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  1. Article ; Online: The magnified view: from ancient trinkets to single nuclear pore complexes.

    Fichtman, Boris / Harel, Amnon

    FEBS letters

    2023  Volume 597, Issue 20, Page(s) 2590–2596

    Abstract: A journey from the earliest known use of lenses and magnifying glasses in ancient times, through the development of microscopes and towards modern electron microscopy techniques. The evolving technology and improved microscopes enabled the discovery of ... ...

    Abstract A journey from the earliest known use of lenses and magnifying glasses in ancient times, through the development of microscopes and towards modern electron microscopy techniques. The evolving technology and improved microscopes enabled the discovery of intracellular organelles, the nucleus and nuclear pore complexes (NPCs). Current advances have led to composite three-dimensional models showing NPC structure in unprecedented detail but relying on the averaging of many images. A complementary approach is field emission scanning electron microscopy providing topographic surface images that are easily and intuitively interpreted by our brain. Recent advances in this technique have made it possible to expose nuclei from human cells and to focus on individual NPCs and their architectural features.
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14746
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 282: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: "Routine trauma"-Awareness of combat trauma in women combatants.

    Daphna-Tekoah, Shir / Harel, Ayelet

    Psychological trauma : theory, research, practice and policy

    2023  

    Abstract: Objective: The current research aims to explore the nature of trauma experienced by female combatants.: Method: Data were collected from two focus groups and a series of personal interviews with 100 women military veterans who had served in the ... ...

    Abstract Objective: The current research aims to explore the nature of trauma experienced by female combatants.
    Method: Data were collected from two focus groups and a series of personal interviews with 100 women military veterans who had served in the Israel Defense Forces as combat or combat-support soldiers.
    Results: Interviews with these veterans revealed a variety of narratives about their war experiences, including an intertwining of the emotional and the physical. The ongoing danger and traumatic events that the combatants and combat-support soldiers faced on a daily basis were woven into their stories. These narratives indicated that-alongside their exposure to traumatic and potentially life-threatening situations-the soldiers also felt empowered and valued as a result of their military service. The women soldiers' perspectives regarding their military service covered three main themes, "experiencing trauma," "meaningful combat experiences," and "the need to be heard."
    Conclusions: Through qualitative research and narrative analysis, this study offers mental health professionals, policy makers, and scholars ways to gain a nuanced insight into women's combat trauma that avoids categorization. Based on the research findings, we suggest that additional aspects of trauma can be understood through the study of women soldiers, who face a "double battle"-combat, with the attendant trauma, and the gendered biases of the masculine military environment. Our findings suggest that there is value in engaging with and listening to diverse narratives of trauma and emphasize the need for a critical perspective in the study of trauma and combat trauma. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0001622
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  3. Article: Utility of Flexion and Extension MRI for Evaluating Isolated Cervical Spinal Cord Lesions: A Case Series.

    Awada, Zeinab / Saba, Sami / Harel, Asaff

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46932

    Abstract: The diagnosis of isolated spinal cord lesions is often challenging in clinical practice, and it is not uncommon for the etiology of such isolated lesions to remain unclear despite extensive workup and investigations. Magnetic resonance imaging (MRI) is ... ...

    Abstract The diagnosis of isolated spinal cord lesions is often challenging in clinical practice, and it is not uncommon for the etiology of such isolated lesions to remain unclear despite extensive workup and investigations. Magnetic resonance imaging (MRI) is extensively utilized for assessing spinal cord disease, despite certain radiological patterns suggesting certain pathologies, diagnostic uncertainty remains. Development of adjunct tests and techniques, radiographic or otherwise, is needed. Here, we present two cases in which flexion-extension cervical spine MRIs improved diagnostic ability by demonstrating dynamic cervical cord compression as an etiology for isolated intramedullary cervical spinal cord lesions.
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46932
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  4. Article ; Online: Editorial: Brain imaging techniques to measure treatment related effect.

    Zahr, Natalie M / Harel, Assaf / Sasson, Efrat

    Frontiers in neuroimaging

    2023  Volume 2, Page(s) 1238295

    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 3123824-5
    ISSN 2813-1193 ; 2813-1193
    ISSN (online) 2813-1193
    ISSN 2813-1193
    DOI 10.3389/fnimg.2023.1238295
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  5. Article ; Online: James Walker Dawson: His fingers and their historical context.

    Huang, Brendan / Raglow-DeFranco, James / Harel, Asaff

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2023  Volume 117, Page(s) 15–19

    Abstract: Multiple Sclerosis (MS) is one of the most prevalent neurologic disorders in the world. James Walker Dawson examined, in considerable depth, the gross and histologic patterns of MS. Today, periventricular plaques that exhibit an appearance typical for ... ...

    Abstract Multiple Sclerosis (MS) is one of the most prevalent neurologic disorders in the world. James Walker Dawson examined, in considerable depth, the gross and histologic patterns of MS. Today, periventricular plaques that exhibit an appearance typical for demyelination are nicknamed "Dawson's Fingers." A literature review was conducted on PubMed and Google Scholar to find articles that chronicle the personal and professional life of James Walker Dawson. Research focused on Dawson's work with disseminated sclerosis, or MS as it is known today. Born in India, Dawson and his family moved to Scotland as a child, and he studied at the Edinburgh Institution. After earning his medical degree, Dawson started his career at the Royal College of Physicians of Edinburgh. While his early career focused on the study of wound healing and inflammation, Dawson transitioned into neurologic research under the guidance of Dr. Alexander Bruce in 1908. Dawson's landmark manuscript, "The Histology of Disseminated Sclerosis," published in 1916, featured findings from extensive research on the pathology of MS in nine patients. His findings earned him recognition as a founder of autoimmune neurology and foremost contributor to the current understanding of MS.
    MeSH term(s) Humans ; Child ; Scotland ; Multiple Sclerosis ; Neurology ; Universities ; Fingers
    Language English
    Publishing date 2023-09-17
    Publishing country Scotland
    Document type Review ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2023.09.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
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  6. Article ; Online: Lingacom muography.

    Harel, A / Yaish, D

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2018  Volume 377, Issue 2137

    Abstract: Lingacom Ltd develops detectors for muography-imaging using cosmic-ray muons-together with imaging algorithms and tools. We present selected simulation results from muon imaging of cargo conta- iners, from a joint muon and X-ray imaging algorithm, and ... ...

    Abstract Lingacom Ltd develops detectors for muography-imaging using cosmic-ray muons-together with imaging algorithms and tools. We present selected simulation results from muon imaging of cargo conta- iners, from a joint muon and X-ray imaging algorithm, and for ground surveys using borehole detectors.This article is part of the Theo Murphy meeting issue 'Cosmic-ray muography'.
    Language English
    Publishing date 2018-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2018.0133
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    In stock of ZB MED Bonn / Germany

    Z 4' 46/25: Show issues
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  7. Book ; Online: Negative SARS-CoV-2 antibody testing following COVID-19 infection in Two MS patients treated with ocrelizumab

    Thornton, JR / Harel, A

    Journal Articles

    2020  

    Keywords Neurology ; covid19
    Publishing date 2020-01-01T08:00:00Z
    Publisher Donald and Barbara Zucker School of Medicine Academic Works
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: What is special about expertise? Visual expertise reveals the interactive nature of real-world object recognition.

    Harel, Assaf

    Neuropsychologia

    2016  Volume 83, Page(s) 88–99

    Abstract: Ever since Diamond and Carey (1986. J. Exp. Psychol.: Gen., vol. 115, pp. 107-117) seminal work, the main model for studying expertise in visual object recognition ("visual expertise") has been face perception. The underlying assumption was that since ... ...

    Abstract Ever since Diamond and Carey (1986. J. Exp. Psychol.: Gen., vol. 115, pp. 107-117) seminal work, the main model for studying expertise in visual object recognition ("visual expertise") has been face perception. The underlying assumption was that since faces may be considered the ultimate domain of visual expertise, any face-processing signature might actually be a general characteristic of visual expertise. However, while humans are clearly experts in face recognition, visual expertise is not restricted to faces and can be observed in a variety of domains. This raises the question of whether face recognition is in fact the right model to study visual expertise, and if not, what are the common cognitive and neural characteristics of visual expertise. The current perspective article addresses this question by revisiting past and recent neuroimaging and behavioural works on visual expertise. The view of visual expertise that emerges from these works is that expertise is a unique phenomenon, with distinctive neural and cognitive characteristics. Specifically, visual expertise is a controlled, interactive process that develops from the reciprocal interactions between the visual system and multiple top-down factors, including semantic knowledge, top-down attentional control, and task relevance. These interactions enable the ability to flexibly access domain-specific information at multiple scales and levels guided by multiple recognition goals. Extensive visual experience with a given object category culminates in the recruitment of these multiple systems, and is reflected in widespread neural activity, extending well beyond visual cortex, to include higher-level cortical areas.
    MeSH term(s) Brain Mapping ; Humans ; Pattern Recognition, Visual/physiology ; Professional Competence ; Recognition (Psychology)/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2015.06.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Glycans as Potential Diagnostic Markers of Traumatic Brain Injury in Children.

    Kvist, Mårten / Välimaa, Lasse / Harel, Adrian / Malmi, Sari / Tuomisto, Aleksi

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: Diagnosing mild traumatic brain injury (TBI) in the acute setting is challenging due to the nonspecific and often transient or delayed symptoms. Further, the criteria for acute head imaging are frequently not fulfilled, which may lead to a missed ... ...

    Abstract Diagnosing mild traumatic brain injury (TBI) in the acute setting is challenging due to the nonspecific and often transient or delayed symptoms. Further, the criteria for acute head imaging are frequently not fulfilled, which may lead to a missed diagnosis. A rapid test to diagnose TBI using body fluids would be highly useful. Urine and saliva samples were collected from 28 pediatric patients (mean [SD] age, eight years two months [four years three months]) with acute, clinically diagnosed mild TBI and 30 healthy volunteers at Satasairaala Hospital, Pori, Finland, over 11 months. The mean (SD) time from trauma to first sampling was 3 h 56 min (1 h 14 min). Samples were analyzed to determine the number of lectin-binding glycan molecules, indicating nerve tissue damage. The relative levels of several lectin-bound glycans were measured by fluorescence. Compared with healthy controls, the TBI group showed significant increases (
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132181
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  10. Article ; Online: Negative SARS-CoV-2 antibody testing following COVID-19 infection in Two MS patients treated with ocrelizumab.

    Thornton, Jeanine Rempe / Harel, Asaff

    Multiple sclerosis and related disorders

    2020  Volume 44, Page(s) 102341

    Abstract: Background: It is unknown whether MS disease modifying therapies impact ability to mount an antibody response to SARS-CoV-2.: Methods: Case series and literature review. We report a series of two MS patients who developed COVID-19 while on ... ...

    Abstract Background: It is unknown whether MS disease modifying therapies impact ability to mount an antibody response to SARS-CoV-2.
    Methods: Case series and literature review. We report a series of two MS patients who developed COVID-19 while on Ocrelizumab therapy and subsequently exhibited negative SARS-CoV-2 serology.
    Results: A 42-year-old man and 39-year-old woman with MS developed COVID-19 while on Ocrelizumab therapy. Neither patient required hospitalization. The man exhibited negative serology at 7- and 9-weeks post-infection. The woman exhibited negative serology at 6- and 12-weeks post-infection.
    Conclusions: Large studies are essential to determine whether certain DMTs may blunt SARS-CoV-2 antibody production.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Serological Testing ; Female ; Humans ; Immunologic Factors/therapeutic use ; Male ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunologic Factors ; ocrelizumab (A10SJL62JY)
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Netherlands
    Document type Case Reports ; Letter ; Review
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2020.102341
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