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  1. AU="Harada, Taisuke"
  2. AU="Kim, Hyejeong"
  3. AU="Schellenberg, Gerard"
  4. AU="N. M. Kalinina"
  5. AU=Jalava Jari
  6. AU="Taylor, Lorna"
  7. AU="Eric C Ip"

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  1. Artikel ; Online: MR vessel-encoded arterial spin labeling with the placement of metallic items to visualize the territorial blood flow after extracranial-intracranial bypass surgery: a proof-of-concept study.

    Hayashi, Tetsuji / Fujima, Noriyuki / Harada, Taisuke / Hamaguchi, Akiyoshi / Kodera, Shuichi

    Acta radiologica (Stockholm, Sweden : 1987)

    2023  Band 64, Heft 5, Seite(n) 2004–2009

    Abstract: Background: Depiction of bypass blood flow in patients who received extracranial-intracranial (EC-IC) bypass surgery is important for patient care.: Purpose: To develop a vessel-encoded arterial spin labeling (VE-ASL) method using surgical staples as ...

    Abstract Background: Depiction of bypass blood flow in patients who received extracranial-intracranial (EC-IC) bypass surgery is important for patient care.
    Purpose: To develop a vessel-encoded arterial spin labeling (VE-ASL) method using surgical staples as a magnetic resonance (MR)-conditional product in patients who received EC-IC bypass surgery.
    Material and methods: Pseudo-continuous labeling was used for VE-ASL acquisition with a 3-T MR unit. First, an experimental study was conducted to determine the appropriate number of surgical staples to obtain a spatially sufficient saturation effect. Thereafter, four healthy normal volunteers underwent a VE-ASL study to confirm the sufficiency of the saturation effect to the right or left common carotid artery. Finally, VE-ASL scanning was performed in seven patients after EC-IC bypass surgery to confirm the ability of VE-ASL to visualize the territorial bypass perfusion. All qualitative evaluation was performed by two neuroradiologists using a 3-point grading system (2 = good, 1 = moderate, 0 = poor).
    Results: A quantity of 200 staples was found to be appropriate for VE-ASL scanning. In healthy volunteers, one neuroradiologist rated the images of all four cases as good, while the other rated three cases as good and one case as moderate. For the seven patients after EC-IC bypass surgery, one neuroradiologist rated all seven cases as good, and the other rated six cases as good and one case as moderate.
    Conclusion: VE-ASL using surgical staples might be useful for the evaluation of territorial bypass perfusion in patients after EC-IC bypass surgery.
    Mesh-Begriff(e) Humans ; Magnetic Resonance Angiography/methods ; Spin Labels ; Magnetic Resonance Imaging/methods ; Hemodynamics ; Cerebrovascular Circulation/physiology ; Magnetic Resonance Spectroscopy
    Chemische Substanzen Spin Labels
    Sprache Englisch
    Erscheinungsdatum 2023-01-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851221151144
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  2. Artikel ; Online: Automated Detection of Cerebral Microbleeds on Two-dimensional Gradient-recalled Echo T2* Weighted Images Using a Morphology Filter Bank and Convolutional Neural Network.

    Nishioka, Noriko / Shimizu, Yukie / Shirai, Toru / Ochi, Hisaaki / Bito, Yoshitaka / Watanabe, Kiichi / Kameda, Hiroyuki / Harada, Taisuke / Kudo, Kohsuke

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2024  

    Abstract: Purpose: We present a novel algorithm for the automated detection of cerebral microbleeds (CMBs) on 2D gradient-recalled echo T2* weighted images (T2*WIs). This approach combines a morphology filter bank with a convolutional neural network (CNN) to ... ...

    Abstract Purpose: We present a novel algorithm for the automated detection of cerebral microbleeds (CMBs) on 2D gradient-recalled echo T2* weighted images (T2*WIs). This approach combines a morphology filter bank with a convolutional neural network (CNN) to improve the efficiency of CMB detection. A technical evaluation was performed to ascertain the algorithm's accuracy.
    Methods: In this retrospective study, 60 patients with CMBs on T2*WIs were included. The gold standard was set by three neuroradiologists based on the Microbleed Anatomic Rating Scale guidelines. Images with CMBs were extracted from the training dataset comprising 30 cases using a morphology filter bank, and false positives (FPs) were removed based on the threshold of size and signal intensity. The extracted images were used to train the CNN (Vgg16). To determine the effectiveness of the morphology filter bank, the outcomes of the following two methods for detecting CMBs from the 30-case test dataset were compared: (a) employing the morphology filter bank and additional FP removal and (b) comprehensive detection without filters. The trained CNN processed both sets of initial CMB candidates, and the final CMB candidates were compared with the gold standard. The sensitivity and FPs per patient of both methods were compared.
    Results: After CNN processing, the morphology-filter-bank-based method had a 95.0% sensitivity with 4.37 FPs per patient. In contrast, the comprehensive method had a 97.5% sensitivity with 25.87 FPs per patient.
    Conclusion: Through effective CMB candidate refinement with a morphology filter bank and FP removal with a CNN, we achieved a high CMB detection rate and low FP count. Combining a CNN and morphology filter bank may facilitate the accurate automated detection of CMBs on T2*WIs.
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1880-2206
    ISSN (online) 1880-2206
    ISSN 1880-2206
    DOI 10.2463/mrms.mp.2023-0146
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  3. Artikel ; Online: Diagnosis of skull-base invasion by nasopharyngeal tumors on CT with a deep-learning approach.

    Nakagawa, Junichi / Fujima, Noriyuki / Hirata, Kenji / Harada, Taisuke / Wakabayashi, Naoto / Takano, Yuki / Homma, Akihiro / Kano, Satoshi / Minowa, Kazuyuki / Kudo, Kohsuke

    Japanese journal of radiology

    2024  Band 42, Heft 5, Seite(n) 450–459

    Abstract: Purpose: To develop a convolutional neural network (CNN) model to diagnose skull-base invasion by nasopharyngeal malignancies in CT images and evaluate the model's diagnostic performance.: Materials and methods: We divided 100 malignant ... ...

    Abstract Purpose: To develop a convolutional neural network (CNN) model to diagnose skull-base invasion by nasopharyngeal malignancies in CT images and evaluate the model's diagnostic performance.
    Materials and methods: We divided 100 malignant nasopharyngeal tumor lesions into a training (n = 70) and a test (n = 30) dataset. Two head/neck radiologists reviewed CT and MRI images and determined the positive/negative skull-base invasion status of each case (training dataset: 29 invasion-positive and 41 invasion-negative; test dataset: 13 invasion-positive and 17 invasion-negative). Preprocessing involved extracting continuous slices of the nasopharynx and clivus. The preprocessed training dataset was used for transfer learning with Residual Neural Networks 50 to create a diagnostic CNN model, which was then tested on the preprocessed test dataset to determine the invasion status and model performance. Original CT images from the test dataset were reviewed by a radiologist with extensive head/neck imaging experience (senior reader: SR) and another less-experienced radiologist (junior reader: JR). Gradient-weighted class activation maps (Grad-CAMs) were created to visualize the explainability of the invasion status classification.
    Results: The CNN model's diagnostic accuracy was 0.973, significantly higher than those of the two radiologists (SR: 0.838; JR: 0.595). Receiver operating characteristic curve analysis gave an area under the curve of 0.953 for the CNN model (versus 0.832 and 0.617 for SR and JR; both p < 0.05). The Grad-CAMs suggested that the invasion-negative cases were present predominantly in bone marrow, while the invasion-positive cases exhibited osteosclerosis and nasopharyngeal masses.
    Conclusions: This CNN technique would be useful for CT-based diagnosis of skull-base invasion by nasopharyngeal malignancies.
    Mesh-Begriff(e) Humans ; Nasopharyngeal Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Neoplasm Invasiveness/diagnostic imaging ; Male ; Deep Learning ; Middle Aged ; Female ; Aged ; Adult ; Skull Base/diagnostic imaging ; Skull Base Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Sensitivity and Specificity ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2024-01-27
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-023-01527-7
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  4. Artikel: [A Diagnostic Imaging Approach for Tremor].

    Harada, Taisuke / Kudo, Kohsuke

    Brain and nerve = Shinkei kenkyu no shinpo

    2018  Band 70, Heft 12, Seite(n) 1331–1340

    Abstract: Tremor is one of the common movement disorders encountered in a clinical practice. Tremor is often difficult to diagnose and can be easily mistaken for another disorder, hence diagnostic imaging is employed to provide objective information. The ... ...

    Abstract Tremor is one of the common movement disorders encountered in a clinical practice. Tremor is often difficult to diagnose and can be easily mistaken for another disorder, hence diagnostic imaging is employed to provide objective information. The morphometry, signal changes, neuromelanin, and iron deposition can be evaluated by MRI, whereas cardiac sympathetic nerve and dopamine transporter degeneration are detected by means of nuclear medicine. The purpose of this article is to provide an overview of the role and indications of imaging test, as well as a review of the methods in which the findings of images are interpreted.
    Mesh-Begriff(e) Humans ; Magnetic Resonance Imaging ; Movement Disorders/complications ; Movement Disorders/diagnosis ; Tremor/etiology
    Sprache Japanisch
    Erscheinungsdatum 2018-12-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201191
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  5. Artikel ; Online: Cerebellar Rotation Abnormalities Observed in Machado-Joseph Disease.

    Nomura, Taichi / Iwata, Ikuko / Harada, Taisuke / Yabe, Ichiro

    Internal medicine (Tokyo, Japan)

    2020  Band 59, Heft 24, Seite(n) 3253–3254

    Sprache Englisch
    Erscheinungsdatum 2020-08-12
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.5070-20
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  6. Artikel ; Online: Neuroimaging Features of Cytokine-related Diseases.

    Kurokawa, Mariko / Kurokawa, Ryo / Baba, Akira / Gomi, Taku / Cho, Shinichi / Yoshioka, Kyohei / Harada, Taisuke / Kim, John / Emile, Pinarbasi / Abe, Osamu / Moritani, Toshio

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2024  Band 44, Heft 6, Seite(n) e230069

    Abstract: Cytokines are small secreted proteins that have specific effects on cellular interactions and are crucial for functioning of the immune system. Cytokines are involved in almost all diseases, but as microscopic chemical compounds they cannot be visualized ...

    Abstract Cytokines are small secreted proteins that have specific effects on cellular interactions and are crucial for functioning of the immune system. Cytokines are involved in almost all diseases, but as microscopic chemical compounds they cannot be visualized at imaging for obvious reasons. Several imaging manifestations have been well recognized owing to the development of cytokine therapies such as those with bevacizumab (antibody against vascular endothelial growth factor) and chimeric antigen receptor (CAR) T cells and the establishment of new disease concepts such as interferonopathy and cytokine release syndrome. For example, immune effector cell-associated neurotoxicity is the second most common form of toxicity after CAR T-cell therapy toxicity, and imaging is recommended to evaluate the severity. The emergence of COVID-19, which causes a cytokine storm, has profoundly impacted neuroimaging. The central nervous system is one of the systems that is most susceptible to cytokine storms, which are induced by the positive feedback of inflammatory cytokines. Cytokine storms cause several neurologic complications, including acute infarction, acute leukoencephalopathy, and catastrophic hemorrhage, leading to devastating neurologic outcomes. Imaging can be used to detect these abnormalities and describe their severity, and it may help distinguish mimics such as metabolic encephalopathy and cerebrovascular disease. Familiarity with the neuroimaging abnormalities caused by cytokine storms is beneficial for diagnosing such diseases and subsequently planning and initiating early treatment strategies. The authors outline the neuroimaging features of cytokine-related diseases, focusing on cytokine storms, neuroinflammatory and neurodegenerative diseases, cytokine-related tumors, and cytokine-related therapies, and describe an approach to diagnosing cytokine-related disease processes and their differentials.
    Mesh-Begriff(e) Humans ; Neuroimaging/methods ; Cytokine Release Syndrome/diagnostic imaging ; Cytokine Release Syndrome/etiology ; COVID-19/diagnostic imaging ; SARS-CoV-2 ; Cytokines
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.230069
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  7. Artikel ; Online: Quality of epicardial adipose tissue predicts major adverse cerebral and cardiovascular events following transcatheter aortic valve implantation.

    Sato, Takaaki / Yufu, Kunio / Yamasaki, Hirochika / Harada, Taisuke / Yamauchi, Shuichiro / Ishii, Yumi / Fukuda, Tomoko / Kawashima, Takayuki / Shuto, Takashi / Akioka, Hidefumi / Shinohara, Tetsuji / Teshima, Yasushi / Wada, Tomoyuki / Miyamoto, Shinji / Takahashi, Naohiko

    Heart and vessels

    2024  

    Abstract: Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation ...

    Abstract Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation determined using computed tomography (CT) imaging, can detect the histologically-assessed remodeled EAT. We tested the hypothesis that quality of EAT would predict major adverse cerebral and cardiovascular events (MACCE) following transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS). A total of 125 consecutive severe AS patients who underwent TAVI were enrolled (39 male, mean 85.4 ± 4.0 years). Using CT imaging before TAVI, we measured the average CT fat attenuation of EAT (EAT attenuation) and investigated the association with MACCE. During the mean follow up period of 567 ± 371 days, 21 cases of MACCE were observed. Patients with MACCE had greater levels of EAT attenuation compared to those without (- 74 ± 3.7 Hounsfield Units (HU) vs - 77 ± 5.5 HU, p = 0.010). Based on the ROC curves, the high EAT attenuation was defined as > - 74.3 HU. According to this cut-off index, 44 patients were classified into the high EAT attenuation group (28 female, mean age 87 ± 3.6 years), whereas 81 patients were classified into the low EAT attenuation group (13 female, 85 ± 4.1 years). Kaplan-Meier survival curve demonstrated that the patients in the high EAT attenuation group showed greater prevalence of MACCE (log-rank 6.64, p = 0.010). Cox proportional hazards regression analysis revealed that EAT attenuation and Logistic EuroSCORE were independently associated with the incidence of MACCE. Our results suggest that quality of EAT, assessed by EAT attenuation detected by CT imaging, can predict the cerebral and cardiovascular events after TAVI in patients with AS.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-024-02374-w
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  8. Artikel ; Online: Improved image quality in contrast-enhanced 3D-T1 weighted sequence by compressed sensing-based deep-learning reconstruction for the evaluation of head and neck.

    Fujima, Noriyuki / Nakagawa, Junichi / Ikebe, Yohei / Kameda, Hiroyuki / Harada, Taisuke / Shimizu, Yukie / Tsushima, Nayuta / Kano, Satoshi / Homma, Akihiro / Kwon, Jihun / Yoneyama, Masami / Kudo, Kohsuke

    Magnetic resonance imaging

    2024  Band 108, Seite(n) 111–115

    Abstract: Purpose: To assess the utility of deep learning (DL)-based image reconstruction with the combination of compressed sensing (CS) denoising cycle by comparing images reconstructed by conventional CS-based method without DL in fat-suppressed (Fs)-contrast ... ...

    Abstract Purpose: To assess the utility of deep learning (DL)-based image reconstruction with the combination of compressed sensing (CS) denoising cycle by comparing images reconstructed by conventional CS-based method without DL in fat-suppressed (Fs)-contrast enhanced (CE) three-dimensional (3D) T1-weighted images (T1WIs) of the head and neck.
    Materials and methods: We retrospectively analyzed the cases of 39 patients who had undergone head and neck Fs-CE 3D T1WI applying reconstructions based on conventional CS and CS augmented by DL, respectively. In the qualitative assessment, we evaluated overall image quality, visualization of anatomical structures, degree of artifacts, lesion conspicuity, and lesion edge sharpness based on a five-point system. In the quantitative assessment, we calculated the signal-to-noise ratios (SNRs) of the lesion and the posterior neck muscle and the contrast-to-noise ratio (CNR) between the lesion and the adjacent muscle.
    Results: For all items of the qualitative analysis, significantly higher scores were awarded to images with DL-based reconstruction (p < 0.001). In the quantitative analysis, DL-based reconstruction resulted in significantly higher values for both the SNR of lesions (p < 0.001) and posterior neck muscles (p < 0.001). Significantly higher CNRs were also observed in images with DL-based reconstruction (p < 0.001).
    Conclusion: DL-based image reconstruction integrating into the CS-based denoising cycle offered superior image quality compared to the conventional CS method. This technique will be useful for the assessment of patients with head and neck disease.
    Mesh-Begriff(e) Humans ; Retrospective Studies ; Deep Learning ; Signal-To-Noise Ratio ; Muscles ; Magnetic Resonance Imaging/methods ; Artifacts
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2024.02.006
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  9. Artikel ; Online: Pearls & Oy-sters: Adult-Onset Alexander Disease With Transient Swelling of the Medulla Oblongata.

    Oshima, Yuki / Takahashi-Iwata, Ikuko / Sato, Shoki / Harada, Taisuke / Yoshida, Tomokatsu / Yabe, Ichiro

    Neurology

    2021  Band 97, Heft 12, Seite(n) 602–605

    Sprache Englisch
    Erscheinungsdatum 2021-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
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    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000012268
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  10. Artikel ; Online: Percutaneous Drainage for Postoperative Fluid Collection after Hepatobiliary Pancreatic Surgery.

    Morita, Ryo / Abo, Daisuke / Harada, Taisuke / Soyama, Takeshi / Takahashi, Bunya / Yoshino, Yuki / Kinota, Naoya / Yasui, Taichi / Kudo, Kohsuke

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2022  Band 42, Heft 6, Seite(n) E171–E172

    Mesh-Begriff(e) Digestive System Surgical Procedures ; Drainage ; Humans ; Postoperative Complications/diagnostic imaging ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2022-10-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
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    DOI 10.1148/rg.220023
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