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  1. Article ; Online: The diurnal variation of wet bulb temperatures and exceedance of physiological thresholds relevant to human health in South Asia

    Jenix Justine / Joy Merwin Monteiro / Hardik Shah / Neethi Rao

    Communications Earth & Environment, Vol 4, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Extreme heat is increasingly being acknowledged as a serious hazard to human health, through a combination of physiological responses to heat, expressed as dry and wet bulb temperatures, and personal factors. Here we present an analysis of the ... ...

    Abstract Abstract Extreme heat is increasingly being acknowledged as a serious hazard to human health, through a combination of physiological responses to heat, expressed as dry and wet bulb temperatures, and personal factors. Here we present an analysis of the diurnal variability of dry and wet bulb temperatures using station data in South Asia during both regular and heatwave days. We find that diurnal cycles differ, with the daily maximum wet bulb temperature occurring several hours after the daily maximum dry bulb temperature. Using radiosonde profiles, we show that the timing and amplitude of the diurnal variability of wet bulb temperature can be explained by changes in boundary layer depths and water content. Physiological thresholds for uncompensable heat stress were exceeded even in the evenings, many hours after dry bulb temperature peaks. Cumulative exceedances occurred in 105 instances, corresponding to at least 300 hours of exposure to uncompensable heat stress in South Asia between 1995 and 2020. We conclude that physiologically relevant thresholds provide a more robust way to estimate health impacts, and that wet bulb temperature alone is insufficient as an indicator of hazardous heat.
    Keywords Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
    Subject code 551
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Multimodality imaging of adult gastric emergencies

    Abhijit Sunnapwar / Vijayanadh Ojili / Rashmi Katre / Hardik Shah / Arpit Nagar

    Indian Journal of Radiology and Imaging, Vol 27, Iss 01, Pp 13-

    A pictorial review

    2017  Volume 22

    Abstract: Acute gastric emergencies require urgent surgical or nonsurgical intervention because they are associated with high morbidity and mortality. Imaging plays an important role in diagnosis since the clinical symptoms are often nonspecific and radiologist ... ...

    Abstract Acute gastric emergencies require urgent surgical or nonsurgical intervention because they are associated with high morbidity and mortality. Imaging plays an important role in diagnosis since the clinical symptoms are often nonspecific and radiologist may be the first one to suggest a diagnosis as the imaging findings are often characteristic. The purpose of this article is to provide a comprehensive review of multimodality imaging (plain radiograph, fluoroscopy, and computed tomography) of various life threatening gastric emergencies.
    Keywords ct ; emergencies ; fluoroscopy ; gastric ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

    Xiaojian Shi / Bryn Reinstadler / Hardik Shah / Tsz-Leung To / Katie Byrne / Luanna Summer / Sarah E. Calvo / Olga Goldberger / John G. Doench / Vamsi K. Mootha / Hongying Shen

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Combinatorial Gene×Gene×Environment CRISPR screen targeting human SLC25 transporter family enables the identification of SLC25A39 in mitochondrial glutathione import and its coordination with mitochondrial iron import in supporting OXPHOS. ...

    Abstract Combinatorial Gene×Gene×Environment CRISPR screen targeting human SLC25 transporter family enables the identification of SLC25A39 in mitochondrial glutathione import and its coordination with mitochondrial iron import in supporting OXPHOS.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Journey of Red Ribbon Express (RRE) through Gujarat

    Hemant Shukla1, / Hardik Shah

    Healthline, Vol 1, Iss 1, Pp 67-

    2010  Volume 69

    Abstract: Generating mass awareness regarding HIV/AIDS is an important strategy under National AIDS Control Programme-III (NACP-III). It not only reduces the transmission but also aims to remove the stigma and discrimination towards People Leaving with HIV/AIDS ( ... ...

    Abstract Generating mass awareness regarding HIV/AIDS is an important strategy under National AIDS Control Programme-III (NACP-III). It not only reduces the transmission but also aims to remove the stigma and discrimination towards People Leaving with HIV/AIDS (PLHA). This in turn, facilitates the PLHA to come out in open with their status, whereby they join the services of care, supports and treatment and are also empowered/ informed to prevent further transmission.
    Keywords Medicine ; R ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2010-07-01T00:00:00Z
    Publisher Indian Association of Preventive and Social Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Isoform-resolved transcriptome of the human preimplantation embryo

    Denis Torre / Nancy J. Francoeur / Yael Kalma / Ilana Gross Carmel / Betsaida S. Melo / Gintaras Deikus / Kimaada Allette / Ron Flohr / Maya Fridrikh / Konstantinos Vlachos / Kent Madrid / Hardik Shah / Ying-Chih Wang / Shwetha H. Sridhar / Melissa L. Smith / Efrat Eliyahu / Foad Azem / Hadar Amir / Yoav Mayshar /
    Ivan Marazzi / Ernesto Guccione / Eric Schadt / Dalit Ben-Yosef / Robert Sebra

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 23

    Abstract: Abstract Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-length mRNAs. Here, we generate an ... ...

    Abstract Abstract Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-length mRNAs. Here, we generate an isoform-resolved transcriptome of early human development by performing long- and short-read RNA sequencing on 73 embryos spanning the zygote to blastocyst stages. We identify 110,212 unannotated isoforms transcribed from known genes, including highly conserved protein-coding loci and key developmental regulators. We further identify 17,964 isoforms from 5,239 unannotated genes, which are largely non-coding, primate-specific, and highly associated with transposable elements. These isoforms are widely supported by the integration of published multi-omics datasets, including single-cell 8CLC and blastoid studies. Alternative splicing and gene co-expression network analyses further reveal that embryonic genome activation is associated with splicing disruption and transient upregulation of gene modules. Together, these findings show that the human embryo transcriptome is far more complex than currently known, and will act as a valuable resource to empower future studies exploring development.
    Keywords Science ; Q
    Subject code 572
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Comparison of Surgical Outcome in Endoscopic Dacryocystorhinostomy with and without Silicon Stent Placement

    Hardik Shah / Suktara Sharma / Neeraj Suri / Alpesh Patel

    National Journal of Medical Research, Vol 3, Iss 1.000, Pp 34-

    2013  Volume 37

    Abstract: Objective: The purpose of this study was to compare the long term surgical outcome in endonasal dacrycystorhinostomy (DCR) with and without silicon stent placement. Subjects and method: A retrospective comparative analysis of 129 patients who underwent ... ...

    Abstract Objective: The purpose of this study was to compare the long term surgical outcome in endonasal dacrycystorhinostomy (DCR) with and without silicon stent placement. Subjects and method: A retrospective comparative analysis of 129 patients who underwent primary endoscopic DCR with stenting (group A) or without stenting (group B) was done. Success was defined as grade 0 or grade 1 epiphora at minimum 6 months follow up and complete patency of the lacrimal drainage system confirmed by irrigation. Patients were followed up for mean 28 weeks, (range 6 months to 2 years). Stents were usually removed at about three to six months (mean 21 weeks). Results: Out of the 129 patients, 90 underwent silicon stent placement (group A) as against 39 patients in which DCR was done without stenting (group B). Out of 90 patients of group A, 84 ( 93.33% ) showed complete recovery of symptoms (epiphora grading 0-1) Out of 39 patients of group B 35( 92.30%) showed complete recovery of symptoms at six months follow up. Patients with stent placements showed a slightly higher rate of success as compared to patients without stenting (93.33%/ 92.30%). There was however no statistical difference in the success rate between group A and group B (p- 0.8086). Conclusion: Silicon intubation of the nasolacrimal duct may not contribute to the success of endonasal DCR. Other factors such as size of the rhinostomy and presence of infection also play an important role in success of endonasal DCR. [Natl J of Med Res 2013; 3(1.000): 34-37]
    Keywords Dacryocystorhinostomy ; endonasal DCR ; silicon stent ; nasolacrimal duct obstruction ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 616
    Language English
    Publishing date 2013-02-01T00:00:00Z
    Publisher National Association for Medical Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

    Juan J Apiz Saab / Lindsey N Dzierozynski / Patrick B Jonker / Roya AminiTabrizi / Hardik Shah / Rosa Elena Menjivar / Andrew J Scott / Zeribe C Nwosu / Zhou Zhu / Riona N Chen / Moses Oh / Colin Sheehan / Daniel R Wahl / Marina Pasca di Magliano / Costas A Lyssiotis / Kay F Macleod / Christopher R Weber / Alexander Muir

    eLife, Vol

    2023  Volume 12

    Abstract: Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical ... ...

    Abstract Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical to understand the metabolism underpinning cancer cell biology. Previously, we performed quantitative metabolomics of the interstitial fluid (the local perfusate) of murine pancreatic ductal adenocarcinoma (PDAC) tumors to comprehensively characterize nutrient availability in the microenvironment of these tumors. Here, we develop Tumor Interstitial Fluid Medium (TIFM), a cell culture medium that contains nutrient levels representative of the PDAC microenvironment, enabling us to study PDAC metabolism ex vivo under physiological nutrient conditions. We show that PDAC cells cultured in TIFM adopt a cellular state closer to that of PDAC cells present in tumors compared to standard culture models. Further, using the TIFM model, we found arginine biosynthesis is active in PDAC and allows PDAC cells to maintain levels of this amino acid despite microenvironmental arginine depletion. We also show that myeloid derived arginase activity is largely responsible for the low levels of arginine in PDAC tumors. Altogether, these data indicate that nutrient availability in tumors is an important determinant of cancer cell metabolism and behavior, and cell culture models that incorporate physiological nutrient availability have improved fidelity to in vivo systems and enable the discovery of novel cancer metabolic phenotypes.
    Keywords metabolism ; tumor microenvironment ; amino acid homeostasis ; arginine ; nutrient stress ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Study of Co2 Laser in Otolaryngology at Gmers Medical College, Sola, Ahmedabad

    Hardik Shah / Neeraj Suri / U B Shah

    National Journal of Medical Research, Vol 2, Iss 4.000, Pp 470-

    2012  Volume 472

    Abstract: Aim: Aim of our study was to compare the surgical otolaryngology cases (vocal cord lesions, dacryocystitis, tonsillitis, and oral cavity growth) operated with laser and with conventional technique. Methods: 89 patients were reviewed. Laser was used in 50 ...

    Abstract Aim: Aim of our study was to compare the surgical otolaryngology cases (vocal cord lesions, dacryocystitis, tonsillitis, and oral cavity growth) operated with laser and with conventional technique. Methods: 89 patients were reviewed. Laser was used in 50 cases. Results: We found that postoperative pain and intraoperative bleeding was less in patients operated with laser technique. Haemostatis was better achieved. But surgical technique in cases operated with laser needs expertise training. Conclusion: The CO2 laser is associated with precise and predictable soft tissue interaction, minimal damage surrounding normal tissue and minimal formation of char. [Natl J of Med Res 2012; 2(4.000): 470-472]
    Keywords CO2 laser ; vocal cord ; dacryocystitis. Oral Sub Mucosal Fibrosis ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher National Association for Medical Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

    Yuchen Zhang / Rui Guo / Sharon H. Kim / Hardik Shah / Shuting Zhang / Jin Hua Liang / Ying Fang / Matteo Gentili / Colin N. O’ Leary / Steven J. Elledge / Deborah T. Hung / Vamsi K. Mootha / Benjamin E. Gewurz

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level. ...

    Abstract Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.
    Keywords Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Review on Virtual Reality

    Pallavi Halarnkar / Sahil Shah / Harsh Shah / Hardik Shah / Anuj Shah

    International Journal of Computer Science Issues, Vol 9, Iss 6, Pp 325-

    2012  Volume 330

    Abstract: Virtual Reality is a major asset and aspect of our future. It is the key to experiencing, feeling and touching the past, present and the future. It is the medium of creating our own world, our own customized reality. It could range from creating a video ... ...

    Abstract Virtual Reality is a major asset and aspect of our future. It is the key to experiencing, feeling and touching the past, present and the future. It is the medium of creating our own world, our own customized reality. It could range from creating a video game to having a virtual stroll around the universe, from walking through our own dream house to experiencing a walk on an alien planet. With virtual reality, we can experience the most intimidating and gruelling situations by playing safe and with a learning perspective. In this review paper, we present our survey about virtual reality: the levels of virtual reality, the components used, the factors affecting the virtual environment, its origin, future and the challenges to overcome in order to obtain an impeccable virtual reality experience.
    Keywords Levels of Virtual Reality ; Immersive Virtual Reality ; Image Resolution ; Frame Rate ; Latency ; HMD ; CAVE ; Virtusphere ; IJCSI ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Subject code 629
    Language English
    Publishing date 2012-11-01T00:00:00Z
    Publisher IJCSI Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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