupational hygiene competency domains and items were discussed and selected by five occupational hygiene specialists using the KJ method and prioritized by 13 occupational hygiene specialists using the Delphi method. Additionally, responses of 53 union members of occupational hygiene specialists from a university were obtained by a questionnaire survey.
    Results: Ten occupational competency domains and 147 items were identified through the literature search, 10 domains and 135 items through the KJ method, six domains and 63 items through the Delphi method, and lastly, five domains and 51 items were identified through the questionnaire survey. The five domains included (1) discovering problems and potential developments and making decisions, (2) solving problems and promoting developmental occupational hygiene, (3) communicating with stakeholders and recovering in an emergency, (4) empowering organizations to which you belong, and (5) educating and facilitating workers.
    Conclusions: Although the 53 subjects in the questionnaire survey were predominantly 20 to 30 years old and more than half of the 13 Delphi method participants were relatively old veterans, there was a positive correlation between the evaluation of 63 items by both methods. These results suggest that the occupational hygiene competency set of five domains and 51 items obtained in this study is a combined competency set that is representative of Japan.
    MeSH term(s) Adult ; Humans ; Japan ; Occupational Health ; Surveys and Questionnaires ; Young Adult
    Language Japanese
    Publishing date 2020-09-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1234922-7
    ISSN 1349-533X ; 1341-0725
    ISSN (online) 1349-533X
    ISSN 1341-0725
    DOI 10.1539/sangyoeisei.2020-029-B
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1162: Show issues Location:
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    Zs.MO 510: Show issues

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  5. Article: Forward viewing liner echoendoscopy for therapeutic interventions.

    Hara, Kazuo / Okuno, Nozomi / Haba, Shin / Kuwahara, Takamichi

    Clinical endoscopy

    2024  Volume 57, Issue 2, Page(s) 175–180

    Abstract: Therapeutic endoscopic ultrasonography (EUS) procedures using the forward-viewing convex EUS (FV-EUS) have been reviewed based on the articles reported to date. The earliest reported procedure is the drainage of pancreatic pseudocysts using FV-EUS. ... ...

    Abstract Therapeutic endoscopic ultrasonography (EUS) procedures using the forward-viewing convex EUS (FV-EUS) have been reviewed based on the articles reported to date. The earliest reported procedure is the drainage of pancreatic pseudocysts using FV-EUS. However, the study on drainage of pancreatic pseudocysts focused on showing that drainage is possible with FV-EUS rather than leveraging its features. Subsequently, studies describing the characteristics of FV-EUS have been reported. By using FV-EUS in EUS-guided choledochoduodenostomy, double punctures in the gastrointestinal tract can be avoided. In postoperative modified anatomical cases, using the endoscopic function of FV-EUS, procedures such as bile duct drainage from anastomosis, pancreatic duct drainage from the afferent limb, and abscess drainage from the digestive tract have been reported. When a perpendicular puncture to the gastrointestinal tract is required or when there is a need to insert the endoscope deep into the gastrointestinal tract, FV-EUS is considered among the options.
    Language English
    Publishing date 2024-02-29
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2643507-X
    ISSN 2234-2443 ; 2234-2400
    ISSN (online) 2234-2443
    ISSN 2234-2400
    DOI 10.5946/ce.2023.271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [Structural Basis of the Multifunctional Hub Protein and Identification of a Small-molecule Compound for Drug Discovery].

    Hara, Kodai

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2019  Volume 139, Issue 7, Page(s) 969–973

    Abstract: Translesion DNA synthesis (TLS) is an emergency system activated to inhibit cell death caused by DNA damage-induced replication arrest. Thus, TLS enables cancer cells to acquire resistance to alkylate anticancer drugs. REV7 functions as the hub protein ... ...

    Abstract Translesion DNA synthesis (TLS) is an emergency system activated to inhibit cell death caused by DNA damage-induced replication arrest. Thus, TLS enables cancer cells to acquire resistance to alkylate anticancer drugs. REV7 functions as the hub protein that interacts with both the inserter DNA polymerase REV1 and the extender DNA polymerase REV3 in TLS. REV7-mediated protein-protein interactions (PPIs) are essential for the activation of TLS, and are therefore attractive targets for anticancer drug development. To clarify the REV7-REV3 and REV7-REV1 PPIs, we determined the structures of REV7-REV3 and REV7-REV3-REV1 complexes. In the structures of REV7-REV3 and REV7-REV3-REV1 complexes, REV7 wraps around the REV3 fragment, and the REV1-binding interface is distinct from the REV3-binding site of REV7. We also identified a novel REV7 binding protein, transcription factor II-I (TFII-I), which is required for TLS. Of note, TFII-I binds the REV7-REV3-REV1 complex, suggesting that REV7-TFII-I PPIs are independent of other REV7-mediated PPIs. Furthermore, we found a small-molecule compound that inhibits TLS by targeting the REV7-REV3 PPIs. Lastly, we determined the structure of REV7 in complex with chromosome alignment maintaining phosphoprotein (CAMP), a known kinetochore-microtubule attachment protein. The overall structure of the REV7-CAMP complex is similar to that of the REV7-REV3 complex, but the REV7-CAMP PPIs are markedly different from the REV7-REV3 PPIs. These findings improve our understanding of multifunctional hub proteins, and are helpful for designing small-molecule compounds for novel anticancer drug development.
    MeSH term(s) Antineoplastic Agents/chemistry ; Crystallography, X-Ray ; DNA/biosynthesis ; DNA Damage ; DNA-Binding Proteins/chemistry ; DNA-Directed DNA Polymerase/chemistry ; Drug Discovery ; Humans ; Mad2 Proteins/chemistry ; Molecular Weight ; Nuclear Proteins/chemistry ; Nucleotidyltransferases/chemistry ; Protein Binding ; Protein Interaction Maps ; Protein Structure, Tertiary
    Chemical Substances Antineoplastic Agents ; DNA-Binding Proteins ; MAD2L2 protein, human ; Mad2 Proteins ; Nuclear Proteins ; DNA (9007-49-2) ; Nucleotidyltransferases (EC 2.7.7.-) ; REV1 protein, human (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; REV3L protein, human (EC 2.7.7.7)
    Language Japanese
    Publishing date 2019-06-18
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  7. Article: Inhibitory Effects of the Heat-Killed Lactic Acid Bacterium

    Matsuo, Tomoe / Nakao, Koji / Hara, Kosuke

    Current therapeutic research, clinical and experimental

    2024  Volume 100, Page(s) 100731

    Abstract: Background: Porphyromonas gingivalis: Objectives: The effects of heat-killed : Methods: Hk: Results: The counts of viable : Conclusions: ... ...

    Abstract Background: Porphyromonas gingivalis
    Objectives: The effects of heat-killed
    Methods: Hk
    Results: The counts of viable
    Conclusions: Hk
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2024.100731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 306: Show issues Location:
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  8. Article ; Online: The use of seismically isolated buildings by urban wildlife in Japan.

    Seki, Yoshikazu / Hara, Keita / Minami, Yoshinori

    The Journal of veterinary medical science

    2024  Volume 86, Issue 3, Page(s) 290–294

    Abstract: Some wildlife species that have expanded their range into urban areas use various anthropogenic structures for breeding and resting. We investigated the use of seismically isolated buildings, with gaps between the structures and ground surface, by urban ... ...

    Abstract Some wildlife species that have expanded their range into urban areas use various anthropogenic structures for breeding and resting. We investigated the use of seismically isolated buildings, with gaps between the structures and ground surface, by urban wildlife in Japan. Camera traps set in a building revealed that masked palm civets (Paguma larvata) continued to use the building for approximately 3 years. Civet feces and footprints were found in two buildings during field sign surveys. To ensure public health, civets should be prevented from invading seismically isolated buildings by covering gaps with elastic materials and avoiding placing pipes that could be used by the animals near these gaps.
    MeSH term(s) Animals ; Animals, Wild ; Viverridae ; Japan ; Public Health ; Phylogeny
    Language English
    Publishing date 2024-01-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.23-0378
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    Zs.B 579: Show issues Location:
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  9. Article: [EUS-guided biliary drainage:past and future prospects].

    Hara, Kazuo / Okuno, Nozomi / Haba, Shin

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2024  Volume 121, Issue 4, Page(s) 287–295

    MeSH term(s) Humans ; Endosonography ; Treatment Outcome ; Drainage ; Cholestasis/diagnostic imaging ; Cholestasis/surgery ; Ultrasonography, Interventional ; Stents
    Language Japanese
    Publishing date 2024-04-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.121.287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.34: Show issues Location:
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    Zs.MO 477: Show issues

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  10. Book ; Online ; E-Book: Body tracking in healthcare

    O'Hara, Kenton / Morrison, Cecily / Sellen, Abigail J. / Bianchi-Berthouze, Nadia / Craig, Cathy

    (Synthesis lectures on assistive, rehabilitative, and health-preserving technologies ; 9)

    2016  

    Author's details Kenton O'Hara, Cecily Morrison, Abigail Sellen, Nadia Bianchi-Berthouze, Cathy Craig
    Series title Synthesis lectures on assistive, rehabilitative, and health-preserving technologies ; 9
    Synthesis lectures on assistive, rehabilitative, and health preserving technologies
    Collection Synthesis lectures on assistive, rehabilitative, and health preserving technologies
    Keywords Gait Disorders, Neurologic / diagnosis ; Monitoring, Physiologic ; Gait / physiology
    Language English
    Size 1 Online-Ressource (xvi, 135 Seiten), Illustrationen
    Publisher Morgan & Claypool Publishers
    Publishing place San Rafael, CA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019392963
    ISBN 9783031016004 ; 9783031004728 ; 3031016009 ; 3031004728
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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