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  1. Article ; Online: Pathophysiology of Hypoxemia in COVID-19 Lung Disease.

    Swenson, Kai E / Hardin, Charles C

    Clinics in chest medicine

    2022  Volume 44, Issue 2, Page(s) 239–248

    Abstract: As the pandemic has progressed, our understanding of hypoxemia in coronavirus disease 2019 (COVID-19) lung disease has become more nuanced, although much remains to be understood. In this article, we review ventilation-perfusion mismatching in COVID-19 ... ...

    Abstract As the pandemic has progressed, our understanding of hypoxemia in coronavirus disease 2019 (COVID-19) lung disease has become more nuanced, although much remains to be understood. In this article, we review ventilation-perfusion mismatching in COVID-19 and the evidence to support various biologic theories offered in explanation. In addition, the relationship between hypoxemia and other features of severe COVID-19 lung disease such as respiratory symptoms, radiographic abnormalities, and pulmonary mechanics is explored. Recognizing and understanding hypoxemia in COVID-19 lung disease remains essential for risk stratification, prognostication, and choice of appropriate treatments in severe COVID-19.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Lung/diagnostic imaging ; Lung Diseases ; Hypoxia/etiology ; Hypoxia/therapy
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2022.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The Case of the Missing Data.

    Takvorian, Katherine S / Sacks, Chana A / Hardin, Charles C

    NEJM evidence

    2022  Volume 1, Issue 4, Page(s) EVIDstat2200065

    Abstract: The Case of the Missing DataThis animated video explores how investigators approach missing data in clinical trials. ...

    Abstract The Case of the Missing DataThis animated video explores how investigators approach missing data in clinical trials.
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is Noninferior Not Inferior?

    Kadire, Siri / Hardin, Charles C / Takvorian, Katherine S / Sacks, Chana A

    NEJM evidence

    2022  Volume 1, Issue 1, Page(s) EVIDstat2100040

    Abstract: Is Noninferior Not Inferior? What is a non-inferiority trial margin? To answer this, ask whether you have ever weighed a tradeoff between the best version of something and an acceptable alternative. Restated, in a choice between two decisions, is one ... ...

    Abstract Is Noninferior Not Inferior? What is a non-inferiority trial margin? To answer this, ask whether you have ever weighed a tradeoff between the best version of something and an acceptable alternative. Restated, in a choice between two decisions, is one option not inferior to the other? Watch an animated video that explores the basis for non-inferiority trials, the meaning of non-inferiority margins, and the interpretation of a non-inferiority trial's results.
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2100040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Problem of Multiple Comparisons.

    Takvorian, Katherine S / Hardin, Charles C / Muller, Daniel / Vining, Tim / Normand, Sharon-Lise / Sacks, Chana A

    NEJM evidence

    2022  Volume 1, Issue 7, Page(s) EVIDstat2200171

    Abstract: The Problem of Multiple Comparisons This animated video reviews the problem of multiple comparisons in research studies and explains how performing multiple statistical hypothesis tests can produce associations simply by chance. ...

    Abstract The Problem of Multiple Comparisons This animated video reviews the problem of multiple comparisons in research studies and explains how performing multiple statistical hypothesis tests can produce associations simply by chance.
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Threats to Blinding.

    Davies, O M / Takvorian, Katherine S / Muller, Daniel / Vining, Tim / Burke, Alison / Sacks, Chana A / Hardin, Charles C

    NEJM evidence

    2022  Volume 1, Issue 11, Page(s) EVIDstat2200284

    Abstract: Blinding is a critical strategy used to limit certain types of bias in randomized controlled trials. This animated video explores the rationale and examines potential threats to keeping group allocation concealed - from study participants and ... ...

    Abstract Blinding is a critical strategy used to limit certain types of bias in randomized controlled trials. This animated video explores the rationale and examines potential threats to keeping group allocation concealed - from study participants and investigators.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Of Climate Change and Competing Risks.

    Takvorian, Katherine S / Hardin, Charles C / Muller, Daniel / Ling, Emily / Vining, Tim / Normand, Sharon-Lise / Sacks, Chana A

    NEJM evidence

    2022  Volume 2, Issue 1, Page(s) EVIDstat2200319

    Abstract: Of Climate Change and Competing Risks This Stats, STAT! animated video explores the concept of competing risks - and discusses why it is so important for investigators to consider whether the occurrence of one event can prevent or change the likelihood ... ...

    Abstract Of Climate Change and Competing Risks This Stats, STAT! animated video explores the concept of competing risks - and discusses why it is so important for investigators to consider whether the occurrence of one event can prevent or change the likelihood of the occurrence of another.
    Language English
    Publishing date 2022-12-27
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Subgroup Analyses: Subpar or Sublime?

    Hughes, Emily / Takvorian, Katherine S / Dodd, Lori E / Koscal, Natalie / Muller, Daniel / Vining, Tim / Hardin, Charles C / Sacks, Chana A

    NEJM evidence

    2022  Volume 1, Issue 9, Page(s) EVIDstat2200228

    Abstract: Subgroup Analyses: Subpar or Sublime?This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how to approach potential findings with caution. ...

    Abstract Subgroup Analyses: Subpar or Sublime?This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how to approach potential findings with caution.
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDstat2200228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Case 23-2019: A 52-Year-Old Man with Fever, Cough, and Hypoxemia.

    Hardin, Charles C / Malhotra, Rajeev / Petranović, Milena / Klassen, Sheila / Mihatov, Nino / Oakley, Derek H

    The New England journal of medicine

    2019  Volume 381, Issue 4, Page(s) 359–369

    MeSH term(s) Cough/etiology ; Diagnosis, Differential ; Echocardiography ; Electrocardiography ; Fever/etiology ; Heart/diagnostic imaging ; Humans ; Hypoxia/etiology ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases/diagnosis ; Male ; Middle Aged ; Mitral Valve/pathology ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/etiology ; Mitral Valve Prolapse/diagnosis ; Mitral Valve Prolapse/etiology ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Radiography, Thoracic ; Tachycardia, Sinus/diagnosis
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc1900598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An organosynthetic soft robotic respiratory simulator.

    Horvath, Markus A / Hu, Lucy / Mueller, Tanja / Hochstein, Jon / Rosalia, Luca / Hibbert, Kathryn A / Hardin, Charles C / Roche, Ellen T

    APL bioengineering

    2020  Volume 4, Issue 2, Page(s) 26108

    Abstract: In this work, we describe a benchtop model that recreates the motion and function of the diaphragm using a combination of advanced robotic and organic tissue. First, we build a high-fidelity anthropomorphic model of the diaphragm using thermoplastic and ... ...

    Abstract In this work, we describe a benchtop model that recreates the motion and function of the diaphragm using a combination of advanced robotic and organic tissue. First, we build a high-fidelity anthropomorphic model of the diaphragm using thermoplastic and elastomeric material based on clinical imaging data. We then attach pneumatic artificial muscles to this elastomeric diaphragm, pre-programmed to move in a clinically relevant manner when pressurized. By inserting this diaphragm as the divider between two chambers in a benchtop model-one representing the thorax and the other the abdomen-and subsequently activating the diaphragm, we can recreate the pressure changes that cause lungs to inflate and deflate during regular breathing. Insertion of organic lungs in the thoracic cavity demonstrates this inflation and deflation in response to the pressures generated by our robotic diaphragm. By tailoring the input pressures and timing, we can represent different breathing motions and disease states. We instrument the model with multiple sensors to measure pressures, volumes, and flows and display these data in real-time, allowing the user to vary inputs such as the breathing rate and compliance of various components, and so they can observe and measure the downstream effect of changing these parameters. In this way, the model elucidates fundamental physiological concepts and can demonstrate pathology and the interplay of components of the respiratory system. This model will serve as an innovative and effective pedagogical tool for educating students on respiratory physiology and pathology in a user-controlled, interactive manner. It will also serve as an anatomically and physiologically accurate testbed for devices or pleural sealants that reside in the thoracic cavity, representing a vast improvement over existing models and ultimately reducing the requirement for testing these technologies in animal models. Finally, it will act as an impactful visualization tool for educating and engaging the broader community.
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/1.5140760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Feasibility and Consistency of Results with Deployment of an In-Line Filter for Exercise-Based Evaluations of Patients With Heart Failure During the Novel Coronavirus Disease-2019 Pandemic.

    Bhat, Rohan R / Schoenike, Mark W / Kowal, Alyssa / White, Casey / Rouvina, Jennifer / Hardin, Charles C / Malhotra, Rajeev / Lewis, Gregory D

    Journal of cardiac failure

    2020  Volume 27, Issue 1, Page(s) 105–108

    Abstract: Background: Exercise testing plays an important role in evaluating heart failure prognosis and selecting patients for advanced therapeutic interventions. However, concern for severe acute respiratory syndrome novel coronavirus-2 transmission during ... ...

    Abstract Background: Exercise testing plays an important role in evaluating heart failure prognosis and selecting patients for advanced therapeutic interventions. However, concern for severe acute respiratory syndrome novel coronavirus-2 transmission during exercise testing has markedly curtailed performance of exercise testing during the novel coronavirus disease-2019 pandemic.
    Methods and results: To examine the feasibility to conducting exercise testing with an in-line filter, 2 healthy volunteer subjects each completed 2 incremental exercise tests, one with discrete stages of increasing resistance and one with a continuous ramp. Each subject performed 1 test with an electrostatic filter in-line with the system measuring gas exchange and air flow, and 1 test without the filter in place. Oxygen uptake and minute ventilation were highly consistent when evaluated with and without use of an electrostatic filter with a >99.9% viral efficiency.
    Conclusions: Deployment of a commercially available in-line electrostatic viral filter during cardiopulmonary exercise testing is feasible and provides consistent data compared with testing without a filter.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Exercise Test/methods ; Exercise Test/standards ; Feasibility Studies ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Male ; Oxygen Consumption/physiology ; Pandemics ; Pulmonary Gas Exchange/physiology ; Reproducibility of Results ; Respiratory Protective Devices/standards
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2020.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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