Article ; Online: Tailoring of Peptide Vesicles: A Bottom-Up Chemical Approach.
2021 Volume 54, Issue 8, Page(s) 1934–1949
Abstract: Spherical ordering from small molecules is a subject of intense interest to chemists. The inherent capability of amphiphiles to assemble spontaneously is the unique feature of the evolutionary process of life. Self-assembly is prevalent in biology and ... ...
| Abstract | Spherical ordering from small molecules is a subject of intense interest to chemists. The inherent capability of amphiphiles to assemble spontaneously is the unique feature of the evolutionary process of life. Self-assembly is prevalent in biology and has attracted the interest of scientists across several disciplines. This is because scientists have realized that nature has extensively used this inherent organizational power contained in the molecules. Judicious use of the self-assembly principle is the cornerstone of nature's exotic assemblies. These exotic assemblies lead to unimaginable functions in biology that might not have been predicted from the monomer building blocks alone. Recently, a number of chemical systems that self-assemble in aqueous or organic solvents to form vesicles were reported. This account provides advances made from our laboratory toward designing and understanding the mechanism of formation of spherical vesicular assembly. A bottom-up approach for the |
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| MeSH term(s) | Dendrimers/chemistry ; Hydrophobic and Hydrophilic Interactions ; Liposomes/chemistry ; Molecular Dynamics Simulation ; Peptides/chemistry ; Polyethylene Glycols/chemistry |
| Chemical Substances | Dendrimers ; Liposomes ; Peptides ; Polyethylene Glycols (3WJQ0SDW1A) |
| Language | English |
| Publishing date | 2021-04-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1483291-4 |
| ISSN | 1520-4898 ; 0001-4842 |
| ISSN (online) | 1520-4898 |
| ISSN | 0001-4842 |
| DOI | 10.1021/acs.accounts.0c00690 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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